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List of works by Roberto Sitia

A RIDDle solved: why an intact IRE1α/XBP-1 signaling relay is key for humoral immune responses.

scientific article

A computer-driven approach to PCR-based differential screening, alternative to differential display

scientific article published in February 1999

A dynamic study of protein secretion and aggregation in the secretory pathway.

scientific article

A new fluorogenic peptide determines proteasome activity in single cells.

scientific article published on October 2010

A novel pathway for secretory proteins?

scientific article published on March 1990

A novel way to get out of the cell ⬇️

scientific article published on January 1, 1993

A pH-regulated quality control cycle for surveillance of secretory protein assembly

scientific article

A peptide extension dictates IgM assembly

scientific article published on 27 September 2017

A persulfidation-based mechanism controls aquaporin-8 conductance.

scientific article

AQP8 transports NOX2-generated H2O2 across the plasma membrane to promote signaling in B cells.

scientific article published on 2 June 2016

Aberrant disulphide bonding contributes to the ER retention of alpha1-antitrypsin deficiency variants.

scientific article published on 8 December 2015

Aspects of gene regulation during the UPR in human cells

scientific article

Assessing Heterogeneity of Osteolytic Lesions in Multiple Myeloma by ¹H HR-MAS NMR Metabolomics

scientific article published on 31 October 2016

Atypical IgM on T cells predict relapse and steroid dependence in idiopathic nephrotic syndrome

scientific article published on 07 May 2019

B- to plasma-cell terminal differentiation entails oxidative stress and profound reshaping of the antioxidant responses

scientific article published in October 2010

Biochemical nature of Russell Bodies

scientific article

Biogenesis and function of IgM: the role of the conserved mu-chain tailpiece glycans

scientific article

Biosynthesis of membrane and secreted epsilon-chains during lipopolysaccharide-induced differentiation of an IgE+ murine B-lymphoma

scientific article published on 01 November 1985

Bortezomib in the treatment of AL amyloidosis: targeted therapy?

scientific article published in October 2007

Building and operating an antibody factory: redox control during B to plasma cell terminal differentiation.

scientific article published on 16 January 2008

CHOP-independent apoptosis and pathway-selective induction of the UPR in developing plasma cells

scientific article

Chemo-metabolic regulation of immune responses by Tregs

scientific article published on 01 October 2009

Conditions of endoplasmic reticulum stress favor the accumulation of cytosolic prion protein

scientific article

Crystal Structure of the ERp44-Peroxiredoxin 4 Complex Reveals the Molecular Mechanisms of Thiol-Mediated Protein Retention

scientific article

Crystal structure of human ERp44 shows a dynamic functional modulation by its carboxy-terminal tail

scientific article

Crystal structures of human Ero1α reveal the mechanisms of regulated and targeted oxidation of PDI

scientific article

Cysteine and glutathione secretion in response to protein disulfide bond formation in the ER.

scientific article published in September 1997

Cysteines as Redox Molecular Switches and Targets of Disease

scientific article

Dampening Ab responses using proteasome inhibitors following in vivo B cell activation

scientific article published in March 2008

Different redox sensitivity of endoplasmic reticulum associated degradation clients suggests a novel role for disulphide bonds in secretory proteins.

scientific article published on 4 February 2014

Differential expression of Galalpha1,3Gal epitope in polymeric and monomeric IgM secreted by mouse myeloma cells deficient in alpha2, 6-sialyltransferase

scientific article

Differentiation in the murine B cell lymphoma I.29: individual mu + clones may be induced by lipopolysaccharide to both IgM secretion and isotype switching.

scientific article published in April 1987

Differentiation in the murine B cell lymphoma I.29: inductive capacities of lipopolysaccharide and Mycoplasma fermentans products

scientific article

Diseases originating from altered protein quality control in the endoplasmic reticulum.

scientific article published on January 2007

Dynamic regulation of Ero1α and peroxiredoxin 4 localization in the secretory pathway

scientific article published on 26 August 2013

Dynamic retention of Ero1alpha and Ero1beta in the endoplasmic reticulum by interactions with PDI and ERp44.

scientific article

Dysregulated IL-1β Secretion in Autoinflammatory Diseases: A Matter of Stress?

scientific article published on 4 April 2017

ER storage diseases: a role for ERGIC-53 in controlling the formation and shape of Russell bodies

scientific article published on 30 May 2006

ERO1-L, a human protein that favors disulfide bond formation in the endoplasmic reticulum

scientific article

ERdj5, an endoplasmic reticulum (ER)-resident protein containing DnaJ and thioredoxin domains, is expressed in secretory cells or following ER stress

scientific article

ERp44 and ERGIC-53 synergize in coupling efficiency and fidelity of IgM polymerization and secretion

scientific article published on May 2010

ERp44, a novel endoplasmic reticulum folding assistant of the thioredoxin family

scientific article

Endoplasmic reticulum stress.

