List of works - Taisuke Tomita

A faster migrating variant masquerades as NICD when performing in vitro gamma-secretase assays with bacterially expressed Notch substrates

scientific article published on April 2006

A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling

scientific article published on October 1999

A noncompetitive BACE1 inhibitor TAK-070 ameliorates Abeta pathology and behavioral deficits in a mouse model of Alzheimer's disease.

scientific article published on August 2010

A novel non-canonical Notch signaling regulates expression of synaptic vesicle proteins in excitatory neurons.

scientific article published on 4 April 2016

A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis

scientific article published on 17 October 2003

A role for presenilin 1 in regulating the delivery of amyloid precursor protein to the cell surface

scientific article published in October 2002

AP180 N-Terminal Homology (ANTH) and Epsin N-Terminal Homology (ENTH) Domains: Physiological Functions and Involvement in Disease

scientific article published on 01 January 2019

APP processing and synaptic function

scientific article (publication date: 27 March 2003)

Aberrant proteolytic processing and therapeutic strategies in Alzheimer disease

scientific article published on 5 January 2017

Abeta42 overproduction associated with structural changes in the catalytic pore of gamma-secretase: common effects of Pen-2 N-terminal elongation and fenofibrate

scientific article published on 28 February 2007

Activation of γ-Secretase Trimming Activity by Topological Changes of Transmembrane Domain 1 of Presenilin 1.

scientific article

Activity-dependent proteolytic cleavage of neuroligin-1.

scientific article published on 17 October 2012

Allosteric regulation of γ-secretase activity by a phenylimidazole-type γ-secretase modulator

scientific article

Alzheimer's disease treatment by inhibition/modulation of the gamma-secretase activity

scientific article published in November 2009

Amyloid precursor proteins inhibit heme oxygenase activity and augment neurotoxicity in Alzheimer's disease

scientific article published in November 2000

Aph-1 contributes to the stabilization and trafficking of the gamma-secretase complex through mechanisms involving intermolecular and intramolecular interactions.

scientific article

Association of active gamma-secretase complex with lipid rafts.

scientific article published on 16 February 2005

Attenuation of the aggregation and neurotoxicity of amyloid-β peptides by catalytic photooxygenation

scientific article published on 11 December 2013

Autism-associated variants of neuroligin 4X impair synaptogenic activity by various molecular mechanisms

scientific article published on 01 September 2020

BACE1 activity is modulated by cell-associated sphingosine-1-phosphate.

scientific article

BIN1 regulates BACE1 intracellular trafficking and amyloid-β production

scientific article

BetaAPP gamma-secretase and SREBP site 2 protease are two different enzymes

scientific article published on March 1998

Binding of longer Aβ to transmembrane domain 1 of presenilin 1 impacts on Aβ42 generation

scientific article published on 13 January 2014

Biochemical characterization of the Drosophila wingless signaling pathway based on RNA interference

scientific article published on March 2004

C-terminal Fragment of Presenilin Is the Molecular Target of a Dipeptidic γ-Secretase-specific Inhibitor DAPT (N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycinet-Butyl Ester)

scientific article published in Journal of Biological Chemistry

CD2-associated protein (CD2AP) overexpression accelerates amyloid precursor protein (APP) transfer from early endosomes to the lysosomal degradation pathway

scientific article published on 28 May 2019

Cell-free methods to produce structurally intact mammalian membrane proteins.

scientific article published on 28 July 2016

Cerebrospinal fluid levels of amyloid beta-peptide1-42, but not tau have positive correlation with brain glucose metabolism in humans

scientific article published in October 1999

Comparison of presenilin 1 and presenilin 2 γ-secretase activities using a yeast reconstitution system

scientific article published on 10 November 2011

Complex N-glycosylated form of nicastrin is stabilized and selectively bound to presenilin fragments

scientific article

Conformational Changes in Transmembrane Domain 4 of Presenilin 1 Are Associated with Altered Amyloid-β 42 Production

scientific article published in January 2016

Conformational Dynamics of Transmembrane Domain 3 of Presenilin 1 Is Associated with the Trimming Activity of γ-Secretase

scientific article published on 16 September 2019

Contribution of the γ-secretase subunits to the formation of catalytic pore of presenilin 1 protein

scientific article

Convenient Synthesis of Photoaffinity Probes and Evaluation of Their Labeling Abilities

scientific article published on 05 May 2007

Cooperative roles of hydrophilic loop 1 and the C-terminus of presenilin 1 in the substrate-gating mechanism of γ-secretase.

