List of works - Brian K Coombes

A Fresh Look at the Type III Secretion System: Two-Step Model of Effector Translocation in Pathogenic Bacteria

scientific article published on 18 May 2011

A Highly Effective Component Vaccine against Nontyphoidal Salmonella enterica Infections.

scientific article

A draft genome of Yersinia pestis from victims of the Black Death

scientific article

A general approach to the construction of structure-switching reporters from RNA aptamers

scientific article published on October 2010

A novel inhibitor of Chlamydophila pneumoniae protein kinase D (PknD) inhibits phosphorylation of CdsD and suppresses bacterial replication

scientific article

A polymicrobial view of disease potential in Crohn's-associated adherent-invasive E. coli

scientific article published on 15 September 2017

Active modification of host inflammation by Salmonella

scientific article published on 18 January 2013

Acute Infectious Gastroenteritis Potentiates a Crohn's Disease Pathobiont to Fuel Ongoing Inflammation in the Post-Infectious Period

scientific article

Analysis of the contribution of Salmonella pathogenicity islands 1 and 2 to enteric disease progression using a novel bovine ileal loop model and a murine model of infectious enterocolitis

scientific article published in November 2005

Aspergillomarasmine A overcomes metallo-β-lactamase antibiotic resistance

scientific article

Bacterial evolution: Making a host-adapted bacterium

scientific article published on 24 February 2016

Bacterial genetic determinants of non-O157 STEC outbreaks and hemolytic-uremic syndrome after infection

scientific article

CD3⁻NK1.1⁺ cells aid in the early induction of a Th1 response to an attaching and effacing enteric pathogen

scientific article published on 12 July 2013

CXCL9 contributes to antimicrobial protection of the gut during citrobacter rodentium infection independent of chemokine-receptor signaling

scientific article

Characterization of DalS, an ATP-binding Cassette Transporter for D-Alanine, and Its Role in Pathogenesis in Salmonella enterica

scientific article

Characterization of Escherichia coli isolated from gut biopsies of newly diagnosed patients with inflammatory bowel disease.

scientific article

Chlamydia pneumoniae and atherosclerosis: does the evidence support a causal or contributory role?

scientific article

Chlamydia pneumoniae infection of endothelial cells induces transcriptional activation of platelet-derived growth factor-B: a potential link to intimal thickening in a rabbit model of atherosclerosis

scientific article published on 09 May 2002

Chlamydia pneumoniae infection of human endothelial cells induces proliferation of smooth muscle cells via an endothelial cell-derived soluble factor(s).

scientific article published on June 1999

Citrobacter rodentium virulence in mice associates with bacterial load and the type III effector NleE

scientific article published on 13 January 2007

Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy

Convergence of External Crohn's Disease Risk Factors on Intestinal Bacteria

scientific article

Crossing the line: selection and evolution of virulence traits

scientific article

Emerging and divergent roles of pyrophosphorylated nucleotides in bacterial physiology and pathogenesis

scientific article published in 2021

Endocytosis of commensal antigens by intestinal epithelial cells regulates mucosal T cell homeostasis

scientific article published on 01 March 2019

Erratum: A draft genome of Yersinia pestis from victims of the Black Death

scientific article published in Nature

Evasive maneuvers by secreted bacterial proteins to avoid innate immune responses.

scientific article published in October 2004

Evolution of Salmonella-Host Cell Interactions through a Dynamic Bacterial Genome

scientific article published on 29 September 2017

Expression and secretion hierarchy in the nonflagellar type III secretion system

scientific article published on February 2011

Expression and secretion of Salmonella pathogenicity island-2 virulence genes in response to acidification exhibit differential requirements of a functional type III secretion apparatus and SsaL.

scientific article published on 20 September 2004

FimH adhesin of type 1 fimbriae is a potent inducer of innate antimicrobial responses which requires TLR4 and type 1 interferon signalling

scientific article

Genetic and molecular analysis of GogB, a phage-encoded type III-secreted substrate in Salmonella enterica serovar typhimurium with autonomous expression from its associated phage.

