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List of works by Andrew B. West

14-3-3 Proteins regulate mutant LRRK2 kinase activity and neurite shortening.

scientific article

Abrogation of α-synuclein-mediated dopaminergic neurodegeneration in LRRK2-deficient rats

scientific article

Achieving neuroprotection with LRRK2 kinase inhibitors in Parkinson disease

scientific article published on 29 July 2017

Autophosphorylation in the leucine-rich repeat kinase 2 (LRRK2) GTPase domain modifies kinase and GTP-binding activities

scientific article

Caught in the act: LRRK2 in exosomes

scientific article published on 05 March 2019

Chromosomal amplification of leucine-rich repeat kinase-2 (LRRK2) is required for oncogenic MET signaling in papillary renal and thyroid carcinomas

scientific article

Clinical, 18F-dopa PET, and genetic analysis of an ethnic Chinese kindred with early-onset parkinsonism and parkin gene mutations

scientific article

Complex relationship between Parkin mutations and Parkinson disease

scientific article

Comprehensive characterization and optimization of anti-LRRK2 (leucine-rich repeat kinase 2) monoclonal antibodies

scientific article published on July 2013

Defining the contribution of CNTNAP2 to autism susceptibility

scientific article

Dependence of leucine-rich repeat kinase 2 (LRRK2) kinase activity on dimerization

scientific article published on 13 October 2009

Differential LRRK2 expression in the cortex, striatum, and substantia nigra in transgenic and nontransgenic rodents

scientific article

Dynamic and redundant regulation of LRRK2 and LRRK1 expression

scientific article

Exaggerated CpH methylation in the autism-affected brain

scientific article

Formation of α-synuclein Lewy neurite-like aggregates in axons impedes the transport of distinct endosomes

scientific article

G2019S-LRRK2 Expression Augments α-Synuclein Sequestration into Inclusions in Neurons.

scientific article published on July 2016

GTPase activity and neuronal toxicity of Parkinson's disease-associated LRRK2 is regulated by ArfGAP1

scientific article

Genetics of parkin-linked disease.

scientific article

Hyperactivity and cortical disinhibition in mice with restricted expression of mutant huntingtin to parvalbumin-positive cells

scientific article published on 11 October 2013

Identification and characterization of a leucine-rich repeat kinase 2 (LRRK2) consensus phosphorylation motif

scientific article

Identification and characterization of the human parkin gene promoter

scientific article published on September 2001

Identification of LRRK2 missense variants in the accelerating medicines partnership Parkinson's disease cohort

scientific article published on 01 April 2021

Identification of a novel gene linked to parkin via a bi-directional promoter

scientific article

Identification of bona-fide LRRK2 kinase substrates

scientific article published on 29 April 2016

Iduna protects the brain from glutamate excitotoxicity and stroke by interfering with poly(ADP-ribose) polymer-induced cell death

scientific article published on 22 May 2011

Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease ⬇️

scientific article published on August 22, 2010

LRRK2 and Rab10 coordinate macropinocytosis to mediate immunological responses in phagocytes

scientific article published on 27 August 2020

LRRK2 autophosphorylation enhances its GTPase activity

scientific article

LRRK2 in Parkinson's disease: function in cells and neurodegeneration

scientific article published on 05 October 2009

LRRK2 inhibition attenuates microglial inflammatory responses

scientific article

LRRK2 secretion in exosomes is regulated by 14-3-3.

scientific article published on 25 July 2013

Leucine-rich Repeat Kinase 2 (LRRK2) Pharmacological Inhibition Abates α-Synuclein Gene-induced Neurodegeneration

scientific article published on 15 June 2015

Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration

scientific article

Leucine-rich repeat kinase 2 deficiency is protective in rhabdomyolysis-induced kidney injury.

scientific article published on 22 April 2015

Localization of LRRK2 to membranous and vesicular structures in mammalian brain

scientific article

Localization of Parkinson's disease-associated LRRK2 in normal and pathological human brain

scientific article

N-myc regulates parkin expression

scientific article published on 12 April 2004

PGC-1α provides a transcriptional framework for synchronous neurotransmitter release from parvalbumin-positive interneurons

scientific article

Parkin is not regulated by the unfolded protein response in human neuroblastoma cells

scientific article published on May 2003

Pathological α-synuclein recruits LRRK2 expressing pro-inflammatory monocytes to the brain

scientific article published on 10 January 2022

RNA-Seq optimization with eQTL gold standards

scientific article

Refinement of the PARK3 locus on chromosome 2p13 and the analysis of 14 candidate genes

scientific article published in September 2001

Revelations and revolutions in the understanding of Parkinson's disease.

scientific article

Ser(P)-1292 LRRK2 in urinary exosomes is elevated in idiopathic Parkinson's disease

scientific article published on 14 June 2016

Sex-based differences in the activation of peripheral blood monocytes in early Parkinson disease

scientific article published on 13 April 2021

Ten years and counting: moving leucine-rich repeat kinase 2 inhibitors to the clinic

scientific article

The G2019S mutation in LRRK2 imparts resiliency to kinase inhibition

scientific article published on 24 July 2018

The NINDS Parkinson's disease biomarkers program

scientific article published on 7 October 2015

The dual enzyme LRRK2 hydrolyzes GTP in both its GTPase and kinase domains in vitro

scientific article published on 7 December 2016

The therapeutic potential of LRRK2 and alpha-synuclein in Parkinson's disease

scientific article published on September 2009

Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease.

scientific article

Transcriptome analysis reveals dysregulation of innate immune response genes and neuronal activity-dependent genes in autism

scientific article

Unique functional and structural properties of the LRRK2 protein ATP-binding pocket

scientific article

Urinary LRRK2 phosphorylation predicts parkinsonian phenotypes in G2019S LRRK2 carriers.

scientific article published on 10 February 2016

Zeroing in on LRRK2-linked pathogenic mechanisms in Parkinson's disease.

scientific article published on 10 October 2008

α-Synuclein fibril-induced inclusion spread in rats and mice correlates with dopaminergic Neurodegeneration

scientific article published on 30 May 2017

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