List of works by Michael R. Duchen

A fluorimetric and amperometric study of calcium and secretion in isolated mouse pancreatic ?-cells

scientific article published on 01 September 1995

A key metabolic integrator, coenzyme A, modulates the activity of peroxiredoxin 5 via covalent modification

scientific article published on 02 August 2019

Actions of ionomycin, 4-BrA23187 and a novel electrogenic Ca2+ ionophore on mitochondria in intact cells

scientific article published on February 2003

Activation of PARP by oxidative stress induced by β-amyloid: implications for Alzheimer's disease

scientific article published on 18 October 2012

Adaptation to heat of cardiomyoblasts in culture protects them against heat shock: role of nitric oxide and heat shock proteins

scientific article published on July 2003

Albumin uptake in OK cells exposed to rotenone: a model for studying the effects of mitochondrial dysfunction on endocytosis in the proximal tubule?

scientific article published on 13 May 2010

Alkalinity of neutrophil phagocytic vacuoles is modulated by HVCN1 and has consequences for myeloperoxidase activity

scientific article (publication date: 2015)

Altered mechanical properties and intracellular calcium signaling in cardiomyocytes from annexin 6 null-mutant mice

scientific journal article

Antiapoptotic effect of heat adaptation in cultured cells

scientific article published on February 2003

Assessing Mitochondrial Potential, Calcium, and Redox State in Isolated Mammalian Cells Using Confocal Microscopy

scientific article published on 01 January 2007

Beta-amyloid activates PARP causing astrocytic metabolic failure and neuronal death

scientific journal article

Beta-amyloid fragment 25-35 causes mitochondrial dysfunction in primary cortical neurons

scientific article published in August 2002

Beta-amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase.

scientific article

CLIC1 function is required for beta-amyloid-induced generation of reactive oxygen species by microglia.

scientific article

Calcium microdomains and oxidative stress

scientific article published on 17 October 2006

Calcium signaling as a mediator of cell energy demand and a trigger to cell death

scientific article

Calcium signals and mitochondria at fertilisation

scientific article

Calcium signals induced by amyloid beta peptide and their consequences in neurons and astrocytes in culture

scientific article

Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes

scientific article published on 17 April 2017

Cellular and molecular mechanisms of mitochondrial function

scientific article published on 23 June 2012

Cellular glutathione content in the organ of Corti and its role during ototoxicity

scientific article

Changes in [Ca2+]i and membrane currents during impaired mitochondrial metabolism in dissociated rat hippocampal neurons

scientific article published in February 1998

Changes in intracellular calcium and glutathione in astrocytes as the primary mechanism of amyloid neurotoxicity.

scientific article published in June 2003

Chloride intracellular channel 1 (CLIC1): Sensor and effector during oxidative stress

scientific article published on 10 April 2010

Constitutive activation of the PI3K-Akt-mTORC1 pathway sustains the m.3243 A > G mtDNA mutation

scientific article published on 04 November 2021

Correction: Impaired cellular bioenergetics caused by GBA1 depletion sensitizes neurons to calcium overload

scientific article published on 09 March 2020

Decellularised cartilage directs chondrogenic differentiation: creation of a fracture callus mimetic.

scientific article published on 27 March 2018

Defective quality control mechanisms and accumulation of damaged mitochondria link Gaucher and Parkinson diseases

scientific article published on 13 August 2013

Deletion of the von Hippel-Lindau gene in pancreatic beta cells impairs glucose homeostasis in mice.

scientific article published on 08 December 2008

Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells

scientific article published on 06 June 2019

Diazepam-induced loss of inhibitory synapses mediated by PLCδ/ Ca2+/calcineurin signalling downstream of GABAA receptors

scientific article published on 14 June 2018

Differential expression of membrane currents in dissociated mouse primary sensory neurons.

