List of works - Jeffrey N Weiser

Age-dependent differences in efferocytosis determine the outcome of opsonophagocytic protection from invasive pathogens

scientific article published in 2023

Age-related differences in IL-1 signaling and capsule serotype affect persistence of Streptococcus pneumoniae colonization

scientific article published on 31 October 2018

Agglutination by anti-capsular polysaccharide antibody is associated with protection against experimental human pneumococcal carriage

scientific article published on 31 August 2016

An Infant Mouse Model of Influenza Virus Transmission Demonstrates the Role of Virus-Specific Shedding, Humoral Immunity, and Sialidase Expression by Colonizing Streptococcus pneumoniae

article

Antibody-enhanced pneumococcal adherence requires IgA1 protease.

scholarly article

Antigenic similarities in lipopolysaccharides of Haemophilus and Neisseria and expression of a digalactoside structure also present on human cells

scientific article

Bacterial colonization of nasal mucosa induces expression of siderocalin, an iron-sequestering component of innate immunity

scientific article published on October 2005

Bacterial exploitation of phosphorylcholine mimicry suppresses inflammation to promote airway infection.

scientific article

Bacteriocin activity of Streptococcus pneumoniae is controlled by the serine protease HtrA via posttranscriptional regulation

scientific article published on 19 December 2008

Binding of human factor H to outer membrane protein P5 of non-typeable Haemophilus influenzae contributes to complement resistance

scientific article published on 18 August 2014

Capsule Type and Amount Affect Shedding and Transmission of Streptococcus pneumoniae

scientific article

Capsule enhances pneumococcal colonization by limiting mucus-mediated clearance.

scientific article published on 6 November 2006

Capsule prolongs survival of Streptococcus pneumoniae during starvation.

scientific article published on 8 January 2018

Characterization of repetitive sequences controlling phase variation of Haemophilus influenzae lipopolysaccharide

scientific article

Characterization of the phosphocholine-substituted oligosaccharide in lipopolysaccharides of type b Haemophilus influenzae

scientific article published on 01 June 2000

Clearance of Pneumococcal Colonization in Infants Is Delayed through Altered Macrophage Trafficking

scientific article published on 24 June 2015

Coinfection with Streptococcus pneumoniae modulates the B cell response to influenza virus

scientific article

Conserved mutations in the pneumococcal bacteriocin transporter gene, blpA, result in a complex population consisting of producers and cheaters

scientific article

Cross-protective mucosal immunity mediated by memory Th17 cells against Streptococcus pneumoniae lung infection.

scientific article published on 27 April 2016

Cross-reactivity of human immunoglobulin G2 recognizing phosphorylcholine and evidence for protection against major bacterial pathogens of the human respiratory tract

scientific article published on 31 August 2004

Deglycosylation of human glycoconjugates by the sequential activities of exoglycosidases expressed by Streptococcus pneumoniae

scientific article published in February 2006

Early bacterial colonization induces toll-like receptor-dependent transforming growth factor beta signaling in the epithelium.

scientific article published on 02 March 2009

Effect of pneumococcal polysaccharide vaccine on nonbacteremic pneumococcal pneumonia

scientific article published in April 2007

Epithelial cells are sensitive detectors of bacterial pore-forming toxins

scientific article

Evasion of killing by human antibody and complement through multiple variations in the surface oligosaccharide of Haemophilus influenzae.

scientific article published on 12 April 2013

Factors contributing to hydrogen peroxide resistance in Streptococcus pneumoniae include pyruvate oxidase (SpxB) and avoidance of the toxic effects of the fenton reaction

scientific article published on December 2003

Fast and flexible bacterial genomic epidemiology with PopPUNK

scientific article published on 24 January 2019

Host and bacterial factors contributing to the clearance of colonization by Streptococcus pneumoniae in a murine model.

scientific article

Host-to-Host Transmission of Streptococcus pneumoniae Is Driven by Its Inflammatory Toxin, Pneumolysin.

scientific article published on January 2017

Human neutrophils kill Streptococcus pneumoniae via serine proteases.

scientific article published on 20 July 2009

Identification of Pneumococcal Factors Affecting Pneumococcal Shedding Shows that the dlt Locus Promotes Inflammation and Transmission

scientific article published on 18 June 2019

Identification of the targets of cross-reactive antibodies induced by Streptococcus pneumoniae colonization.

