List of works - Diana R. Tomchick

A Bacterial Effector Mimics a Host HSP90 Client to Undermine Immunity

scientific article published on 12 September 2019

A Single Active-Site Mutation of P450BM-3 Dramatically Enhances Substrate Binding and Rate of Product Formation

scientific article

A Versatile Conformational Switch Regulates Reactivity in Human Branched-Chain α-Ketoacid Dehydrogenase

A distinct inhibitory mechanism of the V-ATPase by Vibrio VopQ revealed by cryo-EM

scientific article published on 18 May 2020

A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria

scientific article

A protein catalytic framework with an N-terminal nucleophile is capable of self-activation

scientific article

A proximal arginine R206 participates in switching of the Bradyrhizobium japonicum FixL oxygen sensor.

scientific article

A triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor (DSM421) with improved drug-like properties for treatment and prevention of malaria

scientific article (publication date: 9 December 2016)

A versatile conformational switch regulates reactivity in human branched-chain alpha-ketoacid dehydrogenase

scientific article

Alternative pathways utilize or circumvent putrescine for biosynthesis of putrescine-containing rhizoferrin

scientific article published on 04 December 2020

Artificial ligand binding within the HIF2 PAS-B domain of the HIF2 transcription factor

scientific article

Autoinhibition of Mint1 adaptor protein regulates amyloid precursor protein binding and processing

scientific article

Bacterial pseudokinase catalyzes protein polyglutamylation to inhibit the SidE-family ubiquitin ligases

scientific article published on 01 May 2019

Bile salt receptor complex activates a pathogenic type III secretion system

scientific article

Biophysical and bioinformatic analyses implicate the Treponema pallidum Tp34 lipoprotein (Tp0971) in transition metal homeostasis

scientific article

Changes at the KinA PAS-A dimerization interface influence histidine kinase function

scientific article

Coiled-coil coactivators play a structural role mediating interactions in hypoxia-inducible factor heterodimerization

scientific article

Cross-talk between thiamin diphosphate binding and phosphorylation loop conformation in human branched-chain alpha-keto acid decarboxylase/dehydrogenase

scientific article

Crystal Structure of the Formin mDia1 in Autoinhibited Conformation

scientific article

Crystal structure of a 12 ANK repeat stack from human ankyrinR.

scientific article

Crystal structure of a type III pantothenate kinase: insight into the mechanism of an essential coenzyme A biosynthetic enzyme universally distributed in bacteria

scientific article

Crystal structure of human dihydrolipoamide dehydrogenase: NAD+/NADH binding and the structural basis of disease-causing mutations

scientific article

Crystal structure of inhibitor-bound P450BM-3 reveals open conformation of substrate access channel

scientific article

Crystal structure of the 47-kDa lipoprotein of Treponema pallidum reveals a novel penicillin-binding protein

scientific article

Crystal structure of the RIM1alpha C2B domain at 1.7 A resolution

scientific article

Crystal structure of the RIM2 C2A-domain at 1.4 A resolution

scientific article

Crystal structure of the Tp34 (TP0971) lipoprotein of treponema pallidum: implications of its metal-bound state and affinity for human lactoferrin

scientific article

Crystal structure of the cohesin loader Scc2 and insight into cohesinopathy

scientific article

Crystallization and preliminary X-ray crystallographic analysis of carbamoyl phosphate synthetase from Escherichia coli.

scientific article

Dynamic binding mode of a Synaptotagmin-1-SNARE complex in solution

scientific article

Dynamic evolution of the human immunodeficiency virus type 1 pathogenic factor, Nef.

