List of works by Karl Kunzelmann

14-3-3 interacts with regulator of G protein signaling proteins and modulates their activity

scientific article (publication date: 8 September 2000)

A Coding Variant of ANO10, Affecting Volume Regulation of Macrophages, Is Associated with Borrelia Seropositivity

scientific article published on 23 February 2015

A novel microscopy-based assay identifies extended synaptotagmin-1 (ESYT1) as a positive regulator of anoctamin 1 traffic

scientific article published on 15 November 2017

ADAM10 sheddase activation is controlled by cell membrane asymmetry

scientific article published on 01 December 2019

AMPK controls epithelial Na(+) channels through Nedd4-2 and causes an epithelial phenotype when mutated.

scientific article published on 31 March 2009

APC sensitive gastric acid secretion.

scientific article published on 18 February 2009

Actin-dependent activation of ion conductances in bronchial epithelial cells

scientific article published on March 1995

Activation of ion secretion via proteinase-activated receptor-2 in human colon

scientific article published in February 2002

Acute effects of parainfluenza virus on epithelial electrolyte transport.

scientific article published on 10 September 2004

Airway epithelial cells--functional links between CFTR and anoctamin dependent Cl- secretion

scientific article published on 16 June 2012

Airway epithelial cells--hyperabsorption in CF?

scientific article published on 21 April 2012

Allergen-induced airway hyperresponsiveness is absent in ecto-5'-nucleotidase (CD73)-deficient mice

scientific article published on 8 July 2008

An extract from the medicinal plant Phyllanthus acidus and its isolated compounds induce airway chloride secretion: A potential treatment for cystic fibrosis.

scientific article

Anoctamin 1 induces calcium-activated chloride secretion and proliferation of renal cyst-forming epithelial cells.

scientific article

Anoctamin 6 is an essential component of the outwardly rectifying chloride channel

scientific article

Anoctamin 6 mediates effects essential for innate immunity downstream of P2X7 receptors in macrophages

scientific article

Anoctamin-6 controls bone mineralization by activating the calcium transporter NCX1

scientific article

Anoctamin-6 regulates ADAM sheddase function

scientific article published on 23 August 2018

Anoctamins

scientific article

Anoctamins are a family of Ca2+-activated Cl- channels

scientific article

Anoctamins support calcium-dependent chloride secretion by facilitating calcium signaling in adult mouse intestine

Aquaporin 3 cloned from Xenopus laevis is regulated by the cystic fibrosis transmembrane conductance regulator

scientific article published in June 2000

Assessment of CFTR function in rectal biopsies for the diagnosis of cystic fibrosis.

scientific article published in August 2004

Bestrophin 1 and 2 are components of the Ca2+ activated Cl− conductance in mouse airways

scientific article published on 03 July 2008

Bestrophin 1 promotes epithelial-to-mesenchymal transition of renal collecting duct cells

scientific article published on 21 May 2009

Bestrophin and TMEM16-Ca(2+) activated Cl(-) channels with different functions.

scientific article

Bicarbonate in cystic fibrosis

scientific article

CFTR Cl− channel function in native human colon correlates with the genotype and phenotype in cystic fibrosis

scientific article published on 01 October 2004

CFTR and TMEM16A are separate but functionally related Cl- channels

scientific article

CFTR induces extracellular acid sensing in Xenopus oocytes which activates endogenous Ca²⁺-activated Cl⁻ conductance

scientific article published on 7 June 2011

CFTR is activated through stimulation of purinergic P2Y2 receptors

scientific article

CFTR mutations altering CFTR fragmentation

scientific article published on January 2013

CFTR: a hub for kinases and crosstalk of cAMP and Ca2+

scientific article

CLCA1 Regulates Airway Mucus Production and Ion Secretion Through TMEM16A ⬇️

journal article from 'International Journal of Molecular Sciences' published in 2021