scientific article published in December 1994

Direct and cross-protective effects of heat adaptation in cultured cells

scientific article published in February 2003

Dopamine induced neurodegeneration in a PINK1 model of Parkinson's disease

scientific article

Effects of NO on mitochondrial function in cardiomyocytes: Pathophysiological relevance

scientific article

Effects of beauvericin on the metabolic state and ionic homeostasis of ventricular myocytes of the guinea pig.

scientific article published in November 2005

Endoplasmic reticulum and lysosomal Ca²⁺ stores are remodelled in GBA1-linked Parkinson disease patient fibroblasts

scientific article

Endothelial mitochondria: contributing to vascular function and disease

scientific article published on April 2007

Energy metabolism of adult astrocytes in vitro

scientific article published in April 1996

Excitotoxic mitochondrial depolarisation requires both calcium and nitric oxide in rat hippocampal neurons

scientific article published on November 1999

Expression and modulation of an NADPH oxidase in mammalian astrocytes.

scientific article published on October 2005

Expression of mutant SOD1 in astrocytes induces functional deficits in motoneuron mitochondria

scientific article published on 25 October 2008

Extracellular growth factors and mitogens cooperate to drive mitochondrial biogenesis

scientific article

FCCP is cardioprotective at concentrations that cause mitochondrial oxidation without detectable depolarisation.

scientific article

Fantastic beasts and how to find them-Molecular identification of the mitochondrial ATP-sensitive potassium channel

scientific article published on 15 October 2019

G2019S leucine-rich repeat kinase 2 causes uncoupling protein-mediated mitochondrial depolarization

scientific article

Glucocerebrosidase inhibition causes mitochondrial dysfunction and free radical damage

scientific article

Glutamate-induced mitochondrial depolarisation and perturbation of calcium homeostasis in cultured rat hippocampal neurones

scientific article published on September 1999

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases.

scientific article

HDAC6 inhibition induces mitochondrial fusion, autophagic flux and reduces diffuse mutant huntingtin in striatal neurons.

scientific article published on 20 August 2015

Hypothermia protects brain mitochondrial function from hypoxemia in a murine model of sepsis

scientific article

Hypoxia-induced catecholamine secretion in isolated newborn rat adrenal chromaffin cells is mimicked by inhibition of mitochondrial respiration

scientific article published on 01 October 1997

IF(1): setting the pace of the F(1)F(o)-ATP synthase

scientific article published on 24 June 2009

IF1, the endogenous regulator of the F(1)F(o)-ATPsynthase, defines mitochondrial volume fraction in HeLa cells by regulating autophagy

scientific article published on 5 March 2009

IL-6 induces PI 3-kinase and nitric oxide-dependent protection and preserves mitochondrial function in cardiomyocytes

scientific article

Identification of ER-000444793, a Cyclophilin D-independent inhibitor of mitochondrial permeability transition, using a high-throughput screen in cryopreserved mitochondria

scientific article

Imaging Mitochondrial Calcium Signalling with Fluorescent Probes and Single or Two Photon Confocal Microscopy

scientific article published on 01 January 2012

Imaging mitochondrial function in intact cells

scientific article published in January 2003

Impaired Cellular Bioenergetics Causes Mitochondrial Calcium Handling Defects in MT-ND5 Mutant Cybrids

scientific article

Impaired cellular bioenergetics caused by GBA1 depletion sensitizes neurons to calcium overload

scientific article published on 04 November 2019

Impaired mitochondrial bioenergetics determines glutamate-induced delayed calcium deregulation in neurons

scientific article published on 17 August 2009

Impaired mitochondrial homeostasis and neurodegeneration: towards new therapeutic targets?

scientific article published on 13 September 2014

Impulse conduction increases mitochondrial transport in adult mammalian peripheral nerves in vivo

scientific article (publication date: December 2013)

In Vivo Imaging of Flavoprotein Fluorescence During Hypoxia Reveals the Importance of Direct Arterial Oxygen Supply to Cerebral Cortex Tissue.

