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List of works by Stevan R Hubbard

A DNA sequence recognition loop on APOBEC3A controls substrate specificity

scientific article (publication date: 2014)

ATP binding to the pseudokinase domain of JAK2 is critical for pathogenic activation

scientific article

Agrin / MuSK signaling: willing and Abl

scientific article published on 01 July 2003

Agrin Binds to the N-terminal Region of Lrp4 Protein and Stimulates Association between Lrp4 and the First Immunoglobulin-like Domain in Muscle-specific Kinase (MuSK) ⬇️

scientific article published on October 3, 2011

Alternative splicing, gene localization, and binding of SH2-B to the insulin receptor kinase domain.

scientific article

Bisubstrate analog probes for the insulin receptor protein tyrosine kinase: molecular yardsticks for analyzing catalytic mechanism and inhibitor design

scientific article published on 19 April 2005

Closing in on a mechanism for activation

scientific article published on 28 October 2014

Crystal structure of a complex between protein tyrosine phosphatase 1B and the insulin receptor tyrosine kinase

scientific article

Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain.

scientific article

Crystal structure of the C-terminal four-helix bundle of the potassium channel KCa3.1.

scientific article published on 28 June 2018

Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog ⬇️

scientific article published on September 15, 1997

Crystal structure of the agrin-responsive immunoglobulin-like domains 1 and 2 of the receptor tyrosine kinase MuSK

scientific journal article

Crystal structure of the human laminin receptor precursor

scientific article

Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F

scientific article

Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity

scientific article

Cytokine Signaling Exposed

scientific article published on 01 January 2011

EGF Receptor Activation: Push Comes to Shove

scientific article published on 01 June 2006

EGF receptor inhibition: Attacks on multiple fronts

scientific article published on 01 April 2005

Histidine phosphorylation relieves copper inhibition in the mammalian potassium channel KCa3.1.

scientific article published on 19 August 2016

How IRE1 reacts to ER stress

scientific article published on January 2008

IRAK4 activation: a cautious embrace.

scientific article published in September 2014

Identification of substituted 3-[(4,5,6, 7-tetrahydro-1H-indol-2-yl)methylene]-1,3-dihydroindol-2-ones as growth factor receptor inhibitors for VEGF-R2 (Flk-1/KDR), FGF-R1, and PDGF-Rbeta tyrosine kinases

scientific article published on July 2000

Insulin receptor Thr1160 phosphorylation mediates lipid-induced hepatic insulin resistance

scientific article

Janus kinase 2 activation mechanisms revealed by analysis of suppressing mutations

scientific article published on 06 August 2018

Juxtamembrane autoinhibition in receptor tyrosine kinases.

scientific article published on June 2004

KRAS4A directly regulates hexokinase 1

scientific article published on 11 December 2019

Lrp4 is a receptor for Agrin and forms a complex with MuSK

scientific journal article

Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations

scientific article published on 07 February 2020

Mechanism-based design of a protein kinase inhibitor

scientific article

Mechanistic Insights into Regulation of JAK2 Tyrosine Kinase

scientific article

Molecular analysis of the prokaryotic ubiquitin-like protein (Pup) conjugation pathway in Mycobacterium tuberculosis

scientific journal article

Molecular basis for pseudokinase-dependent autoinhibition of JAK2 tyrosine kinase

scientific article

Molecular insights into regulation of JAK2 in myeloproliferative neoplasms

scientific article published on 30 March 2015

New insights into the structure and function of the pseudokinase domain in JAK2.

scientific article published on August 2013

Oncogenic mutations in B-Raf: some losses yield gains.

scientific article published on March 2004

Probing the catalytic mechanism of the insulin receptor kinase with a tetrafluorotyrosine-containing peptide substrate

scientific article published in September 2000

Protein tyrosine kinase structure and function

scientific article (publication date: 2000)

Rap1-interacting adapter molecule (RIAM) associates with the plasma membrane via a proximity detector

scientific article

SU6668 is a potent antiangiogenic and antitumor agent that induces regression of established tumors.

scientific article published on August 2000

Small-molecule inhibition and activation-loop trans-phosphorylation of the IGF1 receptor

scientific article

Structural Basis for the Interaction of the Adaptor Protein Grb14 with Activated Ras ⬇️

scientific article published on August 13, 2013

Structural and biochemical evidence for an autoinhibitory role for tyrosine 984 in the juxtamembrane region of the insulin receptor

scientific article (publication date: 11 July 2003)

Structural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14

scientific article

Structural basis for phosphotyrosine recognition by suppressor of cytokine signaling-3

scientific journal article

Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor

scientific article

Structural biology: Insulin meets its receptor

scientific article

Structural characterization of a novel Cbl phosphotyrosine recognition motif in the APS family of adapter proteins

scientific article

Structure and activation of MuSK, a receptor tyrosine kinase central to neuromuscular junction formation

scientific article published on 05 March 2013

Structure and autoregulation of the insulin-like growth factor 1 receptor kinase

scientific article

Structure-Guided Identification of a Laminin Binding Site on the Laminin Receptor Precursor ⬇️

scientific article published on October 30, 2010

Targeting the Inactive Conformation of JAK2 in Hematological Malignancies.

scientific article

The BPS domain of Grb10 inhibits the catalytic activity of the insulin and IGF1 receptors

scientific article published in March 2001

The cytoplasmic adaptor protein Dok7 activates the receptor tyrosine kinase MuSK via dimerization

scientific article

The insulin and IGF1 receptor kinase domains are functional dimers in the activated state.

scientific article published on 11 March 2015

The insulin receptor: both a prototypical and atypical receptor tyrosine kinase.

scientific article published on March 2013

The juxtamembrane region of EGFR takes center stage.

scientific article published in June 2009

The pseudokinase domain of JAK2 is a dual-specificity protein kinase that negatively regulates cytokine signaling ⬇️

scientific article published on August 14, 2011

Theme and variations: juxtamembrane regulation of receptor protein kinases

scientific article

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