List of works - Francis A. Barr

A GRASP55-rab2 effector complex linking Golgi structure to membrane traffic

scientific article

A GTPase-activating protein controls Rab5 function in endocytic trafficking

scientific article published on 07 August 2005

A PP2A-B55 recognition signal controls substrate dephosphorylation kinetics during mitotic exit.

scientific article published on 22 August 2016

A role for ADP-ribosylation factor 1, but not COP I, in secretory vesicle biogenesis from the trans-Golgi network

scientific article published on 01 April 1996

A signal capture and proofreading mechanism for the KDEL-receptor explains selectivity and dynamic range in ER retrieval

Alpine pathways of membrane traffic

scientific article published on 21 May 2004

Analysis of GTPase-activating proteins: Rab1 and Rab43 are key Rabs required to maintain a functional Golgi complex in human cells

scientific article

Analysis of Rab GTPase and GTPase-activating protein function at primary cilia

scientific article

Analysis of rab GTPases.

scientific article published in December 2012

Arfophilins are dual Arf/Rab 11 binding proteins that regulate recycling endosome distribution and are related to Drosophila nuclear fallout

scientific article published on 17 April 2003

Assay and functional properties of Rabkinesin-6/Rab6-KIFL/MKlp2 in cytokinesis

scientific article published on January 2005

Assay and properties of rab6 interaction with dynein-dynactin complexes

scientific article

Aurora A promotes chromosome congression by activating the condensin-dependent pool of KIF4A

scientific article published on 01 February 2019

Aurora B suppresses microtubule dynamics and limits central spindle size by locally activating KIF4A

scientific article published on 12 August 2013

BLOC-3 mutated in Hermansky-Pudlak syndrome is a Rab32/38 guanine nucleotide exchange factor

scientific journal article

Biophysical Analysis of the Interaction of Rab6a GTPase with Its Effector Domains

scientific article published in Journal of Biological Chemistry

CDK1-CCNB1 creates a spindle checkpoint-permissive state by enabling MPS1 kinetochore localization

scientific article published on 23 January 2019

COP sets TRAPP for vesicles

scientific article published on 01 March 2007

CYK4 inhibits Rac1-dependent PAK1 and ARHGEF7 effector pathways during cytokinesis ⬇️

scientific article published on September 3, 2012

Cell organelles

scientific article published on 26 June 2013

Checkpoint signaling and error correction require regulation of the MPS1 T-loop by PP2A-B56

scientific article published on 11 September 2019

Choice of Plk1 docking partners during mitosis and cytokinesis is controlled by the activation state of Cdk1

scientific article

Compound heterozygous loss-of-function mutations in KIF20A are associated with a novel lethal congenital cardiomyopathy in two siblings.

scientific article published on 22 January 2018

Convergence of cell cycle regulation and growth factor signals on GRASP65

scientific article (publication date: 17 June 2005)

Crystal structure of folliculin reveals a hidDENN function in genetically inherited renal cancer ⬇️

scientific article published on August 1, 2012

Cytokinesis: placing and making the final cut.

scientific article

Dynamics of Golgi matrix proteins after the blockage of ER to Golgi transport.

scientific article published in February 2004

Formation of secretory vesicles in the biosynthetic pathway

scientific article published on August 1997

GORAB Missense Mutations Disrupt RAB6 and ARF5 Binding and Golgi Targeting

scientific article published on 22 May 2015

GRASP55, a second mammalian GRASP protein involved in the stacking of Golgi cisternae in a cell-free system.

scientific article

GRASP65, a Protein Involved in the Stacking of Golgi Cisternae ⬇️

scientific article published on October 17, 1997

Gerodermia osteodysplastica is caused by mutations in SCYL1BP1, a Rab-6 interacting golgin

scientific article

Getting out of mitosis: spatial and temporal control of mitotic exit and cytokinesis by PP1 and PP2A

scientific article published on 18 September 2019

Golgi inheritance: shaken but not stirred

scientific article published on March 2004

Golgi positioning: are we looking at the right MAP?