scientific article published in January 2016

Induction of mitochondrial oxidative stress in astrocytes by nitric oxide precedes disruption of energy metabolism

scientific article published on 16 August 2005

Inhibiting mitochondrial permeability transition pore opening at reperfusion protects against ischaemia-reperfusion injury

scientific article published in December 2003

Inhibition of NAADP signalling on reperfusion protects the heart by preventing lethal calcium oscillations via two-pore channel 1 and opening of the mitochondrial permeability transition pore.

scientific article published on 22 September 2015

Inositol trisphosphate receptor-mediated Ca2+ signalling stimulates mitochondrial function and gene expression in core myopathy patients.

scientific article

Interplay between mitochondria and cellular calcium signalling

scientific article published on January 2004

Interrelationships between astrocyte function, oxidative stress and antioxidant status within the central nervous system.

scientific article published on July 1997

Intracellular distribution of the fluorescent dye nonyl acridine orange responds to the mitochondrial membrane potential: implications for assays of cardiolipin and mitochondrial mass

scientific article

Introduction to Special Issue on Mitochondrial Redox Signaling in Health and Disease

scientific article published on 5 August 2016

Investigating mitochondrial redox state using NADH and NADPH autofluorescence

scientific article

Investigating the Mitochondrial Permeability Transition Pore in Disease Phenotypes and Drug Screening

scientific article published on 13 May 2019

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS.

scientific article

Lack of oxygen deactivates mitochondrial complex I: implications for ischemic injury?

scientific article

Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signaling

scientific article

Maternal diet-induced obesity alters mitochondrial activity and redox status in mouse oocytes and zygotes

scientific article

Mechanism of neurodegeneration of neurons with mitochondrial DNA mutations

scientific article

Mechanisms of intracellular calcium regulation in adult astrocytes

scientific article published on 01 April 1996

Mechanisms underlying the loss of mitochondrial membrane potential in glutamate excitotoxicity

scientific article published on 18 April 2008

Membrane cholesterol content plays a key role in the neurotoxicity of β-amyloid: implications for Alzheimer's disease.

scientific article published on 11 April 2011

Metabolic Profiling of Live Cancer Tissues Using NAD(P)H Fluorescence Lifetime Imaging

scientific article published on 01 January 2019

Mild stress of caffeine increased mtDNA content in skeletal muscle cells: the interplay between Ca2+ transients and nitric oxide

scientific article published on 25 August 2012

Mitochondria and calcium in health and disease

scientific article published on 18 April 2008

Mitochondria and quality control defects in a mouse model of Gaucher disease--links to Parkinson's disease

scientific journal article

Mitochondria exert a negative feedback on the propagation of intracellular Ca2+ waves in rat cortical astrocytes

scientific article published on May 1999

Mitochondria in health and disease: perspectives on a new mitochondrial biology

scientific article published in August 2004

Mitochondria mediated cell death in diabetes

scientific article published on December 2009

Mitochondria modulate the spatio-temporal properties of intra- and intercellular Ca2+ signals in cochlear supporting cells.

scientific article published on 23 July 2009

Mitochondria, Ca2+ and neurodegenerative disease

scientific article

Mitochondria, calcium-dependent neuronal death and neurodegenerative disease

scientific article published on 22 May 2012

Mitochondria: the hub of cellular Ca2+ signaling

scientific article published on April 2008

Mitochondrial 'flashes': a radical concept repHined.

scientific article published on 20 August 2012

Mitochondrial IF₁ preserves cristae structure to limit apoptotic cell death signaling

scientific article published on 29 July 2013

Mitochondrial ND5 gene variation associated with encephalomyopathy and mitochondrial ATP consumption

scientific article

Mitochondrial Permeability Transition: A Molecular Lesion with Multiple Drug Targets

scientific article published on 06 December 2018

Mitochondrial dynamics and quality control in Huntington's disease.