scientific article published in May 2005

Genome sequence of adherent-invasive Escherichia coli and comparative genomic analysis with other E. coli pathotypes

scientific article

GogB is an anti-inflammatory effector that limits tissue damage during Salmonella infection through interaction with human FBXO22 and Skp1

scientific article (publication date: 2012)

High-throughput fitness screening and transcriptomics identify a role for a type IV secretion system in the pathogenesis of Crohn’s disease-associated Escherichia coli

scientific article published in 2021

Host defense peptide resistance contributes to colonization and maximal intestinal pathology by Crohn's disease-associated adherent-invasive Escherichia coli.

scientific article

Humanized mice for Salmonella typhi infection: new tools for an old problem.

scientific article published on May 2011

IL-10 produced by trophoblast cells inhibits phagosome maturation leading to profound intracellular proliferation of Salmonella enterica Typhimurium.

scientific article published on 05 July 2013

Identification of MEK- and phosphoinositide 3-kinase-dependent signalling as essential events during Chlamydia pneumoniae invasion of HEp2 cells

scientific article published on July 2002

Identification of the docking site between a type III secretion system ATPase and a chaperone for effector cargo

scientific article

Identification of the regulatory logic controlling Salmonella pathoadaptation by the SsrA-SsrB two-component system.

scientific article

Infection biology: Cheats never prosper

scientific article published in February 2013

Insertion of the bacterial type III translocon: not your average needle stick.

scientific article

Mapping and regulation of genes within Salmonella pathogenicity island 12 that contribute to in vivo fitness of Salmonella enterica Serovar Typhimurium

scientific article published on 29 April 2013

Molecular analysis as an aid to assess the public health risk of non-O157 Shiga toxin-producing Escherichia coli strains

scientific article

Molecular basis for CesT recognition of type III secretion effectors in enteropathogenic Escherichia coli

scholarly article published by Brian K Coombes in 2018

Multiple histidines in the periplasmic domain of the Salmonella enterica sensor kinase SsrA enhance signaling in response to extracellular acidification

scientific article published on 16 January 2015

Muramyl Dipeptide-Based Postbiotics Mitigate Obesity-Induced Insulin Resistance via IRF4.

scientific article

Mutational analysis of Salmonella translocated effector members SifA and SopD2 reveals domains implicated in translocation, subcellular localization and function

scientific article published on August 2006

NleG Type 3 effectors from enterohaemorrhagic Escherichia coli are U-Box E3 ubiquitin ligases

scientific article published in 2010

Novel repressor of Escherichia coli O157:H7 motility encoded in the putative fimbrial cluster OI-1.

scientific article published on 27 July 2012

Nucleic acid sequence based amplification (NASBA) of Chlamydia pneumoniae major outer membrane protein (ompA) mRNA with bioluminescent detection

scientific article published on August 2000

Pathogenic adaptation of intracellular bacteria by rewiring a cis-regulatory input function

scholarly article

Pentamidine sensitizes Gram-negative pathogens to antibiotics and overcomes acquired colistin resistance.

scientific article published on 6 March 2017

Persistent infection with Crohn's disease-associated adherent-invasive Escherichia coli leads to chronic inflammation and intestinal fibrosis.

scientific article published on January 2013

Psychological stress impairs IL22-driven protective gut mucosal immunity against colonising pathobionts

scientific article published on 18 November 2021

Quantitation of Chlamydia trachomatis 16S rRNA using NASBA amplification and a bioluminescent microtiter plate assay

scientific article published on August 2000

Quantitative mass spectrometry catalogues Salmonella pathogenicity island-2 effectors and identifies their cognate host binding partners

scientific article

Regulatory evolution at the host-pathogen interface

scientific article published on 13 May 2013

Repression of intracellular virulence factors in Salmonella by the Hha and YdgT nucleoid-associated proteins

scientific article published on 16 February 2007

Role of RpoS in the virulence of Citrobacter rodentium

scientific article

RpoE fine tunes expression of a subset of SsrB-regulated virulence factors in Salmonella enterica serovar Typhimurium

scientific article

Salmonella enterica serovar Senftenberg human clinical isolates lacking SPI-1.

