List of works - Daniel S. Greenspan

A missense mutation in type VII collagen in two affected siblings with recessive dystrophic epidermolysis bullosa

scientific article

A translocation interrupts the COL5A1 gene in a patient with Ehlers-Danlos syndrome and hypomelanosis of Ito.

scientific article published in July 1996

ADAMTSL2 mutations in geleophysic dysplasia demonstrate a role for ADAMTS-like proteins in TGF-beta bioavailability regulation

scientific article

Absence of apparent disease causing mutations in COL5A3 in 13 patients with hypermobility Ehlers-Danlos syndrome

scientific article published on 01 December 2008

Attenuated BMP1 function compromises osteogenesis, leading to bone fragility in humans and zebrafish

scientific article published in April 2012

BMP-1/Tolloid-like metalloproteases process endorepellin, the angiostatic C-terminal fragment of perlecan

scientific article

BMP1 controls TGFbeta1 activation via cleavage of latent TGFbeta-binding protein

scientific article

Biosynthetic processing of the Pro-alpha1(V)Pro-alpha2(V)Pro-alpha3(V) procollagen heterotrimer.

scientific article

Biosynthetic processing of the pro-alpha 1(V)2pro-alpha 2(V) collagen heterotrimer by bone morphogenetic protein-1 and furin-like proprotein convertases

scientific article (publication date: 15 February 2002)

Bone Morphogenetic Protein-1 Processes Insulin-like Growth Factor-binding Protein 3 ⬇️

scientific article published on June 22, 2011

Bone morphogenetic protein 1 processes prolactin to a 17-kDa antiangiogenic factor

scientific article

Bone morphogenetic protein 1 prodomain specifically binds and regulates signaling by bone morphogenetic proteins 2 and 4

scientific article published on 25 January 2007

Bone morphogenetic protein-1 processes the NH2-terminal propeptide, and a furin-like proprotein convertase processes the COOH-terminal propeptide of pro-alpha1(V) collagen

scientific article published on 01 October 1998

Bone morphogenetic protein-1/tolloid-related metalloproteinases process osteoglycin and enhance its ability to regulate collagen fibrillogenesis

scientific article published on 29 July 2004

BstUI and DpnII RFLPs at the COL5A1 gene

scientific article published on 01 February 1994

COL5A1: fine genetic mapping and exclusion as candidate gene in families with nail-patella syndrome, tuberous sclerosis 1, hereditary hemorrhagic telangiectasia, and Ehlers-Danlos Syndrome type II

scientific article published on 01 February 1995

Characterization of a novel gene product (mammalian tolloid-like) with high sequence similarity to mammalian tolloid/bone morphogenetic protein-1

scientific article

Characterization of the six zebrafish clade B fibrillar procollagen genes, with evidence for evolutionarily conserved alternative splicing within the pro-alpha1(V) C-propeptide.

scientific article

Cleavage and oligomerization of gliomedin, a transmembrane collagen required for node of ranvier formation

scientific journal article

Coding sequence and expression patterns of mouse chordin and mapping of the cognate mouse chrd and human CHRD genes

scientific article

Complete structural organization of the human alpha 1 (V) collagen gene (COL5A1): divergence from the conserved organization of other characterized fibrillar collagen genes.

scientific article

Comprehensive mass spectrometric mapping of the hydroxylated amino acid residues of the α1(V) collagen chain

scientific article

Developmental roles of the BMP1/TLD metalloproteinases.

scientific article

Differential requirement for P2X7R function in IL-17 dependent vs. IL-17 independent cellular immune responses

scientific article published on 27 May 2014

ECM roles in the function of metabolic tissues.

scientific article published on 8 November 2011

Expression of alpha 2 type I collagen in W8 cells increases cell adhesion and decreases colony formation in soft agar

scientific article published on January 1994

Homozygosity and Heterozygosity for Null Col5a2 Alleles Produce Embryonic Lethality and a Novel Classic Ehlers-Danlos Syndrome-Related Phenotype

scientific article published on 16 May 2015

Human collagen gene COL5A1 maps to the q34.2----q34.3 region of chromosome 9, near the locus for nail-patella syndrome

scientific article published on April 1, 1992

IL-17 induces type V collagen overexpression and EMT via TGF-β-dependent pathways in obliterative bronchiolitis ⬇️

scientific article published on December 21, 2012

Induced ablation of Bmp1 and Tll1 produces osteogenesis imperfecta in mice

scientific article

Inhibition of bone morphogenetic protein 1 by native and altered forms of alpha2-macroglobulin.