scientific article published on 17 September 2015

Mitochondrial dysfunction and Purkinje cell loss in autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS)

scientific article published on 17 January 2012

Mitochondrial dysfunction is an important cause of neurological deficits in an inflammatory model of multiple sclerosis.

scientific article

Mitochondrial function and redox state in mammalian embryos.

scientific article published on May 2009

Mitochondrial oxidative stress and cell death in astrocytes--requirement for stored Ca2+ and sustained opening of the permeability transition pore

scientific article published in March 2002

Mitochondrial permeability transition pore as a target for cardioprotection in the human heart

scientific article published in July 2005

Mitochondrial permeability transition pore: sensitivity to opening and mechanistic dependence on substrate availability

scientific article

Mitochondrial quality control and communications with the nucleus are important in maintaining mitochondrial function and cell health

scientific article

Mitochondrial uncoupling, with low concentration FCCP, induces ROS-dependent cardioprotection independent of KATP channel activation

Modelling mitochondrial dysfunction in Alzheimer's disease using human induced pluripotent stem cells

scientific article published on 01 May 2019

Monitoring exocytosis from single mast cells by fast voltammetry

scientific article published on 01 October 1991

Multiphoton NAD(P)H FLIM reveals metabolic changes in individual cell types of the intact cochlea upon sensorineural hearing loss

scientific article published on 11 December 2019

Multiphoton imaging of the functioning kidney

scientific article

Multiphoton imaging reveals differences in mitochondrial function between nephron segments

scientific article

NRF2 Orchestrates the Metabolic Shift during Induced Pluripotent Stem Cell Reprogramming.

scientific article published on 16 February 2016

PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons

scientific article

PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death

scientific article published on March 2009

PPARγ activation rescues mitochondrial function from inhibition of complex I and loss of PINK1.

scientific article published on 26 December 2013

PPARγ and PGC-1α as therapeutic targets in Parkinson's

scientific article published on 10 July 2014

PPARγ as a therapeutic target to rescue mitochondrial function in neurological disease

scientific article

Polarized Two-Photon Absorption and Heterogeneous Fluorescence Dynamics in NAD(P)H.

scientific article published on 22 May 2019

Preconditioning protects by inhibiting the mitochondrial permeability transition

scientific article

Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing

scientific article published on 17 August 2018

Prostaglandin F2alpha potentiates the calcium dependent activation of mitochondrial metabolism in luteal cells

scientific article published in January 2005

Protection of cerebral microcirculation, mitochondrial function, and electrocortical activity by small-volume resuscitation with terlipressin in a rat model of haemorrhagic shock

scientific article published on 05 December 2017

Quality control gone wrong: mitochondria, lysosomal storage disorders and neurodegeneration

scientific article published on April 2014

Quantitative imaging of glutathione in hippocampal neurons and glia in culture using monochlorobimane

scientific article published in December 2001

Regulation of mitochondrial structure and function by the F1Fo-ATPase inhibitor protein, IF1.

scientific article published in July 2008

Regulation of redox metabolism in the mouse oocyte and embryo.

scientific article published on 21 December 2006

Renal Tubular Cell Mitochondrial Dysfunction Occurs Despite Preserved Renal Oxygen Delivery in Experimental Septic Acute Kidney Injury.

scientific article published on 2 January 2018

Renal function and mitochondrial cytopathy (MC): more questions than answers?

scientific article published on 16 May 2008

Reversal of Mitochondrial Transhydrogenase Causes Oxidative Stress in Heart Failure.

scientific article

Roles of mitochondria in health and disease.

scientific article published on February 2004

Roles of mitochondria in human disease

scientific article published on January 2010

RyR1 deficiency in congenital myopathies disrupts excitation-contraction coupling.

