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List of works by Friedrich Koch-Nolte

"Agouti NOD": identification of a CBA-derived Idd locus on Chromosome 7 and its use for chimera production with NOD embryonic stem cells

scientific article published on 29 October 2005

A Heterologous Model of Thrombospondin Type 1 Domain-Containing 7A-Associated Membranous Nephropathy

scientific article published on 16 August 2017

A PKR-like eukaryotic initiation factor 2alpha kinase from zebrafish contains Z-DNA binding domains instead of dsRNA binding domains

scientific article

A cDNA Immunization Strategy to Generate Nanobodies against Membrane Proteins in Native Conformation.

scientific article

A new monoclonal antibody detects a developmentally regulated mouse ecto-ADP-ribosyltransferase on T cells: subset distribution, inbred strain variation, and modulation upon T cell activation

scientific article

A panel of monoclonal antibodies recognizing GPI-anchored ADP-ribosyltransferase ART4, the carrier of the Dombrock blood group antigens.

scientific article published in July 2005

A recombinant heavy chain antibody approach blocks ART2 mediated deletion of an iNKT cell population that upon activation inhibits autoimmune diabetes

scientific article

A simple, sensitive, and low-cost FACS assay for detecting antibodies against the native SARS-CoV-2 spike protein

scientific article published on 12 May 2021

A transplant "immunome" screening platform defines a targetable epitope fingerprint of multiple myeloma

scientific article published on 31 March 2016

ADP-ribosylation at R125 gates the P2X7 ion channel by presenting a covalent ligand to its nucleotide binding site

scientific article

ADP-ribosylation of P2X7: a matter of life and death for regulatory T cells and natural killer T cells.

scientific article

ADP-ribosylation of arginine

scientific article

ADP-ribosylation of membrane proteins: unveiling the secrets of a crucial regulatory mechanism in mammalian cells.

scientific article

ADP-ribosyltransferases: plastic tools for inactivating protein and small molecular weight targets.

scientific article

ARTC1-mediated ADP-ribosylation of GRP78/BiP: a new player in endoplasmic-reticulum stress responses.

scientific article published on 8 October 2014

ATP induces P2X7 receptor-independent cytokine and chemokine expression through P2X1 and P2X3 receptors in murine mast cells

scientific article published on 21 January 2009

Actin is ADP-ribosylated by the Salmonella enterica virulence-associated protein SpvB.

scientific article

Activation of the P2X7 ion channel by soluble and covalently bound ligands

scientific article published on 3 March 2009

Activity and specificity of toxin-related mouse T cell ecto-ADP-ribosyltransferase ART2.2 depends on its association with lipid rafts.

scientific article

Alternative splicing of the N-terminal cytosolic and transmembrane domains of P2X7 controls gating of the ion channel by ADP-ribosylation.

scientific article

Analysis of subcellular calcium signals in T-lymphocytes

scientific article

Assignment of the Human RT6 Gene to 11q13 by PCR Screening of Somatic Cell Hybrids and in Situ Hybridization

article

Assignment of the human and mouse genes for muscle ecto mono (ADPribosyl)transferase to a conserved linkage group on human chromosome 11p15 and mouse chromosome 7.

scientific article published in August 1996

Autoantibodies against thrombospondin type 1 domain-containing 7A induce membranous nephropathy

scientific article published on 23 May 2016

Basal and inducible expression of the thiol-sensitive ART2.1 ecto-ADP-ribosyltransferase in myeloid and lymphoid leukocytes

scientific article published on 30 April 2009

BglII identifies a frequent biallelic DNA polymorphism of the human RT6 gene

scientific article published in June 1994

Blockade of P2X7 receptors or pannexin-1 channels similarly attenuates postischemic damage.

scientific article published on 21 January 2015

Both allelic forms of the rat T cell differentiation marker RT6 display nicotinamide adenine dinucleotide (NAD)-glycohydrolase activity, yet only RT6.2 is capable of automodification upon incubation with NAD

scientific article published on 01 August 1995

CD38 controls ADP-ribosyltransferase-2-catalyzed ADP-ribosylation of T cell surface proteins

scientific article

CD38 controls the innate immune response against Listeria monocytogenes

scientific article published on 26 August 2013

CD38 exacerbates focal cytokine production, postischemic inflammation and brain injury after focal cerebral ischemia

scientific article

CD38 is expressed on inflammatory cells of the intestine and promotes intestinal inflammation

scientific article published on 4 May 2015

CD38 promotes pristane-induced chronic inflammation and increases susceptibility to experimental lupus by an apoptosis-driven and TRPM2-dependent mechanism

