List of works - Robert D. Moir

A protease activity associated with acetylcholinesterase releases the membrane-bound form of the amyloid protein precursor of Alzheimer's disease

scientific article published in November 1991

A spectrophotometric assay for 6-phosphogluconolactonase involving the use of immobilized enzymes to prepare the labile 6-phosphoglucono-delta-lactone substrate

scientific article published on 15 November 1988

Alzheimer's Disease-Associated β-Amyloid Is Rapidly Seeded by Herpesviridae to Protect against Brain Infection

scientific article published on 01 December 2018

Alzheimer's disease amyloid-beta links lens and brain pathology in Down syndrome

scientific article

Alzheimer's disease drug discovery targeted to the APP mRNA 5'untranslated region

scientific article

Alzheimer's disease: the potential therapeutic role of the natural antibiotic amyloid-β peptide

scientific article published on 7 September 2016

Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells.

scientific article

Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer's disease

scientific article

An abnormality of plasma amyloid protein precursor in Alzheimer's disease

scientific article published in July 1992

Anesthetic propofol attenuates the isoflurane-induced caspase-3 activation and Aβ oligomerization

scientific article

Association of membrane-bound amyloid precursor protein APP with the apolipoprotein E receptor LRP.

scientific article published in March 2001

Autoantibodies to redox-modified oligomeric Abeta are attenuated in the plasma of Alzheimer's disease patients

scientific article published on 21 February 2005

Cerebrospinal fluid levels of amyloid precursor protein and amyloid beta-peptide in Alzheimer's disease and major depression - inverse correlation with dementia severity.

scientific article published in January 1998

Characterization of Copper Interactions with Alzheimer Amyloid β Peptides

article

Characterization of a Drosophila Alzheimer's disease model: pharmacological rescue of cognitive defects

scientific article

Chronic traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model.

scientific article

Clearance of Alzheimer's Abeta peptide: the many roads to perdition.

scientific article published in September 2004

Copper mediates dityrosine cross-linking of Alzheimer's amyloid-beta

scientific article

Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction.

scientific article published in December 1999

Cytosolic beta-amyloid deposition and supranuclear cataracts in lenses from people with Alzheimer's disease

scientific article

Differential effects of apolipoprotein E isoforms on metal-induced aggregation of A beta using physiological concentrations

scientific article published in April 1999

Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis

scientific article published in May 1998

Functions and dysfunctions of the nuclear lamin Ig-fold domain in nuclear assembly, growth, and Emery-Dreifuss muscular dystrophy.

scientific article

Human amyloid-derived aßcontains tyrosine cross-linked oligomers

article published in 2000

Human brain beta A4 amyloid protein precursor of Alzheimer's disease: purification and partial characterization

scientific article published in October 1992

Hypocapnia induces caspase-3 activation and increases Abeta production

scientific article published on January 2004

In Vivo Quasi-Elastic Light Scattering Eye Scanner Detects Molecular Aging in Humans

scientific article published on 09 June 2020

Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's disease

scientific article

Isoflurane-induced apoptosis: a potential pathogenic link between delirium and dementia

scientific article published in December 2006

LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted β-amyloid precursor protein and mediates its degradation

article

LRP-mediated clearance of Abeta is inhibited by KPI-containing isoforms of APP.

scientific article published in April 2005

Low Evolutionary Selection Pressure in Senescence Does Not Explain the Persistence of Aβ in the Vertebrate Genome

Metal exposure and Alzheimer's pathogenesis.

scientific article published on 9 February 2006

Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).

scientific article published on 20 August 2002

Near-infrared fluorescence molecular imaging of amyloid beta species and monitoring therapy in animal models of Alzheimer's disease

scientific article

Neuroinflammatory Responses in the Alzheimer's Disease Brain Promote the Oxidative Post-translational Modification of Amyloid Deposits

article

Non-conjugated small molecule FRET for differentiating monomers from higher molecular weight amyloid beta species

scientific article

P1-131 (Aβ) in human lens & aqueous humor: further characterization of a novel AD biomarker