scientific article published on February 2015

Decreased CALM expression reduces Aβ42 to total Aβ ratio through clathrin-mediated endocytosis of γ-secretase

scientific article

Development of Alzheimer's disease treatment based on the molecular mechanism of ^|^gamma;-secretase activity

scientific article published on January 1, 2012

Development of photoaffinity probes for gamma-secretase equipped with a nitrobenzenesulfonamide-type cleavable linker

scientific article published on 23 October 2009

Differentiation of CD11c+ CX3CR1+ cells in the small intestine requires Notch signaling

scientific article published on 07 April 2014

Distinct Neurotoxic Effects of Extracellular Tau Species in Primary Neuronal-Glial Cultures

scientific article published on 01 October 2020

Divergent Synthesis of Multifunctional Molecular Probes To Elucidate the Enzyme Specificity of Dipeptidic γ-Secretase Inhibitors

Dual antitumor mechanisms of Notch signaling inhibitor in a T-cell acute lymphoblastic leukemia xenograft model.

scientific article published on 27 August 2009

Dysregulated Metabolism of the Amyloid-β Protein and Therapeutic Approaches in Alzheimer Disease

scientific article

Effect of helical conformation and side chain structure on γ-secretase inhibition by β-peptide foldamers: insight into substrate recognition.

scientific article published on 6 February 2013

Effects of PS1 deficiency on membrane protein trafficking in neurons

scientific article

Efficient four-drug cocktail therapy targeting amyloid-β peptide for Alzheimer's disease

scientific article published on October 2010

Enhancement of amyloid beta 42 secretion by 28 different presenilin 1 mutations of familial Alzheimer's disease

scientific article

Evidence That Intramolecular Associations between Presenilin Domains Are Obligatory for Endoproteolytic Processing

scientific article published in Journal of Biological Chemistry

Experimental detection of proteolytic activity in a signal peptide peptidase of Arabidopsis thaliana.

scientific article

FTY720/fingolimod, a sphingosine analogue, reduces amyloid-β production in neurons.

scientific article

Familial Alzheimer's disease-linked mutations at Val717 of amyloid precursor protein are specific for the increased secretion of A beta 42(43).

scientific article published in October 1996

Functional analysis of the transmembrane domains of presenilin 1: participation of transmembrane domains 2 and 6 in the formation of initial substrate-binding site of gamma-secretase.

scientific article

Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble alpha-synuclein.

scientific article published in September 1998

High performance plasma amyloid-β biomarkers for Alzheimer's disease

scientific article published on 31 January 2018

Highly efficient synthesis of medium-sized lactams via intramolecular Staudinger–aza-Wittig reaction of ω-azido pentafluorophenyl ester: synthesis and biological evaluation of LY411575 analogues

Histidine 131 in presenilin 1 is the pH-sensitive residue that causes the increase in Aβ42 level in acidic pH

scientific article published on 09 December 2019

Human tauopathy-derived tau strains determine the substrates recruited for templated amplification

scientific article published on 01 September 2021

Imbalance of Clara cell-mediated homeostatic inflammation is involved in lung metastasis.

scientific article

Inhibition of gamma-secretase activity by helical beta-peptide foldamers.

scientific article published in June 2009

Inhibition of γ-secretase activity by a monoclonal antibody against the extracellular hydrophilic loop of presenilin 1.

scientific article published on 14 December 2012

Loss of kallikrein-related peptidase 7 exacerbates amyloid pathology in Alzheimer's disease model mice

scientific article published on 8 January 2018

Mechanism of Ca2+ disruption in Alzheimer's disease by presenilin regulation of InsP3 receptor channel gating.

scientific article

Memantine inhibits β-amyloid aggregation and disassembles preformed β-amyloid aggregates.

