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List of works by Chuanshu Huang

A Feedback Loop Formed by ATG7/Autophagy, FOXO3a/miR-145 and PD-L1 Regulates Stem-Like Properties and Invasion in Human Bladder Cancer

A JNK1/AP-1-dependent, COX-2 induction is implicated in 12-O-tetradecanoylphorbol-13-acetate-induced cell transformation through regulating cell cycle progression

scientific article published in January 2008

A critical role of PI-3K/Akt/JNKs pathway in benzo[a]pyrene diol-epoxide (B[a]PDE)-induced AP-1 transactivation in mouse epidermal Cl41 cells

scientific article published in May 2004

A cross-talk between NFAT and NF-κB pathways is crucial for nickel-induced COX-2 expression in Beas-2B cells

scientific article published on June 2011

A new tumour suppression mechanism by p27Kip1: EGFR down-regulation mediated by JNK/c-Jun pathway inhibition.

scientific article

A novel post-translational modification of nucleolin, SUMOylation at Lys-294, mediates arsenite-induced cell death by regulating gadd45α mRNA stability

scientific article

A novel role of IKKalpha in the mediation of UVB-induced G0/G1 cell cycle arrest response by suppressing Cyclin D1 expression

scientific article

ATG7 Overexpression Is Crucial for Tumorigenic Growth of Bladder Cancer In Vitro and In Vivo by Targeting the ETS2/miRNA196b/FOXO1/p27 Axis

scientific article

Abstract 4641: Crucial role of c-Jun phosphorylation at Ser63/73 mediated by PHLPP protein degradation in the Cheliensisin A (Chel A) inhibition of cell transformation

Abstract 5103: Loss of p27 upregulates MnSOD in a STAT3-dependent manner, disrupts intracellular redox activity and enhances cell migration

Abstract 5104: Isorhapontigenin (ISO) inhibits cancer invasion by enhancing FOXO1 transcription through targeting STAT1 phosphorylation at Tyr701

Abstract 5107: Divergent behaviors and underlying mechanisms of cell migration and invasion in non-metastatic T24 and its metastatic derivative T24T bladder cancer cell lines

Activation of JNK by vanadate induces a Fas-associated death domain (FADD)- dependent death of cerebellar granule progenitors in vitro ⬇️

journal article published in 2003

Activation of PKC is required for arsenite-induced signal transduction

scientific article published on 01 January 2000

Activation of a PKC is required for vanadate-induced phosphorylation of protein kinase B (Akt), but not p70S6k in mouse epidermal JB6 cells

journal article published in 2004

Activation of both nuclear factor of activated T cells and inhibitor of nuclear factor-kappa B kinase beta-subunit-/nuclear factor-kappa B is critical for cyclooxygenase-2 induction by benzo[a]pyrene in human bronchial epithelial cells

scientific article

Activation of corticotropin-releasing factor-containing neurons in the paraventricular nucleus of the hypothalamus by interleukin-1 in the rat.

scientific article published in November 1991

Anti-cancer drug discovery: update and comparisons in yeast, Drosophila, and zebrafish.

scientific article published on January 2014

Anti-cancer effects of JKA97 are associated with its induction of cell apoptosis via a Bax-dependent and p53-independent pathway

scientific article published on 23 January 2008

Arsenic induces apoptosis through a c-Jun NH2-terminal kinase-dependent, p53-independent pathway.

scientific article published on July 1999

Arsenic-induced NFkappaB transactivation through Erks- and JNKs-dependent pathways in mouse epidermal JB6 cells

scientific article published on June 1, 2001

Arsenite stabilizes HIF-1α protein through p85α-mediated up-regulation of inducible Hsp70 protein expression

scientific article published on 12 September 2010

Autophagy-mediated Mir6981 degradation exhibits CDKN1B promotion of PHLPP1 protein translation

scientific article published on 08 March 2019

Benzo (a) pyrene-induced human embryo lung cell cycle alterations through positive regulation of mitogen-activated protein kinase signal pathways

scientific article published in July 2007

Benzo(a)pyrene-caused increased G(1)-S transition requires the activation of c-Jun through p53-dependent PI-3K/Akt/ERK pathway in human embryo lung fibroblasts

journal article published in 2008

Benzo[a]pyrene diol-epoxide (B[a]PDE) upregulates COX-2 expression through MAPKs/AP-1 and IKKbeta/NF-kappaB in mouse epidermal Cl41 cells.