scientific article

Golgins and GTPases, giving identity and structure to the Golgi apparatus

scientific article

I-proteins - a proposed switch in myotubularin function

scientific article published in February 2004

ICA69 is a novel Rab2 effector regulating ER-Golgi trafficking in insulinoma cells

scientific article published on 9 January 2008

Insights regarding guanine nucleotide exchange from the structure of a DENN-domain protein complexed with its Rab GTPase substrate

scientific article

Joining tethers and SNAREs

scientific article published on 01 October 2000

KIF14 and citron kinase act together to promote efficient cytokinesis

scientific article

KIF4A and PP2A-B56 form a spatially restricted feedback loop opposing Aurora B at the anaphase central spindle

scientific article

Loss-of-Function Mutations in RAB18 Cause Warburg Micro Syndrome.

scientific article published in May 2011

Loss-of-function mutations in RAB18 cause Warburg micro syndrome.

scientific article

Loss-of-function mutations in TBC1D20 cause cataracts and male infertility in blind sterile mice and Warburg micro syndrome in humans

scientific article

MAD1-dependent recruitment of CDK1-CCNB1 to kinetochores promotes spindle checkpoint signaling

scientific article published on 23 January 2019

Mapping the interaction between GRASP65 and GM130, components of a protein complex involved in the stacking of Golgi cisternae ⬇️

scientific article published on June 15, 1998

Melanoma-associated mutations in protein phosphatase 6 cause chromosome instability and DNA damage owing to dysregulated Aurora-A.

scientific article published on 31 May 2013

Membrane traffic: Golgi stumbles over cilia

scientific article published in March 2009

Membrane traffic: do cones mark sites of fission?

scientific article

Membrane traffic: exocyst III--makes a family

scientific article published on 01 January 2002

Mitogen-inducible gene 6 is an endogenous inhibitor of HGF/Met-induced cell migration and neurite growth

scientific article published on October 2005

Molecular basis for KDEL-mediated retrieval of escaped ER-resident proteins - SWEET talking the COPs

scientific article published on 09 October 2020

Multiple Rab GTPase binding sites in GCC185 suggest a model for vesicle tethering at the trans-Golgi.

scientific article published on 22 October 2008

Phosphatidylinositol-5-phosphate activation and conserved substrate specificity of the myotubularin phosphatidylinositol 3-phosphatases

scientific article

Phosphorylation of Nlp by Plk1 negatively regulates its dynein-dynactin-dependent targeting to the centrosome

scientific article

Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis

scientific article

Plk1 docking to GRASP65 phosphorylated by Cdk1 suggests a mechanism for Golgi checkpoint signalling.

scientific article published on 27 January 2005

Plk1 negatively regulates Cep55 recruitment to the midbody to ensure orderly abscission

scientific article

Polo-like kinases and the orchestration of cell division

scientific article (publication date: June 2004)

Protein phosphatases and the regulation of mitosis.

scientific article published in July 2011

Purification and functional interactions of GRASP55 with Rab2

scientific article published on 01 January 2005

RUTBC1 protein, a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins

scientific article

RUTBC2 protein, a Rab9A effector and GTPase-activating protein for Rab36

scientific journal article

Rab GEFs and GAPs

scientific article published on 11 May 2010

Rab GTPase function in Golgi trafficking

scientific article published on September 2009

Rab regulation by GEFs and GAPs during membrane traffic

scientific article published on 10 April 2019

Rab14 and its exchange factor FAM116 link endocytic recycling and adherens junction stability in migrating cells

scientific article

Rab18 and a Rab18 GEF complex are required for normal ER structure

scientific article

Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C.

scientific article

Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2

scientific article

Review series: Rab GTPases and membrane identity: causal or inconsequential?