scientific article published on 13 September 2017

Memantine reduces the production of amyloid-β peptides through modulation of amyloid precursor protein trafficking.

scientific article published on 3 February 2017

Membrane trafficking and proteolytic activity of γ-secretase in Alzheimer's disease

scientific article

Molecular cell biology of presenilins

scientific article published on 01 December 1999

Molecular cloning and characterization of CALP/KChIP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4

scientific article

Molecular cloning and expression of the novel splice variants of K(+) channel-interacting protein 2

scientific article (publication date: 23 March 2001)

Molecular cloning of a novel basic helix-loop-helix protein from the rat brain

scientific article published in February 1996

Molecular dissection of domains in mutant presenilin 2 that mediate overproduction of amyloidogenic forms of amyloid beta peptides. Inability of truncated forms of PS2 with familial Alzheimer's disease mutation to increase secretion of Abeta42.

scientific article published on August 1998

Molecular mechanism of intramembrane proteolysis by γ-secretase

scientific article

Naphthyl and coumarinyl biarylpiperazine derivatives as highly potent human beta-secretase inhibitors. Design, synthesis, and enzymatic BACE-1 and cell assays.

scientific article published on July 2006

Near-Infrared Photoactivatable Oxygenation Catalysts of Amyloid Peptide

Neprilysin degrades both amyloid beta peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases

scientific journal article

Neutralization of the γ-secretase activity by monoclonal antibody against extracellular domain of nicastrin.

scientific article

New photocleavable linker: α-Thioacetophenone-type linker

scientific article published on 09 May 2014

Notch1 signaling influences v2 interneuron and motor neuron development in the spinal cord

scientific article published in January 2006

Novel Notch-sparing gamma-secretase inhibitors derived from a peroxisome proliferator-activated receptor agonist library.

scientific article

Novel gamma-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates

scientific article published on 8 May 2006

NrCAM is a marker for substrate-selective activation of ADAM10 in Alzheimer's disease

scientific article published on 01 April 2019

ORIGINAL ARTICLE: Both Notch1 and Notch2 contribute to the regulation of melanocyte homeostasis

scientific article published on 01 February 2008

Parallel synthesis of DAPT derivatives and their gamma-secretase-inhibitory activity

scientific article published in April 2004

Partial loss of CALM function reduces Aβ42 production and amyloid deposition in vivo.

scientific article published on 27 July 2016

Participation of transmembrane domain 1 of presenilin 1 in the catalytic pore structure of the γ-secretase

scientific article published on November 2010

Peptide-based short single β-strand mimics without hydrogen bonding or aggregation

scientific article published on 01 February 2020

Phenylpiperidine-type γ-secretase modulators target the transmembrane domain 1 of presenilin 1 ⬇️

scientific article published on October 14, 2011

Photo-oxygenation inhibits tau amyloid formation

scientific article published on 01 May 2019

Physiological and pathological functions of LRRK2: implications from substrate proteins

scientific article published on 10 October 2018

Presenilin 2 regulates the systolic function of heart by modulating Ca2+ signaling

scientific journal article

Presenilin-dependent gamma-secretase activity mediates the intramembranous cleavage of CD44.

scientific article published in March 2003

Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.

scientific article published on October 2002

Primary cultures of neuronal and non-neuronal rat brain cells secrete similar proportions of amyloid β peptides ending at Aβ40 and Aβ42

article

Probing the Structure and Function Relationships of Presenilin by Substituted-Cysteine Accessibility Method.

scientific article published on 23 November 2016

Protein trafficking and maturation regulate intramembrane proteolysis

scientific article published on 11 June 2013

Rab10 Phosphorylation Detection by LRRK2 Activity Using SDS-PAGE with a Phosphate-binding Tag.

scientific article published on 14 December 2017

Rescue of Hypovitaminosis A Induces Non-Amyloidogenic Amyloid Precursor Protein (APP) Processing.