scientific article published on 13 February 2008

Salmonella enterica serovar typhimurium exploits Toll-like receptor signaling during the host-pathogen interaction

scientific article published on 31 August 2009

Salmonella evades D-amino acid oxidase to promote infection in neutrophils.

scientific article

Salmonella pathogenicity island 2 is expressed prior to penetrating the intestine

scientific article

Salmonella phage ST64B encodes a member of the SseK/NleB effector family

scientific article

Salmonella-containing vacuoles display centrifugal movement associated with cell-to-cell transfer in epithelial cells.

scientific article published on 22 December 2008

SseA is required for translocation of Salmonella pathogenicity island-2 effectors into host cells

scientific article published on June 2003

SseL is a salmonella-specific translocated effector integrated into the SsrB-controlled salmonella pathogenicity island 2 type III secretion system.

scientific article published on 11 December 2006

Strategic targeting of essential host-pathogen interactions in chlamydial disease.

scientific article

Structural and biochemical characterization of SrcA, a multi-cargo type III secretion chaperone in Salmonella required for pathogenic association with a host

scientific article

Subinhibitory concentrations of tetracycline affect virulence gene expression in a multi-resistant Salmonella enterica subsp. enterica serovar Typhimurium DT104.

scientific article published on 18 June 2008

Targeted enrichment of ancient pathogens yielding the pPCP1 plasmid of Yersinia pestis from victims of the Black Death

scientific article

Targeting bacterial secretion systems: benefits of disarmament in the microcosm.

scientific article published on March 2007

The SseC translocon component in Salmonella enterica serovar Typhimurium is chaperoned by SscA

scientific journal article

The evolution of virulence in non-o157 shiga toxin-producing Escherichia coli

scientific article published on 25 April 2011

The non-motile phenotype of Salmonella hha ydgT mutants is mediated through PefI-SrgD.

scientific article

The transcriptional regulator SsrB is involved in a molecular switch controlling virulence lifestyles of Salmonella.

scientific article published on 13 July 2017

Thermosensing coordinates a cis-regulatory module for transcriptional activation of the intracellular virulence system in Salmonella enterica serovar Typhimurium

scientific article published on 25 September 2007

Transcriptional priming of Salmonella Pathogenicity Island-2 precedes cellular invasion

scientific article

Type III secretion systems in symbiotic adaptation of pathogenic and non-pathogenic bacteria.

scientific article published on 11 February 2009

Type VI secretion system-associated gene clusters contribute to pathogenesis of Salmonella enterica serovar Typhimurium

scientific article

Virulence is positively selected by transmission success between mammalian hosts

scientific article

Zinc Chelation by a Small-Molecule Adjuvant Potentiates Meropenem Activity in Vivo against NDM-1-Producing Klebsiella pneumoniae

scientific article published on 26 May 2015

cDNA array analysis of altered gene expression in human endothelial cells in response to Chlamydia pneumoniae infection

scientific article published on March 2001

List of works by Brian K Coombes

A Fresh Look at the Type III Secretion System: Two-Step Model of Effector Translocation in Pathogenic Bacteria

A Highly Effective Component Vaccine against Nontyphoidal Salmonella enterica Infections.

