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List of works by Helle S. Waagepetersen

A possible role of the non-GAT1 GABA transporters in transfer of GABA from GABAergic to glutamatergic neurons in mouse cerebellar neuronal cultures

scientific article published on 30 May 2010

A subconvulsive dose of kainate selectively compromises astrocytic metabolism in the mouse brain in vivo

scientific article

AMP-activated protein kinase (AMPK) regulates astrocyte oxidative metabolism by balancing TCA cycle dynamics

scientific article published on 24 February 2020

AMPK Activation Affects Glutamate Metabolism in Astrocytes.

scientific article

Abstracts from the 20th International Symposium on Signal Transduction at the Blood-Brain Barriers.

scientific article published on 27 October 2017

Activity of the lactate-alanine shuttle is independent of glutamate-glutamine cycle activity in cerebellar neuronal-astrocytic cultures.

scientific article published in January 2005

Alterations in Cerebral Cortical Glucose and Glutamine Metabolism Precedes Amyloid Plaques in the APPswe/PSEN1dE9 Mouse Model of Alzheimer's Disease.

scientific article published on 29 September 2016

Among the branched-chain amino acids, only valine metabolism is up-regulated in astrocytes during glutamate exposure.

scientific article

Analysis of glutamine accumulation in rat brain mitochondria in the presence of a glutamine uptake inhibitor, histidine, reveals glutamine pools with a distinct access to deamidation

scientific article published in November 2004

Anaplerosis for Glutamate Synthesis in the Neonate and in Adulthood.

scientific article published in January 2016

Aspects of astrocyte energy metabolism, amino acid neurotransmitter homoeostasis and metabolic compartmentation

scientific article published on 27 April 2012

Astrocyte glycogen metabolism is required for neural activity during aglycemia or intense stimulation in mouse white matter.

scientific article published in January 2005

Astrocyte glycogenolysis is triggered by store-operated calcium entry and provides metabolic energy for cellular calcium homeostasis

scientific article published on 24 January 2014

Astrocytic Control of Biosynthesis and Turnover of the Neurotransmitters Glutamate and GABA ⬇️

scientific article published on August 15, 2013

Astrocytic pyruvate carboxylation: Status after 35 years

scientific article published on 23 February 2019

Availability of neurotransmitter glutamate is diminished when beta-hydroxybutyrate replaces glucose in cultured neurons.

scientific article

Brain Alanine Formation as an Ammonia-Scavenging Pathway during Hyperammonemia: Effects of Glutamine Synthetase Inhibition in Rats and Astrocyte—Neuron Co-Cultures ⬇️

scientific article published on May 15, 2013

Brain glycogen and its role in supporting glutamate and GABA homeostasis in a type 2 diabetes rat model

scientific article published on 5 January 2012

Brain glycogen-new perspectives on its metabolic function and regulation at the subcellular level

scientific article published on 2 March 2012

Branched-chain amino acids increase arterial blood ammonia in spite of enhanced intrinsic muscle ammonia metabolism in patients with cirrhosis and healthy subjects

scientific article published on 02 June 2011

Cellular mitochondrial heterogeneity in cultured astrocytes as demonstrated by immunogold labeling of alpha-ketoglutarate dehydrogenase

scientific article

Characterization of 1,4-dideoxy-1,4-imino-d-arabinitol (DAB) as an inhibitor of brain glycogen shunt activity

scientific article published on 24 January 2008

Characterization of depolarization-coupled release of glutamate from cultured mouse cerebellar granule cells using dl-threo-β-benzyloxyaspartate (DL-TBOA) to distinguish between the vesicular and cytoplasmic pools ⬇️

scientific article published on September 1, 2003

Characterization of energy and neurotransmitter metabolism in cortical glutamatergic neurons derived from human induced pluripotent stem cells: A novel approach to study metabolism in human neurons.

scientific article

Characterization of primary and secondary cultures of astrocytes prepared from mouse cerebral cortex.

scientific article published on 3 December 2010

Characterization of the L-glutamate clearance pathways across the blood-brain barrier and the effect of astrocytes in an in vitro blood-brain barrier model.

scientific article published in January 2017

Chronic Pyruvate Supplementation Increases Exploratory Activity and Brain Energy Reserves in Young and Middle-Aged Mice.

