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List of works by Leo A van Grunsven

3D in vitro models of liver fibrosis.

scientific article

A PDGFRβ-based score predicts significant liver fibrosis in patients with chronic alcohol abuse, NAFLD and viral liver disease

scientific article published on 27 April 2019

A role for autophagy during hepatic stellate cell activation

scientific article published on 29 July 2011

Advanced glycation end products induce production of reactive oxygen species via the activation of NADPH oxidase in murine hepatic stellate cells

scientific article published on 24 December 2009

Advances in hepatic stem/progenitor cell biology

scientific article

Aldehyde Dehydrogenase Activity in Adipose Tissue: Isolation and Gene Expression Profile of Distinct Sub-population of Mesenchymal Stromal Cells.

scientific article published on 15 January 2018

Alteration in N-glycomics during mouse aging: a role for FUT8.

scientific article published in December 2011

Are dietary emulsifiers making us fat?

scientific article published on 18 June 2015

Atypical Mowat-Wilson patient confirms the importance of the novel association between ZFHX1B/SIP1 and NuRD corepressor complex

scientific article published on 8 January 2008

Blebbistatin inhibits contraction and accelerates migration in mouse hepatic stellate cells

scientific article published on 18 December 2009

Brief Report: The Deletion of the Phosphatase Regulator NIPP1 Causes Progenitor Cell Expansion in the Adult Liver

scientific article published on 12 April 2016

CRBP-I in the renal tubulointerstitial compartment of healthy rats and rats with renal fibrosis

scientific article published on 25 May 2008

Capsaicin modulates proliferation, migration, and activation of hepatic stellate cells.

scientific article published on March 2014

Cdyl: a new transcriptional co-repressor

scientific article published on 8 August 2003

Chronic administration of valproic acid inhibits activation of mouse hepatic stellate cells in vitro and in vivo

scientific article published in February 2010

Circulating ECV-Associated miRNAs as Potential Clinical Biomarkers in Early Stage HBV and HCV Induced Liver Fibrosis

scientific article published on 09 February 2017

Class II HDAC inhibition hampers hepatic stellate cell activation by induction of microRNA-29

scientific article

Combination of tauroursodeoxycholic acid and N-acetylcysteine exceeds standard treatment for acetaminophen intoxication

scientific article published on 5 October 2016

Comparison of the Opn-CreER and Ck19-CreER Drivers in Bile Ducts of Normal and Injured Mouse Livers

scientific article published on 25 April 2019

Comparison of trichostatin A and valproic acid treatment regimens in a mouse model of kidney fibrosis

scientific article published on 22 May 2013

Complex Smad-dependent transcriptional responses in vertebrate development and human disease

scientific article

Cooperation of Sp1 and p300 in the induction of the CDK inhibitor p21WAF1/CIP1 during NGF-mediated neuronal differentiation

scientific article published in May 1999

Correlation between epidermal growth factor receptor-specific nanobody uptake and tumor burden: a tool for noninvasive monitoring of tumor response to therapy

scientific article published on October 2011

Direct regulation of the Nrarp gene promoter by the Notch signaling pathway

scientific article

Distinct biological properties of two RET isoforms activated by MEN 2A and MEN 2B mutations

scientific article published in January 1997

Distinct roles for non-muscle myosin II isoforms in mouse hepatic stellate cells

scientific article published on 26 August 2010

Downregulation of Sox9 expression associates with hepatogenic differentiation of human liver mesenchymal stem/progenitor cells

scientific article published on 5 May 2014

Dynamic regulation of Brachyury expression in the amphibian embryo by XSIP1.

scientific article published in February 2002

Efficient definitive endoderm induction from mouse embryonic stem cell adherent cultures: a rapid screening model for differentiation studies

scientific article

EpCAM and the biology of hepatic stem/progenitor cells

scientific article

Epigenetic regulation of hepatic stellate cell activation and liver fibrosis

scientific article

FXR agonist obeticholic acid reduces hepatic inflammation and fibrosis in a rat model of toxic cirrhosis

scientific article published on 16 September 2016

Foreskin-derived mesenchymal stromal cells with aldehyde dehydrogenase activity: isolation and gene profiling.

scientific article published on 6 April 2018

Functionality based method for simultaneous isolation of rodent hepatic sinusoidal cells.