scientific article

Bid mediates anti-apoptotic COX-2 induction through the IKKbeta/NFkappaB pathway due to 5-MCDE exposure

scientific article published on February 2010

Black raspberry extracts inhibit benzo(a)pyrene diol-epoxide-induced activator protein 1 activation and VEGF transcription by targeting the phosphotidylinositol 3-kinase/Akt pathway

journal article published in 2006

Both IKKalpha and IKKbeta are implicated in the arsenite-induced AP-1 transactivation correlating with cell apoptosis through NF-kappaB activity-independent manner

scientific article published on 11 April 2008

Cancer prevention with freeze-dried berries and berry components

scientific article

Cannabinoid-receptor-independent cell signalling by N-acylethanolamines

scientific article

Carcinogenic effect of nickel compounds

scientific article

Cdh1, a substrate-recruiting component of anaphase-promoting complex/cyclosome (APC/C) ubiquitin E3 ligase, specifically interacts with phosphatase and tensin homolog (PTEN) and promotes its removal from chromatin

scientific article

Cheliensisin A (Chel A) induces apoptosis in human bladder cancer cells by promoting PHLPP2 protein degradation

scientific article published on 20 August 2016

Cheliensisin A inhibits EGF-induced cell transformation with stabilization of p53 protein via a hydrogen peroxide/Chk1-dependent axis

scientific article published on 12 July 2013

Controlled surface radical graft polymerization of N-halamine monomers on polyester fabrics and potential application in bioprotective medical scrubs

journal article published in 2022

Coordination of JNK1 and JNK2 is critical for GADD45alpha induction and its mediated cell apoptosis in arsenite responses.

scientific article

Cortical complexity in world trade center responders with chronic posttraumatic stress disorder

journal article published in 2021

Crucial role of c-Jun phosphorylation at Ser63/73 mediated by PHLPP protein degradation in the cheliensisin a inhibition of cell transformation

scientific article published on 3 October 2014

Cyclin D1 induction through IkappaB kinase beta/nuclear factor-kappaB pathway is responsible for arsenite-induced increased cell cycle G1-S phase transition in human keratinocytes

scientific article published in October 2005

Cyclin d1 downregulation contributes to anticancer effect of isorhapontigenin on human bladder cancer cells.

scientific article published on 30 May 2013

Cyclooxygenase-2 (COX-2) mediates arsenite inhibition of UVB-induced cellular apoptosis in mouse epidermal Cl41 cells

scientific article

Cyclooxygenase-2 induction by arsenite is through a nuclear factor of activated T-cell-dependent pathway and plays an antiapoptotic role in Beas-2B cells

scientific article published on 29 June 2006

Cyclooxygenase-2 induction by arsenite through the IKKbeta/NFkappaB pathway exerts an antiapoptotic effect in mouse epidermal Cl41 cells

scientific article published on 14 December 2006

DTI connectometry analysis reveals white matter changes in cognitively impaired World Trade Center responders at midlife

journal article published in 2022

Deferoxamine synergistically enhances iron-mediated AP-1 activation: a showcase of the interplay between extracellular-signal-regulated kinase and tyrosine phosphatase

scientific article

Differential effects of black raspberry and strawberry extracts on BaPDE-induced activation of transcription factors and their target genes

scientific article published on April 2008

Differential effects of polycyclic aromatic hydrocarbons on transactivation of AP-1 and NF-kappaB in mouse epidermal cl41 cells

scientific article

Differential inhibition of UV-induced activation of NF kappa B and AP-1 by extracts from black raspberries, strawberries, and blueberries

scientific article

Differential requirement of EGF receptor and its tyrosine kinase for AP-1 transactivation induced by EGF and TPA.

scientific article published on January 2003

Differential requirement of signal pathways for benzo[a]pyrene (B[a]P)-induced nitric oxide synthase (iNOS) in rat esophageal epithelial cells.