scientific article published on 16 March 2016

Citrate, a Ubiquitous Key Metabolite with Regulatory Function in the CNS.

scientific article published on 5 January 2017

Clearance of activity-evoked K+ transients and associated glia cell swelling occur independently of AQP4: A study with an isoform-selective AQP4 inhibitor

scientific article published on 07 June 2020

Comparison of effects of DL-threo-beta-benzyloxyaspartate (DL-TBOA) and L-trans-pyrrolidine-2,4-dicarboxylate (t-2,4-PDC) on uptake and release of [3h]D-aspartate in astrocytes and glutamatergic neurons

scientific article published in June 2001

Comparison of lactate and glucose metabolism in cultured neocortical neurons and astrocytes using 13C-NMR spectroscopy

scientific article published in January 1998

Compartmentation of Glutamine, Glutamate, and GABA Metabolism in Neurons and Astrocytes: Functional Implications ⬇️

scientific article published on October 1, 2003

Compartmentation of TCA cycle metabolism in cultured neocortical neurons revealed by 13C MR spectroscopy

scientific article published on 01 April 2000

Compartmentation of lactate originating from glycogen and glucose in cultured astrocytes

scientific article

Complex actions of ionomycin in cultured cerebellar astrocytes affecting both calcium-induced calcium release and store-operated calcium entry.

scientific article published on 22 March 2013

Complex glutamate labeling from [U-13C]glucose or [U-13C]lactate in co-cultures of cerebellar neurons and astrocytes

scientific article published on 5 October 2006

Conditional Knockout of GLT-1 in Neurons Leads to Alterations in Aspartate Homeostasis and Synaptic Mitochondrial Metabolism in Striatum and Hippocampus

scientific article published on 06 March 2020

Corrigendum: Chronic Pyruvate Supplementation Increases Exploratory Activity and Brain Energy Reserves in Young and Middle-Aged Mice.

scientific article published on 20 March 2017

Deletion of Neuronal GLT-1 in Mice Reveals Its Role in Synaptic Glutamate Homeostasis and Mitochondrial Function

scientific article published on 29 March 2019

Deletion of glutamate dehydrogenase 1 (Glud1) in the central nervous system affects glutamate handling without altering synaptic transmission

scientific article published on 28 September 2012

Delineation of glutamate pathways and secretory responses in pancreatic islets with β-cell–specific abrogation of the glutamate dehydrogenase ⬇️

scientific article published on August 8, 2012

Demonstration of extensive GABA synthesis in the small population of GAD positive neurons in cerebellar cultures by the use of pharmacological tools

scientific article published on 3 March 2006

Demonstration of neuron-glia transfer of precursors for GABA biosynthesis in a co-culture system of dissociated mouse cerebral cortex

scientific article published on 16 August 2008

Demonstration of pyruvate recycling in primary cultures of neocortical astrocytes but not in neurons

scientific article

Detoxification of ammonia in mouse cortical GABAergic cell cultures increases neuronal oxidative metabolism and reveals an emerging role for release of glucose-derived alanine

scientific article published on 18 May 2010

Differential expression of glutamate dehydrogenase in cultured neurons and astrocytes from mouse cerebellum and cerebral cortex

scientific article published in December 2001

Differential roles of alanine in GABAergic and glutamatergic neurons.

scientific article

Direct measurement of backflux between oxaloacetate and fumarate following pyruvate carboxylation.

scientific article

Distinct differences in rates of oxygen consumption and ATP synthesis of regionally isolated non-synaptic mouse brain mitochondria

scientific article published on 24 January 2019

Dual Properties of Lactate in Müller Cells: The Effect of GPR81 Activation

scientific article published on 01 March 2019

Dynamic Changes in Cytosolic ATP Levels in Cultured Glutamatergic Neurons During NMDA-Induced Synaptic Activity Supported by Glucose or Lactate

scientific article published on 17 July 2015

Dysfunctional TCA-Cycle Metabolism in Glutamate Dehydrogenase Deficient Astrocytes

scientific article published on 29 July 2015

Effect of glutamine synthetase inhibition on brain and interorgan ammonia metabolism in bile duct ligated rats

scientific article published on 18 December 2013

Effects of adrenergic agents on intracellular Ca2+ homeostasis and metabolism of glucose in astrocytes with an emphasis on pyruvate carboxylation, oxidative decarboxylation and recycling: implications for glutamate neurotransmission and excitotoxici

scientific article published on 23 December 2011

Effects of diabetes on brain metabolism--is brain glycogen a significant player?