scientific article published on 30 May 2017

Gene expression profiling and secretome analysis differentiate adult-derived human liver stem/progenitor cells and human hepatic stellate cells

scientific article

Gene expression profiling of early hepatic stellate cell activation reveals a role for Igfbp3 in cell migration

scientific article

Generation of Hepatic Stellate Cells from Human Pluripotent Stem Cells Enables In Vitro Modeling of Liver Fibrosis

scientific article published on 28 June 2018

Genome-wide analysis of DNA methylation and gene expression patterns in purified, uncultured human liver cells and activated hepatic stellate cells

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

HDAC inhibitors in experimental liver and kidney fibrosis

scientific article published on 2 January 2013

Hepatic Stellate Cells Improve Engraftment of Human Primary Hepatocytes: A Preclinical Transplantation Study in an Animal Model.

scientific article published on 20 February 2015

High throughput micro-well generation of hepatocyte micro-aggregates for tissue engineering

scientific article

Histone deacetylase inhibition and the regulation of cell growth with particular reference to liver pathobiology

scientific article published on 6 July 2009

Human hepatic stellate cells and inflammation: A regulated cytokine network balance

scientific article published on 16 November 2016

Human liver mesenchymal stem/progenitor cells inhibit hepatic stellate cell activation: in vitro and in vivo evaluation.

scientific article

Immuno-biological comparison of hepatic stellate cells in a reverted and activated state

scientific article published on 12 December 2017

In vitro reversion of activated primary human hepatic stellate cells

scientific article published on 6 August 2015

In vivo hepatocyte MR imaging using lactose functionalized magnetoliposomes

scientific article published on 5 November 2013

Infliximab and Dexamethasone Attenuate the Ductular Reaction in Mice.

scientific article

Influence of inflammation on the immunological profile of adult-derived human liver mesenchymal stromal cells and stellate cells.

scientific article published on 21 November 2014

Inhibition of placental growth factor activity reduces the severity of fibrosis, inflammation, and portal hypertension in cirrhotic mice

scientific article

Inhibitory effect of dietary capsaicin on liver fibrosis in mice

scientific article published on 29 April 2015

Initiation of hepatic stellate cell activation extends into chronic liver disease

scientific article published on 27 November 2021

Integrative miRNA and Gene Expression Profiling Analysis of Human Quiescent Hepatic Stellate Cells

scientific article published on 22 June 2015

Interaction between Smad-interacting protein-1 and the corepressor C-terminal binding protein is dispensable for transcriptional repression of E-cadherin

scientific article published on 24 April 2003

Isolation and Characterization of Bone Marrow Mesenchymal Stromal Cell Subsets in Culture Based on Aldehyde Dehydrogenase Activity

scientific article published on 16 January 2018

Keratin 19: a key role player in the invasion of human hepatocellular carcinomas

scientific article published on 19 August 2013

Laminin-332 sustains chemoresistance and quiescence as part of the human hepatic cancer stem cell niche.

scientific article published on 17 November 2015

Leptin-mediated reactive oxygen species production does not significantly affect primary mouse hepatocyte functions in vitro

scientific article

Liposome based systems for systemic siRNA delivery: stability in blood sets the requirements for optimal carrier design

scientific article published on 14 October 2011

Loss of RASSF4 expression in multiple myeloma promotes RAS-driven malignant progression.

scientific article published on 19 December 2017

Macrophage Depletion Attenuates Extracellular Matrix Deposition and Ductular Reaction in a Mouse Model of Chronic Cholangiopathies

scientific article (publication date: 2016)

Mitochondrial uncouplers inhibit hepatic stellate cell activation

scientific article

Modulation of the Unfolded Protein Response by Tauroursodeoxycholic Acid Counteracts Apoptotic Cell Death and Fibrosis in a Mouse Model for Secondary Biliary Liver Fibrosis

scientific article published on 20 January 2017

NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.

scientific article

Neural crest-specific removal of Zfhx1b in mouse leads to a wide range of neurocristopathies reminiscent of Mowat-Wilson syndrome

scientific article published on 3 May 2007

Next generation of ALDH substrates and their potential to study maturational lineage biology in stem and progenitor cells

scientific article

Novel human hepatic organoid model enables testing of drug-induced liver fibrosis in vitro

scientific article published on 17 November 2015

Organization of the mouse Zfhx1b gene encoding the two-handed zinc finger repressor Smad-interacting protein-1.