scientific article published on July 2013

Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways

scientific article

Structural basis for pH-dependent retrieval of ER proteins from the Golgi by the KDEL receptor

scientific article

TBC1D14 regulates autophagosome formation via Rab11- and ULK1-positive recycling endosomes

scientific article

The BEG (PP2A-B55/ENSA/Greatwall) pathway ensures cytokinesis follows chromosome separation

scientific article published on 10 October 2013

The Golgi apparatus.

scientific article

The Golgi apparatus: going round in circles?

scientific article published on 01 March 2002

The Mon1-Ccz1 GEF activates the Rab7 GTPase Ypt7 via a longin-fold-Rab interface and association with PI3P-positive membranes

scientific article

The Msb3/Gyp3 GAP controls the activity of the Rab GTPases Vps21 and Ypt7 at endosomes and vacuoles

scientific article

The Rab6 GTPase regulates recruitment of the dynactin complex to Golgi membranes

scientific article (publication date: 15 October 2002)

The astrin-kinastrin/SKAP complex localizes to microtubule plus ends and facilitates chromosome alignment

scientific article

The yeast orthologue of GRASP65 forms a complex with a coiled-coil protein that contributes to ER to Golgi traffic

scientific article

Trimeric G proteins and vesicle formation

scientific article published on 01 April 1992

Use of the novel Plk1 inhibitor ZK-thiazolidinone to elucidate functions of Plk1 in early and late stages of mitosis

scientific article

YSK1 is activated by the Golgi matrix protein GM130 and plays a role in cell migration through its substrate 14-3-3zeta

scientific article

List of works by Francis A. Barr

A GRASP55-rab2 effector complex linking Golgi structure to membrane traffic

A GTPase-activating protein controls Rab5 function in endocytic trafficking

A PP2A-B55 recognition signal controls substrate dephosphorylation kinetics during mitotic exit.

A role for ADP-ribosylation factor 1, but not COP I, in secretory vesicle biogenesis from the trans-Golgi network

A signal capture and proofreading mechanism for the KDEL-receptor explains selectivity and dynamic range in ER retrieval

Alpine pathways of membrane traffic

Analysis of GTPase-activating proteins: Rab1 and Rab43 are key Rabs required to maintain a functional Golgi complex in human cells

Analysis of Rab GTPase and GTPase-activating protein function at primary cilia

Analysis of rab GTPases.

Arfophilins are dual Arf/Rab 11 binding proteins that regulate recycling endosome distribution and are related to Drosophila nuclear fallout

Assay and functional properties of Rabkinesin-6/Rab6-KIFL/MKlp2 in cytokinesis

Assay and properties of rab6 interaction with dynein-dynactin complexes

Aurora A promotes chromosome congression by activating the condensin-dependent pool of KIF4A

Aurora B suppresses microtubule dynamics and limits central spindle size by locally activating KIF4A

BLOC-3 mutated in Hermansky-Pudlak syndrome is a Rab32/38 guanine nucleotide exchange factor

Biophysical Analysis of the Interaction of Rab6a GTPase with Its Effector Domains

CDK1-CCNB1 creates a spindle checkpoint-permissive state by enabling MPS1 kinetochore localization

COP sets TRAPP for vesicles

CYK4 inhibits Rac1-dependent PAK1 and ARHGEF7 effector pathways during cytokinesis ⬇️

Cell organelles

Checkpoint signaling and error correction require regulation of the MPS1 T-loop by PP2A-B56

Choice of Plk1 docking partners during mitosis and cytokinesis is controlled by the activation state of Cdk1

Compound heterozygous loss-of-function mutations in KIF20A are associated with a novel lethal congenital cardiomyopathy in two siblings.

Convergence of cell cycle regulation and growth factor signals on GRASP65

Crystal structure of folliculin reveals a hidDENN function in genetically inherited renal cancer ⬇️

Cytokinesis: placing and making the final cut.

Dynamics of Golgi matrix proteins after the blockage of ER to Golgi transport.