scientific article published on 17 February 2005

Differential role of hydrogen peroxide in UV-induced signal transduction

journal article published in 2002

Direct Evidence for an Important Role of Sphingomyelinase in Ultraviolet-induced Activation of c-Jun N-Terminal Kinase ⬇️

scientific article published on October 31, 1997

Direct evidence for the critical role of NFAT3 in benzo[a]pyrene diol-epoxide-induced cell transformation through mediation of inflammatory cytokine TNF induction in mouse epidermal Cl41 cells

journal article published in 2007

Divergent behaviors and underlying mechanisms of cell migration and invasion in non-metastatic T24 and its metastatic derivative T24T bladder cancer cell lines

scientific article

Diverse roles of GADD45alpha in stress signaling

scientific article

Downregulation of cyclin D1-CDK4 protein in human embryonic lung fibroblasts (HELF) induced by silica is mediated through the ERK and JNK pathway

scientific article published on 25 July 2008

E3 ligase activity of XIAP RING domain is required for XIAP-mediated cancer cell migration, but not for its RhoGDI binding activity

scientific article

ERKs activation and calcium signaling are both required for VEGF induction by vanadium in mouse epidermal Cl41 cells

scientific article published on November 2005

Effect of microglia activation on dopaminergic neuronal injury induced by manganese, and its possible mechanism.

scientific article

Effects of nickel on cyclin expression, cell cycle progression and cell proliferation in human pulmonary cells

scientific article published on June 2009

Effects of polycyclic aromatic hydrocarbons (PAHs) on vascular endothelial growth factor induction through phosphatidylinositol 3-kinase/AP-1-dependent, HIF-1alpha-independent pathway

scientific article published on 6 February 2006

Epidermal growth factor up-regulates the transcription of mouse lon homology ATP-dependent protease through extracellular signal-regulated protein kinase- and phosphatidylinositol-3-kinase-dependent pathways

scientific article published on October 2002

Epigenetic Inactivation of SOX30 Is Associated with Male Infertility and Offers a Therapy Target for Non-obstructive Azoospermia

scientific article published on 14 November 2019

Essential role of PI-3K, ERKs and calcium signal pathways in nickel-induced VEGF expression

scientific article published on November 2005

Essential role of p53 in phenethyl isothiocyanate-induced apoptosis

scientific article published on 01 September 1998

Essential roles of ERKs and p38K in up-regulation of GST A1 expression by Maotai content in human hepatoma cell line Hep3B.

scientific article published on 20 June 2006

Essential roles of PI-3K/Akt/IKKbeta/NFkappaB pathway in cyclin D1 induction by arsenite in JB6 Cl41 cells

scientific article published on 29 December 2005

Expression of dominant negative Erk2 inhibits AP-1 transactivation and neoplastic transformation

scientific article published on December 1998

FGFR3b Extracellular Loop Mutation Lacks Tumorigenicity In Vivo but Collaborates with p53/pRB Deficiency to Induce High-grade Papillary Urothelial Carcinoma

scientific article published on 9 May 2016

GADD45α induction by nickel negatively regulates JNKs/p38 activation via promoting PP2Cα expression

scientific article

GADD45β mediates p53 protein degradation via Src/PP2A/MDM2 pathway upon arsenite treatment ⬇️

scientific article published on May 16, 2013

Gadd45 proteins as critical signal transducers linking NF-kappaB to MAPK cascades

scientific article

Hemorrhagic fever with renal syndrome: relationship between pathogenesis and cellular immunity

scientific article published on April 1994

Hexavalent chromium Cr(VI) up-regulates COX-2 expression through an NFκB/c-Jun/AP-1-dependent pathway

scientific article

High mobility group Box-1 inhibits cancer cell motility and metastasis by suppressing activation of transcription factor CREB and nWASP expression

scientific article

Hydrogen peroxide contributes to the manganese superoxide dismutase promotion of migration and invasion in glioma cells

scientific article published on 5 August 2011

Hydrogen peroxide mediates activation of nuclear factor of activated T cells (NFAT) by nickel subsulfide ⬇️

journal article published in 2001

Hydrogen peroxide/ATR-Chk2 activation mediates p53 protein stabilization and anti-cancer activity of cheliensisin A in human cancer cells

scientific article

Hypoxia-induced mitogenic factor enhances angiogenesis by promoting proliferation and migration of endothelial cells

scientific article published on 9 August 2006

IKK-β/NF-κB p65 mediates p27(Kip1) protein degradation in arsenite response

scientific article published on 18 April 2014

IKKbeta programs to turn on the GADD45alpha-MKK4-JNK apoptotic cascade specifically via p50 NF-kappaB in arsenite response

scientific article

ISO, via Upregulating MiR-137 Transcription, Inhibits GSK3β-HSP70-MMP-2 Axis, Resulting in Attenuating Urothelial Cancer Invasion.

