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List of works by Paul Jennings

"The future of in vitro toxicology".

scientific article

"Watching the Detectives" report of the general assembly of the EU project DETECTIVE Brussels, 24-25 November 2015.

scientific article published on 29 April 2016

A Protocol for One-Step Differentiation of Human Induced Pluripotent Stem Cells into Mature Podocytes

scientific article published on 01 January 2019

A SAGE based approach to human glomerular endothelium: defining the transcriptome, finding a novel molecule and highlighting endothelial diversity

scientific article

A fluorescent microplate assay for exocytosis in alveolar type II cells

scientific article

A mode-of-action ontology model for safety evaluation of chemicals: Outcome of a series of workshops on repeated dose toxicity

scientific article published on 04 April 2019

A review of the evidence that ochratoxin A is an Nrf2 inhibitor: implications for nephrotoxicity and renal carcinogenicity

scientific article published on 20 January 2014

A snapshot on the progress of in vitro toxicology for safety assessment

scientific article published on 01 December 2017

Advanced Good Cell Culture Practice for human primary, stem cell-derived and organoid models as well as microphysiological systems

scientific article published on 13 April 2018

Adverse outcome pathways: opportunities, limitations and open questions

scientific article published on 19 October 2017

An overview of transcriptional regulation in response to toxicological insult.

scientific article published on 28 August 2012

Analysis of glutathione in supernatants and lysates of a human proximal tubular cell line from perfusion culture upon intoxication with cadmium chloride by HPLC and LC-ESI-MS.

scientific article

Application of RPTEC/TERT1 cells for investigation of repeat dose nephrotoxicity: A transcriptomic study

scientific article

Application of a population balance model to a perfusion in vitro toxicity system

scientific article published on 25 April 2006

Application of integrated transcriptomic, proteomic and metabolomic profiling for the delineation of mechanisms of drug induced cell stress

scientific article published on 10 December 2012

Assessment of a new cell culture perfusion apparatus for in vitro chronic toxicity testing. Part 1: technical description.

scientific article

Assessment of a new cell culture perfusion apparatus for in vitro chronic toxicity testing. Part 2: toxicological evaluation.

scientific article

Ca2+ entry is essential for cell strain-induced lamellar body fusion in isolated rat type II pneumocytes.

scientific article published on 22 September 2003

Ca2+ induced surfactant secretion in alveolar type II cultures isolated from the H-2Kb-tsA58 transgenic mouse

scientific article published in January 2005

Carcinogens induce loss of the primary cilium in human renal proximal tubular epithelial cells independently of effects on the cell cycle

scientific article

Characterisation of cadmium chloride induced molecular and functional alterations in airway epithelial cells

scientific article

Comparative analysis of perturbed molecular pathways identified in in vitro and in vivo toxicology studies

scientific article published on 09 April 2012

Comparison of base-line and chemical-induced transcriptomic responses in HepaRG and RPTEC/TERT1 cells using TempO-Seq

scientific article published on 14 July 2018

Comprehensive summary--Predict-IV: A systems toxicology approach to improve pharmaceutical drug safety testing

scientific article published on 29 October 2014

Correction to: Multiparametric assessment of mitochondrial respiratory inhibition in HepG2 and RPTEC/TERT1 cells using a panel of mitochondrial targeting agrochemicals

scientific article published on 01 August 2020

Corrigendum: Investigation of Nrf2, AhR and ATF4 Activation in Toxicogenomic Databases.

scientific article published on 4 June 2019

Cyclosporine A induces senescence in renal tubular epithelial cells

scientific article

Cyclosporine A kinetics in brain cell cultures and its potential of crossing the blood-brain barrier

scientific article published on 12 February 2015

Delineation of the key aspects in the regulation of epithelial monolayer formation

scientific article published on 22 April 2013

Development and characterization of a pseudo multiple reaction monitoring method for the quantification of human uromodulin in urine

scientific article published on 17 May 2016

Development of a neurotoxicity assay that is tuned to detect mitochondrial toxicants

scientific article published on 12 June 2019

Development of an in vitro renal epithelial disease state model for xenobiotic toxicity testing.

scientific article published on December 2014

Differential effects of hypoxic stress in alveolar epithelial cells and microvascular endothelial cells

scientific article

Differentiation of human iPSCs into functional podocytes

scientific article published in PLoS ONE

Effect of exogenous surfactants on viability and DNA synthesis in A549, immortalized mouse type II and isolated rat alveolar type II cells

scientific article

Effect of tissue fixatives on telomere length determination by quantitative PCR.

scientific article published on 22 September 2005

Ensuring the Quality of Stem Cell-Derived In Vitro Models for Toxicity Testing

scientific article published on January 2016

Evidence for a role of claudin 2 as a proximal tubular stress responsive paracellular water channel

scientific article published on 5 June 2014

Evidence for a role of uromodulin in chronic kidney disease progression.

scientific article published on 14 January 2010

Expression of xenobiotic transporters in the human renal proximal tubule cell line RPTEC/TERT1.

scientific article published on 10 December 2014

Familial juvenile hyperuricemic nephropathy: report on a new mutation and a pregnancy

scientific article published in January 2009

Function, essentiality, and expression of cytochrome P450 enzymes and their cognate redox partners in Mycobacterium tuberculosis: are they drug targets?