scientific article published on 29 April 2014

Effects of hyperammonemia on brain energy metabolism: controversial findings in vivo and in vitro.

scientific article published on March 2014

Effects of ketone bodies in Alzheimer's disease in relation to neural hypometabolism, β-amyloid toxicity, and astrocyte function

scientific article published on 23 April 2015

Effects of thiopental on transport and metabolism of glutamate in cultured cerebellar granule neurons

scientific article published in August 2000

Elucidation of the quantitative significance of pyruvate carboxylation in cultured cerebellar neurons and astrocytes

scientific article published in December 2001

Energy substrates to support glutamatergic and GABAergic synaptic function: role of glycogen, glucose and lactate

scientific article published on December 2007

Enhanced cerebral branched-chain amino acid metabolism in R6/2 mouse model of Huntington's disease

scientific article published on 04 March 2019

Epigallocatechin-3-gallate (EGCG) activates AMPK through the inhibition of glutamate dehydrogenase in muscle and pancreatic ß-cells: A potential beneficial effect in the pre-diabetic state?

scientific article

Essential Roles of Lactate in Müller Cell Survival and Function.

scientific article published on 11 April 2018

Expression of the human isoform of glutamate dehydrogenase, hGDH2, augments TCA cycle capacity and oxidative metabolism of glutamate during glucose deprivation in astrocytes

scientific article

Extensive astrocyte metabolism of γ-aminobutyric acid (GABA) sustains glutamine synthesis in the mammalian cerebral cortex

scientific article published on 25 June 2020

First direct demonstration of extensive GABA synthesis in mouse cerebellar neuronal cultures.

scientific article published in November 2004

Fluidic system for long-term in vitro culturing and monitoring of organotypic brain slices

scientific article

Functional Differences between Synaptic Mitochondria from the Striatum and the Cerebral Cortex

scientific article published on 13 March 2019

Functional importance of the astrocytic glycogen-shunt and glycolysis for maintenance of an intact intra/extracellular glutamate gradient.

scientific article published on 20 March 2010

Functional significance of brain glycogen in sustaining glutamatergic neurotransmission.

scientific article

GABA: homeostatic and pharmacological aspects

scientific article

GAD65 is essential for synthesis of GABA destined for tonic inhibition regulating epileptiform activity

scientific article published on 4 November 2010

GDH-Dependent Glutamate Oxidation in the Brain Dictates Peripheral Energy Substrate Distribution.

scientific article published on 30 September 2015

Glucose is necessary to maintain neurotransmitter homeostasis during synaptic activity in cultured glutamatergic neurons

scientific article published in February 2006

Glucose replaces glutamate as energy substrate to fuel glutamate uptake in glutamate dehydrogenase-deficient astrocytes

scientific article published on 4 February 2015

Glucose, Lactate and Glutamine but not Glutamate Support Depolarization-Induced Increased Respiration in Isolated Nerve Terminals

scientific article

Glutamate Transporters in the Blood-Brain Barrier

scientific article published in January 2017

Glutamate and ATP at the Interface Between Signaling and Metabolism in Astroglia: Examples from Pathology

scientific article published on 25 February 2016

Glutamate dehydrogenase is essential to sustain neuronal oxidative energy metabolism during stimulation.

scientific article published in January 2017

Glutamate dehydrogenase isoforms with N-terminal (His)6- or FLAG-tag retain their kinetic properties and cellular localization.

scientific article published on 26 April 2013

Glutamate metabolism in the brain focusing on astrocytes.

scientific article published in January 2014

Glutamate neurotransmission is affected in prenatally stressed offspring

scientific article

Glutamate oxidation in astrocytes: Roles of glutamate dehydrogenase and aminotransferases

scientific article published on 15 September 2016

Glutamine in the central nervous system: function and dysfunction.

