List of works - Ghanshyam Swarup

661W is a retinal ganglion precursor-like cell line in which glaucoma-associated optineurin mutants induce cell death selectively

scientific article published on 4 December 2017

A Glaucoma-Associated Mutant of Optineurin Selectively Induces Death of Retinal Ganglion Cells Which Is Inhibited by Antioxidants

scientific article published on 01 April 2007

A Glaucoma-Associated Variant of Optineurin, M98K, Activates Tbk1 to Enhance Autophagosome Formation and Retinal Cell Death Dependent on Ser177 Phosphorylation of Optineurin

scientific article

A cataract-causing connexin 50 mutant is mislocalized to the ER due to loss of the fourth transmembrane domain and cytoplasmic domain

scientific article published on 27 November 2012

A nuclear protein tyrosine phosphatase activates p53 and induces caspase-1-dependent apoptosis

scientific article (publication date: 4 December 2002)

A nuclear protein tyrosine phosphatase induces shortening of G1 phase and increase in c-Myc protein level

scientific article

Activation of a cellular tyrosine-specific protein kinase by phosphorylation

scientific article published on 01 August 1985

Autophagy receptor optineurin promotes autophagosome formation by potentiating LC3-II production and phagophore maturation

scientific article published on 17 May 2018

C3G is required for c-Abl-induced filopodia and its overexpression promotes filopodia formation

scientific article published on 30 March 2007

Defects in autophagy caused by glaucoma-associated mutations in optineurin.

scientific article published on 21 August 2015

Direct transcriptional activation of human caspase-1 by tumor suppressor p53.

scientific article published on 13 February 2001

Downregulation of phospho-tyrosine phosphatases in a macrophage tumor

scientific article published in July 1993

E50K-OPTN-induced retinal cell death involves the Rab GTPase-activating protein, TBC1D17 mediated block in autophagy

scientific article

Emerging role of tyrosine phosphatase, TCPTP, in the organelles of the early secretory pathway

scientific article published on 15 January 2013

Focus on molecules: optineurin

scientific article published on 5 November 2007

Functional analysis of optineurin and some of its disease-associated mutants

scientific article

HSC70 regulates cold-induced caspase-1 hyperactivation by an autoinflammation-causing mutant of cytoplasmic immune receptor NLRC4

scientific article published on 09 October 2019

IRF-1-binding site in the first intron mediates interferon-γ-induced optineurin promoter activation

scientific article published on 27 June 2013

Induction of cytochrome c release and apoptosis by Hck-SH3 domain-mediated signalling requires caspase-3.

scientific article

Induction of p53 dependent apoptosis upon overexpression of a nuclear protein tyrosine phosphatase

scientific article published on 01 June 1999

Inhibition of anchorage-independent cell growth, adhesion, and cyclin D1 gene expression by a dominant negative mutant of a tyrosine phosphatase

scientific article

Inhibition of membrane phosphotyrosyl-protein phosphatase activity by vanadate

scientific article published on 01 August 1982

Interaction with Sug1 enables Ipaf ubiquitination leading to caspase 8 activation and cell death.

scientific article published on 15 March 2010

Involvement of caspase 1 and its activator Ipaf upstream of mitochondrial events in apoptosis.

scientific article

M98K-OPTN induces transferrin receptor degradation and RAB12-mediated autophagic death in retinal ganglion cells

scientific journal article

Modulation of phosphorylation and dephosphorylation of keratin and other polypeptides by estradiol-17β in rat vaginal epithelium

scientific article published on 01 October 1990

Molecular cloning and expresion of a protein-tyrosine phosphatase showing homology with transcription factors Fos and Jun ⬇️

scientific article published on March 11, 1991

NF-kappaB mediates tumor necrosis factor alpha-induced expression of optineurin, a negative regulator of NF-kappaB.

scientific article

Optineurin and its mutants: molecules associated with some forms of glaucoma

scientific article published on 07 August 2009

Optineurin is required for CYLD-dependent inhibition of TNFα-induced NF-κB activation

scientific article

Optineurin mediates a negative regulation of Rab8 by the GTPase-activating protein TBC1D17

scientific article

Optineurin promotes autophagosome formation by recruiting the autophagy-related Atg12-5-16L1 complex to phagophores containing the Wipi2 protein ⬇️

scientific article published on 13 November 2017

Optineurin, a multifunctional protein involved in glaucoma, amyotrophic lateral sclerosis and antiviral signalling

scientific article published in December 2010

Overexpression of a nuclear protein tyrosine phosphatase increases cell proliferation

scientific article published on 01 June 1997

Phosphorylated guanine nucleotide exchange factor C3G, induced by pervanadate and Src family kinases localizes to the Golgi and subcortical actin cytoskeleton

scientific article

Physical and functional interaction between Hck tyrosine kinase and guanine nucleotide exchange factor C3G results in apoptosis, which is independent of C3G catalytic domain

scientific article (publication date: 26 December 2003)

Regulation of endocytic trafficking of transferrin receptor by optineurin and its impairment by a glaucoma-associated mutant

scientific article

Regulation of p73 by Hck through kinase-dependent and independent mechanisms

scientific article

Role of p73 in regulating human caspase-1 gene transcription induced by interferon-{gamma} and cisplatin

scientific article published on 31 August 2005

Sp1-like sequences mediate human caspase-3 promoter activation by p73 and cisplatin

scientific article

Stabilization of a protein-tyrosine phosphatase mRNA upon mitogenic stimulation of T-lymphocytes

scientific article published on 01 November 1993

Syntaxin 17 cycles between the ER and ERGIC and is required to maintain the architecture of ERGIC and Golgi

scientific article

Tumor necrosis factor-alpha-induced caspase-1 gene expression. Role of p73.