scientific article

Enzyme structure and dynamics affect hydrogen tunneling: The impact of a remote side chain (I553) in soybean lipoxygenase-1

scientific article

Erratum: A protein catalytic framework with an N-terminal nucleophile is capable of self-activation

scientific article published in Nature

Evidence for Posttranslational Protein Flavinylation in the Syphilis Spirochete Treponema pallidum: Structural and Biochemical Insights from the Catalytic Core of a Periplasmic Flavin-Trafficking Protein

scientific article published on 5 May 2015

Evolution of Substrate Specificity within a Diverse Family of / -Barrel-fold Basic Amino Acid Decarboxylases: X-RAY STRUCTURE DETERMINATION OF ENZYMES WITH SPECIFICITY FOR L-ARGININE AND CARBOXYNORSPERMIDINE

scientific article

Exceptionally tight membrane-binding may explain the key role of the synaptotagmin-7 C2A domain in asynchronous neurotransmitter release

scientific article published on 18 September 2017

Full-length structure of a monomeric histidine kinase reveals basis for sensory regulation

scientific article

Functional clues from the crystal structure of an orphan periplasmic ligand-binding protein from Treponema pallidum

scientific article

High-resolution cryo-EM structures of the E. coli hemolysin ClyA oligomers

scientific article published on 02 May 2019

Identification and mechanistic understanding of dihydroorotate dehydrogenase point mutations in Plasmodium falciparum that confer in vitro resistance to the clinical candidate DSM265

scientific article published on 13 November 2018

Identification of Lysine Residues in the Borrelia burgdorferi DbpA Adhesin Required for Murine Infection

scientific article

Importin-9 wraps around the H2A-H2B core to act as nuclear importer and histone chaperone

scientific article published on 11 March 2019

Insights into Mad2 Regulation in the Spindle Checkpoint Revealed by the Crystal Structure of the Symmetric Mad2 Dimer

scientific article

Interactions of substrates at the surface of P450s can greatly enhance substrate potency

scientific article

Kinetic and structural insights into the mechanism of AMPylation by VopS Fic domain

scientific journal article

Lead Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series for the Treatment of Malaria

scientific article published on 06 April 2020

Localization and Structure of the Ankyrin-binding Site on 2-Spectrin

scientific article

Mechanism of actin filament nucleation by the bacterial effector VopL

scientific article

Mechanism of the synergistic end-product regulation of Bacillus subtilis glutamine phosphoribosylpyrophosphate amidotransferase by nucleotides

scientific article

Mechanistic insights into neurotransmitter release and presynaptic plasticity from the crystal structure of Munc13-1 C1C2BMUN.

scientific article published on 08 February 2017

Molecular Discrimination between Two Conformations of Sphingomyelin in Plasma Membranes

scientific article published on 21 February 2019

Molecular insights into the enzymatic diversity of flavin-trafficking protein (Ftp; formerly ApbE) in flavoprotein biogenesis in the bacterial periplasm

scientific article published on 2 December 2015

Molecular mechanism for regulation of the human mitochondrial branched-chain alpha-ketoacid dehydrogenase complex by phosphorylation

scientific article

Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis

scientific article

Pathogenic C9ORF72 Antisense Repeat RNA Forms a Double Helix with Tandem C:C Mismatches

scientific article

Phosphorylation of spore coat proteins by a family of atypical protein kinases.

scientific article published on 16 May 2016

Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series

scientific article published on 20 April 2021

Protein AMPylation by an Evolutionarily Conserved Pseudokinase

scientific article published on 27 September 2018

Re-examining how complexin inhibits neurotransmitter release

scientific article

Relief of autoinhibition by conformational switch explains enzyme activation by a catalytically dead paralog

scientific article published on 15 December 2016

Roles of His291-alpha and His146-beta' in the reductive acylation reaction catalyzed by human branched-chain alpha-ketoacid dehydrogenase: refined phosphorylation loop structure in the active site

scientific article

SAV1 promotes Hippo kinase activation through antagonizing the PP2A phosphatase STRIPAK.

scientific article published on 24 October 2017

Strategies for macromolecular synchrotron crystallography.