scientific article

Glycogen Shunt Activity and Glycolytic Supercompensation in Astrocytes May Be Distinctly Mediated via the Muscle Form of Glycogen Phosphorylase

scientific article published on 11 May 2017

Glycogen metabolism is impaired in the brain of male type 2 diabetic Goto-Kakizaki rats

scientific article published on 01 May 2019

Hepatic encephalopathy is associated with decreased cerebral oxygen metabolism and blood flow, not increased ammonia uptake.

scientific article

Hippocampal disruptions of synaptic and astrocyte metabolism are primary events of early amyloid pathology in the 5xFAD mouse model of Alzheimer's disease

scientific article published on 16 October 2021

Homeostasis of neuroactive amino acids in cultured cerebellar and neocortical neurons is influenced by environmental cues

scientific article published in January 2005

Hypermetabolism and impaired endothelium-dependent vasodilation in mesenteric arteries of type 2 diabetes mellitus db/db mice

scientific article published on 31 July 2019

Impaired Hippocampal Glutamate and Glutamine Metabolism in the db/db Mouse Model of Type 2 Diabetes Mellitus

scientific article published on 14 June 2017

Impairment of the organization of locomotor and exploratory behaviors in bile duct-ligated rats

scientific article

Improved cerebral energetics and ketone body metabolism in db/db mice

scientific article published in January 2016

In vitro evidence for the brain glutamate efflux hypothesis: brain endothelial cells cocultured with astrocytes display a polarized brain-to-blood transport of glutamate

scientific article published on 5 March 2012

Inhibition of glutamine synthesis induces glutamate dehydrogenase-dependent ammonia fixation into alanine in co-cultures of astrocytes and neurons

scientific article published on 21 March 2011

Integrative Characterization of the R6/2 Mouse Model of Huntington's Disease Reveals Dysfunctional Astrocyte Metabolism

scientific article published on 01 May 2018

Interorgan metabolism of ornithine phenylacetate (OP)--a novel strategy for treatment of hyperammonemia

scientific article published on 24 October 2012

Isoform-selective regulation of glycogen phosphorylase by energy deprivation and phosphorylation in astrocytes

scientific article published on 18 August 2014

Knockout of GAD65 has major impact on synaptic GABA synthesized from astrocyte-derived glutamine

scientific article

Lactate-Mediated Protection of Retinal Ganglion Cells

scientific article published on 13 March 2019

Limited energy supply in Müller cells alters glutamate uptake

scientific article published on 4 April 2014

Low cerebral oxygen consumption and blood flow in patients with cirrhosis and an acute episode of hepatic encephalopathy

scientific article

Metabolic Characterization of Acutely Isolated Hippocampal and Cerebral Cortical Slices Using [U-13C]Glucose and [1,2-13C]Acetate as Substrates

scientific article published on 8 December 2016

Metabolic fate of isoleucine in a rat model of hepatic encephalopathy and in cultured neural cells exposed to ammonia.

scientific article

Metabolism of [1,6-(13)C]glucose and [U-(13)C]glutamine and depolarization induced GABA release in superfused mouse cerebral cortical mini-slices.

scientific article published on 25 April 2008

Metabolism of [U-13C]glutamine and [U-13C]glutamate in isolated rat brain mitochondria suggests functional phosphate-activated glutaminase activity in matrix

scientific article published on 01 September 2007

Mitochondrial function in Müller cells - Does it matter?

scientific article published on 5 February 2017

Multiple compartments with different metabolic characteristics are involved in biosynthesis of intracellular and released glutamine and citrate in astrocytes

scientific article published in September 2001

Neuron-glia interactions in glutamatergic neurotransmission: roles of oxidative and glycolytic adenosine triphosphate as energy source

scientific article published on 14 September 2011

Neuronal Cell Death Induced by Mechanical Percussion Trauma in Cultured Neurons is not Preceded by Alterations in Glucose, Lactate and Glutamine Metabolism.

scientific article published on 4 January 2016

Neuronal glucose but not lactate utilization is positively correlated with NMDA-induced neurotransmission and fluctuations in cytosolic Ca2+ levels.

scientific article published in May 2009

Novel model of neuronal bioenergetics: postsynaptic utilization of glucose but not lactate correlates positively with Ca2+ signalling in cultured mouse glutamatergic neurons.

