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List of works by Roberto Sitia

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Protein degradation in the endoplasmic reticulum

scientific article published on August 1990
Quality control in the endoplasmic reticulum protein factory

scientific article published on December 2003
Protein quality control in the early secretory pathway

scientific article
Sequential waves of functionally related proteins are expressed when B cells prepare for antibody secretion

scientific article published on February 2003
Plasma cells require autophagy for sustainable immunoglobulin production.

scientific article
ERO1-L, a human protein that favors disulfide bond formation in the endoplasmic reticulum

scientific article
Manipulation of oxidative protein folding and PDI redox state in mammalian cells

scientific article published on November 15, 2001
ERp44, a novel endoplasmic reticulum folding assistant of the thioredoxin family

scientific article
Thiol-mediated protein retention in the endoplasmic reticulum: the role of ERp44

scientific article
A novel pathway for secretory proteins?

scientific article published on March 1990
The proteasome load versus capacity balance determines apoptotic sensitivity of multiple myeloma cells to proteasome inhibition.

scientific article published on 22 January 2009
ERdj5, an endoplasmic reticulum (ER)-resident protein containing DnaJ and thioredoxin domains, is expressed in secretory cells or following ER stress

scientific article
Ero1α regulates Ca(2+) fluxes at the endoplasmic reticulum-mitochondria interface (MAM).

scientific article
Sequential steps and checkpoints in the early exocytic compartment during secretory IgM biogenesis

scientific article
Glycoprotein quality control in the endoplasmic reticulum. Mannose trimming by endoplasmic reticulum mannosidase I times the proteasomal degradation of unassembled immunoglobulin subunits

scientific article published on 24 January 2001
Glutathione limits Ero1-dependent oxidation in the endoplasmic reticulum.

scientific article
Endoplasmic reticulum stress.

scientific article published on 4 May 2007
Progressively impaired proteasomal capacity during terminal plasma cell differentiation

scientific article
Managing and exploiting stress in the antibody factory.

scientific article published on 24 April 2007
Crystal structures of human Ero1α reveal the mechanisms of regulated and targeted oxidation of PDI

scientific article
Conditions of endoplasmic reticulum stress favor the accumulation of cytosolic prion protein

scientific article
HIV-I Tat: a polypeptide for all seasons

scientific article published on 01 December 1998
Dynamic retention of Ero1alpha and Ero1beta in the endoplasmic reticulum by interactions with PDI and ERp44.

scientific article
Formation, isomerisation and reduction of disulphide bonds during protein quality control in the endoplasmic reticulum

scientific article published on 19 January 2002
Bortezomib in the treatment of AL amyloidosis: targeted therapy?

scientific article published in October 2007
Peroxides and peroxidases in the endoplasmic reticulum: integrating redox homeostasis and oxidative folding

scientific article published on 25 January 2012
Reduction of interchain disulfide bonds precedes the dislocation of Ig-mu chains from the endoplasmic reticulum to the cytosol for proteasomal degradation

scientific article
Glutathione peroxidase 7 utilizes hydrogen peroxide generated by Ero1α to promote oxidative protein folding

scientific article published on 17 September 2013
Oxidative protein folding in the secretory pathway and redox signaling across compartments and cells

scientific article published on 20 September 2010
Molecular bases of cyclic and specific disulfide interchange between human ERO1alpha protein and protein-disulfide isomerase (PDI).

scientific article published on 11 March 2011
B- to plasma-cell terminal differentiation entails oxidative stress and profound reshaping of the antioxidant responses

scientific article published in October 2010
A pH-regulated quality control cycle for surveillance of secretory protein assembly

scientific article
ER storage diseases: a role for ERGIC-53 in controlling the formation and shape of Russell bodies

scientific article published on 30 May 2006
Stress Regulates Aquaporin-8 Permeability to Impact Cell Growth and Survival

scientific article
SEL1L and HRD1 are involved in the degradation of unassembled secretory Ig-mu chains

scientific article
Redox homeostasis modulates the sensitivity of myeloma cells to bortezomib

scientific article published on 12 March 2008
Crystal structure of human ERp44 shows a dynamic functional modulation by its carboxy-terminal tail

scientific article
Cysteine and glutathione secretion in response to protein disulfide bond formation in the ER.

scientific article published in September 1997
Multistep, sequential control of the trafficking and function of the multiple sulfatase deficiency gene product, SUMF1 by PDI, ERGIC-53 and ERp44.

scientific article published on 28 May 2008
Synthesis, processing, and intracellular transport of CD36 during monocytic differentiation

scientific article published on January 1996
Metabolomics of B to plasma cell differentiation

scientific article published on 29 July 2011
Pivotal Advance: Protein synthesis modulates responsiveness of differentiating and malignant plasma cells to proteasome inhibitors

scientific article
Dampening Ab responses using proteasome inhibitors following in vivo B cell activation

scientific article published in March 2008
Redox remodeling allows and controls B-cell activation and differentiation

scientific article published in October 2010
Ero1-PDI interactions, the response to redox flux and the implications for disulfide bond formation in the mammalian endoplasmic reticulum

scientific article published on 25 March 2013
Tyrosine kinase signal modulation: a matter of H2O2 membrane permeability?

scientific article published on 18 September 2013
CHOP-independent apoptosis and pathway-selective induction of the UPR in developing plasma cells

scientific article
Exposed Thiols Confer Localization in the Endoplasmic Reticulum by Retention Rather than Retrieval

scientific article published in Journal of Biological Chemistry
ERp44 and ERGIC-53 synergize in coupling efficiency and fidelity of IgM polymerization and secretion

scientific article published on May 2010
Redox crosstalk at endoplasmic reticulum (ER) membrane contact sites (MCS) uses toxic waste to deliver messages

scientific article published on 28 February 2018

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