scientific article

Structural Basis and IP6 Requirement for Pds5-Dependent Cohesin Dynamics

scientific article

Structural Basis for Autoactivation of Human Mst2 Kinase and Its Regulation by RASSF5

scientific article

Structural analysis of Xanthomonas XopD provides insights into substrate specificity of ubiquitin-like protein proteases

scientific article

Structural analysis of human Cdc20 supports multisite degron recognition by APC/C

scientific article

Structural and Biochemical Basis for Polyamine Binding to the Tp0655 Lipoprotein of Treponema pallidum: Putative Role for Tp0655 (TpPotD) as a Polyamine Receptor

scientific article

Structural and Energetic Mechanisms of Cooperative Autoinhibition and Activation of Vav1

scientific article

Structural and Molecular Characterization of Iron-sensing Hemerythrin-like Domain within F-box and Leucine-rich Repeat Protein 5 (FBXL5)

scientific article

Structural and Thermodynamic Characterization of the Interaction between Two Periplasmic Treponema pallidum Lipoproteins that are Components of a TPR-Protein-Associated TRAP Transporter (TPAT)

scientific article

Structural and functional analysis of the YAP-binding domain of human TEAD2

scientific article

Structural and mutational analysis of functional differentiation between synaptotagmins-1 and -7

scientific article

Structural basis for CoREST-dependent demethylation of nucleosomes by the human LSD1 histone demethylase

scientific article published in August 2006

Structural basis for a Munc13-1 homodimer to Munc13-1/RIM heterodimer switch

scientific article

Structural basis for the evolutionary inactivation of Ca2+ binding to synaptotagmin 4

scientific journal article

Structural basis of Rho GTPase-mediated activation of the formin mDia1.

scientific article published in April 2005

Structural basis of actin filament nucleation and processive capping by a formin homology 2 domain

scientific article published on 5 January 2005

Structural basis of histone demethylation by LSD1 revealed by suicide inactivation

scientific article

Structural evidence that the 32-kilodalton lipoprotein (Tp32) of Treponema pallidum is an L-methionine-binding protein

scientific article published on 15 October 2004

Structural insight into interactions between dihydrolipoamide dehydrogenase (E3) and E3 binding protein of human pyruvate dehydrogenase complex

scientific article

Structural, Bioinformatic, and In Vivo Analyses of Two Treponema pallidum Lipoproteins Reveal a Unique TRAP Transporter

scientific article

Structure and Ca²⁺-binding properties of the tandem C₂ domains of E-Syt2

scientific article

Structure and Substrate Recruitment of the Human Spindle Checkpoint Kinase Bub1

scientific article

Structure and function of the glutamine phosphoribosylpyrophosphate amidotransferase glutamine site and communication with the phosphoribosylpyrophosphate site

scientific article

Structure of Cdc42 in a complex with the GTPase-binding domain of the cell polarity protein, Par6

scientific article

Structure of cohesin subcomplex pinpoints direct shugoshin-Wapl antagonism in centromeric cohesion

scientific article

Structure of human Mad1 C-terminal domain reveals its involvement in kinetochore targeting

scientific article

Structure of human nicotinamide/nicotinic acid mononucleotide adenylyltransferase. Basis for the dual substrate specificity and activation of the oncolytic agent tiazofurin

scientific article

Structure of rat BCKD kinase: Nucleotide-induced domain communication in a mitochondrial protein kinase

scientific article

Structure of the human cohesin inhibitor Wapl

scientific article

Structure of the photolyase-like domain of cryptochrome 1 from Arabidopsis thaliana

scholarly article

Substrate-specific activation of the mitotic kinase Bub1 through intramolecular autophosphorylation and kinetochore targeting

scientific article

Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity

scientific article published on 29 April 2016

The Bacterial Effector VopL Organizes Actin into Filament-like Structures

scientific article

The Crystal Structure of a Munc13 C-terminal Module Exhibits a Remarkable Similarity to Vesicle Tethering Factors

scientific article

The PnrA (Tp0319; TmpC) lipoprotein represents a new family of bacterial purine nucleoside receptor encoded within an ATP-binding cassette (ABC)-like operon in Treponema pallidum

scientific article

The Purine Repressor of Bacillus subtilis: a Novel Combination of Domains Adapted for Transcription Regulation

scientific article

The TP0796 Lipoprotein of Treponema pallidum Is a Bimetal-dependent FAD Pyrophosphatase with a Potential Role in Flavin Homeostasis

scientific article

The assembly of a GTPase–kinase signalling complex by a bacterial catalytic scaffold

scientific article

Three-dimensional structure of the complexin/SNARE complex

scientific article

Trypanosomatid Deoxyhypusine Synthase Activity Is Dependent on Shared Active-Site Complementation between Pseudoenzyme Paralogs

p31comet blocks Mad2 activation through structural mimicry

scientific article

List of works by Diana R. Tomchick

A Bacterial Effector Mimics a Host HSP90 Client to Undermine Immunity

A Single Active-Site Mutation of P450BM-3 Dramatically Enhances Substrate Binding and Rate of Product Formation