scientific article

Interleukin-17-dependent autoimmunity to collagen type V in atherosclerosis

scientific article

Low resolution structure determination shows procollagen C-proteinase enhancer to be an elongated multidomain glycoprotein.

scientific article

Mammalian tolloid metalloproteinase, and not matrix metalloprotease 2 or membrane type 1 metalloprotease, processes laminin-5 in keratinocytes and skin

scientific article published on 07 December 2002

Metalloproteinases in Drosophila to humans that are central players in developmental processes.

scientific article published on 25 October 2011

Mucosal Administration of Collagen V Ameliorates the Atherosclerotic Plaque Burden by Inducing Interleukin 35-dependent Tolerance.

scientific article published on 31 December 2015

Mutational analysis of the BMP-1 gene in patients with gastroschisis

Order of intron removal influences multiple splice outcomes, including a two-exon skip, in a COL5A1 acceptor-site mutation that results in abnormal pro-alpha1(V) N-propeptides and Ehlers-Danlos syndrome type I

scientific article

Post-translational proteolytic processing of procollagen C-terminal proteinase enhancer releases a metalloproteinase inhibitor.

scientific article

Procollagen C proteinase enhancer 1 genes are important determinants of the mechanical properties and geometry of bone and the ultrastructure of connective tissues.

scientific article

Secreted Frizzled-related protein 2 is a procollagen C proteinase enhancer with a role in fibrosis associated with myocardial infarction

scientific article

Simian virus 40 large T antigen isoelectric focuses as multiple species with varying phosphate content

scientific article published on December 1979

Structural organization and expression patterns of the human and mouse genes for the type I procollagen COOH-terminal proteinase enhancer protein.

scientific article

Structural organization and genetic localization of the human bone morphogenetic protein 1/mammalian tolloid gene

scientific article

TIMP-3 inhibits the procollagen N-proteinase ADAMTS-2.

scientific article published in September 2006

Th-17, monokines, collagen type V, and primary graft dysfunction in lung transplantation.

scientific article

The bone morphogenetic protein 1/Tolloid-like metalloproteinases

scientific article published on 18 May 2007

Transforming growth factor-beta regulation of bone morphogenetic protein-1/procollagen C-proteinase and related proteins in fibrogenic cells and keratinocytes

scientific article published on 01 July 1997

Use of Bmp1/Tll1 doubly homozygous null mice and proteomics to identify and validate in vivo substrates of bone morphogenetic protein 1/tolloid-like metalloproteinases

scientific article

bmp1 and mini fin are functionally redundant in regulating formation of the zebrafish dorsoventral axis

scientific article

α3(V) collagen is critical for glucose homeostasis in mice due to effects in pancreatic islets and peripheral tissues

scientific article

List of works by Daniel S. Greenspan

A missense mutation in type VII collagen in two affected siblings with recessive dystrophic epidermolysis bullosa

A translocation interrupts the COL5A1 gene in a patient with Ehlers-Danlos syndrome and hypomelanosis of Ito.

ADAMTSL2 mutations in geleophysic dysplasia demonstrate a role for ADAMTS-like proteins in TGF-beta bioavailability regulation

Absence of apparent disease causing mutations in COL5A3 in 13 patients with hypermobility Ehlers-Danlos syndrome

Attenuated BMP1 function compromises osteogenesis, leading to bone fragility in humans and zebrafish

BMP-1/Tolloid-like metalloproteases process endorepellin, the angiostatic C-terminal fragment of perlecan

BMP1 controls TGFbeta1 activation via cleavage of latent TGFbeta-binding protein

Biosynthetic processing of the Pro-alpha1(V)Pro-alpha2(V)Pro-alpha3(V) procollagen heterotrimer.

Biosynthetic processing of the pro-alpha 1(V)2pro-alpha 2(V) collagen heterotrimer by bone morphogenetic protein-1 and furin-like proprotein convertases

Bone Morphogenetic Protein-1 Processes Insulin-like Growth Factor-binding Protein 3 ⬇️

Bone morphogenetic protein 1 processes prolactin to a 17-kDa antiangiogenic factor

Bone morphogenetic protein 1 prodomain specifically binds and regulates signaling by bone morphogenetic proteins 2 and 4

Bone morphogenetic protein-1 processes the NH2-terminal propeptide, and a furin-like proprotein convertase processes the COOH-terminal propeptide of pro-alpha1(V) collagen

