List of works - Paul W. Denton

A Novel Toll-Like Receptor 9 Agonist, MGN1703, Enhances HIV-1 Transcription and NK Cell-Mediated Inhibition of HIV-1-Infected Autologous CD4+ T Cells

scientific article published on 17 February 2016

ART influences HIV persistence in the female reproductive tract and cervicovaginal secretions

scientific article published on 8 February 2016

Acute Appendicitis as the Initial Clinical Presentation of Primary HIV-1 Infection

scientific article published on 9 January 2018

Administration of Panobinostat Is Associated with Increased IL-17A mRNA in the Intestinal Epithelium of HIV-1 Patients

scientific article published on December 2015

Administration of broadly neutralizing anti-HIV-1 antibodies at ART initiation maintains long-term CD8+ T cell immunity

scientific article published on 29 October 2022

Antiretroviral pre-exposure prophylaxis prevents vaginal transmission of HIV-1 in humanized BLT mice

scientific article

Broad activation of latent HIV-1 in vivo

scientific article published on 08 September 2016

CD8+ T cells reduce in vitro interferon-gamma production in Theiler's murine encephalomyelitis virus-induced demyelinating disease model

scientific article published in August 2004

Characterization of Intact Proviruses in Blood and Lymph Node from HIV-Infected Individuals Undergoing Analytical Treatment Interruption

article

Combined effect of Vacc-4x, recombinant human granulocyte macrophage colony-stimulating factor vaccination, and romidepsin on the HIV-1 reservoir (REDUC): a single-arm, phase 1B/2A trial

scientific article

Cryptopatches are essential for the development of human GALT.

scientific article published on 20 June 2013

Effects of 24 Week Toll-Like Receptor 9 Agonist Treatment in HIV-1+ Individuals

article

Generation of HIV latency in humanized BLT mice

scientific article published on 19 October 2011

Genetic characterization of the HIV-1 reservoir after Vacc-4x and romidepsin therapy in HIV-1-infected individuals

article

HIV-1 transcriptional activity during frequent longitudinal sampling in aviremic patients on antiretroviral therapy

scientific article

Histone deacetylase inhibitor romidepsin inhibits de novo HIV-1 infections.

scientific article published on 20 April 2015

Human breast milk and antiretrovirals dramatically reduce oral HIV-1 transmission in BLT humanized mice

scientific article published in 2012

Humanized mice mount specific adaptive and innate immune responses to EBV and TSST-1.

scientific article published on 22 October 2006

Hypogammaglobulinemia in BLT humanized mice--an animal model of primary antibody deficiency.

scientific article

Immune checkpoints and the HIV-1 reservoir: proceed with caution

scientific article published on July 2016

Immune reconstitution of the female reproductive tract of humanized BLT mice and their susceptibility to human immunodeficiency virus infection

scientific article

Impacts of HIV Cure Interventions on Viral Reservoirs in Tissues

scientific article published on 21 August 2019

In vivo analysis of highly conserved Nef activities in HIV-1 replication and pathogenesis

scientific article published on 30 October 2013

Inhibition of lysosome and proteasome function enhances human immunodeficiency virus type 1 infection

scientific article

Interferon priming is essential for human CD34+ cell-derived plasmacytoid dendritic cell maturation and function

scientific article published in Nature Communications

Intrarectal transmission, systemic infection, and CD4+ T cell depletion in humanized mice infected with HIV-1

scientific article

Mucosal HIV-1 transmission and prevention strategies in BLT humanized mice

scientific article published on 12 April 2012

Nef functions in BLT mice to enhance HIV-1 replication and deplete CD4+CD8+ thymocytes.

scientific article

Non-covalent hitchhiking on endogenous carriers as a protraction mechanism for antiviral macromolecular prodrugs

scientific article published on 12 December 2018

Novel humanized murine models for HIV research

scientific article published on February 2009

One percent tenofovir applied topically to humanized BLT mice and used according to the CAPRISA 004 experimental design demonstrates partial protection from vaginal HIV infection, validating the BLT model for evaluation of new microbicide candidates

scientific article

Predicting HIV Pre-exposure Prophylaxis Efficacy for Women using a Preclinical Pharmacokinetic-Pharmacodynamic In Vivo Model

scientific article published on February 2017

Predictive value of galectin-1 in the development and progression of HIV-associated lymphoma

scientific article published on October 2017

Rectal transmission of transmitted/founder HIV-1 is efficiently prevented by topical 1% tenofovir in BLT humanized mice

scientific article

Short-Course Toll-Like Receptor 9 Agonist Treatment Impacts Innate Immunity and Plasma Viremia in Individuals With Human Immunodeficiency Virus Infection

scientific article published on 9 March 2017

Susceptibility to Theiler's murine encephalomyelitis virus-induced demyelinating disease in BALB/cAnNCr mice is related to absence of a CD4+ T-cell subset

scientific article published in December 2002

Systemic administration of antiretrovirals prior to exposure prevents rectal and intravenous HIV-1 transmission in humanized BLT mice

scientific article

TLR9 agonist MGN1703 enhances B cell differentiation and function in lymph nodes

scientific article published on 09 July 2019

Targeted cytotoxic therapy kills persisting HIV infected cells during ART

scientific article (publication date: 2014)

The Depsipeptide Romidepsin Reverses HIV-1 Latency In Vivo

scientific article published on 17 September 2015

The TLR9 agonist MGN1703 triggers a potent type I interferon response in the sigmoid colon.