Ca(2+)- and swelling-induced activation of ion conductances in bronchial epithelial cells

scientific article published on October 1994

Ca2+-induced Cl- efflux at rat distal colonic epithelium

scientific article published on 24 January 2008

Ca<sup>2+</sup> Dependence of Volume-Regulated VRAC/LRRC8 and TMEM16A Cl<sup>-</sup> Channels

scientific article published on 01 December 2020

Calcium-activated and apoptotic phospholipid scrambling induced by Ano6 can occur independently of Ano6 ion currents

scientific article published on 25 April 2013

Calcium-dependent chloride conductance in epithelia: is there a contribution by Bestrophin?

scientific article published on 15 March 2007

Calmodulin-dependent activation of the epithelial calcium-dependent chloride channel TMEM16A

scientific article published on 29 November 2010

Cellular defects by deletion of ANO10 are due to deregulated local calcium signaling

scientific article published on 9 November 2016

Cellular volume regulation by anoctamin 6: Ca²⁺, phospholipase A2 and osmosensing

scientific article published on 6 October 2015

Characteristics of apical chloride channels in human colon cells (HT29).

scientific article

Characterization of novel airway submucosal gland cell models for cystic fibrosis studies

scientific article

Cl transport in complemented CF bronchial epithelial cells correlates with CFTR mRNA expression levels

scientific article published on 25 July 2008

Cl- channels in apoptosis.

scientific article

Cl- interference with the epithelial Na+ channel ENaC

scientific journal article

Cl- transport by cystic fibrosis transmembrane conductance regulator (CFTR) contributes to the inhibition of epithelial Na+ channels (ENaCs) in Xenopus oocytes co-expressing CFTR and ENaC.

scientific article published in May 1998

Cloning and function of the rat colonic epithelial K+ channel KVLQT1

scientific article

Comparative Analysis of Microfluidics Thrombus Formation in Multiple Genetically Modified Mice: Link to Thrombosis and Hemostasis

scientific article published on 30 July 2019

Compartmentalized crosstalk of CFTR and TMEM16A (ANO1) through EPAC1 and ADCY1.

scientific article published on 10 January 2018

Contribution of Anoctamins to Cell Survival and Cell Death

scientific article published on 19 March 2019

Contribution of TMEM16F to pyroptotic cell death

scientific article published on 20 February 2018

Contribution of casein kinase 2 and spleen tyrosine kinase to CFTR trafficking and protein kinase A-induced activity.

scientific article

Control of Ion Transport by Tmem16a Expressed in Murine Intestine

scientific article published on 04 October 2019

Control of Ion Transport in Mouse Proximal and Distal Colon by Prolactin

scientific article published on 01 January 2007

Control of TMEM16A by INO-4995 and other inositolphosphates

scientific article published on January 2013

Control of cystic fibrosis transmembrane conductance regulator expression by BAP31.

scientific article published on 26 March 2001

Control of epithelial Na

Control of epithelial ion transport by Cl- and PDZ proteins

scientific article published in May 2004

Control of ion transport in mammalian airways by protease activated receptors type 2 (PAR-2).

scientific article

Correction of the CF defect by curcumin: hypes and disappointments.

scientific article

Culture-dependent expression of Na+ conductances in airway epithelial cells

scientific article published on February 1996

Cyst growth in ADPKD is prevented by pharmacological and genetic inhibition of TMEM16A in vivo

scientific article published on 28 August 2020

Cystic fibrosis transmembrane conductance regulator activates water conductance in Xenopus oocytes

scientific article published in November 1997

Cystic fibrosis transmembrane conductance regulator inhibits epithelial Na+ channels carrying Liddle's syndrome mutations

scientific article published in May 1999

Differential contribution of SLC26A9 to Cl(-) conductance in polarized and non-polarized epithelial cells

scientific article

Disruption of the K+ channel beta-subunit KCNE3 reveals an important role in intestinal and tracheal Cl- transport

scientific article

ER-localized bestrophin 1 activates Ca2+-dependent ion channels TMEM16A and SK4 possibly by acting as a counterion channel.