Bone morphogenetic protein-1/tolloid-related metalloproteinases process osteoglycin and enhance its ability to regulate collagen fibrillogenesis

BstUI and DpnII RFLPs at the COL5A1 gene

COL5A1: fine genetic mapping and exclusion as candidate gene in families with nail-patella syndrome, tuberous sclerosis 1, hereditary hemorrhagic telangiectasia, and Ehlers-Danlos Syndrome type II

Characterization of a novel gene product (mammalian tolloid-like) with high sequence similarity to mammalian tolloid/bone morphogenetic protein-1

Characterization of the six zebrafish clade B fibrillar procollagen genes, with evidence for evolutionarily conserved alternative splicing within the pro-alpha1(V) C-propeptide.

Cleavage and oligomerization of gliomedin, a transmembrane collagen required for node of ranvier formation

Coding sequence and expression patterns of mouse chordin and mapping of the cognate mouse chrd and human CHRD genes

Complete structural organization of the human alpha 1 (V) collagen gene (COL5A1): divergence from the conserved organization of other characterized fibrillar collagen genes.

Comprehensive mass spectrometric mapping of the hydroxylated amino acid residues of the α1(V) collagen chain

Developmental roles of the BMP1/TLD metalloproteinases.

Differential requirement for P2X7R function in IL-17 dependent vs. IL-17 independent cellular immune responses

ECM roles in the function of metabolic tissues.

Expression of alpha 2 type I collagen in W8 cells increases cell adhesion and decreases colony formation in soft agar

Homozygosity and Heterozygosity for Null Col5a2 Alleles Produce Embryonic Lethality and a Novel Classic Ehlers-Danlos Syndrome-Related Phenotype

Human collagen gene COL5A1 maps to the q34.2----q34.3 region of chromosome 9, near the locus for nail-patella syndrome

IL-17 induces type V collagen overexpression and EMT via TGF-β-dependent pathways in obliterative bronchiolitis ⬇️

Induced ablation of Bmp1 and Tll1 produces osteogenesis imperfecta in mice

Inhibition of bone morphogenetic protein 1 by native and altered forms of alpha2-macroglobulin.

Interleukin-17-dependent autoimmunity to collagen type V in atherosclerosis

Low resolution structure determination shows procollagen C-proteinase enhancer to be an elongated multidomain glycoprotein.

Mammalian tolloid metalloproteinase, and not matrix metalloprotease 2 or membrane type 1 metalloprotease, processes laminin-5 in keratinocytes and skin

Metalloproteinases in Drosophila to humans that are central players in developmental processes.

Mucosal Administration of Collagen V Ameliorates the Atherosclerotic Plaque Burden by Inducing Interleukin 35-dependent Tolerance.

Mutational analysis of the BMP-1 gene in patients with gastroschisis

Order of intron removal influences multiple splice outcomes, including a two-exon skip, in a COL5A1 acceptor-site mutation that results in abnormal pro-alpha1(V) N-propeptides and Ehlers-Danlos syndrome type I

Post-translational proteolytic processing of procollagen C-terminal proteinase enhancer releases a metalloproteinase inhibitor.

Procollagen C proteinase enhancer 1 genes are important determinants of the mechanical properties and geometry of bone and the ultrastructure of connective tissues.

Secreted Frizzled-related protein 2 is a procollagen C proteinase enhancer with a role in fibrosis associated with myocardial infarction

Simian virus 40 large T antigen isoelectric focuses as multiple species with varying phosphate content

Structural organization and expression patterns of the human and mouse genes for the type I procollagen COOH-terminal proteinase enhancer protein.

Structural organization and genetic localization of the human bone morphogenetic protein 1/mammalian tolloid gene

TIMP-3 inhibits the procollagen N-proteinase ADAMTS-2.

Th-17, monokines, collagen type V, and primary graft dysfunction in lung transplantation.

The bone morphogenetic protein 1/Tolloid-like metalloproteinases

Transforming growth factor-beta regulation of bone morphogenetic protein-1/procollagen C-proteinase and related proteins in fibrogenic cells and keratinocytes

Use of Bmp1/Tll1 doubly homozygous null mice and proteomics to identify and validate in vivo substrates of bone morphogenetic protein 1/tolloid-like metalloproteinases

bmp1 and mini fin are functionally redundant in regulating formation of the zebrafish dorsoventral axis

α3(V) collagen is critical for glucose homeostasis in mice due to effects in pancreatic islets and peripheral tissues