scientific article published on September 2007

Two Splice Variants of a Tyrosine Phosphatase Differ in Substrate Specificity, DNA Binding, and Subcellular Location

scientific article published in Journal of Biological Chemistry

Tyrosine phosphorylation of a SNARE protein, syntaxin 17: implications for membrane trafficking in the early secretory pathway

scientific article

Tyrosine-specific protein kinases of normal tissues

scientific article published on 01 January 1984

List of works by Ghanshyam Swarup

661W is a retinal ganglion precursor-like cell line in which glaucoma-associated optineurin mutants induce cell death selectively

A Glaucoma-Associated Mutant of Optineurin Selectively Induces Death of Retinal Ganglion Cells Which Is Inhibited by Antioxidants

A Glaucoma-Associated Variant of Optineurin, M98K, Activates Tbk1 to Enhance Autophagosome Formation and Retinal Cell Death Dependent on Ser177 Phosphorylation of Optineurin

A cataract-causing connexin 50 mutant is mislocalized to the ER due to loss of the fourth transmembrane domain and cytoplasmic domain

A nuclear protein tyrosine phosphatase activates p53 and induces caspase-1-dependent apoptosis

A nuclear protein tyrosine phosphatase induces shortening of G1 phase and increase in c-Myc protein level

Activation of a cellular tyrosine-specific protein kinase by phosphorylation

Autophagy receptor optineurin promotes autophagosome formation by potentiating LC3-II production and phagophore maturation

C3G is required for c-Abl-induced filopodia and its overexpression promotes filopodia formation

Defects in autophagy caused by glaucoma-associated mutations in optineurin.

Direct transcriptional activation of human caspase-1 by tumor suppressor p53.

Downregulation of phospho-tyrosine phosphatases in a macrophage tumor

E50K-OPTN-induced retinal cell death involves the Rab GTPase-activating protein, TBC1D17 mediated block in autophagy

Emerging role of tyrosine phosphatase, TCPTP, in the organelles of the early secretory pathway

Focus on molecules: optineurin

Functional analysis of optineurin and some of its disease-associated mutants

HSC70 regulates cold-induced caspase-1 hyperactivation by an autoinflammation-causing mutant of cytoplasmic immune receptor NLRC4

IRF-1-binding site in the first intron mediates interferon-γ-induced optineurin promoter activation

Induction of cytochrome c release and apoptosis by Hck-SH3 domain-mediated signalling requires caspase-3.

Induction of p53 dependent apoptosis upon overexpression of a nuclear protein tyrosine phosphatase

Inhibition of anchorage-independent cell growth, adhesion, and cyclin D1 gene expression by a dominant negative mutant of a tyrosine phosphatase

Inhibition of membrane phosphotyrosyl-protein phosphatase activity by vanadate

Interaction with Sug1 enables Ipaf ubiquitination leading to caspase 8 activation and cell death.

Involvement of caspase 1 and its activator Ipaf upstream of mitochondrial events in apoptosis.

M98K-OPTN induces transferrin receptor degradation and RAB12-mediated autophagic death in retinal ganglion cells

Modulation of phosphorylation and dephosphorylation of keratin and other polypeptides by estradiol-17β in rat vaginal epithelium

Molecular cloning and expresion of a protein-tyrosine phosphatase showing homology with transcription factors Fos and Jun ⬇️

NF-kappaB mediates tumor necrosis factor alpha-induced expression of optineurin, a negative regulator of NF-kappaB.

Optineurin and its mutants: molecules associated with some forms of glaucoma

Optineurin is required for CYLD-dependent inhibition of TNFα-induced NF-κB activation

Optineurin mediates a negative regulation of Rab8 by the GTPase-activating protein TBC1D17

Optineurin promotes autophagosome formation by recruiting the autophagy-related Atg12-5-16L1 complex to phagophores containing the Wipi2 protein ⬇️

Optineurin, a multifunctional protein involved in glaucoma, amyotrophic lateral sclerosis and antiviral signalling

Overexpression of a nuclear protein tyrosine phosphatase increases cell proliferation

Phosphorylated guanine nucleotide exchange factor C3G, induced by pervanadate and Src family kinases localizes to the Golgi and subcortical actin cytoskeleton

Physical and functional interaction between Hck tyrosine kinase and guanine nucleotide exchange factor C3G results in apoptosis, which is independent of C3G catalytic domain

Regulation of endocytic trafficking of transferrin receptor by optineurin and its impairment by a glaucoma-associated mutant

Regulation of p73 by Hck through kinase-dependent and independent mechanisms

Role of p73 in regulating human caspase-1 gene transcription induced by interferon-{gamma} and cisplatin

Sp1-like sequences mediate human caspase-3 promoter activation by p73 and cisplatin

Stabilization of a protein-tyrosine phosphatase mRNA upon mitogenic stimulation of T-lymphocytes

Syntaxin 17 cycles between the ER and ERGIC and is required to maintain the architecture of ERGIC and Golgi

Tumor necrosis factor-alpha-induced caspase-1 gene expression. Role of p73.

Two Splice Variants of a Tyrosine Phosphatase Differ in Substrate Specificity, DNA Binding, and Subcellular Location

Tyrosine phosphorylation of a SNARE protein, syntaxin 17: implications for membrane trafficking in the early secretory pathway

Tyrosine-specific protein kinases of normal tissues