scientific article published on 4 July 2018

Identification of cyanidin glycosides as constituents of freeze-dried black raspberries which inhibit anti-benzo[a]pyrene-7,8-diol-9,10-epoxide induced NFkappaB and AP-1 activity

scientific article

Increased synthesis of phosphocholine is required for UV-induced AP-1 activation

scientific article published on October 1998

Induction of DNMT3B by PGE2 and IL6 at distant metastatic sites promotes epigenetic modification and breast cancer colonization

scientific article published on 07 April 2020

Induction of activator protein-1 through reactive oxygen species by crystalline silica in JB6 cells ⬇️

journal article published in 2001

Induction of miR-137 by Isorhapontigenin (ISO) Directly Targets Sp1 Protein Translation and Mediates Its Anticancer Activity Both In Vitro and In Vivo.

scientific article

Inflammation, a key event in cancer development

scientific article

Inhibition of AP-1 and neoplastic transformation by fresh apple peel extract

journal article published in 2004

Inhibition of PHLPP2/cyclin D1 protein translation contributes to the tumor suppressive effect of NFκB2 (p100).

scientific article published on 15 April 2016

Inhibition of activator protein 1 activity and cell growth by purified green tea and black tea polyphenols in H-ras-transformed cells: structure-activity relationship and mechanisms involved.

scientific article published on September 1999

Inhibition of activator protein 1 activity and neoplastic transformation by aspirin

scientific article published on April 1997

Inhibition of atypical PKC blocks ultraviolet-induced AP-1 activation by specifically inhibiting ERKs activation

scientific article

Inhibition of tumor promoter-induced activator protein 1 activation and cell transformation by tea polyphenols, (-)-epigallocatechin gallate, and theaflavins.

scientific article published on October 1997

Inhibition of ultraviolet B-induced AP-1 activation by theaflavins from black tea.

scientific article published on July 2000

Inhibition of ultraviolet B-induced activator protein-1 (AP-1) activity by aspirin in AP-1-luciferase transgenic mice

scientific article published on October 1997

Inhibition of ultraviolet C irradiation-induced AP-1 activity by aspirin is through inhibition of JNKs but not erks or P38 MAP kinase.

scientific article published on March 1998

Inhibitory effects of perillyl alcohol on UVB-induced murine skin cancer and AP-1 transactivation

scientific article published on 01 February 1998

Inositol hexaphosphate inhibits cell transformation and activator protein 1 activation by targeting phosphatidylinositol-3' kinase

scientific article published on July 1997

Involvement of Erks activation in cadmium-induced AP-1 transactivation in vitro and in vivo

journal article published in 2001

Involvement of c-jun NH(2)-terminal kinases in resveratrol-induced activation of p53 and apoptosis

scientific article published on April 2002

Involvement of nuclear factor of activated T cells 3 (NFAT3) in cyclin D1 induction by B[a]PDE or B[a]PDE and ionizing radiation in mouse epidermal Cl 41 cells

scientific article published on 28 April 2006

Involvement of nuclear factor of activated T cells activation in UV response. Evidence from cell culture and transgenic mice.

scientific article published on March 2000

Ionizing radiation synergistic induction of cyclooxygenase-2 with benzo[a]pyrene diol-epoxide through nuclear factor of activated T cells in mouse epidermal Cl 41 cells.

scientific article published on March 2006

Iron-induced interleukin-6 gene expression: possible mediation through the extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways

journal article published in 2004

Isorhapontigenin (ISO) Inhibits Invasive Bladder Cancer Formation In Vivo and Human Bladder Cancer Invasion In Vitro by Targeting STAT1/FOXO1 Axis

scientific article

Isorhapontigenin (ISO) inhibited cell transformation by inducing G0/G1 phase arrest via increasing MKP-1 mRNA Stability

scientific article

Isorhapontigenin suppresses growth of patient-derived glioblastoma spheres through regulating miR-145/SOX2/cyclin D1 axis

scientific article published on 17 December 2015

JNK activation is required for JB6 cell transformation induced by tumor necrosis factor-alpha but not by 12-O-tetradecanoylphorbol-13-acetate

scientific article published on October 1999

JNK1 is required for sulindac-mediated inhibition of cell proliferation and induction of apoptosis in vitro and in vivo

scientific article

JNK1 mediates degradation HIF-1alpha by a VHL-independent mechanism that involves the chaperones Hsp90/Hsp70.