scientific article published on 2 August 2017

The role of miR-29a in HIV-1 replication and latency

scientific article

Treatment of HIV-Infected Individuals with the Histone Deacetylase Inhibitor Panobinostat Results in Increased Numbers of Regulatory T Cells and Limits Ex Vivo Lipopolysaccharide-Induced Inflammatory Responses

scientific article published in January 2018

Using animal models to overcome temporal, spatial and combinatorial challenges in HIV persistence research

scientific article

cAIMP administration in humanized mice induces a chimerization‐level‐dependent STING response

scientific article published on 06 May 2019

List of works by Paul W. Denton

A Novel Toll-Like Receptor 9 Agonist, MGN1703, Enhances HIV-1 Transcription and NK Cell-Mediated Inhibition of HIV-1-Infected Autologous CD4+ T Cells

ART influences HIV persistence in the female reproductive tract and cervicovaginal secretions

Acute Appendicitis as the Initial Clinical Presentation of Primary HIV-1 Infection

Administration of Panobinostat Is Associated with Increased IL-17A mRNA in the Intestinal Epithelium of HIV-1 Patients

Administration of broadly neutralizing anti-HIV-1 antibodies at ART initiation maintains long-term CD8+ T cell immunity

Antiretroviral pre-exposure prophylaxis prevents vaginal transmission of HIV-1 in humanized BLT mice

Broad activation of latent HIV-1 in vivo

CD8+ T cells reduce in vitro interferon-gamma production in Theiler's murine encephalomyelitis virus-induced demyelinating disease model

Characterization of Intact Proviruses in Blood and Lymph Node from HIV-Infected Individuals Undergoing Analytical Treatment Interruption

Combined effect of Vacc-4x, recombinant human granulocyte macrophage colony-stimulating factor vaccination, and romidepsin on the HIV-1 reservoir (REDUC): a single-arm, phase 1B/2A trial

Cryptopatches are essential for the development of human GALT.

Effects of 24 Week Toll-Like Receptor 9 Agonist Treatment in HIV-1+ Individuals

Generation of HIV latency in humanized BLT mice

Genetic characterization of the HIV-1 reservoir after Vacc-4x and romidepsin therapy in HIV-1-infected individuals

HIV-1 transcriptional activity during frequent longitudinal sampling in aviremic patients on antiretroviral therapy

Histone deacetylase inhibitor romidepsin inhibits de novo HIV-1 infections.

Human breast milk and antiretrovirals dramatically reduce oral HIV-1 transmission in BLT humanized mice

Humanized mice mount specific adaptive and innate immune responses to EBV and TSST-1.

Hypogammaglobulinemia in BLT humanized mice--an animal model of primary antibody deficiency.

Immune checkpoints and the HIV-1 reservoir: proceed with caution

Immune reconstitution of the female reproductive tract of humanized BLT mice and their susceptibility to human immunodeficiency virus infection

Impacts of HIV Cure Interventions on Viral Reservoirs in Tissues

In vivo analysis of highly conserved Nef activities in HIV-1 replication and pathogenesis

Inhibition of lysosome and proteasome function enhances human immunodeficiency virus type 1 infection

Interferon priming is essential for human CD34+ cell-derived plasmacytoid dendritic cell maturation and function

Intrarectal transmission, systemic infection, and CD4+ T cell depletion in humanized mice infected with HIV-1

Mucosal HIV-1 transmission and prevention strategies in BLT humanized mice

Nef functions in BLT mice to enhance HIV-1 replication and deplete CD4+CD8+ thymocytes.

Non-covalent hitchhiking on endogenous carriers as a protraction mechanism for antiviral macromolecular prodrugs

Novel humanized murine models for HIV research

One percent tenofovir applied topically to humanized BLT mice and used according to the CAPRISA 004 experimental design demonstrates partial protection from vaginal HIV infection, validating the BLT model for evaluation of new microbicide candidates

Predicting HIV Pre-exposure Prophylaxis Efficacy for Women using a Preclinical Pharmacokinetic-Pharmacodynamic In Vivo Model

Predictive value of galectin-1 in the development and progression of HIV-associated lymphoma

Rectal transmission of transmitted/founder HIV-1 is efficiently prevented by topical 1% tenofovir in BLT humanized mice

Short-Course Toll-Like Receptor 9 Agonist Treatment Impacts Innate Immunity and Plasma Viremia in Individuals With Human Immunodeficiency Virus Infection

Susceptibility to Theiler's murine encephalomyelitis virus-induced demyelinating disease in BALB/cAnNCr mice is related to absence of a CD4+ T-cell subset

Systemic administration of antiretrovirals prior to exposure prevents rectal and intravenous HIV-1 transmission in humanized BLT mice

TLR9 agonist MGN1703 enhances B cell differentiation and function in lymph nodes

Targeted cytotoxic therapy kills persisting HIV infected cells during ART

The Depsipeptide Romidepsin Reverses HIV-1 Latency In Vivo

The TLR9 agonist MGN1703 triggers a potent type I interferon response in the sigmoid colon.

The role of miR-29a in HIV-1 replication and latency

Treatment of HIV-Infected Individuals with the Histone Deacetylase Inhibitor Panobinostat Results in Increased Numbers of Regulatory T Cells and Limits Ex Vivo Lipopolysaccharide-Induced Inflammatory Responses

Using animal models to overcome temporal, spatial and combinatorial challenges in HIV persistence research

cAIMP administration in humanized mice induces a chimerization‐level‐dependent STING response