scientific article

Osteopontin neutralisation abrogates the liver progenitor cell response and fibrogenesis in mice

scientific article published on 5 June 2014

P311 modulates hepatic stellate cells migration

scientific article published on 10 October 2014

P311, Friend, or Foe of Tissue Fibrosis?

scientific article published on 12 October 2018

PU.1 drives specification of pluripotent stem cell-derived endothelial cells to LSEC-like cells

scientific article published on 14 January 2021

Pentraxin-3 modulates lipopolysaccharide-induced inflammatory response and attenuates liver injury.

scientific article published on 19 April 2017

Peritumoral activation of the Hippo pathway effectors YAP and TAZ suppresses liver cancer in mice

scientific article published on 01 November 2019

Prospects in non-invasive assessment of liver fibrosis: Liquid biopsy as the future gold standard?

scientific article published on 9 January 2018

Protective effect of genetic deletion of pannexin1 in experimental mouse models of acute and chronic liver disease.

scientific article

RNA-sequencing-based comparative analysis of human hepatic progenitor cells and their niche from alcoholic steatohepatitis livers

scientific article published on 2 November 2017

Role of liver progenitors in acute liver injury

scientific article

Role of liver progenitors in liver regeneration

scientific article

Sharpen your look on liver progenitor cells

scientific article published on 01 January 2012

Smads and chromatin modulation

scientific article

Smicl is a novel Smad interacting protein and cleavage and polyadenylation specificity factor associated protein

scientific article

Stellate Cells, Hepatocytes, and Endothelial Cells Imprint the Kupffer Cell Identity on Monocytes Colonizing the Liver Macrophage Niche

scientific article published on 24 September 2019

Successful isolation of liver progenitor cells by aldehyde dehydrogenase activity in naïve mice

scientific article published on 01 February 2012

Syncoilin is an intermediate filament protein in activated hepatic stellate cells

scientific article published on 17 September 2013

The GALAD scoring algorithm based on AFP, AFP-L3, and DCP significantly improves detection of BCLC early stage hepatocellular carcinoma.

scientific article published on 9 December 2016

The Hippo pathway effector YAP controls mouse hepatic stellate cell activation.

scientific article

The biliary epithelium gives rise to liver progenitor cells

scientific article published on 21 August 2014

The combination of 4-1BBL and CD40L strongly enhances the capacity of dendritic cells to stimulate HIV-specific T cell responses

scientific article published on 22 March 2011

The quest for liver progenitor cells: a practical point of view

scientific article published on 28 October 2009

The role of miRNAs in stress-responsive hepatic stellate cells during liver fibrosis

scientific article

The roles of transforming growth factor-β, Wnt, Notch and hypoxia on liver progenitor cells in primary liver tumours (Review).

scientific article published on 03 February 2014

The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion

scientific article (publication date: June 2001)

Time-dependent effect of hypoxia on tumor progression and liver progenitor cell markers in primary liver tumors

scientific article published on 20 March 2015

Transforming growth factor beta signalling in vitro and in vivo: activin ligand-receptor interaction, Smad5 in vasculogenesis, and repression of target genes by the deltaEF1/ZEB-related SIP1 in the vertebrate embryo.

scientific article

Tumor-initiating capacity of CD138- and CD138+ tumor cells in the 5T33 multiple myeloma model

scientific article published on 6 January 2012

Unfolded protein response is an early, non-critical event during hepatic stellate cell activation

scientific article published on 04 February 2019

Valproic acid attenuates proteinuria and kidney injury

scientific article published on 25 August 2011

Vinculin and cellular retinol-binding protein-1 are markers for quiescent and activated hepatic stellate cells in formalin-fixed paraffin embedded human liver

scientific article published on 4 December 2008

XSIP1, a Xenopus zinc finger/homeodomain encoding gene highly expressed during early neural development

scientific article published in June 2000

XSip1 neuralizing activity involves the co-repressor CtBP and occurs through BMP dependent and independent mechanisms

scientific article published on 20 March 2007

Zeb2 Regulates Cell Fate at the Exit from Epiblast State in Mouse Embryonic Stem Cells

scientific article

deltaEF1 and SIP1 are differentially expressed and have overlapping activities during Xenopus embryogenesis

scientific article published in June 2006

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