scientific article

JNK1, but not JNK2, is required for COX-2 induction by nickel compounds

scientific article published on 25 October 2006

Knockdown of NFAT3 blocked TPA-induced COX-2 and iNOS expression, and enhanced cell transformation in Cl41 cells

scientific article published on November 2006

Lack of associations between several polymorphisms in cytokine genes and the risk of chronic obstructive pulmonary diseases in Taiwan

journal article published in 2008

Lead induces COX-2 expression in glial cells in a NFAT-dependent, AP-1/NFκB-independent manner

scientific article

Loss of p27 upregulates MnSOD in a STAT3-dependent manner, disrupts intracellular redox activity and enhances cell migration.

scientific article

Loss of tumor suppressor p53 decreases PTEN expression and enhances signaling pathways leading to activation of activator protein 1 and nuclear factor kappaB induced by UV radiation

scientific article

MEG3, as a Competing Endogenous RNA, Binds with miR-27a to Promote PHLPP2 Protein Translation and Impairs Bladder Cancer Invasion

article by Chao Huang et al published 7 February 2019 in Molecular therapy. Nucleic acids

Manganese induces tau hyperphosphorylation through the activation of ERK MAPK pathway in PC12 cells

scientific article published on 11 October 2010

MicroRNA-411 Downregulation Enhances Tumor Growth by Upregulating MLLT11 Expression in Human Bladder Cancer.

scientific article published on 10 March 2018

Mitochondrial catalase induces cells transformation through nucleolin-dependent Cox-2 mRNA stabilization

scientific article

Molecular mechanisms involved in chemoprevention of black raspberry extracts: from transcription factors to their target genes

scientific article published on January 2006

NF-κB p65 Overexpression Promotes Bladder Cancer Cell Migration via FBW7-Mediated Degradation of RhoGDIα Protein

scientific article

NF-κB1 inhibits c-Myc protein degradation through suppression of FBW7 expression

scientific article published on January 2014

NF-κB1 p50 promotes p53 protein translation through miR-190 downregulation of PHLPP1 ⬇️

scientific article published on February 11, 2013

NFAT3 is required for EGF-induced COX-2 transcription, but neither iNOS transcription nor cell transformation in Cl 41 cells

scientific article published on 23 May 2006

NFAT3 is specifically required for TNF-alpha-induced cyclooxygenase-2 (COX-2) expression and transformation of Cl41 cells

scientific article

NFκB1 (p50) suppresses SOD2 expression by inhibiting FoxO3a transactivation in a miR190/PHLPP1/Akt-dependent axis

scientific article

NFκB2 p52 stabilizes rhogdiβ mRNA by inhibiting AUF1 protein degradation via a miR-145/Sp1/USP8-dependent axis

scientific article published on 29 January 2019

Neuroinflammation in World Trade Center responders at midlife: a pilot study using [18F]-FEPPA PET imaging

journal article published in 2021

Neutrophilic Granule Protein Is a Novel Murine LPS Antagonist

scientific article published on 17 October 2019

New compound ChlA-F induces autophagy-dependent anti-cancer effect via upregulating Sestrin-2 in human bladder cancer

Nickel carcinogenesis: epigenetics and hypoxia signaling

scientific article

Nickel compounds render anti-apoptotic effect to human bronchial epithelial Beas-2B cells by induction of cyclooxygenase-2 through an IKKbeta/p65-dependent and IKKalpha- and p50-independent pathway

scientific article published on 18 September 2006

Oncogenic HRAS Activates Epithelial-to-Mesenchymal Transition and Confers Stemness to p53-Deficient Urothelial Cells to Drive Muscle Invasion of Basal Subtype Carcinomas

scientific article published on 20 March 2015

Overexpressed miR-200a promotes bladder cancer invasion through direct regulating Dicer/miR-16/JNK2/MMP-2 axis

scientific article published on 26 November 2019

Overexpression of cyclin D1-CDK4 in silica-induced transformed cells is due to activation of ERKs, JNKs/AP-1 pathway

scientific article published on 25 August 2005

PHLPP2 Downregulation Contributes to Lung Carcinogenesis Following B[a]P/B[a]PDE Exposure

scientific article

PHLPP2 stabilization by p27 mediates its inhibition of bladder cancer invasion by promoting autophagic degradation of MMP2 protein

scientific article published on 21 June 2018

PI-3 kinase in signal transduction, cell transformation, and as a target for chemoprevention of cancer.

