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List of works by Frank N van Leeuwen

A First Step toward Personalized Medicine in Osteosarcoma: Pharmacogenetics as Predictive Marker of Outcome after Chemotherapy-Based Treatment

scientific article published on 31 March 2015

A germ line mutation in cathepsin B points toward a role in asparaginase pharmacokinetics

scientific article published on 01 November 2014

Activation of TRPM7 channels by phospholipase C-coupled receptor agonists

scientific article published on 9 November 2006

B-lineage transcription factors and cooperating gene lesions required for leukemia development

scientific article published on 10 October 2012

BTG1 regulates glucocorticoid receptor autoinduction in acute lymphoblastic leukemia

scientific article published on 30 March 2010

Biological activity of soluble wingless protein in cultured Drosophila imaginal disc cells

scientific article published on March 1994

Clinical outcomes after zotarolimus and everolimus drug eluting stent implantation in coronary artery bifurcation lesions: insights from the RESOLUTE All Comers Trial

article

Comparison of zotarolimus-eluting and everolimus-eluting coronary stents

scientific article published on 16 June 2010

Cytoskeletal restraints regulate homotypic ALCAM-mediated adhesion through PKCalpha independently of Rho-like GTPases

scientific article

DNA copy number alterations mark disease progression in paediatric chronic myeloid leukaemia

scientific article published on 27 March 2014

Diffusion-driven device for a high-resolution dose-response profiling of combination chemotherapy.

scientific article published in July 2009

Distinct kinetic and mechanical properties govern ALCAM-mediated interactions as shown by single-molecule force spectroscopy

scientific article published on 30 October 2007

Expression of Tiam-1 in the developing brain suggests a role for the Tiam-1-Rac signaling pathway in cell migration and neurite outgrowth.

scientific article published in January 1997

Geometry sensing by dendritic cells dictates spatial organization and PGE(2)-induced dissolution of podosomes

scientific article published on 28 December 2011

High-resolution genomic profiling of childhood ALL reveals novel recurrent genetic lesions affecting pathways involved in lymphocyte differentiation and cell cycle progression

scientific article published on 19 April 2007

Human and murine model cell lines for dendritic cell biology evaluated

scientific article published on 11 March 2008

Impact of body mass index on long-term clinical outcomes after second-generation drug eluting stent implantation: Insights from the international global RESOLUTE program

scientific article published on 17 February 2015

Impact of overlapping newer generation drug-eluting stents on clinical and angiographic outcomes: pooled analysis of five trials from the international Global RESOLUTE Program

scientific article published on 6 March 2013

Influence of genetic variants in TPMT and COMT associated with cisplatin induced hearing loss in patients with cancer: two new cohorts and a meta-analysis reveal significant heterogeneity between cohorts.

scientific article

Integrated use of minimal residual disease classification and IKZF1 alteration status accurately predicts 79% of relapses in pediatric acute lymphoblastic leukemia

scientific article

Kinase activity profiling reveals active signal transduction pathways in pediatric acute lymphoblastic leukemia: a new approach for target discovery.

scientific article published on 21 January 2015

Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.

scientific article

Long-term engagement of CD6 and ALCAM is essential for T-cell proliferation induced by dendritic cells

scientific article

Massive autophosphorylation of the Ser/Thr-rich domain controls protein kinase activity of TRPM6 and TRPM7.

scientific article

Mechanoregulation of cytoskeletal dynamics by TRP channels

scientific article published on 21 June 2012

Microdomains of the C-type lectin DC-SIGN are portals for virus entry into dendritic cells

scientific article

Myosin II and mechanotransduction: a balancing act.

scientific article published on 21 February 2007

Oncogene activation and oncogene cooperation in MMTV-induced mouse mammary cancer

scientific article published on June 1995

Organization of the integrin LFA-1 in nanoclusters regulates its activity

scientific article

PGE2-mediated podosome loss in dendritic cells is dependent on actomyosin contraction downstream of the RhoA-Rho-kinase axis

scientific article published on 11 March 2008

Rac activation by lysophosphatidic acid LPA1 receptors through the guanine nucleotide exchange factor Tiam1

scientific article (publication date: 3 January 2003)

Rac regulates phosphorylation of the myosin-II heavy chain, actinomyosin disassembly and cell spreading

scientific article

Regulation of MYCN expression in human neuroblastoma cells.

scientific article published on 18 July 2009

Revertant somatic mosaicism by mitotic recombination in dyskeratosis congenita.

scientific article

TLR4-mediated podosome loss discriminates gram-negative from gram-positive bacteria in their capacity to induce dendritic cell migration and maturation

scientific article published on 28 December 2009

TRPM7 is required for breast tumor cell metastasis

scientific article

TRPM7 regulates myosin IIA filament stability and protein localization by heavy chain phosphorylation

scientific article

TRPM7 triggers Ca2+ sparks and invadosome formation in neuroblastoma cells

scientific article published on 16 October 2013

TRPM7, a novel regulator of actomyosin contractility and cell adhesion

scientific article

Targeted Deletion of Btg1 and Btg2 Results in Homeotic Transformation of the Axial Skeleton

scientific article published on 28 July 2015

Targeting of Tiam1 to the plasma membrane requires the cooperative function of the N-terminal pleckstrin homology domain and an adjacent protein interaction domain

scientific article published on November 1997

The Origin and Nature of Tightly Clustered BTG1 Deletions in Precursor B-Cell Acute Lymphoblastic Leukemia Support a Model of Multiclonal Evolution ⬇️

scientific article published on February 16, 2012

The alpha-kinase family: an exceptional branch on the protein kinase tree.

scientific article published on 12 December 2009

The alpha-kinases TRPM6 and TRPM7, but not eEF-2 kinase, phosphorylate the assembly domain of myosin IIA, IIB and IIC.

scientific article

The dishevelled protein is modified by wingless signaling in Drosophila

scientific journal article

Tumor suppressors BTG1 and BTG2: Beyond growth control

scientific article published on 23 October 2018

Vascular Smooth Muscle Cell Differentiation to an Osteogenic Phenotype Involves TRPM7 Modulation by Magnesium

scientific article published on 09 August 2010

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