A Versatile Conformational Switch Regulates Reactivity in Human Branched-Chain α-Ketoacid Dehydrogenase

A distinct inhibitory mechanism of the V-ATPase by Vibrio VopQ revealed by cryo-EM

A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria

A protein catalytic framework with an N-terminal nucleophile is capable of self-activation

A proximal arginine R206 participates in switching of the Bradyrhizobium japonicum FixL oxygen sensor.

A triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor (DSM421) with improved drug-like properties for treatment and prevention of malaria

A versatile conformational switch regulates reactivity in human branched-chain alpha-ketoacid dehydrogenase

Alternative pathways utilize or circumvent putrescine for biosynthesis of putrescine-containing rhizoferrin

Artificial ligand binding within the HIF2 PAS-B domain of the HIF2 transcription factor

Autoinhibition of Mint1 adaptor protein regulates amyloid precursor protein binding and processing

Bacterial pseudokinase catalyzes protein polyglutamylation to inhibit the SidE-family ubiquitin ligases

Bile salt receptor complex activates a pathogenic type III secretion system

Biophysical and bioinformatic analyses implicate the Treponema pallidum Tp34 lipoprotein (Tp0971) in transition metal homeostasis

Changes at the KinA PAS-A dimerization interface influence histidine kinase function

Coiled-coil coactivators play a structural role mediating interactions in hypoxia-inducible factor heterodimerization

Cross-talk between thiamin diphosphate binding and phosphorylation loop conformation in human branched-chain alpha-keto acid decarboxylase/dehydrogenase

Crystal Structure of the Formin mDia1 in Autoinhibited Conformation

Crystal structure of a 12 ANK repeat stack from human ankyrinR.

Crystal structure of a type III pantothenate kinase: insight into the mechanism of an essential coenzyme A biosynthetic enzyme universally distributed in bacteria

Crystal structure of human dihydrolipoamide dehydrogenase: NAD+/NADH binding and the structural basis of disease-causing mutations

Crystal structure of inhibitor-bound P450BM-3 reveals open conformation of substrate access channel

Crystal structure of the 47-kDa lipoprotein of Treponema pallidum reveals a novel penicillin-binding protein

Crystal structure of the RIM1alpha C2B domain at 1.7 A resolution

Crystal structure of the RIM2 C2A-domain at 1.4 A resolution

Crystal structure of the Tp34 (TP0971) lipoprotein of treponema pallidum: implications of its metal-bound state and affinity for human lactoferrin

Crystal structure of the cohesin loader Scc2 and insight into cohesinopathy

Crystallization and preliminary X-ray crystallographic analysis of carbamoyl phosphate synthetase from Escherichia coli.

Dynamic binding mode of a Synaptotagmin-1-SNARE complex in solution

Dynamic evolution of the human immunodeficiency virus type 1 pathogenic factor, Nef.

Enzyme structure and dynamics affect hydrogen tunneling: The impact of a remote side chain (I553) in soybean lipoxygenase-1

Erratum: A protein catalytic framework with an N-terminal nucleophile is capable of self-activation

Evidence for Posttranslational Protein Flavinylation in the Syphilis Spirochete Treponema pallidum: Structural and Biochemical Insights from the Catalytic Core of a Periplasmic Flavin-Trafficking Protein

Evolution of Substrate Specificity within a Diverse Family of / -Barrel-fold Basic Amino Acid Decarboxylases: X-RAY STRUCTURE DETERMINATION OF ENZYMES WITH SPECIFICITY FOR L-ARGININE AND CARBOXYNORSPERMIDINE

Exceptionally tight membrane-binding may explain the key role of the synaptotagmin-7 C2A domain in asynchronous neurotransmitter release

Full-length structure of a monomeric histidine kinase reveals basis for sensory regulation