scientific article

Identifying mutator phenotypes among fluoroquinolone-resistant strains of Streptococcus pneumoniae using fluctuation analysis.

scientific article

Increased chain length promotes pneumococcal adherence and colonization

scientific article

Influenza promotes pneumococcal growth during coinfection by providing host sialylated substrates as a nutrient source.

scientific article

Inhibition of the pneumococcal virulence factor StrH and molecular insights into N-glycan recognition and hydrolysis

scientific article published on 9 November 2011

Interaction of lipocalin 2, transferrin, and siderophores determines the replicative niche of Klebsiella pneumoniae during pneumonia.

scientific article

Interleukin-8 secretion in response to aferric enterobactin is potentiated by siderocalin

scientific article published on 9 April 2007

Intracellular sensors of extracellular bacteria

scientific article published on September 2011

Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis

scholarly article

Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis

scientific article published on 15 May 2019

Klebsiella pneumoniae yersiniabactin promotes respiratory tract infection through evasion of lipocalin 2

scientific article

Limited role of antibody in clearance of Streptococcus pneumoniae in a murine model of colonization

scientific article published on October 2004

Live attenuated Streptococcus pneumoniae strains induce serotype-independent mucosal and systemic protection in mice.

scientific article published on 5 March 2007

MARCO is required for TLR2- and Nod2-mediated responses to Streptococcus pneumoniae and clearance of pneumococcal colonization in the murine nasopharynx.

scientific article

Macrophage migration inhibitory factor promotes clearance of pneumococcal colonization

scientific article

Mechanisms of Bacterial Colonization of the Respiratory Tract

scientific article

Microbial modulation of host immunity with the small molecule phosphorylcholine

scientific article published on 10 December 2012

Minimization of bacterial size allows for complement evasion and is overcome by the agglutinating effect of antibody

scientific article

Modifications to the peptidoglycan backbone help bacteria to establish infection

scientific article

Mucosal clearance of capsule-expressing bacteria requires both TLR and nucleotide-binding oligomerization domain 1 signaling

scientific article

Mucosal lipocalin 2 has pro-inflammatory and iron-sequestering effects in response to bacterial enterobactin

scientific article

Multiple mechanisms for choline transport and utilization in Haemophilus influenzae

scientific article published in October 2003

Natural antibody to conserved targets of Haemophilus influenzae limits colonization of the murine nasopharynx.

scientific article published on 18 May 2009

Neuraminidase expressed by Streptococcus pneumoniae desialylates the lipopolysaccharide of Neisseria meningitidis and Haemophilus influenzae: a paradigm for interbacterial competition among pathogens of the human respiratory tract

scientific article published on December 2002

Neutrophil-toxin interactions promote antigen delivery and mucosal clearance of Streptococcus pneumoniae

scientific article published on 01 May 2008

Nod1 mediates cytoplasmic sensing of combinations of extracellular bacteria

scientific article published on May 2007

Nod1 signaling overcomes resistance of S. pneumoniae to opsonophagocytic killing

scientific article

Nod2 sensing of lysozyme-digested peptidoglycan promotes macrophage recruitment and clearance of S. pneumoniae colonization in mice.

scientific article

Peptidoglycan from the gut microbiota governs the lifespan of circulating phagocytes at homeostasis

scientific article published on 17 March 2016

Phase variable desialylation of host proteins that bind to Streptococcus pneumoniae in vivo and protect the airway

scientific article

Phase-variable lipopolysaccharide structures enhance the invasive capacity of Haemophilus influenzae ⬇️

scientific article

Pneumococcal quorum sensing drives an asymmetric owner-intruder competitive strategy during carriage via the competence regulon

scientific article published in January 2019

Pneumolysin Induces 12-Lipoxygenase-Dependent Neutrophil Migration during Streptococcus pneumoniae Infection

scientific article published on 27 November 2019

Pneumolysin expression by streptococcus pneumoniae protects colonized mice from influenza virus-induced disease

scientific article

Protection from the acquisition of Staphylococcus aureus nasal carriage by cross-reactive antibody to a pneumococcal dehydrogenase

scientific article

Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity

scientific article published on 17 January 2010

Regenerative therapy based on miRNA-302 mimics for enhancing host recovery from pneumonia caused by Streptococcus pneumoniae

scientific article published on 10 April 2019

Resistance to mucosal lysozyme compensates for the fitness deficit of peptidoglycan modifications by Streptococcus pneumoniae

scientific article

Role of p38 MAP kinase and transforming growth factor-beta signaling in transepithelial migration of invasive bacterial pathogens

scientific article published on 24 July 2007

Sensing of interleukin-1 cytokines during Streptococcus pneumoniae colonization contributes to macrophage recruitment and bacterial clearance.