scientific article published on 2 June 2016

Retrograde transport of γ-secretase from endosomes to the trans-Golgi network regulates Aβ42 production

scientific article published on 16 August 2018

Retromer and Rab2-dependent trafficking mediate PS1 degradation by proteasomes in endocytic disturbance

scientific article published on 20 February 2016

S-palmitoylation of gamma-secretase subunits nicastrin and APH-1

scientific article

Secretase inhibitors and modulators for Alzheimer's disease treatment

scientific article published on May 2009

Selective reconstitution and recovery of functional gamma-secretase complex on budded baculovirus particles

scientific article

Selectivity to amyloid-β precursor protein cleavage provides hope against Alzheimer's

scientific article published on 11 March 2011

Single chain variable fragment against nicastrin inhibits the gamma-secretase activity.

scientific article published on 14 August 2009

Slater to Mott Crossover in the Metal to Insulator Transition ofNd2Ir2O7 ⬇️

scientific article published in Physical Review Letters

Solid-phase synthesis of photoaffinity probes: highly efficient incorporation of biotin-tag and cross-linking groups

scientific article published in September 2003

Specific mutations in presenilin 1 cause conformational changes in γ-secretase to modulate amyloid beta trimming

scientific article published on 01 January 2019

Structural biology of presenilins and signal peptide peptidases

scientific article published on 12 April 2013

Structural interactions between inhibitor and substrate docking sites give insight into mechanisms of human PS1 complexes

scientific article

Structure of the catalytic pore of gamma-secretase probed by the accessibility of substituted cysteines.

scientific article published on November 2006

Structure-function relationship of γ-secretase

scientific article published on 7 February 2012

Structures of α-synuclein filaments from multiple system atrophy

scientific article published on 27 May 2020

Subcellular compartment and molecular subdomain of beta-amyloid precursor protein relevant to the Abeta 42-promoting effects of Alzheimer mutant presenilin 2.

scientific article published on 30 March 2001

Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces Abeta 42 generation

scientific article published on 10 March 2003

Suppressor Mutations for Presenilin 1 Familial Alzheimer Disease Mutants Modulate γ-Secretase Activities

scientific article published on 11 November 2015

Synthesis and biological activity of N-substituted spiro[benzoxazepine-piperidine] Aβ-peptide production inhibitors

article

Synthesis of biotinylated photoaffinity probes based on arylsulfonamide γ-secretase inhibitors

scientific article published in 2006

Synthetic ceramide analogues increase amyloid-β 42 production by modulating γ-secretase activity

scientific article published on 27 December 2014

Targeted introduction of V642I mutation in amyloid precursor protein gene causes functional abnormality resembling early stage of Alzheimer's disease in aged mice.

scientific article

Targeting the structure and function relationships of the gamma-secretase for the development of Alzheimer's disease

scientific article published in November 2008

The C-terminal PAL motif and transmembrane domain 9 of presenilin 1 are involved in the formation of the catalytic pore of the gamma-secretase.

scientific article

The crystal structure of mouse LC3B in complex with the FYCO1 LIR reveals the importance of the flanking region of the LIR motif

scientific article published on 21 February 2017

The first proline of PALP motif at the C terminus of presenilins is obligatory for stabilization, complex formation, and gamma-secretase activities of presenilins

scientific article

The intracellular domain of the amyloid precursor protein (AICD) enhances the p53-mediated apoptosis

scientific article published on 9 October 2006

The mechanism of gamma-secretase activities through high molecular weight complex formation of presenilins is conserved in Drosophila melanogaster and mammals

scientific article published on 17 October 2002

The nonconserved hydrophilic loop domain of presenilin (PS) is not required for PS endoproteolysis or enhanced abeta 42 production mediated by familial early onset Alzheimer's disease-linked PS variants

scientific article published in June 2000

The presenilin 1 mutation (M146V) linked to familial Alzheimer's disease attenuates the neuronal differentiation of NTera 2 cells

scientific article

The role of presenilin cofactors in the gamma-secretase complex

scientific article published on 16 March 2003

Three-dimensional structure of the signal peptide peptidase

scientific article

Three-dimensional structure of the γ-secretase complex

scientific article published on 09 March 2006

Variant Alzheimer's disease with spastic paraparesis and cotton wool plaques is caused by PS-1 mutations that lead to exceptionally high amyloid-beta concentrations

scientific article published on 01 November 2000

[Alzheimer disease: experimental approaches to genetic and environmental risk factors].

scientific article

γ -Secretase Pharmacology: What Pharmacology Will Work for Alzheimer's Disease?

scientific article published on 18 April 2013

List of works by Taisuke Tomita

A faster migrating variant masquerades as NICD when performing in vitro gamma-secretase assays with bacterially expressed Notch substrates

A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling

A noncompetitive BACE1 inhibitor TAK-070 ameliorates Abeta pathology and behavioral deficits in a mouse model of Alzheimer's disease.