scientific article published on 27 February 2019

Generation and characterization of iPSC-derived renal proximal tubule-like cells with extended stability

scientific article published on 02 June 2021

Glucose reintroduction triggers the activation of Nrf2 during experimental ischemia reperfusion ⬇️

scientific article published on March 30, 2012

IFN-alpha induces barrier destabilization and apoptosis in renal proximal tubular epithelium

scientific article published on 21 November 2007

Identification and dissection of the Nrf2 mediated oxidative stress pathway in human renal proximal tubule toxicity

scientific article published on 21 December 2010

Improving global feature detectabilities through scan range splitting for untargeted metabolomics by high-performance liquid chromatography-Orbitrap mass spectrometry.

scientific article

In vitro evaluation of the toxicity induced by nickel soluble and particulate forms in human airway epithelial cells

scientific article published on 25 November 2010

Influence of microvascular endothelial cells on transcriptional regulation of proximal tubular epithelial cells

scientific article published on 5 December 2007

Inter-laboratory comparison of human renal proximal tubule (HK-2) transcriptome alterations due to Cyclosporine A exposure and medium exhaustion

scientific article

Inter-laboratory study of human in vitro toxicogenomics-based tests as alternative methods for evaluating chemical carcinogenicity: a bioinformatics perspective

scientific article published on 2 November 2015

Interleukin-19 as a translational indicator of renal injury

scientific article published on 9 April 2014

Investigation of Nrf2, AhR and ATF4 Activation in Toxicogenomic Databases

scientific article published on 02 October 2018

Kinetics and dynamics of cyclosporine A in three hepatic cell culture systems

scientific article published on 17 July 2015

LLC-PK(1) cells maintained in a new perfusion cell culture system exhibit an improved oxidative metabolism

scientific article

Lactate is an ideal non-invasive marker for evaluating temporal alterations in cell stress and toxicity in repeat dose testing regimes

scientific article published on 24 May 2011

Mechanism of cisplatin proximal tubule toxicity revealed by integrating transcriptomics, proteomics, metabolomics and biokinetics

scientific article

Mechanisms of neutrophil transmigration across renal proximal tubular HK-2 cells.

scientific article published on 20 June 2006

Membrane targeting and secretion of mutant uromodulin in familial juvenile hyperuricemic nephropathy

scientific article published on 6 December 2006

Metabolic response to low-level toxicant exposure in a novel renal tubule epithelial cell system

scientific article published on 19 November 2010

Migration of leukocytes across an endothelium-epithelium bilayer as a model of renal interstitial inflammation

scientific article published on 11 April 2007

Moving forward in carcinogenicity assessment: Report of an EURL ECVAM/ESTIV workshop

scientific article published on 11 September 2017

Multiparametric assessment of mitochondrial respiratory inhibition in HepG2 and RPTEC/TERT1 cells using a panel of mitochondrial targeting agrochemicals

scientific article published on 30 June 2020

Nephron Toxicity Profiling via Untargeted Metabolome Analysis Employing a High Performance Liquid Chromatography-Mass Spectrometry-based Experimental and Computational Pipeline

scientific article published on 8 June 2015

Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors

scientific article published on 29 January 2021

New approach methodologies (NAMs) for human-relevant biokinetics predictions: Meeting the paradigm shift in toxicology towards an animal-free chemical risk assessment

scientific article published on 08 June 2020

Nrf2 inducibility of aldo-keto reductases

scientific article published in June 2013

Opposing roles of EGF in IFN-alpha-induced epithelial barrier destabilization and tissue repair.

scientific article

Oxidative stress induced by potassium bromate exposure results in altered tight junction protein expression in renal proximal tubule cells

scientific article

Persistence of Epigenomic Effects After Recovery From Repeated Treatment With Two Nephrocarcinogens

scientific article published on 03 December 2018

SEURAT-1 liver gold reference compounds: a mechanism-based review

scientific article

Stem cell-derived systems in toxicology assessment

scientific article

Stress response pathways, toxicity pathways and adverse outcome pathways ⬇️

scientific article published on November 13, 2012

Systems Toxicology: Real World Applications and Opportunities.

scientific article

Systems biology modeling of omics data: effect of cyclosporine a on the Nrf2 pathway in human renal cells

scientific article

Tacrolimus increases Nox4 expression in human renal fibroblasts and induces fibrosis-related genes by aberrant TGF-beta receptor signalling

scientific article

The EU-ToxRisk method documentation, data processing and chemical testing pipeline for the regulatory use of new approach methods

scientific article published on 06 July 2020

The Predict-IV project: Towards predictive toxicology using in vitro techniques

scientific article published in December 2015

The Use of Renal Cell Culture for Nephrotoxicity Investigations

article

The carcinoGENOMICS project: critical selection of model compounds for the development of omics-based in vitro carcinogenicity screening assays

scientific article published on 26 April 2008

The surface properties of nanocrystalline diamond and nanoparticulate diamond powder and their suitability as cell growth support surfaces.

scientific article

Towards optimisation of induced pluripotent cell culture: Extracellular acidification results in growth arrest of iPSC prior to nutrient exhaustion.

scientific article published on 15 August 2017

Transcriptomic alterations induced by Ochratoxin A in rat and human renal proximal tubular in vitro models and comparison to a rat in vivo model

scientific article

Transcriptomics hit the target: Monitoring of ligand-activated and stress response pathways for chemical testing

scientific article

Uromodulin facilitates neutrophil migration across renal epithelial monolayers

scientific article

Vision of a near future: Bridging the human health-environment divide. Toward an integrated strategy to understand mechanisms across species for chemical safety assessment

scientific article published on 25 October 2019

hTERT alone immortalizes epithelial cells of renal proximal tubules without changing their functional characteristics.

scientific article

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