scientific article published on 13 October 2009

Eag1 and Bestrophin 1 are up-regulated in fast-growing colonic cancer cells

scientific article published on 25 January 2008

Effect of Annexin A5 on CFTR: regulated traffic or scaffolding?

scientific article published on 11 November 2010

Effects of P-glycoprotein expression on cyclic AMP and volume-activated ion fluxes and conductances in HT-29 colon adenocarcinoma cells.

scientific article

Effects of dietary lectins on ion transport in epithelia

scientific article published on 5 July 2004

Effects of purinergic stimulation, CFTR and osmotic stress on amiloride-sensitive Na+ transport in epithelia and Xenopus oocytes

scientific article published in March 2003

Electrolyte transport in the mouse trachea: no evidence for a contribution of luminal K(+) conductance

scientific article published in September 2002

Enhanced expression of ANO1 in head and neck squamous cell carcinoma causes cell migration and correlates with poor prognosis

scientific article

Epithelial Chloride Transport by CFTR Requires TMEM16A.

scientific article published on 29 September 2017

Erratum to: AMPK controls epithelial Na+ channels through Nedd4-2 and causes an epithelial phenotype when mutated

scholarly article published in Pfluegers Archiv

Escherichia coli alpha-hemolysin triggers shrinkage of erythrocytes via K(Ca)3.1 and TMEM16A channels with subsequent phosphatidylserine exposure

scientific article

Establishment and characterization of a novel polarized MDCK epithelial cellular model for CFTR studies.

scientific article published on January 2005

Expression and function of colonic epithelial KvLQT1 K+ channels.

scientific article

Expression and function of epithelial anoctamins

scientific article

Expression and function of epithelial anoctamins

scientific journal article

Expression of Voltage-Gated Potassium Channels in Human and Mouse Colonic Carcinoma

scientific article published on 01 February 2007

F508del-CFTR increases intracellular Ca(2+) signaling that causes enhanced calcium-dependent Cl(-) conductance in cystic fibrosis

scientific article published on 30 August 2011

Feedback inhibition of epithelial Na(+) channels in Xenopus oocytes does not require G(0) or G(i2) proteins

scientific article

Flagellin of Pseudomonas aeruginosa inhibits Na+ transport in airway epithelia

scientific article published on 12 January 2006

Forskolin and PMA pretreatment of HT29 cells alters their chloride conductance induced by cAMP, Ca2+ and hypotonic cell swelling.

scientific article published on August 1994

Functional assembly and purinergic activation of bestrophins

scientific article

Functional characterization and genomic organization of the human Na(+)-sulfate cotransporter hNaS2 gene (SLC13A4).

scientific article published in January 2005

Functional genomics assays to study CFTR traffic and ENaC function

scientific article

Functional properties of the type-3 InsP3 receptor in 16HBE14o- bronchial mucosal cells

scientific article published on April 1998

GFP-tagged CFTR transgene is functional in the G551D cystic fibrosis mouse colon.

scientific article published in April 2003

Gene complementation of airway epithelium in the cystic fibrosis mouse is necessary and sufficient to correct the pathogen clearance and inflammatory abnormalities

scientific article published in May 2002

High-content siRNA screen reveals global ENaC regulators and potential cystic fibrosis therapy targets.

scientific article

IADS, a decomposition product of DIDS activates a cation conductance in Xenopus oocytes and human erythrocytes: new compound for the diagnosis of cystic fibrosis

scientific article published in January 2006

Impaired Renal HCO3 - Excretion in Cystic Fibrosis

scientific article published on 23 July 2020

Increase in intracellular Cl- concentration by cAMP- and Ca2+-dependent stimulation of M1 collecting duct cells

scientific article

Inhibition of epithelial Na+ currents by intracellular domains of the cystic fibrosis transmembrane conductance regulator

scientific article published in January 1997

Inhibition of protein kinase CK2 closes the CFTR Cl channel, but has no effect on the cystic fibrosis mutant deltaF508-CFTR.