Peroxidase activity of cyclooxygenase-2 (COX-2) cross-links beta-amyloid (Abeta) and generates Abeta-COX-2 hetero-oligomers that are increased in Alzheimer's disease

scientific article

Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate {alpha}-secretase activity

scientific article published on 15 July 2009

Preliminary studies of a novel bifunctional metal chelator targeting Alzheimer's amyloidogenesis

scientific article

Redox-active metals, oxidative stress, and Alzheimer's disease pathology

scientific article published on March 2004

Reduced amyloidogenic processing of the amyloid beta-protein precursor by the small-molecule Differentiation Inducing Factor-1

scientific article published on 25 December 2008

Relative increase in Alzheimer's disease of soluble forms of cerebral Abeta amyloid protein precursor containing the Kunitz protease inhibitory domain.

scientific article published in February 1998

Response

article in Science 268:5219

Role of common and rare APP DNA sequence variants in Alzheimer disease

scientific article published on 4 April 2012

Synaptic abnormalities in a Drosophila model of Alzheimer's disease

scientific article

The ACAT inhibitor CP-113,818 markedly reduces amyloid pathology in a mouse model of Alzheimer's disease

scientific article published in October 2004

The Alzheimer's disease-associated amyloid beta-protein is an antimicrobial peptide

scientific article published in 2010

The Aβ Peptide of Alzheimer's Disease Directly Produces Hydrogen Peroxide through Metal Ion Reduction†

article

The Emerging Role of Innate Immunity in Alzheimer's Disease

scientific article published in January 2017

The amino-terminal sequence of the 85–90K nonhormone binding component of the molybdate-stabilized estradiol receptor from calf uterus

scientific article published on 01 February 1987

The amyloid protein precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neurite outgrowth

scientific article published in July 1992

The antimicrobial protection hypothesis of Alzheimer's disease

article

The common inhalation anesthetic isoflurane induces caspase activation and increases amyloid beta-protein level in vivo

scientific article published on December 2008

The common inhalational anesthetic sevoflurane induces apoptosis and increases beta-amyloid protein levels

scientific article published on May 2009

The gene defects responsible for familial Alzheimer's disease

scientific article

The inhalation anesthetic desflurane induces caspase activation and increases amyloid beta-protein levels under hypoxic conditions

scientific article published on 6 March 2008

The inhalation anesthetic isoflurane induces a vicious cycle of apoptosis and amyloid beta-protein accumulation.

scientific article

Trace metal contamination initiates the apparent auto-aggregation, amyloidosis, and oligomerization of Alzheimer's Abeta peptides

scientific article published on 3 November 2004

Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

scientific article

Zinc-induced Alzheimer's Abeta1-40 aggregation is mediated by conformational factors.

scientific article published in October 1997

List of works by Robert D. Moir

A protease activity associated with acetylcholinesterase releases the membrane-bound form of the amyloid protein precursor of Alzheimer's disease

A spectrophotometric assay for 6-phosphogluconolactonase involving the use of immobilized enzymes to prepare the labile 6-phosphoglucono-delta-lactone substrate

Alzheimer's Disease-Associated β-Amyloid Is Rapidly Seeded by Herpesviridae to Protect against Brain Infection

Alzheimer's Disease-Associated β-Amyloid Is Rapidly Seeded by Herpesviridae to Protect against Brain Infection

Alzheimer's disease amyloid-beta links lens and brain pathology in Down syndrome

Alzheimer's disease drug discovery targeted to the APP mRNA 5'untranslated region

Alzheimer's disease: the potential therapeutic role of the natural antibiotic amyloid-β peptide

Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells.

Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer's disease

An abnormality of plasma amyloid protein precursor in Alzheimer's disease

Anesthetic propofol attenuates the isoflurane-induced caspase-3 activation and Aβ oligomerization

Association of membrane-bound amyloid precursor protein APP with the apolipoprotein E receptor LRP.

Autoantibodies to redox-modified oligomeric Abeta are attenuated in the plasma of Alzheimer's disease patients

Cerebrospinal fluid levels of amyloid precursor protein and amyloid beta-peptide in Alzheimer's disease and major depression - inverse correlation with dementia severity.