scientific article published in June 2015

Sequential evolution of virulence and resistance during clonal spread of community-acquired methicillin-resistant

scientific article

Serum immunoglobulin G response to candidate vaccine antigens during experimental human pneumococcal colonization

scientific article

Shielding of a lipooligosaccharide IgM epitope allows evasion of neutrophil-mediated killing of an invasive strain of nontypeable Haemophilus influenzae ⬇️

scientific article

Short-sequence tandem and nontandem DNA repeats and endogenous hydrogen peroxide production contribute to genetic instability of Streptococcus pneumoniae

scientific article published on August 2002

Streptococcus pneumoniae Transmission Is Blocked by Type-Specific Immunity in an Infant Mouse Model

scientific article published on 14 March 2017

Streptococcus pneumoniae resistance to complement-mediated immunity is dependent on the capsular serotype

scientific article published on 30 November 2009

Streptococcus pneumoniae: transmission, colonization and invasion. ⬇️

scientific article published on 29 March 2018

Structural studies of the saccharide part of the cell envelope lipopolysaccharide from Haemophilus influenzae strain AH1-3 (lic3+)

scientific article published on 01 August 1993

Synergistic proinflammatory responses induced by polymicrobial colonization of epithelial surfaces

scientific article

Synergistic stimulation of type I interferons during influenza virus coinfection promotes Streptococcus pneumoniae colonization in mice

scientific article

TLR2 signaling decreases transmission of Streptococcus pneumoniae by limiting bacterial shedding in an infant mouse Influenza A co-infection model

scientific article

The atypical amino-terminal LPNTG-containing domain of the pneumococcal human IgA1-specific protease is required for proper enzyme localization and function

scientific article published on 15 June 2006

The battle with the host over microbial size

scientific article published on 08 February 2013

The blp bacteriocins of Streptococcus pneumoniae mediate intraspecies competition both in vitro and in vivo.

scientific article published on 30 October 2006

The immune response to pneumococcal proteins during experimental human carriage

scientific article published on February 2002

The immunological mechanisms that control pneumococcal carriage.

scientific article published on 21 December 2017

The inhibitory effect of C-reactive protein on bacterial phosphorylcholine platelet-activating factor receptor-mediated adherence is blocked by surfactant

scientific article

The microbiota regulates neutrophil homeostasis and host resistance to Escherichia coli K1 sepsis in neonatal mice

scientific article

The molecular mechanism of phase variation of H. influenzae lipopolysaccharide

scientific article published on November 1989

The neonatal window of opportunity-early priming for life.

scientific article published on 13 December 2017

The pneumococcus: why a commensal misbehaves

scientific article

The role of innate immune responses in the outcome of interspecies competition for colonization of mucosal surfaces

scientific article published in September 2005

Three surface exoglycosidases from Streptococcus pneumoniae, NanA, BgaA, and StrH, promote resistance to opsonophagocytic killing by human neutrophils

scientific article published on 16 February 2010

Tolerance of a phage element by Streptococcus pneumoniae leads to a fitness defect during colonization

scientific article

Toll-like receptor 4 mediates innate immune responses to Haemophilus influenzae infection in mouse lung

scientific article

Transcriptional profile of the Escherichia coli response to the antimicrobial insect peptide cecropin A.

scientific article

Unravelling the multiple functions of the architecturally intricate Streptococcus pneumoniae β-galactosidase, BgaA

scientific article (publication date: September 2014)