scientific article

Introduction to section V: assessment of CFTR function

scientific article published in January 2011

Involvement of Ca2+ Activated Cl- Channel Ano6 in Platelet Activation and Apoptosis

scientific article published on 20 November 2015

Ion transport induced by proteinase-activated receptors (PAR2) in colon and airways

scientific article

KCNMA1 gene amplification promotes tumor cell proliferation in human prostate cancer

scientific article published on 4 December 2006

KLF4 Acts as a wt-CFTR Suppressor through an AKT-Mediated Pathway

scientific article published on 02 July 2020

KVLQT channels are inhibited by the K+ channel blocker 293B.

scientific article

Lack of correlation between CFTR expression, CFTR Cl- currents, amiloride-sensitive Na+ conductance, and cystic fibrosis phenotype.

scientific article

Lipid Peroxidation Drives Renal Cyst Growth In Vitro through Activation of TMEM16A

scientific article published on 03 January 2019

Localization and functional characterization of the human NKCC2 isoforms.

scientific article published on 8 February 2010

Loss of TMEM16A causes a defect in epithelial Ca2+-dependent chloride transport

scientific article published on 13 August 2009

Measurements of CFTR-mediated Cl- secretion in human rectal biopsies constitute a robust biomarker for Cystic Fibrosis diagnosis and prognosis.

scientific article

Mechanisms for the inhibition of amiloride-sensitive Na+ absorption by extracellular nucleotides in mouse trachea

scientific article published on 14 February 2002

Mechanisms of the inhibition of epithelial Na(+) channels by CFTR and purinergic stimulation.

scientific article

Mechanistic insight into control of CFTR by AMPK.

scientific article published on 18 December 2008

Metformin treatment of diabetes mellitus increases the risk for pancreatitis in patients bearing the CFTR-mutation S573C.

scientific article published on 23 March 2010

Modulating Ca²⁺ signals: a common theme for TMEM16, Ist2, and TMC.

scientific article

Modulation of Ca2+-activated Cl- secretion by basolateral K+ channels in human normal and cystic fibrosis airway epithelia

scientific article (publication date: April 2003)

Molecular and functional characterization of CBAVD-causing mutations located in CFTR nucleotide-binding domains

scientific article published on 25 July 2008

Molecular and functional characterization of the small Ca(2+)-regulated K+ channel (rSK4) of colonic crypts

scientific article published on September 1999

Molecular cloning and characterization of the mouse Na+ sulfate cotransporter gene (Slc13a4): Structure and expression

scientific article published on August 2006

Molecular evolution and functional divergence of the bestrophin protein family

scientific article (publication date: 28 February 2008)

Molecular functions of anoctamin 6 (TMEM16F): a chloride channel, cation channel, or phospholipid scramblase?

scientific article published on 08 June 2013

Molecular targeting of CFTR as a therapeutic approach to cystic fibrosis.

scientific article published on 18 June 2007

Mucus Release and Airway Constriction by TMEM16A May Worsen Pathology in Inflammatory Lung Disease ⬇️

journal article from 'International Journal of Molecular Sciences' published in 2021

N-Acetyl-L-cysteine and its derivatives activate a Cl- conductance in epithelial cells

scientific article published in February 1996

NCX1 represents an ionic Na+ sensing mechanism in macrophages

scientific article published on 22 June 2020

Na+ and Cl? conductances in airway epithelial cells: increased Na+ conductance in cystic fibrosis

scientific article published on 01 November 1995

Niclosamide repurposed for the treatment of inflammatory airway disease

scientific article published on 08 August 2019

No evidence for direct activation of the cystic fibrosis transmembrane conductance regulator by 8-cyclopentyl-1,3-dipropylxanthine

scientific article published on January 1998

No evidence for inhibition of ENaC through CFTR-mediated release of ATP.