Functional clues from the crystal structure of an orphan periplasmic ligand-binding protein from Treponema pallidum

High-resolution cryo-EM structures of the E. coli hemolysin ClyA oligomers

Identification and mechanistic understanding of dihydroorotate dehydrogenase point mutations in Plasmodium falciparum that confer in vitro resistance to the clinical candidate DSM265

Identification of Lysine Residues in the Borrelia burgdorferi DbpA Adhesin Required for Murine Infection

Importin-9 wraps around the H2A-H2B core to act as nuclear importer and histone chaperone

Insights into Mad2 Regulation in the Spindle Checkpoint Revealed by the Crystal Structure of the Symmetric Mad2 Dimer

Interactions of substrates at the surface of P450s can greatly enhance substrate potency

Kinetic and structural insights into the mechanism of AMPylation by VopS Fic domain

Lead Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series for the Treatment of Malaria

Localization and Structure of the Ankyrin-binding Site on 2-Spectrin

Mechanism of actin filament nucleation by the bacterial effector VopL

Mechanism of the synergistic end-product regulation of Bacillus subtilis glutamine phosphoribosylpyrophosphate amidotransferase by nucleotides

Mechanistic insights into neurotransmitter release and presynaptic plasticity from the crystal structure of Munc13-1 C1C2BMUN.

Molecular Discrimination between Two Conformations of Sphingomyelin in Plasma Membranes

Molecular insights into the enzymatic diversity of flavin-trafficking protein (Ftp; formerly ApbE) in flavoprotein biogenesis in the bacterial periplasm

Molecular mechanism for regulation of the human mitochondrial branched-chain alpha-ketoacid dehydrogenase complex by phosphorylation

Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis

Pathogenic C9ORF72 Antisense Repeat RNA Forms a Double Helix with Tandem C:C Mismatches

Phosphorylation of spore coat proteins by a family of atypical protein kinases.

Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series

Protein AMPylation by an Evolutionarily Conserved Pseudokinase

Re-examining how complexin inhibits neurotransmitter release

Relief of autoinhibition by conformational switch explains enzyme activation by a catalytically dead paralog

Roles of His291-alpha and His146-beta' in the reductive acylation reaction catalyzed by human branched-chain alpha-ketoacid dehydrogenase: refined phosphorylation loop structure in the active site

SAV1 promotes Hippo kinase activation through antagonizing the PP2A phosphatase STRIPAK.

Strategies for macromolecular synchrotron crystallography.

Structural Basis and IP6 Requirement for Pds5-Dependent Cohesin Dynamics

Structural Basis for Autoactivation of Human Mst2 Kinase and Its Regulation by RASSF5

Structural analysis of Xanthomonas XopD provides insights into substrate specificity of ubiquitin-like protein proteases

Structural analysis of human Cdc20 supports multisite degron recognition by APC/C

Structural and Biochemical Basis for Polyamine Binding to the Tp0655 Lipoprotein of Treponema pallidum: Putative Role for Tp0655 (TpPotD) as a Polyamine Receptor

Structural and Energetic Mechanisms of Cooperative Autoinhibition and Activation of Vav1

Structural and Molecular Characterization of Iron-sensing Hemerythrin-like Domain within F-box and Leucine-rich Repeat Protein 5 (FBXL5)

Structural and Thermodynamic Characterization of the Interaction between Two Periplasmic Treponema pallidum Lipoproteins that are Components of a TPR-Protein-Associated TRAP Transporter (TPAT)

Structural and functional analysis of the YAP-binding domain of human TEAD2

Structural and mutational analysis of functional differentiation between synaptotagmins-1 and -7

Structural basis for CoREST-dependent demethylation of nucleosomes by the human LSD1 histone demethylase

Structural basis for a Munc13-1 homodimer to Munc13-1/RIM heterodimer switch

Structural basis for the evolutionary inactivation of Ca2+ binding to synaptotagmin 4

Structural basis of Rho GTPase-mediated activation of the formin mDia1.

Structural basis of actin filament nucleation and processive capping by a formin homology 2 domain

Structural basis of histone demethylation by LSD1 revealed by suicide inactivation