A novel non-canonical Notch signaling regulates expression of synaptic vesicle proteins in excitatory neurons.

A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis

A role for presenilin 1 in regulating the delivery of amyloid precursor protein to the cell surface

AP180 N-Terminal Homology (ANTH) and Epsin N-Terminal Homology (ENTH) Domains: Physiological Functions and Involvement in Disease

APP processing and synaptic function

Aberrant proteolytic processing and therapeutic strategies in Alzheimer disease

Abeta42 overproduction associated with structural changes in the catalytic pore of gamma-secretase: common effects of Pen-2 N-terminal elongation and fenofibrate

Activation of γ-Secretase Trimming Activity by Topological Changes of Transmembrane Domain 1 of Presenilin 1.

Activity-dependent proteolytic cleavage of neuroligin-1.

Allosteric regulation of γ-secretase activity by a phenylimidazole-type γ-secretase modulator

Alzheimer's disease treatment by inhibition/modulation of the gamma-secretase activity

Amyloid precursor proteins inhibit heme oxygenase activity and augment neurotoxicity in Alzheimer's disease

Aph-1 contributes to the stabilization and trafficking of the gamma-secretase complex through mechanisms involving intermolecular and intramolecular interactions.

Association of active gamma-secretase complex with lipid rafts.

Attenuation of the aggregation and neurotoxicity of amyloid-β peptides by catalytic photooxygenation

Autism-associated variants of neuroligin 4X impair synaptogenic activity by various molecular mechanisms

BACE1 activity is modulated by cell-associated sphingosine-1-phosphate.

BIN1 regulates BACE1 intracellular trafficking and amyloid-β production

BetaAPP gamma-secretase and SREBP site 2 protease are two different enzymes

Binding of longer Aβ to transmembrane domain 1 of presenilin 1 impacts on Aβ42 generation

Biochemical characterization of the Drosophila wingless signaling pathway based on RNA interference

C-terminal Fragment of Presenilin Is the Molecular Target of a Dipeptidic γ-Secretase-specific Inhibitor DAPT (N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycinet-Butyl Ester)

CD2-associated protein (CD2AP) overexpression accelerates amyloid precursor protein (APP) transfer from early endosomes to the lysosomal degradation pathway

Cell-free methods to produce structurally intact mammalian membrane proteins.

Cerebrospinal fluid levels of amyloid beta-peptide1-42, but not tau have positive correlation with brain glucose metabolism in humans

Comparison of presenilin 1 and presenilin 2 γ-secretase activities using a yeast reconstitution system

Complex N-glycosylated form of nicastrin is stabilized and selectively bound to presenilin fragments

Conformational Changes in Transmembrane Domain 4 of Presenilin 1 Are Associated with Altered Amyloid-β 42 Production

Conformational Dynamics of Transmembrane Domain 3 of Presenilin 1 Is Associated with the Trimming Activity of γ-Secretase

Contribution of the γ-secretase subunits to the formation of catalytic pore of presenilin 1 protein

Convenient Synthesis of Photoaffinity Probes and Evaluation of Their Labeling Abilities

Cooperative roles of hydrophilic loop 1 and the C-terminus of presenilin 1 in the substrate-gating mechanism of γ-secretase.