scientific article

PI-3K and Akt are mediators of AP-1 induction by 5-MCDE in mouse epidermal Cl41 cells

scientific article

PI-3K/Akt pathway-dependent cyclin D1 expression is responsible for arsenite-induced human keratinocyte transformation

scientific article

PI-3K/Akt signal pathway plays a crucial role in arsenite-induced cell proliferation of human keratinocytes through induction of cyclin D1.

scientific article published on July 2007

PUMA is directly activated by NF-kappaB and contributes to TNF-alpha-induced apoptosis

scientific article

Participation of the PI-3K/Akt-NF-kappa B signaling pathways in hypoxia-induced mitogenic factor-stimulated Flk-1 expression in endothelial cells

scientific article published on 27 July 2006

Phosphatidylinositol-3 kinase is necessary for 12-O-tetradecanoylphorbol-13-acetate-induced cell transformation and activated protein 1 activation

scientific article published on February 1997

Phosphatidylinositol-3 kinase/Akt/p70S6K/AP-1 signaling pathway mediated benzo(a)pyrene-induced cell cycle alternation via cell cycle regulatory proteins in human embryo lung fibroblasts.

scientific article published on 21 February 2007

Plasticity of GAP-43 innervation of the spleen during immune response in the mouse. Evidence for axonal sprouting and redistribution of the nerve fibers

scientific article published in January 1998

Potentiation of insulin-induced phosphatidylinositol-3 kinase activity by phorbol ester is mediated by protein kinase C epsilon

scientific article published on March 1998

Proteinase inhibitors I and II from potatoes specifically block UV-induced activator protein-1 activation through a pathway that is independent of extracellular signal-regulated kinases, c-Jun N-terminal kinases, and P38 kinase ⬇️

scientific article published on October 28, 1997

Regulation of Fas (CD95)-induced apoptosis by nuclear factor-KB and tumor necrosis factor- alpha in macrophages

journal article published in 2002

Requirement for phosphatidylinositol 3-kinase in epidermal growth factor-induced AP-1 transactivation and transformation in JB6 P+ cells

scientific article published on November 1996

Resveratrol suppresses cell transformation and induces apoptosis through a p53-dependent pathway

scientific article published on February 1999

RhoGDI SUMOylation at Lys-138 increases its binding activity to Rho GTPase and its inhibiting cancer cell motility.

scientific article published on 5 March 2012

RhoGDIβ Promotes Sp1/MMP-2 Expression and Bladder Cancer Invasion Through Perturbing miR-200c-Targeted JNK2 Protein Translation

scientific article published on 28 August 2017

Role of N-acylethanolamines in cell signaling.

scientific article

Role of STAT3 and FOXO1 in the Divergent Therapeutic Responses of Non-metastatic and Metastatic Bladder Cancer Cells to miR-145.

scientific article published on 21 February 2017

Role of bioavailable iron in coal dust-induced activation of activator protein-1 and nuclear factor of activated T cells: difference between Pennsylvania and Utah coal dusts

journal article published in 2002

Role of reactive oxygen species and MAPKs in vanadate-induced G2/M phase arrest ⬇️

scientific article published on May 15, 2003

SESN2/sestrin 2 induction-mediated autophagy and inhibitory effect of isorhapontigenin (ISO) on human bladder cancers

scientific article published on 12 May 2016

SOX30 Inhibits Tumor Metastasis through Attenuating Wnt-Signaling via Transcriptional and Posttranslational Regulation of β-Catenin in Lung Cancer.

scientific article

SOX30, a novel epigenetic silenced tumor suppressor, promotes tumor cell apoptosis by transcriptional activating p53 in lung cancer

scientific article

SUMOylation of RhoGDIα is required for its repression of cyclin D1 expression and anchorage-independent growth of cancer cells

scientific article published on 3 December 2013

Shortage of mitogen-activated protein kinase is responsible for resistance to AP-1 transactivation and transformation in mouse JB6 cells.