scientific article published on 20 February 2018

CD8-β ADP-ribosylation affects CD8(+) T-cell function

scientific article published on 17 May 2013

CD83 modulates B cell function in vitro: increased IL-10 and reduced Ig secretion by CD83Tg B cells

scientific article

Changing patterns of cell surface mono (ADP-ribosyl) transferase antigen ART2.2 on resting versus cytopathically-activated T cells in NOD/Lt mice

scientific article published on July 2001

Characterisation of a novel glycosylphosphatidylinositol-anchored mono-ADP-ribosyltransferase isoform in ovary cells

scientific article published on 26 May 2011

Characterisation of the R276A gain-of-function mutation in the ectodomain of murine P2X7

scientific article published on 21 February 2009

Characterization of multiple alleles of the T-cell differentiation marker ART2 (RT6) in inbred and wild rats

scientific article

Chromosomal localization, DNA polymorphism, and expression of Rt-6, the mouse homologue of rat T-lymphocyte differentiation marker RT6.

scientific article published in January 1991

Cloning, expression, purification and crystallization as well as X-ray fluorescence and preliminary X-ray diffraction analyses of human ADP-ribosylhydrolase 1.

scientific article

Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of human ARH3, the first eukaryotic protein-ADP-ribosylhydrolase

scientific article

Clostridium difficile toxin CDT hijacks microtubule organization and reroutes vesicle traffic to increase pathogen adherence

scientific article

Compartmentation of NAD+-dependent signalling.

scientific article

Complex regulation of the human gene for the Z-DNA binding protein DLM-1.

scientific article

Correction: CD38 Exacerbates Focal Cytokine Production, Postischemic Inflammation and Brain Injury after Focal Cerebral Ischemia

scientific article published in PLoS ONE

Cutting edge: a natural P451L mutation in the cytoplasmic domain impairs the function of the mouse P2X7 receptor

scientific journal article

DNA methylation and Z-DNA formation as mediators of quantitative differences in the expression of alleles

scientific article

DNA methylation contributes to tissue- and allele-specific expression of the T-cell differentiation marker RT6.

scientific article

Daratumumab and Nanobody-Based Heavy Chain Antibodies Inhibit the ADPR Cyclase but not the NAD<sup>+</sup> Hydrolase Activity of CD38-Expressing Multiple Myeloma Cells

scientific article published on 30 December 2020

Deficiency of the tetraspanin CD63 associated with kidney pathology but normal lysosomal function

scientific article published on 15 December 2008

Differential regulation of P2X7 receptor activation by extracellular nicotinamide adenine dinucleotide and ecto-ADP-ribosyltransferases in murine macrophages and T cells.

scientific article published on July 2009

Ecto-ADP-ribosyltransferase ARTC2.1 functionally modulates FcγR1 and FcγR2B on murine microglia

scientific article published on 28 November 2017

Ecto-ADP-ribosyltransferases (ARTs): emerging actors in cell communication and signaling

scientific article

Emerging functions of extracellular pyridine nucleotides

scientific article

Emerging roles of NAD+ and its metabolites in cell signaling.

scientific article published on 10 February 2009

Endogenous relatives of ADP-ribosylating bacterial toxins in mice and men: potential regulators of immune cell function

scientific article published on 01 July 1998

Evidence of promiscuous endothelial binding by Plasmodium falciparum-infected erythrocytes

scientific article

Evidence that allelic variations in the main RT6 promoter modulate transcriptional activity

scientific article published on May 1999

Expression of insulin-like factor 3 protein in the rat testis during fetal and postnatal development and in relation to cryptorchidism induced by in utero exposure to di (n-Butyl) phthalate

scientific journal article

Expression of the RT6 mono(ADP-ribosyl)transferases is regulated by two promoter regions

scientific article published on 01 January 1997

Expression of the T-cell differentiation antigen RT6.2 in T-cell lines is correlated with hypomethylation of the RT6 promoter

scientific article published on May 1999

Expression of toxin-related human mono-ADP-ribosyltransferase 3 in human testes

scientific article

Expression, purification, crystallization and preliminary X-ray analysis of rat ecto-ADP-ribosyltransferase 2 (ART2.2).

scientific article published on 20 June 2002

Extracellular NAD and ATP: Partners in immune cell modulation.

scientific article

Extracellular NAD(+): a danger signal hindering regulatory T cells.