scientific article published in September 2002

Non-essential contribution of LRRC8A to volume regulation

scientific article published on 13 February 2016

Oligonucleotide-based gene targeting approaches.

scientific article

Organoids as a personalized medicine tool for ultra-rare mutations in cystic fibrosis: The case of S955P and 1717-2A > G

scientific article published on 27 July 2020

Pharmacological Inhibition and Activation of the Ca2+ Activated Cl- Channel TMEM16A

scientific article published on 07 April 2020

Pharmacotherapy of the ion transport defect in cystic fibrosis.

scientific article

Pharmacotherapy of the ion transport defect in cystic fibrosis: role of purinergic receptor agonists and other potential therapeutics

scientific article published on January 2003

Plasma membrane-localized TMEM16 proteins are indispensable for expression of CFTR

scientific article published on 26 March 2019

Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels

scholarly article

Polycystin-2 activity is controlled by transcriptional coactivator with PDZ binding motif and PALS1-associated tight junction protein

scientific article

Properties and function of KCNQ1 K+ channels isolated from the rectal gland of Squalus acanthias.

scientific article published in October 2001

Protein kinase CK2, cystic fibrosis transmembrane conductance regulator, and the deltaF508 mutation: F508 deletion disrupts a kinase-binding site.

scientific article published on 8 February 2007

Protein traffic disorders: an effective high-throughput fluorescence microscopy pipeline for drug discovery.

scientific article published on 12 March 2015

Purinergic P2Y6 receptors induce Ca2+ and CFTR dependent Cl- secretion in mouse trachea

scientific article published in January 2005

Purinergic inhibition of the epithelial Na+ transport via hydrolysis of PIP2.

scientific article published on 25 October 2004

Rapamycin inhibits oncogenic intestinal ion channels and neoplasia in APC(Min/+) mice

scientific article published on 7 December 2009

Rectal forceps biopsy procedure in cystic fibrosis: technical aspects and patients perspective for clinical trials feasibility.

scientific article

Regulation and Function of TMEM16F in Renal Podocytes

scientific article published on 18 June 2018

Regulation of Cl(-) secretion by AMPK in vivo

scientific article published on 28 August 2008

Regulation of ENaC biogenesis by the stress response protein SERP1.

scientific article

Regulation of TMEM16A by CK2 and Its Role in Cellular Proliferation

scientific article published on 05 May 2020

Regulation of TMEM16A/ANO1 and TMEM16F/ANO6 ion currents and phospholipid scrambling by Ca2+ and plasma membrane lipid.

scientific article

Regulation of the epithelial Na+ channel by the protein kinase CK2.

scientific article published on 28 February 2008

Relationship between TMEM16A/anoctamin 1 and LRRC8A.

scientific article published on 12 August 2016

Rescue of the mineralocorticoid receptor knock-out mouse

scientific article published on 01 August 1999

Role of CFTR's PDZ1-binding domain, NBF1 and Cl(-) conductance in inhibition of epithelial Na(+) channels in Xenopus oocytes

scientific article

Role of KCNMA1 in breast cancer

scientific article

Role of anoctamins in cancer and apoptosis

scientific article published on 03 February 2014

Role of the Ca2+ -activated Cl- channels bestrophin and anoctamin in epithelial cells

scientific article

Rotavirus toxin NSP4 induces diarrhea by activation of TMEM16A and inhibition of Na+ absorption

scientific article published on 12 March 2011

Simultaneous recording of the cell membrane potential and properties of the cell attached membrane of HT29 colon carcinoma and CF-PAC cells

scientific article published on September 1991

Slc26a11 is prominently expressed in the brain and functions as a chloride channel: expression in Purkinje cells and stimulation of V H⁺-ATPase

scientific article published on 4 June 2013

Small and intermediate conductance chloride channels in HT29 cells

scientific article published on September 1993

Small-conductance Cl? channels in HT29 cells: activation by Ca2+, hypotonic cell swelling and 8-Br-cGMP

scientific article published on 01 June 1992

Small-conductance chloride channels induced by cAMP, Ca2+, and hypotonicity in HT29 cells: ion selectivity, additivity and stilbene sensitivity

scientific article published on August 1992

Specific blockade of slowly activating I(sK) channels by chromanols -- impact on the role of I(sK) channels in epithelia

scientific article published in November 1996

Survival protein anoctamin-6 controls multiple platelet responses including phospholipid scrambling, swelling, and protein cleavage.