scientific article published on January 1998

Signal transduction through atypical PKCs, but not the EGF receptor, is necessary for UVC-induced AP-1 activation in immortal murine cells

scientific article published on April 1997

Soluble and insoluble nickel compounds exert a differential inhibitory effect on cell growth through IKKalpha-dependent cyclin D1 down-regulation

scientific article published on January 2009

Suberoylanilide hydroxamic acid (SAHA) inhibits EGF-induced cell transformation via reduction of cyclin D1 mRNA stability

scientific article published on 28 June 2012

Superoxide plays critical roles in electrotaxis of fibrosarcoma cells via activation of ERK and reorganization of the cytoskeleton

scientific article

TMEM196 acts as a novel functional tumour suppressor inactivated by DNA methylation and is a potential prognostic biomarker in lung cancer

scientific article

The Chinese herb isolate isorhapontigenin induces apoptosis in human cancer cells by down-regulating overexpression of antiapoptotic protein XIAP.

scientific article

The Chinese herb isolate yuanhuacine (YHL-14) induces G2/M arrest in human cancer cells by up-regulating p21 protein expression through an p53 protein-independent cascade

scientific article published on 22 January 2014

The N-terminal region of p27 inhibits HIF-1α protein translation in ribosomal protein S6-dependent manner by regulating PHLPP-Ras-ERK-p90RSK axis

scientific article

The biological functions of NF-kappaB1 (p50) and its potential as an anti-cancer target

scientific article published on June 2009

The effects of hybridoma growth factor in conditioned media upon the growth, cloning, and antibody production of heterohybridoma cell lines

scientific article published on January 1993

The extracellular-signal-regulated protein kinases (Erks) are required for UV-induced AP-1 activation in JB6 cells

scientific article published on May 1999

The requirement of c-Jun N-terminal kinase 2 in regulation of hypoxia-inducing factor-1α mRNA stability

scientific article (publication date: 5 October 2012)

The role of epidermal growth factor receptor in ethanol-mediated inhibition of activator protein-1 transactivation

scientific article

The role of phosphatidylinositol-3 kinase in vanadate-promoted S phase entry

journal article published in 2004

Transactivation of AP-1 in AP-1-luciferase reporter transgenic mice by arsenite and arsenate.

scientific article published on January 2001

Transactivation of RARE and GRE in the cellular response to arsenic

journal article published in 2001

Transcriptional and Posttranscriptional Upregulation of p27 Mediates Growth Inhibition of Isorhapontigenin (ISO) on Human Bladder Cancer Cells

scientific article published on 2 February 2018

Translocation of protein kinase Cepsilon and protein kinase Cdelta to membrane is required for ultraviolet B-induced activation of mitogen-activated protein kinases and apoptosis

scientific article published on May 1999

Tumor-suppressor NFκB2 p100 interacts with ERK2 and stabilizes PTEN mRNA via inhibition of miR-494

scientific article published on 21 December 2015

UV induces phosphorylation of protein kinase B (Akt) at Ser-473 and Thr-308 in mouse epidermal C1 41 cells through hydrogen peroxide ⬇️

journal article published in 2001

Ultraviolet B-induced activated protein-1 activation does not require epidermal growth factor receptor but is blocked by a dominant negative PKClambda/iota

scientific article published on 01 December 1996

Ultraviolet-induced phosphorylation of p70(S6k) at Thr(389) and Thr(421)/Ser(424) involves hydrogen peroxide and mammalian target of rapamycin but not Akt and atypical protein kinase c ⬇️

journal article published in 2002

Upregulation of SQSTM1/p62 contributes to nickel-induced malignant transformation of human bronchial epithelial cells

scientific article

Urothelial tumor initiation requires deregulation of multiple signaling pathways: implications in target-based therapies

scientific article

VEGF is upregulated by hypoxia-induced mitogenic factor via the PI-3K/Akt-NF-kappaB signaling pathway

scientific article published on 2 March 2006

Vanadate activated Akt and promoted S phase entry

journal article published in 2004

Vanadate induces p53 transactivation through hydrogen peroxide and causes apoptosis

journal article published in 2000

Vanadate-induced cell growth regulation and the role of reactive oxygen species

journal article published in 2001

Vanadium induces AP-1- and NFkappB-dependent transcription activity

scientific article published on October 1998

Vanadium-induced apoptosis and pulmonary inflammation in mice: role of reactive oxygen species