Formation of secretory vesicles in the biosynthetic pathway

GORAB Missense Mutations Disrupt RAB6 and ARF5 Binding and Golgi Targeting

GRASP55, a second mammalian GRASP protein involved in the stacking of Golgi cisternae in a cell-free system.

GRASP65, a Protein Involved in the Stacking of Golgi Cisternae ⬇️

Gerodermia osteodysplastica is caused by mutations in SCYL1BP1, a Rab-6 interacting golgin

Getting out of mitosis: spatial and temporal control of mitotic exit and cytokinesis by PP1 and PP2A

Golgi inheritance: shaken but not stirred

Golgi positioning: are we looking at the right MAP?

Golgins and GTPases, giving identity and structure to the Golgi apparatus

I-proteins - a proposed switch in myotubularin function

ICA69 is a novel Rab2 effector regulating ER-Golgi trafficking in insulinoma cells

Insights regarding guanine nucleotide exchange from the structure of a DENN-domain protein complexed with its Rab GTPase substrate

Joining tethers and SNAREs

KIF14 and citron kinase act together to promote efficient cytokinesis

KIF4A and PP2A-B56 form a spatially restricted feedback loop opposing Aurora B at the anaphase central spindle

Loss-of-Function Mutations in RAB18 Cause Warburg Micro Syndrome.

Loss-of-function mutations in RAB18 cause Warburg micro syndrome.

Loss-of-function mutations in TBC1D20 cause cataracts and male infertility in blind sterile mice and Warburg micro syndrome in humans

MAD1-dependent recruitment of CDK1-CCNB1 to kinetochores promotes spindle checkpoint signaling

Mapping the interaction between GRASP65 and GM130, components of a protein complex involved in the stacking of Golgi cisternae ⬇️

Melanoma-associated mutations in protein phosphatase 6 cause chromosome instability and DNA damage owing to dysregulated Aurora-A.

Membrane traffic: Golgi stumbles over cilia

Membrane traffic: do cones mark sites of fission?

Membrane traffic: exocyst III--makes a family

Mitogen-inducible gene 6 is an endogenous inhibitor of HGF/Met-induced cell migration and neurite growth

Molecular basis for KDEL-mediated retrieval of escaped ER-resident proteins - SWEET talking the COPs

Multiple Rab GTPase binding sites in GCC185 suggest a model for vesicle tethering at the trans-Golgi.

Phosphatidylinositol-5-phosphate activation and conserved substrate specificity of the myotubularin phosphatidylinositol 3-phosphatases

Phosphorylation of Nlp by Plk1 negatively regulates its dynein-dynactin-dependent targeting to the centrosome

Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis

Plk1 docking to GRASP65 phosphorylated by Cdk1 suggests a mechanism for Golgi checkpoint signalling.

Plk1 negatively regulates Cep55 recruitment to the midbody to ensure orderly abscission

Polo-like kinases and the orchestration of cell division

Protein phosphatases and the regulation of mitosis.

Purification and functional interactions of GRASP55 with Rab2

RUTBC1 protein, a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins

RUTBC2 protein, a Rab9A effector and GTPase-activating protein for Rab36

Rab GEFs and GAPs

Rab GTPase function in Golgi trafficking

Rab regulation by GEFs and GAPs during membrane traffic

Rab14 and its exchange factor FAM116 link endocytic recycling and adherens junction stability in migrating cells

Rab18 and a Rab18 GEF complex are required for normal ER structure

Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C.

Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2

Review series: Rab GTPases and membrane identity: causal or inconsequential?

Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways

Structural basis for pH-dependent retrieval of ER proteins from the Golgi by the KDEL receptor

TBC1D14 regulates autophagosome formation via Rab11- and ULK1-positive recycling endosomes

The BEG (PP2A-B55/ENSA/Greatwall) pathway ensures cytokinesis follows chromosome separation

The Golgi apparatus.

The Golgi apparatus: going round in circles?

The Mon1-Ccz1 GEF activates the Rab7 GTPase Ypt7 via a longin-fold-Rab interface and association with PI3P-positive membranes