scientific article

TMC8 (EVER2) attenuates intracellular signaling by Zn2+ and Ca2+ and suppresses activation of Cl- currents

scientific article published on 15 September 2014

TMEM16 proteins produce volume-regulated chloride currents that are reduced in mice lacking TMEM16A.

scientific article

TMEM16A Mediated Mucus Production in Human Airway Epithelial Cells

scientific article published on 07 October 2020

TMEM16A deficiency: a potentially fatal neonatal disease resulting from impaired chloride currents

scientific article published on 02 June 2020

TMEM16A drives renal cyst growth by augmenting Ca2+ signaling in M1 cells

scientific article published on 18 March 2020

TMEM16A in Cystic Fibrosis: Activating or Inhibiting?

scholarly article by Karl Kunzelmann et al published 2019 in Frontiers in Pharmacology

TMEM16A induces MAPK and contributes directly to tumorigenesis and cancer progression.

scientific article published on 7 May 2012

TMEM16A is indispensable for basal mucus secretion in airways and intestine

scientific article published on 26 December 2018

TMEM16F-Mediated Platelet Membrane Phospholipid Scrambling Is Critical for Hemostasis and Thrombosis but not Thromboinflammation in Mice-Brief Report.

scientific article published on 15 September 2016

TMEM16F/Anoctamin 6 in Ferroptotic Cell Death

scientific article published on 05 May 2019

Targeted replacement of normal and mutant CFTR sequences in human airway epithelial cells using DNA fragments

scientific article published on November 1998

Targeting of Intracellular TMEM16 Proteins to the Plasma Membrane and Activation by Purinergic Signaling

scientific article published on 05 June 2020

The DeltaF508 mutation results in loss of CFTR function and mature protein in native human colon

scientific article

The calcium-activated chloride channel Anoctamin 1 contributes to the regulation of renal function

scientific article published on 29 January 2014

The cystic fibrosis transmembrane conductance regulator attenuates the endogenous Ca2+ activated Cl- conductance of Xenopus oocytes

scientific article published in December 1997

The first-nucleotide binding domain of the cystic-fibrosis transmembrane conductance regulator is important for inhibition of the epithelial Na+ channel.

scientific article

The kappa-opioid receptor agonist asimadoline inhibits epithelial transport in mouse trachea and colon

scientific article published in October 2004

The rat Na+-sulfate cotransporter rNaS2: functional characterization, tissue distribution, and gene (slc13a4) structure.

scientific article published on 12 May 2005

The role of the IsK protein in the specific pharmacological properties of the IKs channel complex

scientific article

Transport properties in CFTR-/- knockout piglets suggest normal airway surface liquid pH and enhanced amiloride-sensitive Na+ absorption

scientific article published on 25 July 2020

Upregulation of colonic ion channels in APC ( Min/+ ) mice

scientific article

Voltage-gated K+ channels support proliferation of colonic carcinoma cells

scientific article published on 29 November 2006

Wild type but not deltaF508 CFTR inhibits Na+ conductance when coexpressed in Xenopus oocytes

scientific article published in February 1996

cAMP stimulation of CFTR-expressing Xenopus oocytes activates a chromanol-inhibitable K+ conductance

scientific article published in July 1996

cAMP-dependent activation of ion conductances in bronchial epithelial cells

scientific article published on October 1994

cAMP-dependent activation of small-conductance Cl- channels in HT29 colon carcinoma cells

scientific article

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