Characterization of Copper Interactions with Alzheimer Amyloid β Peptides

Characterization of a Drosophila Alzheimer's disease model: pharmacological rescue of cognitive defects

Chronic traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model.

Clearance of Alzheimer's Abeta peptide: the many roads to perdition.

Copper mediates dityrosine cross-linking of Alzheimer's amyloid-beta

Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction.

Cytosolic beta-amyloid deposition and supranuclear cataracts in lenses from people with Alzheimer's disease

Differential effects of apolipoprotein E isoforms on metal-induced aggregation of A beta using physiological concentrations

Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis

Functions and dysfunctions of the nuclear lamin Ig-fold domain in nuclear assembly, growth, and Emery-Dreifuss muscular dystrophy.

Human amyloid-derived aßcontains tyrosine cross-linked oligomers

Human brain beta A4 amyloid protein precursor of Alzheimer's disease: purification and partial characterization

Hypocapnia induces caspase-3 activation and increases Abeta production

In Vivo Quasi-Elastic Light Scattering Eye Scanner Detects Molecular Aging in Humans

Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's disease

Isoflurane-induced apoptosis: a potential pathogenic link between delirium and dementia

LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted β-amyloid precursor protein and mediates its degradation

LRP-mediated clearance of Abeta is inhibited by KPI-containing isoforms of APP.

Low Evolutionary Selection Pressure in Senescence Does Not Explain the Persistence of Aβ in the Vertebrate Genome

Metal exposure and Alzheimer's pathogenesis.

Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).

Near-infrared fluorescence molecular imaging of amyloid beta species and monitoring therapy in animal models of Alzheimer's disease

Neuroinflammatory Responses in the Alzheimer's Disease Brain Promote the Oxidative Post-translational Modification of Amyloid Deposits

Non-conjugated small molecule FRET for differentiating monomers from higher molecular weight amyloid beta species

P1-131 (Aβ) in human lens & aqueous humor: further characterization of a novel AD biomarker

Peroxidase activity of cyclooxygenase-2 (COX-2) cross-links beta-amyloid (Abeta) and generates Abeta-COX-2 hetero-oligomers that are increased in Alzheimer's disease

Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate {alpha}-secretase activity

Preliminary studies of a novel bifunctional metal chelator targeting Alzheimer's amyloidogenesis

Redox-active metals, oxidative stress, and Alzheimer's disease pathology

Reduced amyloidogenic processing of the amyloid beta-protein precursor by the small-molecule Differentiation Inducing Factor-1

Relative increase in Alzheimer's disease of soluble forms of cerebral Abeta amyloid protein precursor containing the Kunitz protease inhibitory domain.

Response

Role of common and rare APP DNA sequence variants in Alzheimer disease

Synaptic abnormalities in a Drosophila model of Alzheimer's disease

The ACAT inhibitor CP-113,818 markedly reduces amyloid pathology in a mouse model of Alzheimer's disease

The Alzheimer's disease-associated amyloid beta-protein is an antimicrobial peptide

The Aβ Peptide of Alzheimer's Disease Directly Produces Hydrogen Peroxide through Metal Ion Reduction†

The Emerging Role of Innate Immunity in Alzheimer's Disease

The amino-terminal sequence of the 85–90K nonhormone binding component of the molybdate-stabilized estradiol receptor from calf uterus

The amyloid protein precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neurite outgrowth

The antimicrobial protection hypothesis of Alzheimer's disease

The common inhalation anesthetic isoflurane induces caspase activation and increases amyloid beta-protein level in vivo

The common inhalational anesthetic sevoflurane induces apoptosis and increases beta-amyloid protein levels

The gene defects responsible for familial Alzheimer's disease

The inhalation anesthetic desflurane induces caspase activation and increases amyloid beta-protein levels under hypoxic conditions

The inhalation anesthetic isoflurane induces a vicious cycle of apoptosis and amyloid beta-protein accumulation.

Trace metal contamination initiates the apparent auto-aggregation, amyloidosis, and oligomerization of Alzheimer's Abeta peptides

Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

Zinc-induced Alzheimer's Abeta1-40 aggregation is mediated by conformational factors.