scientific article published on 24 May 2012

Extracellular NAD+ shapes the Foxp3+ regulatory T cell compartment through the ART2-P2X7 pathway ⬇️

scientific article

FK778 and tacrolimus prevent the development of obliterative airway disease after heterotopic rat tracheal transplantation

scientific article

FK778 attenuates lymphocyte-endothelium interaction after cardiac transplantation: in vivo and in vitro studies

scientific article published in July 2004

FK778 in experimental xenotransplantation: a detailed analysis of drug efficacy

scientific article published in January 2007

FK778: New Cellular and Molecular Mechanisms of Action

scientific article published on 01 April 2006

Flow cytometric and immunoblot assays for cell surface ADP-ribosylation using a monoclonal antibody specific for ethenoadenosine

scientific article published in March 2003

Functional localization of two poly(ADP-ribose)-degrading enzymes to the mitochondrial matrix

scientific article published on 8 November 2007

Generation and characterization of ecto-ADP-ribosyltransferase ART2.1/ART2.2-deficient mice

scientific article

High sensitivity of intestinal CD8+ T cells to nucleotides indicates P2X7 as a regulator for intestinal T cell responses

scientific article

Identification of the ectoenzyme CD38 as a marker of committed preadipocytes.

scientific article published on 14 June 2017

Immuno-targeting the multifunctional CD38 using nanobody

scientific article published on 02 June 2016

Immunosuppressive Yersinia Effector YopM Binds DEAD Box Helicase DDX3 to Control Ribosomal S6 Kinase in the Nucleus of Host Cells

scientific article

In silico characterization of the family of PARP-like poly(ADP-ribosyl)transferases (pARTs)

scientific article published on 4 October 2005

In vivo near-infrared fluorescence targeting of T cells: comparison of nanobodies and conventional monoclonal antibodies

scientific article published on March 2014

Independent integration of rodent identifier (ID) elements into orthologous sites of some RT6 alleles of Rattus norvegicus and Rattus rattus

scientific article published on September 2002

Lipopolysaccharide, IFN-gamma, and IFN-beta induce expression of the thiol-sensitive ART2.1 Ecto-ADP-ribosyltransferase in murine macrophages

scientific article published in November 2007

Liver-Resident Memory CD8+ T Cells Form a Front-Line Defense against Malaria Liver-Stage Infection

scientific article published on 17 September 2016

Long-term CD38 saturation by daratumumab interferes with diagnostic myeloma cell detection

scientific article published on 18 May 2017

Loss of RT6 message and most circulating T cells after thymectomy of diabetes prone BB rats

scientific article published on 01 January 1994

Mammalian ADP-ribosyltransferases and ADP-ribosylhydrolases

scientific article published on May 2008

Melittin modulates keratinocyte function through P2 receptor-dependent ADAM activation

scientific article published on 21 May 2012

Metalloprotease-Mediated Shedding of Enzymatically Active Mouse ecto-ADP-ribosyltransferase ART2.2 Upon T Cell Activation

scientific article published on 01 October 2000

Modulating ion channel function with antibodies and nanobodies

scientific article published on 23 March 2018

Molecular characterization and expression of the gene for mouse NAD+:arginine ecto-mono(ADP-ribosyl)transferase, Art1

scientific journal article

Molecular characterization of mouse T-cell ecto-ADP-ribosyltransferase Rt6: cloning of a second functional gene and identification of the Rt6 gene products

scientific article

Molecular cloning and characterization of the T-cell mono(ADP-ribosyl)transferase RT6. Relationships to other mADPRTs and possible functions

scientific article published on January 1997

Molecular imaging of tumors with nanobodies and antibodies: Timing and dosage are crucial factors for improved in vivo detection

scientific article published on 27 April 2015

Molecular polymorphism in the Rt6 genes of laboratory mice correlates with the allotypes of the H1 minor histocompatibility system

article

Monitoring the expression of purinoceptors and nucleotide-metabolizing ecto-enzymes with antibodies directed against proteins in native conformation

scientific article

Mono(ADP-ribosyl)transferases and related enzymes in animal tissues. Emerging gene families

scientific article published on January 1997

Mono-ADP-ribosyltransferases in human monocytes: regulation by lipopolysaccharide

scientific article

Mono-ADP-ribosyltransferases in human monocytes: regulation by lipopolysaccharide

scientific article published in 2002

Monoclonal antibodies for the identification and purification of vNAR domains and IgNAR immunoglobulins from the horn shark Heterodontus francisci.

scientific article

Mouse T cell membrane proteins Rt6-1 and Rt6-2 are arginine/protein mono(ADPribosyl)transferases and share secondary structure motifs with ADP-ribosylating bacterial toxins

scientific journal article

Mucolipidosis II-related mutations inhibit the exit from the endoplasmic reticulum and proteolytic cleavage of GlcNAc-1-phosphotransferase precursor protein (GNPTAB)

scientific article

Mutation of a putative TATA motif does not affect transcription by the promoter of the rat T cell differentiation marker RT6.