Decreased CALM expression reduces Aβ42 to total Aβ ratio through clathrin-mediated endocytosis of γ-secretase

Development of Alzheimer's disease treatment based on the molecular mechanism of ^|^gamma;-secretase activity

Development of photoaffinity probes for gamma-secretase equipped with a nitrobenzenesulfonamide-type cleavable linker

Differentiation of CD11c+ CX3CR1+ cells in the small intestine requires Notch signaling

Distinct Neurotoxic Effects of Extracellular Tau Species in Primary Neuronal-Glial Cultures

Divergent Synthesis of Multifunctional Molecular Probes To Elucidate the Enzyme Specificity of Dipeptidic γ-Secretase Inhibitors

Dual antitumor mechanisms of Notch signaling inhibitor in a T-cell acute lymphoblastic leukemia xenograft model.

Dysregulated Metabolism of the Amyloid-β Protein and Therapeutic Approaches in Alzheimer Disease

Effect of helical conformation and side chain structure on γ-secretase inhibition by β-peptide foldamers: insight into substrate recognition.

Effects of PS1 deficiency on membrane protein trafficking in neurons

Efficient four-drug cocktail therapy targeting amyloid-β peptide for Alzheimer's disease

Enhancement of amyloid beta 42 secretion by 28 different presenilin 1 mutations of familial Alzheimer's disease

Evidence That Intramolecular Associations between Presenilin Domains Are Obligatory for Endoproteolytic Processing

Experimental detection of proteolytic activity in a signal peptide peptidase of Arabidopsis thaliana.

FTY720/fingolimod, a sphingosine analogue, reduces amyloid-β production in neurons.

Familial Alzheimer's disease-linked mutations at Val717 of amyloid precursor protein are specific for the increased secretion of A beta 42(43).

Functional analysis of the transmembrane domains of presenilin 1: participation of transmembrane domains 2 and 6 in the formation of initial substrate-binding site of gamma-secretase.

Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble alpha-synuclein.

High performance plasma amyloid-β biomarkers for Alzheimer's disease

Highly efficient synthesis of medium-sized lactams via intramolecular Staudinger–aza-Wittig reaction of ω-azido pentafluorophenyl ester: synthesis and biological evaluation of LY411575 analogues

Histidine 131 in presenilin 1 is the pH-sensitive residue that causes the increase in Aβ42 level in acidic pH

Human tauopathy-derived tau strains determine the substrates recruited for templated amplification

Imbalance of Clara cell-mediated homeostatic inflammation is involved in lung metastasis.

Inhibition of gamma-secretase activity by helical beta-peptide foldamers.

Inhibition of γ-secretase activity by a monoclonal antibody against the extracellular hydrophilic loop of presenilin 1.

Loss of kallikrein-related peptidase 7 exacerbates amyloid pathology in Alzheimer's disease model mice

Mechanism of Ca2+ disruption in Alzheimer's disease by presenilin regulation of InsP3 receptor channel gating.

Memantine inhibits β-amyloid aggregation and disassembles preformed β-amyloid aggregates.

Memantine reduces the production of amyloid-β peptides through modulation of amyloid precursor protein trafficking.

Membrane trafficking and proteolytic activity of γ-secretase in Alzheimer's disease

Molecular cell biology of presenilins

Molecular cloning and characterization of CALP/KChIP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4

Molecular cloning and expression of the novel splice variants of K(+) channel-interacting protein 2

Molecular cloning of a novel basic helix-loop-helix protein from the rat brain

Molecular dissection of domains in mutant presenilin 2 that mediate overproduction of amyloidogenic forms of amyloid beta peptides. Inability of truncated forms of PS2 with familial Alzheimer's disease mutation to increase secretion of Abeta42.

Molecular mechanism of intramembrane proteolysis by γ-secretase

Naphthyl and coumarinyl biarylpiperazine derivatives as highly potent human beta-secretase inhibitors. Design, synthesis, and enzymatic BACE-1 and cell assays.

Near-Infrared Photoactivatable Oxygenation Catalysts of Amyloid Peptide

Neprilysin degrades both amyloid beta peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases

Neutralization of the γ-secretase activity by monoclonal antibody against extracellular domain of nicastrin.

New photocleavable linker: α-Thioacetophenone-type linker

Notch1 signaling influences v2 interneuron and motor neuron development in the spinal cord

Novel Notch-sparing gamma-secretase inhibitors derived from a peroxisome proliferator-activated receptor agonist library.

Novel gamma-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates