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List of works by Alexander Cameron

1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles: identification of a potent Aurora kinase inhibitor with a favorable antitumor kinase inhibition profile.

scientific article published on November 2006

3-Amino-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles: a new class of CDK2 inhibitors.

scientific article published on 14 November 2005

3-Aminopyrazole inhibitors of CDK2/cyclin A as antitumor agents. 1. Lead finding

scientific article

3-Aminopyrazole inhibitors of CDK2/cyclin A as antitumor agents. 2. Lead optimization

scientific article

A two-domain elevator mechanism for sodium/proton antiport

scientific article

Allosteric activation in Bacillus stearothermophilus lactate dehydrogenase investigated by an X-ray crystallographic analysis of a mutant designed to prevent tetramerization of the enzyme.

scientific article

Alternating access mechanism in the POT family of oligopeptide transporters

scientific article

An evolutionary approach to the design of glutathione-linked enzymes.

scientific article

Benchmarking membrane protein detergent stability for improving throughput of high-resolution X-ray structures

scientific article published on January 2011

Benzodipyrazoles: a new class of potent CDK2 inhibitors.

scientific article published on March 2005

Clustering procedures for the optimal selection of data sets from multiple crystals in macromolecular crystallography.

scientific article

Cryo-EM of multiple cage architectures reveals a universal mode of clathrin self-assembly

scientific article published on 03 October 2019

Crystal structure of a bacterial homologue of the bile acid sodium symporter ASBT

scientific article

Crystal structure of a prokaryotic homologue of the mammalian oligopeptide-proton symporters, PepT1 and PepT2

scientific article

Crystal structure of glucansucrase from the dental caries pathogen Streptococcus mutans

scientific article

Crystal structure of human glyoxalase I_evidence for gene duplication and 3D domain swapping ⬇️

scientific article published on June 16, 1997

Crystal structure of the T315I Abl mutant in complex with the aurora kinases inhibitor PHA-739358

scientific article

Crystal structure of the anion exchanger domain of human erythrocyte band 3

scientific article

Crystal structure of the sodium-proton antiporter NhaA dimer and new mechanistic insights

scientific article

Crystal structures reveal the molecular basis of ion translocation in sodium/proton antiporters

scientific article

Energetics of the proposed rate-determining step of the glyoxalase I reaction

scientific article published on 01 June 1999

Errors and reproducibility in electron-density map interpretation.

scientific article

G-protein-coupled receptor inactivation by an allosteric inverse-agonist antibody

scientific article

GFP-based expression screening of membrane proteins in insect cells using the baculovirus system

scientific article published on January 2015

Involvement of an Active-site Zn2+ Ligand in the Catalytic Mechanism of Human Glyoxalase I ⬇️

scientific article published on August 21, 1998

Molecular Basis of Alternating Access Membrane Transport by the Sodium-Hydantoin Transporter Mhp1

scientific article

Molecular mechanism of ligand recognition by membrane transport protein, Mhp1 ⬇️

scientific article

Overcoming the challenges of membrane protein crystallography.

scientific article

Potent and selective Aurora inhibitors identified by the expansion of a novel scaffold for protein kinase inhibition

scientific article

Reaction mechanism of glyoxalase I explored by an X-ray crystallographic analysis of the human enzyme in complex with a transition state analogue

scientific article

Structural Basis of Glycerophosphodiester Recognition by the Mycobacterium tuberculosis Substrate-Binding Protein UgpB

scientific article published on 21 August 2019

Structural and functional determination of homologs of the Mycobacterium tuberculosis N-acetylglucosamine-6-phosphate deacetylase (NagA).

scientific article published on 4 May 2018

Structural basis of carnitine monooxygenase CntA substrate specificity, inhibition and inter-subunit electron transfer

scientific article published on 06 November 2020

Structure and Molecular Mechanism of a Nucleobase-Cation-Symport-1 Family Transporter

scientific article

Structure and mechanism of the chalcogen-detoxifying protein TehB from Escherichia coli

scientific article

Structure of eukaryotic purine/H(+) symporter UapA suggests a role for homodimerization in transport activity.

scientific article published on 18 April 2016

Structure-based approaches to improve selectivity: CDK2-GSK3beta binding site analysis

scientific article published in September 2005

Structures of the human eIF4E homologous protein, h4EHP, in its m7GTP-bound and unliganded forms

scientific article

The Leishmania PABP1–eIF4E4 interface: a novel 5′–3′ interaction architecture for trans-spliced mRNAs ⬇️

scientific article published on 01 February 2019

The X-ray crystal structure of the Trichoderma reesei family 12 endoglucanase 3, Cel12A, at 1.9 A resolution

scientific article

The active-site residue tyr-175 in human glyoxalase II contributes to binding of glutathione derivatives

scientific article published on 01 September 2000

The alternating access mechanism of transport as observed in the sodium-hydantoin transporter Mhp1.

scientific article published on 5 November 2010

The structure of the yeast NADH dehydrogenase (Ndi1) reveals overlapping binding sites for water- and lipid-soluble substrates

scientific article

Thieno[3,2-c]pyrazoles: a novel class of Aurora inhibitors with favorable antitumor activity

scientific article

Transporter oligomerization: form and function

scientific article

Tricks of the trade used to accelerate high-resolution structure determination of membrane proteins

scientific article published on 13 April 2010

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