A draft genome of Yersinia pestis from victims of the Black Death

A general approach to the construction of structure-switching reporters from RNA aptamers

A novel inhibitor of Chlamydophila pneumoniae protein kinase D (PknD) inhibits phosphorylation of CdsD and suppresses bacterial replication

A polymicrobial view of disease potential in Crohn's-associated adherent-invasive E. coli

Active modification of host inflammation by Salmonella

Acute Infectious Gastroenteritis Potentiates a Crohn's Disease Pathobiont to Fuel Ongoing Inflammation in the Post-Infectious Period

Analysis of the contribution of Salmonella pathogenicity islands 1 and 2 to enteric disease progression using a novel bovine ileal loop model and a murine model of infectious enterocolitis

Aspergillomarasmine A overcomes metallo-β-lactamase antibiotic resistance

Bacterial evolution: Making a host-adapted bacterium

Bacterial genetic determinants of non-O157 STEC outbreaks and hemolytic-uremic syndrome after infection

CD3⁻NK1.1⁺ cells aid in the early induction of a Th1 response to an attaching and effacing enteric pathogen

CXCL9 contributes to antimicrobial protection of the gut during citrobacter rodentium infection independent of chemokine-receptor signaling

Characterization of DalS, an ATP-binding Cassette Transporter for D-Alanine, and Its Role in Pathogenesis in Salmonella enterica

Characterization of Escherichia coli isolated from gut biopsies of newly diagnosed patients with inflammatory bowel disease.

Chlamydia pneumoniae and atherosclerosis: does the evidence support a causal or contributory role?

Chlamydia pneumoniae infection of endothelial cells induces transcriptional activation of platelet-derived growth factor-B: a potential link to intimal thickening in a rabbit model of atherosclerosis

Chlamydia pneumoniae infection of human endothelial cells induces proliferation of smooth muscle cells via an endothelial cell-derived soluble factor(s).

Citrobacter rodentium virulence in mice associates with bacterial load and the type III effector NleE

Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy

Convergence of External Crohn's Disease Risk Factors on Intestinal Bacteria

Crossing the line: selection and evolution of virulence traits

Emerging and divergent roles of pyrophosphorylated nucleotides in bacterial physiology and pathogenesis

Endocytosis of commensal antigens by intestinal epithelial cells regulates mucosal T cell homeostasis

Erratum: A draft genome of Yersinia pestis from victims of the Black Death

Evasive maneuvers by secreted bacterial proteins to avoid innate immune responses.

Evolution of Salmonella-Host Cell Interactions through a Dynamic Bacterial Genome

Expression and secretion hierarchy in the nonflagellar type III secretion system

Expression and secretion of Salmonella pathogenicity island-2 virulence genes in response to acidification exhibit differential requirements of a functional type III secretion apparatus and SsaL.

FimH adhesin of type 1 fimbriae is a potent inducer of innate antimicrobial responses which requires TLR4 and type 1 interferon signalling

Genetic and molecular analysis of GogB, a phage-encoded type III-secreted substrate in Salmonella enterica serovar typhimurium with autonomous expression from its associated phage.

Genome sequence of adherent-invasive Escherichia coli and comparative genomic analysis with other E. coli pathotypes

GogB is an anti-inflammatory effector that limits tissue damage during Salmonella infection through interaction with human FBXO22 and Skp1

High-throughput fitness screening and transcriptomics identify a role for a type IV secretion system in the pathogenesis of Crohn’s disease-associated Escherichia coli

Host defense peptide resistance contributes to colonization and maximal intestinal pathology by Crohn's disease-associated adherent-invasive Escherichia coli.

Humanized mice for Salmonella typhi infection: new tools for an old problem.

IL-10 produced by trophoblast cells inhibits phagosome maturation leading to profound intracellular proliferation of Salmonella enterica Typhimurium.

Identification of MEK- and phosphoinositide 3-kinase-dependent signalling as essential events during Chlamydia pneumoniae invasion of HEp2 cells

Identification of the docking site between a type III secretion system ATPase and a chaperone for effector cargo

Identification of the regulatory logic controlling Salmonella pathoadaptation by the SsrA-SsrB two-component system.