journal article published in 2003

Vanadium-induced nuclear factor of activated T cells activation through hydrogen peroxide ⬇️

journal article published in 2001

Vitamin C inhibits benzo[a]pyrene-induced cell cycle changes partly via cyclin D1/E2F pathway in human embryo lung fibroblasts ⬇️

journal article published in 2006

White matter connectivity in incident mild cognitive impairment: a diffusion spectrum imaging study of World Trade Center responders at midlife

journal article published in 2021

World Trade Center site exposure duration is associated with hippocampal and cerebral white matter neuroinflammation

journal article published in 2022

X-linked Inhibitor of Apoptosis Protein (XIAP) Regulation of Cyclin D1 Protein Expression and Cancer Cell Anchorage-independent Growth via Its E3 Ligase-mediated Protein Phosphatase 2A/c-Jun Axis ⬇️

scientific article published on May 29, 2013

X-linked inhibitor of apoptosis protein (XIAP) lacking RING domain localizes to the nuclear and promotes cancer cell anchorage-independent growth by targeting the E2F1/Cyclin E axis

scientific article published on August 2014

X-linked inhibitor of apoptosis protein (XIAP) mediates cancer cell motility via Rho GDP dissociation inhibitor (RhoGDI)-dependent regulation of the cytoskeleton

scientific article

XIAP BIR domain suppresses miR-200a expression and subsequently promotes EGFR protein translation and anchorage-independent growth of bladder cancer cell

scientific article

XIAP RING domain mediates miR-4295 expression and subsequently inhibiting p63α protein translation and promoting transformation of bladder epithelial cells

scientific article published on 18 July 2016

XIAP overexpression promotes bladder cancer invasion in vitro and lung metastasis in vivo via enhancing nucleolin-mediated Rho-GDIβ mRNA stability

scientific article published on 18 December 2017

[ERK and JNK/AP-1 pathways involved in benzo(a)pyrene induced cell cycle changes in human embryo lung fibroblasts].

scientific article

[The activation of MAPK/cyclin D1-CDK4 signaling pathway caused by quartz].

scientific article published in January 2007

[Vitamin C reverses benzo (a) pyrene-induced cell cycle changes by E2F pathway].

scientific article

c-Jun NH2-terminal kinase 1 plays a critical role in intestinal homeostasis and tumor suppression

scientific article published in July 2007

c-Jun NH2-terminal kinase and extracellular signal-regulated protein kinase signaling pathways in regulation of benzo(a)pyrene-induced c-Jun activation in human embryo lung fibroblasts

scientific article published in July 2007

c-Jun/AP-1 pathway-mediated cyclin D1 expression participates in low dose arsenite-induced transformation in mouse epidermal JB6 Cl41 cells

scientific article

gamma-Aminobutyric acid(A) (GABA(A)) receptor regulates ERK1/2 phosphorylation in rat hippocampus in high doses of methyl tert-butyl ether (MTBE)-induced impairment of spatial memory

scientific article

intCC: an efficient weighted integrative consensus clustering of multimodal data

conference proceedings item published in 2023

miR-3687 Overexpression Promotes Bladder Cancer Cell Growth by Inhibiting the Negative Effect of FOXP1 on Cyclin E2 Transcription

scientific article published on 15 March 2019

microRNA, Cancer and Cancer Chemoprevention.

scientific article published on 30 May 2012

p27 suppresses arsenite-induced Hsp27/Hsp70 expression through inhibiting JNK2/c-Jun- and HSF-1-dependent pathways

scientific article

p27 suppresses cyclooxygenase-2 expression by inhibiting p38β and p38δ-mediated CREB phosphorylation upon arsenite exposure ⬇️

scientific article published on April 29, 2013

p38 kinase mediates UV-induced phosphorylation of p53 protein at serine 389.

scientific article

p63α protein upregulates heat shock protein 70 expression via E2F1 transcription factor 1, promoting Wasf3/Wave3/MMP9 signaling and bladder cancer invasion

scientific article published on 09 August 2017

p85alpha acts as a novel signal transducer for mediation of cellular apoptotic response to UV radiation

scientific journal article

p85α mediates p53 K370 acetylation by p300 and regulates its promoter-specific transactivity in the cellular UVB response

scientific journal article

p85α promotes nucleolin transcription and subsequently enhances EGFR mRNA stability and EGF-induced malignant cellular transformation

scientific article

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