scientific article published on 4 May 2007

Entry of exogenous polypeptides into the nucleus of living cells: facts and speculations.

scientific article published on November 1995

Ero1-PDI interactions, the response to redox flux and the implications for disulfide bond formation in the mammalian endoplasmic reticulum

scientific article published on 25 March 2013

Ero1α regulates Ca(2+) fluxes at the endoplasmic reticulum-mitochondria interface (MAM).

scientific article

Evolution, role in inflammation, and redox control of leaderless secretory proteins

scientific article published on 24 April 2020

Exposed Thiols Confer Localization in the Endoplasmic Reticulum by Retention Rather than Retrieval

scientific article published in Journal of Biological Chemistry

Expression of KIF3C kinesin during neural development and in vitro neuronal differentiation.

scientific article

Expression of mutant or cytosolic PrP in transgenic mice and cells is not associated with endoplasmic reticulum stress or proteasome dysfunction

scientific article

Fibroblasts from FAD-linked presenilin 1 mutations display a normal unfolded protein response but overproduce Abeta42 in response to tunicamycin

scientific article published in March 2004

Formation, isomerisation and reduction of disulphide bonds during protein quality control in the endoplasmic reticulum

scientific article

From antibodies to adiponectin: role of ERp44 in sizing and timing protein secretion ⬇️

scientific article published on October 1, 2010

Genomic organization and transcriptional analysis of the human genes coding for caveolin-1 and caveolin-2

scientific article (publication date: 8 February 2000)

Glutathione limits Ero1-dependent oxidation in the endoplasmic reticulum.

scientific article

Glutathione peroxidase 7 utilizes hydrogen peroxide generated by Ero1α to promote oxidative protein folding

scientific article published on 17 September 2013

Glycoprotein quality control in the endoplasmic reticulum. Mannose trimming by endoplasmic reticulum mannosidase I times the proteasomal degradation of unassembled immunoglobulin subunits

scientific article

HIV-1 Tat: immunosuppression via TGF-beta1 induction

scientific article (publication date: August 1999)

HIV-I Tat: a polypeptide for all seasons

scientific article published on 01 December 1998

Human aquaporin-11 guarantees efficient transport of H2O2 across the endoplasmic reticulum membrane

scientific article published on 12 September 2019

IgM polymerization inhibits the Golgi-mediated processing of the mu-chain carboxy-terminal glycans

scientific article published on 01 January 1996

Inadequate BiP availability defines endoplasmic reticulum stress

scientific article published on 14 March 2019

Iron increases the susceptibility of multiple myeloma cells to bortezomib.

scientific article published on 14 December 2012

KIF3C, a Novel Member of the Kinesin Superfamily: Sequence, Expression, and Mapping to Human Chromosome 2 at 2p23 ⬇️

scientific article published on February 1, 1998

Lymphocyte membrane immunoglobulins: similarities between human IgD and mouse IgD-like molecules ⬇️

scientific article published on August 1, 1977

MHC class II transactivator is an in vivo regulator of osteoclast differentiation and bone homeostasis co-opted from adaptive immunity

scientific article

Managing and exploiting stress in the antibody factory.

scientific article published on 24 April 2007

Manipulation of oxidative protein folding and PDI redox state in mammalian cells ⬇️

scientific article published on November 15, 2001

Maturation of chronic lymphocytic leukemia B cells: correlation between the capacity of responding to T-cell factors in vitro and the stage of maturation reached in vivo.

scientific article

Metabolomics of B to plasma cell differentiation

scientific article published on 29 July 2011

Molecular bases of cyclic and specific disulfide interchange between human ERO1alpha protein and protein-disulfide isomerase (PDI).

scientific article published on 11 March 2011

Monitoring cytosolic H2O2 fluctuations arising from altered plasma membrane gradients or from mitochondrial activity

scientific article published on 04 October 2019

Multistep, sequential control of the trafficking and function of the multiple sulfatase deficiency gene product, SUMF1 by PDI, ERGIC-53 and ERp44.

scientific article published on 28 May 2008

On the redox control of B lymphocyte differentiation and function

scientific article published on 24 February 2012

Oxidative protein folding in the secretory pathway and redox signaling across compartments and cells

scientific article published on 20 September 2010

Pathogenesis of ER storage disorders: modulating Russell body biogenesis by altering proximal and distal quality control

scientific article published on 6 April 2010

Peroxides and peroxidases in the endoplasmic reticulum: integrating redox homeostasis and oxidative folding

scientific article published on 25 January 2012

Physiology and pathology of proteostasis in the early secretory compartment

scientific article published on 21 February 2010

Pivotal Advance: Protein synthesis modulates responsiveness of differentiating and malignant plasma cells to proteasome inhibitors

scientific article

Plasma cells require autophagy for sustainable immunoglobulin production.