Within-host competition drives selection for the capsule virulence determinant of Streptococcus pneumoniae

scientific article

beta-Defensin 1 contributes to pulmonary innate immunity in mice

scientific journal article

pyseer: a comprehensive tool for microbial pangenome-wide association studies

scientific article published on 01 December 2018

List of works by Jeffrey N Weiser

Age-dependent differences in efferocytosis determine the outcome of opsonophagocytic protection from invasive pathogens

Age-related differences in IL-1 signaling and capsule serotype affect persistence of Streptococcus pneumoniae colonization

Agglutination by anti-capsular polysaccharide antibody is associated with protection against experimental human pneumococcal carriage

An Infant Mouse Model of Influenza Virus Transmission Demonstrates the Role of Virus-Specific Shedding, Humoral Immunity, and Sialidase Expression by Colonizing Streptococcus pneumoniae

Antibody-enhanced pneumococcal adherence requires IgA1 protease.

Antigenic similarities in lipopolysaccharides of Haemophilus and Neisseria and expression of a digalactoside structure also present on human cells

Bacterial colonization of nasal mucosa induces expression of siderocalin, an iron-sequestering component of innate immunity

Bacterial exploitation of phosphorylcholine mimicry suppresses inflammation to promote airway infection.

Bacteriocin activity of Streptococcus pneumoniae is controlled by the serine protease HtrA via posttranscriptional regulation

Binding of human factor H to outer membrane protein P5 of non-typeable Haemophilus influenzae contributes to complement resistance

Capsule Type and Amount Affect Shedding and Transmission of Streptococcus pneumoniae

Capsule enhances pneumococcal colonization by limiting mucus-mediated clearance.

Capsule prolongs survival of Streptococcus pneumoniae during starvation.

Characterization of repetitive sequences controlling phase variation of Haemophilus influenzae lipopolysaccharide

Characterization of the phosphocholine-substituted oligosaccharide in lipopolysaccharides of type b Haemophilus influenzae

Clearance of Pneumococcal Colonization in Infants Is Delayed through Altered Macrophage Trafficking

Coinfection with Streptococcus pneumoniae modulates the B cell response to influenza virus

Conserved mutations in the pneumococcal bacteriocin transporter gene, blpA, result in a complex population consisting of producers and cheaters

Cross-protective mucosal immunity mediated by memory Th17 cells against Streptococcus pneumoniae lung infection.

Cross-reactivity of human immunoglobulin G2 recognizing phosphorylcholine and evidence for protection against major bacterial pathogens of the human respiratory tract

Deglycosylation of human glycoconjugates by the sequential activities of exoglycosidases expressed by Streptococcus pneumoniae

Early bacterial colonization induces toll-like receptor-dependent transforming growth factor beta signaling in the epithelium.

Effect of pneumococcal polysaccharide vaccine on nonbacteremic pneumococcal pneumonia

Epithelial cells are sensitive detectors of bacterial pore-forming toxins

Evasion of killing by human antibody and complement through multiple variations in the surface oligosaccharide of Haemophilus influenzae.

Factors contributing to hydrogen peroxide resistance in Streptococcus pneumoniae include pyruvate oxidase (SpxB) and avoidance of the toxic effects of the fenton reaction

Fast and flexible bacterial genomic epidemiology with PopPUNK

Host and bacterial factors contributing to the clearance of colonization by Streptococcus pneumoniae in a murine model.

Host-to-Host Transmission of Streptococcus pneumoniae Is Driven by Its Inflammatory Toxin, Pneumolysin.

Human neutrophils kill Streptococcus pneumoniae via serine proteases.

Identification of Pneumococcal Factors Affecting Pneumococcal Shedding Shows that the dlt Locus Promotes Inflammation and Transmission

Identification of the targets of cross-reactive antibodies induced by Streptococcus pneumoniae colonization.

Identifying mutator phenotypes among fluoroquinolone-resistant strains of Streptococcus pneumoniae using fluctuation analysis.

Increased chain length promotes pneumococcal adherence and colonization

Influenza promotes pneumococcal growth during coinfection by providing host sialylated substrates as a nutrient source.

Inhibition of the pneumococcal virulence factor StrH and molecular insights into N-glycan recognition and hydrolysis

Interaction of lipocalin 2, transferrin, and siderophores determines the replicative niche of Klebsiella pneumoniae during pneumonia.

Interleukin-8 secretion in response to aferric enterobactin is potentiated by siderocalin

Intracellular sensors of extracellular bacteria

Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis

Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis

Klebsiella pneumoniae yersiniabactin promotes respiratory tract infection through evasion of lipocalin 2

Limited role of antibody in clearance of Streptococcus pneumoniae in a murine model of colonization

Live attenuated Streptococcus pneumoniae strains induce serotype-independent mucosal and systemic protection in mice.

MARCO is required for TLR2- and Nod2-mediated responses to Streptococcus pneumoniae and clearance of pneumococcal colonization in the murine nasopharynx.

Macrophage migration inhibitory factor promotes clearance of pneumococcal colonization

Mechanisms of Bacterial Colonization of the Respiratory Tract

Microbial modulation of host immunity with the small molecule phosphorylcholine

Minimization of bacterial size allows for complement evasion and is overcome by the agglutinating effect of antibody

Modifications to the peptidoglycan backbone help bacteria to establish infection

Mucosal clearance of capsule-expressing bacteria requires both TLR and nucleotide-binding oligomerization domain 1 signaling

Mucosal lipocalin 2 has pro-inflammatory and iron-sequestering effects in response to bacterial enterobactin

Multiple mechanisms for choline transport and utilization in Haemophilus influenzae

Natural antibody to conserved targets of Haemophilus influenzae limits colonization of the murine nasopharynx.

Neuraminidase expressed by Streptococcus pneumoniae desialylates the lipopolysaccharide of Neisseria meningitidis and Haemophilus influenzae: a paradigm for interbacterial competition among pathogens of the human respiratory tract

Neutrophil-toxin interactions promote antigen delivery and mucosal clearance of Streptococcus pneumoniae

Nod1 mediates cytoplasmic sensing of combinations of extracellular bacteria

Nod1 signaling overcomes resistance of S. pneumoniae to opsonophagocytic killing

Nod2 sensing of lysozyme-digested peptidoglycan promotes macrophage recruitment and clearance of S. pneumoniae colonization in mice.

Peptidoglycan from the gut microbiota governs the lifespan of circulating phagocytes at homeostasis

Phase variable desialylation of host proteins that bind to Streptococcus pneumoniae in vivo and protect the airway

Phase-variable lipopolysaccharide structures enhance the invasive capacity of Haemophilus influenzae ⬇️

Pneumococcal quorum sensing drives an asymmetric owner-intruder competitive strategy during carriage via the competence regulon

Pneumolysin Induces 12-Lipoxygenase-Dependent Neutrophil Migration during Streptococcus pneumoniae Infection

Pneumolysin expression by streptococcus pneumoniae protects colonized mice from influenza virus-induced disease

Protection from the acquisition of Staphylococcus aureus nasal carriage by cross-reactive antibody to a pneumococcal dehydrogenase

Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity

Regenerative therapy based on miRNA-302 mimics for enhancing host recovery from pneumonia caused by Streptococcus pneumoniae

Resistance to mucosal lysozyme compensates for the fitness deficit of peptidoglycan modifications by Streptococcus pneumoniae

Role of p38 MAP kinase and transforming growth factor-beta signaling in transepithelial migration of invasive bacterial pathogens

Sensing of interleukin-1 cytokines during Streptococcus pneumoniae colonization contributes to macrophage recruitment and bacterial clearance.

Sequential evolution of virulence and resistance during clonal spread of community-acquired methicillin-resistant

Serum immunoglobulin G response to candidate vaccine antigens during experimental human pneumococcal colonization

Shielding of a lipooligosaccharide IgM epitope allows evasion of neutrophil-mediated killing of an invasive strain of nontypeable Haemophilus influenzae ⬇️

Short-sequence tandem and nontandem DNA repeats and endogenous hydrogen peroxide production contribute to genetic instability of Streptococcus pneumoniae

Streptococcus pneumoniae Transmission Is Blocked by Type-Specific Immunity in an Infant Mouse Model

Streptococcus pneumoniae resistance to complement-mediated immunity is dependent on the capsular serotype

Streptococcus pneumoniae: transmission, colonization and invasion. ⬇️

Structural studies of the saccharide part of the cell envelope lipopolysaccharide from Haemophilus influenzae strain AH1-3 (lic3+)