scientific article published on May 1999

NAD+ and ATP released from injured cells induce P2X7-dependent shedding of CD62L and externalization of phosphatidylserine by murine T cells

scientific article published in March 2009

NAD+ released during inflammation participates in T cell homeostasis by inducing ART2-mediated death of naive T cells in vivo

scientific article published in July 2007

NAD-induced T cell death: ADP-ribosylation of cell surface proteins by ART2 activates the cytolytic P2X7 purinoceptor

scientific article published in October 2003

Nanobodies and Nanobody-Based Human Heavy Chain Antibodies As Antitumor Therapeutics.

scientific article published on 22 November 2017

Nanobodies as modulators of inflammation: potential applications for acute brain injury

scientific article

Nanobodies effectively modulate the enzymatic activity of CD38 and allow specific imaging of CD38+ tumors in mouse models in vivo

scientific article published on 30 October 2017

Nanobodies that block gating of the P2X7 ion channel ameliorate inflammation.

scientific article published in November 2016

Nanobody-Based Biologics for Modulating Purinergic Signaling in Inflammation and Immunity.

scientific article

Nucleotide-Induced Membrane-Proximal Proteolysis Controls the Substrate Specificity of T Cell Ecto-ADP-Ribosyltransferase ARTC2.2.

scientific article published on 24 July 2015

P2X7 on Mouse T Cells: One Channel, Many Functions

scientific article published on 19 May 2015

P2X7 receptor-dependent and -independent T cell death is induced by nicotinamide adenine dinucleotide

scientific article published in February 2005

Pathogen-induced tissue-resident memory TH17 (TRM17) cells amplify autoimmune kidney disease

scientific article published on 01 August 2020

Physiology of ADP‐ribosylation ⬇️

scientific article published on July 12, 2013

Polymorphic microsatellite within the main promoter of the rat T cell differentiation antigen RT6 on chromosome 1

scientific article published on 01 May 1997

Premature stop codons inactivate the RT6 genes of the human and chimpanzee species

scientific article published in October 1994

Probing the expression and function of the P2X7 purinoceptor with antibodies raised by genetic immunization.

scientific article published on July 2005

Progress in the function and regulation of ADP-Ribosylation

scientific article published on 24 May 2011

Quantitative magnetic resonance imaging of enzyme activity on the cell surface: in vitro and in vivo monitoring of ADP-ribosyltransferase 2 on T cells.

scientific article published on August 2010

Rapid induction of naive T cell apoptosis by ecto-nicotinamide adenine dinucleotide: requirement for mono(ADP-ribosyl)transferase 2 and a downstream effector

scientific article published in July 2001

Rat T cell differentiation alloantigens RT6.1 and RT6.2 are NAD+-metabolizing ecto-enzymes that differ in their enzymatic activities

scientific article published on 01 May 1997

Selection of nanobodies that block the enzymatic and cytotoxic activities of the binary Clostridium difficile toxin CDT

scientific article published on 19 January 2015

Selection of nanobodies with broad neutralizing potential against primary HIV-1 strains using soluble subtype C gp140 envelope trimers

scientific article

Sequence and structural links between distant ADP-ribosyltransferase families.

scientific article published on January 1997

Short-term TNFα shedding is independent of cytoplasmic phosphorylation or furin cleavage of ADAM17.

scientific article published on 14 October 2013

Sialylated ligands on pathogenic Trypanosoma cruzi interact with Siglec-E (sialic acid-binding Ig-like lectin-E).

scientific article published on 22 June 2009

Signal-peptide-peptidase-like 2a (SPPL2a) is targeted to lysosomes/late endosomes by a tyrosine motif in its C-terminal tail

scientific article

Similarities of viral proteins to toxins that interact with monovalent cation channels ⬇️

scientific article published on November 1, 1991

Single domain antibodies from llama effectively and specifically block T cell ecto-ADP-ribosyltransferase ART2.2 in vivo

scientific article published on 15 June 2007

Single domain antibodies: promising experimental and therapeutic tools in infection and immunity

scientific article

Single-domain llama antibodies as specific intracellular inhibitors of SpvB, the actin ADP-ribosylating toxin of Salmonella typhimurium

scientific article published on 12 October 2010

Sirolimus and FK778: a comparison of two anti-proliferative immunosuppressants for prevention of experimental obliterative airway disease

scientific article published on 01 April 2006

Species specificity of ADAM10 and ADAM17 proteins in interleukin-6 (IL-6) trans-signaling and novel role of ADAM10 in inducible IL-6 receptor shedding

scientific article published on 15 March 2011

Staphylococcus aureus recruits Cdc42GAP through recycling endosomes and the exocyst to invade human endothelial cells.