scientific article

Post-translational regulation of interleukin 1 beta secretion

scientific article published on 01 March 1993

Production of H₂O₂ in the endoplasmic reticulum promotes in vivo disulfide bond formation

scientific article

Progressive quality control of secretory proteins in the early secretory compartment by ERp44

scientific article

Progressive waves of IL-1β release by primary human monocytes via sequential activation of vesicular and gasdermin D-mediated secretory pathways

scientific article published on 23 October 2018

Progressively impaired proteasomal capacity during terminal plasma cell differentiation

scientific article

Protein degradation in the endoplasmic reticulum

scientific article published on August 1990

Protein quality control in the early secretory pathway

scientific article

Proteostasis and "redoxtasis" in the secretory pathway: Tales of tails from ERp44 and immunoglobulins

scientific article

Proteostenosis and plasma cell pathophysiology

scientific article published on 18 December 2010

Proteotoxic stress and cell lifespan control.

scientific article published on 23 July 2008

Quality control in the endoplasmic reticulum protein factory

scientific article published on December 2003

Ratiometric sensing of BiP-client versus BiP levels by the unfolded protein response determines its signaling amplitude.

scientific article published on 18 December 2017

Redox crosstalk at endoplasmic reticulum (ER) membrane contact sites (MCS) uses toxic waste to deliver messages

scientific article published on 28 February 2018

Redox homeostasis modulates the sensitivity of myeloma cells to bortezomib

scientific article published on 12 March 2008

Redox remodeling allows and controls B-cell activation and differentiation

scientific article published in October 2010

Reduction of interchain disulfide bonds precedes the dislocation of Ig-mu chains from the endoplasmic reticulum to the cytosol for proteasomal degradation

scientific article

Regulation of Calcium Fluxes by GPX8, a Type-II Transmembrane Peroxidase Enriched at the Mitochondria-Associated Endoplasmic Reticulum Membrane

scientific article published on 27 January 2017

Regulation of IgM biosynthesis in human chronic lymphocytic leukemia. Normal and neoplastic B cells respond differently to TPA

scientific article published on 01 January 1989

Response to Marinelli and Marchissio.

scientific article

Role of Selenof as a Gatekeeper of Secreted Disulfide-Rich Glycoproteins

scientific article published in May 2018

Roles of N-glycans in the polymerization-dependent aggregation of mutant Ig-μ chains in the early secretory pathway

scientific article

SEL1L and HRD1 are involved in the degradation of unassembled secretory Ig-mu chains

scientific article

Sequential steps and checkpoints in the early exocytic compartment during secretory IgM biogenesis

scientific article

Sequential waves of functionally related proteins are expressed when B cells prepare for antibody secretion

scientific article published on February 2003

Sialylation of N-linked glycans influences the immunomodulatory effects of IgM on T cells

scientific article published on 24 November 2014

Stress Regulates Aquaporin-8 Permeability to Impact Cell Growth and Survival

scientific article

Structural basis of pH-dependent client binding by ERp44, a key regulator of protein secretion at the ER-Golgi interface.

scientific article published on 3 April 2017

Synthesis, processing, and intracellular transport of CD36 during monocytic differentiation

scientific article published on January 1996

The Association of HIV-1 Tat with Nuclei Is Regulated by Ca2+Ions and Cytosolic Factors

scientific article published in Journal of Biological Chemistry

The C-terminal domain of yeast Ero1p mediates membrane localization and is essential for function

scientific article

The Diversity of Oxidative Protein Folding

scientific article published on 01 March 2006

The Importance Of Naturally Attenuated Sars-Cov-2 In The Fight Against Covid-19

scientific article published on 28 April 2020

The making of a professional secretory cell: architectural and functional changes in the ER during B lymphocyte plasma cell differentiation

scientific article published on September 2003

The proteasome load versus capacity balance determines apoptotic sensitivity of multiple myeloma cells to proteasome inhibition.

scientific article published on 22 January 2009

The role of glycosylation in secretion and membrane expression of immunoglobulins M and A

scientific article published on 01 August 1984

The unconventional secretion of IL-1β: Handling a dangerous weapon to optimize inflammatory responses

scientific article published on 05 April 2018

The unfolded protein response switches from pro-survival to pro-apoptotic to cap the extent of endoplasmic reticulum expansion

scientific article

Thiol-mediated protein retention in the endoplasmic reticulum: the role of ERp44

scientific article

Transit of H2O2 across the endoplasmic reticulum membrane is not sluggish

scientific article

Two conserved cysteine triads in human Ero1alpha cooperate for efficient disulfide bond formation in the endoplasmic reticulum

scientific article

Tyrosine kinase signal modulation: a matter of H2O2 membrane permeability?

scientific article published on 18 September 2013

Zinc regulates ERp44-dependent protein quality control in the early secretory pathway

scientific article published in Nature Communications

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