scientific article published on 17 April 2013

SCaMC-1 promotes cancer cell survival by desensitizing mitochondrial permeability transition via ATP/ADP-mediated matrix Ca(2+) buffering

scientific article

Selective Inhibition of the Mitochondrial Permeability Transition Pore Protects against Neurodegeneration in Experimental Multiple Sclerosis

scientific article published on 17 December 2015

Separating NADH and NADPH fluorescence in live cells and tissues using FLIM

scientific article

Signal transducer and activator of transcription 2 deficiency is a novel disorder of mitochondrial fission

scientific journal article

Signalling via the reperfusion injury signalling kinase (RISK) pathway links closure of the mitochondrial permeability transition pore to cardioprotection

scientific article

Skeletal muscle dysfunction is associated with derangements in mitochondrial bioenergetics (but not UCP3) in a rodent model of sepsis

scientific article published on 24 February 2015

Slow calcium waves and redox changes precede mitochondrial permeability transition pore opening in the intact heart during hypoxia and reoxygenation

scientific article published on 23 December 2011

Sperm-triggered [Ca2+] oscillations and Ca2+ homeostasis in the mouse egg have an absolute requirement for mitochondrial ATP production.

scientific article

Sulforaphane preconditioning of the Nrf2/HO-1 defense pathway protects the cerebral vasculature against blood-brain barrier disruption and neurological deficits in stroke

scientific article published on 7 September 2013

Targeted polyphosphatase expression alters mitochondrial metabolism and inhibits calcium-dependent cell death

scholarly article

The 'mitoflash' probe cpYFP does not respond to superoxide

scientific article published in October 2014

The APPswe/PS1A246E mutations in an astrocytic cell line leads to increased vulnerability to oxygen and glucose deprivation, Ca2+ dysregulation and mitochondrial abnormalities.

scientific article published on 6 January 2018

The compound BTB06584 is an IF1 -dependent selective inhibitor of the mitochondrial F1 Fo-ATPase.

scientific article published on July 2014

The effect of nitric oxide on cell respiration: A key to understanding its role in cell survival or death.

scientific article published in December 2000

The intracellular localization and function of the ATP-sensitive K+ channel subunit Kir6.1.

scientific article published on 20 March 2010

The large-conductance Ca2+-activated K+ channel is essential for innate immunity

scientific article

The legs at odd angles (Loa) mutation in cytoplasmic dynein ameliorates mitochondrial function in SOD1G93A mouse model for motor neuron disease

scientific article

The mitochondrial calcium uniporter regulates breast cancer progression via HIF-1α.

scientific article published on 2 May 2016

The regulation of neuronal mitochondrial metabolism by calcium

scientific article

The role of an astrocytic NADPH oxidase in the neurotoxicity of amyloid beta peptides

scientific article

The role of mitochondria in sepsis-induced cardiomyopathy

scientific article published on 17 October 2018

The role of mitochondrial function in the oocyte and embryo

scientific article published on January 2007

Three distinct mechanisms generate oxygen free radicals in neurons and contribute to cell death during anoxia and reoxygenation.

scientific article

Three-Dimensional Human iPSC-Derived Artificial Skeletal Muscles Model Muscular Dystrophies and Enable Multilineage Tissue Engineering.

scientific article published in April 2018

Toxicity of amyloid beta peptide: tales of calcium, mitochondria, and oxidative stress

scientific article published on March 2004

Transient mitochondrial depolarizations reflect focal sarcoplasmic reticular calcium release in single rat cardiomyocytes

scientific article published on August 1998

Transient mitochondrial permeability transition pore opening mediates preconditioning-induced protection

scientific article published on 5 April 2004

Unexpected low-dose toxicity of the universal solvent DMSO.

scientific article published on 10 December 2013

Vascular endothelial growth factor (VEGF)-D and VEGF-A differentially regulate KDR-mediated signaling and biological function in vascular endothelial cells

scientific article

‘What nourishes me, destroys me’: towards a new mitochondrial biology

scientific article published on 01 October 2001

Paulina is supported by:

About Paulina

Help