scientific article published on 16 June 2016

Strategies for the identification of arginine ADP-ribosylation sites

scientific article

Structure of mouse ADP-ribosylhydrolase 3 (mARH3)

scientific article

Structure of the ecto-ADP-ribosyl transferase ART2.2 from rat

scientific article

Structure of the gene encoding the rat T cell ecto-ADP-ribosyltransferase RT6.

scientific article published in September 1996

Structure, chromosomal localization, and expression of the gene for mouse ecto-mono(ADP-ribosyl)transferase ART5

scientific journal article

Substrate binding and catalysis of ecto-ADP-ribosyltransferase 2.2 from rat

scientific article

T RM maintenance is regulated by tissue damage via P2RX7

scientific article published on 01 December 2018

T cells of different developmental stages differ in sensitivity to apoptosis induced by extracellular NAD.

scientific article published in December 2002

T-cell survival regulator LKLF is not involved in inappropriate apoptosis of diabetes-prone BBDP rat T cells

scientific article published in December 2003

Targeted disruption of CD38 accelerates autoimmune diabetes in NOD/Lt mice by enhancing autoimmunity in an ADP-ribosyltransferase 2-dependent fashion

scientific article published in April 2006

Technical Advance: a new cell preparation strategy that greatly improves the yield of vital and functional Tregs and NKT cells

scientific article

The European antibody network's practical guide to finding and validating suitable antibodies for research

scientific article published on 29 September 2015

The Most N-Terminal Region of THSD7A Is the Predominant Target for Autoimmunity in THSD7A-Associated Membranous Nephropathy

scientific article published on 19 March 2018

The art of blocking ADP-ribosyltransferases (ARTs): nanobodies as experimental and therapeutic tools to block mammalian and toxin ARTs

scientific article published in August 2013

The binary toxin CDT enhances Clostridium difficile virulence by suppressing protective colonic eosinophilia

scientific article

The expression of CD39 on regulatory T cells is genetically driven and further upregulated at sites of inflammation

scientific article

The family of toxin-related ecto-ADP-ribosyltransferases in humans and the mouse

scientific article

The phytoestrogen biochaninA weakens acute cardiac allograft rejection without affecting the reproductive system

scientific article

The spvB gene-product of the Salmonella enterica virulence plasmid is a mono(ADP-ribosyl)transferase.

scientific article

The structure of human ADP-ribosylhydrolase 3 (ARH3) provides insights into the reversibility of protein ADP-ribosylation

scientific article

The vertebrate gene family of mono(ADP-ribosyl)transferases. Proposal for a unified nomenclature.

scientific article published in January 1997

Toward a unified nomenclature for mammalian ADP-ribosyltransferases.

scientific article published on 26 January 2010

Transcription of the gene for the rat T cell differentiation marker RT6 is mainly mediated by a promoter 5′ of exon 2

article

Transgenic Overexpression of the Disordered Prion Protein N1 Fragment in Mice Does Not Protect Against Neurodegenerative Diseases Due to Impaired ER Translocation

scientific article published on 04 May 2020

Transgenic overexpression of toxin-related ecto-ADP-ribosyltransferase ART2.2 sensitizes T cells but not B cells to NAD-induced cell death.

scientific article published in September 2011

Triggering of T-cell apoptosis by toxin-related ecto-ADP-ribosyltransferase ART2.

scientific article published in December 2003

Tuning IL-2 signaling by ADP-ribosylation of CD25.

scientific article published on 10 March 2015

Two novel human members of an emerging mammalian gene family related to mono-ADP-ribosylating bacterial toxins

scientific article

Uncovered: the family relationship of a T-cell-membrane protein and bacterial toxins

scientific article published on September 1996

Use of genetic immunization to raise antibodies recognizing toxin-related cell surface ADP-ribosyltransferases in native conformation

scientific article published on July 2005

Use of the EST database resource to identify and clone novel mono(ADP-ribosyl)transferase gene family members

scientific article published on January 1997

Validation of nanobody and antibody based in vivo tumor xenograft NIRF-imaging experiments in mice using ex vivo flow cytometry and microscopy

scientific article

ZBP1 subcellular localization and association with stress granules is controlled by its Z-DNA binding domains

scientific article

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