scientific article published on 5 April 2012

Obesity and type 2 diabetes in rats are associated with altered brain glycogen and amino-acid homeostasis.

scientific article published on 28 April 2010

Oxidative metabolism of astrocytes is not reduced in hepatic encephalopathy: a PET study with [(11)C]acetate in humans

scientific article

PARK2 Mutation Causes Metabolic Disturbances and Impaired Survival of Human iPSC-Derived Neurons

scientific article published on 05 July 2019

Patient iPSC-Derived Neurons for Disease Modeling of Frontotemporal Dementia with Mutation in CHMP2B

scientific article published on 06 February 2017

Phosphorylation of Glutamine Synthetase on Threonine 301 Contributes to Its Inactivation During Epilepsy

scientific article published on 21 May 2019

Primary cultures of astrocytes: their value in understanding astrocytes in health and disease.

scientific article published on 28 August 2012

Reply: To PMID 22886493.

scientific article published on 24 June 2013

Robust glycogen shunt activity in astrocytes: Effects of glutamatergic and adrenergic agents

scientific article

Role of astrocytes in depolarization-coupled release of glutamate in cerebellar cultures

scientific article published in January 2004

Role of astrocytic transport processes in glutamatergic and GABAergic neurotransmission.

scientific article published on September 2004

Role of branched chain amino acids in cerebral ammonia homeostasis related to hepatic encephalopathy.

scientific article published on 31 January 2013

Role of glutamine and neuronal glutamate uptake in glutamate homeostasis and synthesis during vesicular release in cultured glutamatergic neurons

scientific article published in July 2005

Specificity of exogenous acetate and glutamate as astrocyte substrates examined in acute brain slices from female mice using methionine sulfoximine (MSO) to inhibit glutamine synthesis

scientific article

State-Dependent Changes in Brain Glycogen Metabolism

scientific article published on 01 January 2019

Synthesis of neurotransmitter GABA via the neuronal tricarboxylic acid cycle is elevated in rats with liver cirrhosis consistent with a high GABAergic tone in chronic hepatic encephalopathy

scientific article published on 07 April 2011

Synthesis of vesicular GABA from glutamine involves TCA cycle metabolism in neocortical neurons

scientific article

The 11th International Conference on Brain Energy Metabolism "how energy metabolism shapes brain function". Preface

scientific article

The antidiabetic drug metformin decreases mitochondrial respiration and tricarboxylic acid cycle activity in cultured primary rat astrocytes

scientific article

The effect of pH and ADP on ammonia affinity for human glutamate dehydrogenases.

scientific article published on 20 February 2013

The effects of isofagomine, a potent glycogen phosphorylase inhibitor, on glycogen metabolism in cultured mouse cortical astrocytes

scientific article published on 01 April 2000

The glutamate/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer.

scientific article

The glutamine-glutamate/GABA cycle: function, regional differences in glutamate and GABA production and effects of interference with GABA metabolism.

scientific article

The inhibitors of soluble adenylate cyclase 2-OHE, KH7, and bithionol compromise mitochondrial ATP production by distinct mechanisms

scientific article published on 22 June 2018

The metabolic role of isoleucine in detoxification of ammonia in cultured mouse neurons and astrocytes

scientific article published on 06 February 2007

The micro-architecture of the cerebral cortex: functional neuroimaging models and metabolism

scientific article

The novel anticonvulsant neuropeptide and galanin analogue, NAX-5055, does not alter energy and amino acid metabolism in cultured brain cells.

scientific article published on 11 April 2017

The role of astrocytes in seizure generation: insights from a novel in vitro seizure model based on mitochondrial dysfunction

scientific article published on 01 February 2019

The transcriptome and metabolic gene signature of protoplasmic astrocytes in the adult murine cortex

scientific article published on 01 November 2007

The tricarboxylic acid cycle activity in cultured primary astrocytes is strongly accelerated by the protein tyrosine kinase inhibitor tyrphostin 23.

scientific article published on 25 November 2016

Valine but not leucine or isoleucine supports neurotransmitter glutamate synthesis during synaptic activity in cultured cerebellar neurons.

scientific article

siRNA knock down of glutamate dehydrogenase in astrocytes affects glutamate metabolism leading to extensive accumulation of the neuroactive amino acids glutamate and aspartate

scientific article

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