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List of works by Iain G. Johnston

A novel quantitative assay of mitophagy: Combining high content fluorescence microscopy and mitochondrial DNA load to quantify mitophagy and identify novel pharmacological tools against pathogenic heteroplasmic mtDNA.

scientific article published on 18 July 2015

A tractable genotype-phenotype map modelling the self-assembly of protein quaternary structure.

scientific article published on 9 April 2014

Cell identity and nucleo-mitochondrial genetic context modulate OXPHOS performance and determine somatic heteroplasmy dynamics

scientific article published on 29 July 2020

Closed-form stochastic solutions for non-equilibrium dynamics and inheritance of cellular components over many cell divisions ⬇️

scientific article

Efficient parametric inference for stochastic biological systems with measured variability

scientific article published in June 2014

Energetic costs of cellular and therapeutic control of stochastic mitochondrial DNA populations

scientific article published on 26 June 2019

Epistasis can lead to fragmented neutral spaces and contingency in evolution.

scientific article published on 7 December 2011

Evolution of Cell-to-Cell Variability in Stochastic, Controlled, Heteroplasmic mtDNA Populations

scientific article published on 27 October 2016

Evolutionary Inference across Eukaryotes Identifies Specific Pressures Favoring Mitochondrial Gene Retention

scientific article

Evolutionary dynamics in a simple model of self-assembly.

scientific article published on 13 June 2011

Evolving mtDNA populations within cells

scientific article published on 01 October 2019

Explicit tracking of uncertainty increases the power of quantitative rule-of-thumb reasoning in cell biology ⬇️

scientific article published on 2 December 2014

FRIENDLY regulates mitochondrial distribution, fusion, and quality control in Arabidopsis

scientific article

Forecasted trends in vaccination coverage and correlations with socioeconomic factors: a global time-series analysis over 30 years

scientific article published on 25 August 2016

Global Topological Order Emerges through Local Mechanical Control of Cell Divisions in the Arabidopsis Shoot Apical Meristem

scientific article published on 16 January 2019

HyperTraPS: Inferring Probabilistic Patterns of Trait Acquisition in Evolutionary and Disease Progression Pathways

scientific article published on 27 November 2019

Identification of a bet-hedging network motif generating noise in hormone concentrations and germination propensity in Arabidopsis.

scientific article published in April 2018

Intracellular Energy Variability Modulates Cellular Decision-Making Capacity

scientific article published on 27 December 2019

Large-scale genetic analysis reveals mammalian mtDNA heteroplasmy dynamics and variance increase through lifetimes and generations.

scientific article published on 27 June 2018

Mitochondrial DNA density homeostasis accounts for a threshold effect in a cybrid model of a human mitochondrial disease

scientific article published on 27 October 2017

Mitochondrial DNA disease and developmental implications for reproductive strategies

scientific article

Mitochondrial Heterogeneity

scientific article published on 01 January 2018

Mitochondrial Network State Scales mtDNA Genetic Dynamics

scientific article published on 28 June 2019

Mitochondrial heterogeneity, metabolic scaling and cell death.

scientific article published on 08 June 2017

Mitochondrial variability as a source of extrinsic cellular noise

scientific article

Model selection and parameter estimation for root architecture models using likelihood-free inference

scientific article published on 10 July 2019

Modelling the self-assembly of virus capsids.

scientific article published on 23 February 2010

Modulating mitochondrial quality in disease transmission: towards enabling mitochondrial DNA disease carriers to have healthy children

scientific article

Monitoring Intracellular Oxygen Concentration: Implications for Hypoxia Studies and Real-Time Oxygen Monitoring.

scientific article published on January 2016

MtDNA segregation in heteroplasmic tissues is common in vivo and modulated by haplotype differences and developmental stage

scientific article

Multiple hypothesis correction is vital and undermines reported mtDNA links to diseases including AIDS, cancer, and Huntingdon's

scientific article

Phenotypic landscape inference reveals multiple evolutionary paths to C4 photosynthesis ⬇️

scientific article published in 2013

Precision identification of high-risk phenotypes and progression pathways in severe malaria without requiring longitudinal data

scientific article published on 10 July 2019

Pulsing of membrane potential in individual mitochondria: a stress-induced mechanism to regulate respiratory bioenergetics in Arabidopsis

scientific article

Regulation of Mother-to-Offspring Transmission of mtDNA Heteroplasmy

scientific article published on 03 October 2019

Self-assembly, modularity, and physical complexity

scientific article published on 27 August 2010

Stochastic modelling, Bayesian inference, and new in vivo measurements elucidate the debated mtDNA bottleneck mechanism. ⬇️

scientific article

Stochastic organelle genome segregation through <i>Arabidopsis</i> development and reproduction

Temperature variability is integrated by a spatially embedded decision-making center to break dormancy in Arabidopsis seeds.

scientific article

Tension and Resolution: Dynamic, Evolving Populations of Organelle Genomes within Plant Cells

scientific article published on 13 November 2018

The 'mitoflash' probe cpYFP does not respond to superoxide

scientific article published in October 2014

The Essential Genome of Escherichia coli K-12.

scientific article published on 20 February 2018

The State of Vaccine Confidence 2016: Global Insights Through a 67-Country Survey

scientific article

The chaos within: Exploring noise in cellular biology

The effect of scale-free topology on the robustness and evolvability of genetic regulatory networks

scientific article published on 07 August 2010

The self-assembly of DNA Holliday junctions studied with a minimal model

scientific article published on 01 February 2009

Toward Precision Healthcare: Context and Mathematical Challenges

scientific article published on 21 March 2017

Variability in seeds: biological, ecological, and agricultural implications.

scientific article

Varied Mechanisms and Models for the Varying Mitochondrial Bottleneck

scientific article published on 20 November 2019

What is the function of mitochondrial networks? A theoretical assessment of hypotheses and proposal for future research

scientific article

mtDNA diversity in human populations highlights the merit of haplotype matching in gene therapies

scientific article published on 8 September 2016

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