Infection biology: Cheats never prosper

Insertion of the bacterial type III translocon: not your average needle stick.

Mapping and regulation of genes within Salmonella pathogenicity island 12 that contribute to in vivo fitness of Salmonella enterica Serovar Typhimurium

Molecular analysis as an aid to assess the public health risk of non-O157 Shiga toxin-producing Escherichia coli strains

Molecular basis for CesT recognition of type III secretion effectors in enteropathogenic Escherichia coli

Multiple histidines in the periplasmic domain of the Salmonella enterica sensor kinase SsrA enhance signaling in response to extracellular acidification

Muramyl Dipeptide-Based Postbiotics Mitigate Obesity-Induced Insulin Resistance via IRF4.

Mutational analysis of Salmonella translocated effector members SifA and SopD2 reveals domains implicated in translocation, subcellular localization and function

NleG Type 3 effectors from enterohaemorrhagic Escherichia coli are U-Box E3 ubiquitin ligases

Novel repressor of Escherichia coli O157:H7 motility encoded in the putative fimbrial cluster OI-1.

Nucleic acid sequence based amplification (NASBA) of Chlamydia pneumoniae major outer membrane protein (ompA) mRNA with bioluminescent detection

Pathogenic adaptation of intracellular bacteria by rewiring a cis-regulatory input function

Pentamidine sensitizes Gram-negative pathogens to antibiotics and overcomes acquired colistin resistance.

Persistent infection with Crohn's disease-associated adherent-invasive Escherichia coli leads to chronic inflammation and intestinal fibrosis.

Psychological stress impairs IL22-driven protective gut mucosal immunity against colonising pathobionts

Quantitation of Chlamydia trachomatis 16S rRNA using NASBA amplification and a bioluminescent microtiter plate assay

Quantitative mass spectrometry catalogues Salmonella pathogenicity island-2 effectors and identifies their cognate host binding partners

Regulatory evolution at the host-pathogen interface

Repression of intracellular virulence factors in Salmonella by the Hha and YdgT nucleoid-associated proteins

Role of RpoS in the virulence of Citrobacter rodentium

RpoE fine tunes expression of a subset of SsrB-regulated virulence factors in Salmonella enterica serovar Typhimurium

Salmonella enterica serovar Senftenberg human clinical isolates lacking SPI-1.

Salmonella enterica serovar typhimurium exploits Toll-like receptor signaling during the host-pathogen interaction

Salmonella evades D-amino acid oxidase to promote infection in neutrophils.

Salmonella pathogenicity island 2 is expressed prior to penetrating the intestine

Salmonella phage ST64B encodes a member of the SseK/NleB effector family

Salmonella-containing vacuoles display centrifugal movement associated with cell-to-cell transfer in epithelial cells.

SseA is required for translocation of Salmonella pathogenicity island-2 effectors into host cells

SseL is a salmonella-specific translocated effector integrated into the SsrB-controlled salmonella pathogenicity island 2 type III secretion system.

Strategic targeting of essential host-pathogen interactions in chlamydial disease.

Structural and biochemical characterization of SrcA, a multi-cargo type III secretion chaperone in Salmonella required for pathogenic association with a host

Subinhibitory concentrations of tetracycline affect virulence gene expression in a multi-resistant Salmonella enterica subsp. enterica serovar Typhimurium DT104.

Targeted enrichment of ancient pathogens yielding the pPCP1 plasmid of Yersinia pestis from victims of the Black Death

Targeting bacterial secretion systems: benefits of disarmament in the microcosm.

The SseC translocon component in Salmonella enterica serovar Typhimurium is chaperoned by SscA

The evolution of virulence in non-o157 shiga toxin-producing Escherichia coli

The non-motile phenotype of Salmonella hha ydgT mutants is mediated through PefI-SrgD.

The transcriptional regulator SsrB is involved in a molecular switch controlling virulence lifestyles of Salmonella.