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List of works by Jan B. Hoek

A Ca2+-induced mitochondrial permeability transition causes complete release of rat liver endonuclease G activity from its exclusive location within the mitochondrial intermembrane space. Identification of a novel endo-exonuclease activity residing

scientific article published on 01 February 2003

A novel comparative pattern analysis approach identifies chronic alcohol mediated dysregulation of transcriptomic dynamics during liver regeneration

scientific article

A novel comparative pattern count analysis reveals a chronic ethanol-induced dynamic shift in immediate early NF-κB genome-wide promoter binding during liver regeneration.

scientific article published on 5 February 2016

A novel, dynamic pattern-based analysis of NF-κB binding during the priming phase of liver regeneration reveals switch-like functional regulation of target genes.

scientific article published on 7 July 2015

Acetate causes alcohol hangover headache in rats

scientific article published in 2010

Activation of glycogen synthase kinase 3beta disrupts the binding of hexokinase II to mitochondria by phosphorylating voltage-dependent anion channel and potentiates chemotherapy-induced cytotoxicity

scientific article published on 01 November 2005

Adenine nucleotide changes in the remnant liver: An early signal for regeneration after partial hepatectomy.

scientific article published on September 2008

Adiponectin fine-tuning of liver regeneration dynamics revealed through cellular network modeling

scientific article

Advancing alcohol biomarkers research

scientific article

Aging effects on pedicled fasciocutaneous flap survival in rats

scientific article published on 31 August 2015

Alcohol and breast cancer: reconciling epidemiological and molecular data

scientific article

Alcohol and mitochondria in cardiac apoptosis: mechanisms and visualization

scientific article

Alcohol-Mediated Missplicing of Mcl-1 Pre-mRNA is Involved in Neurotoxicity

scientific article

Amygdalar neuronal plasticity and the interactions of alcohol, sex, and stress.

scientific article

Biochemical Effects of Exercise on a Fasciocutaneous Flap in a Rat Model

scientific article

CELL SIGNALING: Mitochondrial Longevity Pathways

scientific article published in Science

Ca 2+ -dependent allosteric regulation of nicotinamide nucleotide transhydrogenase from Pseudomonas aeruginosa

scientific article published on 01 May 1973

Calcium ion-dependent signalling and mitochondrial dysfunction: mitochondrial calcium uptake during hormonal stimulation in intact liver cells and its implication for the mitochondrial permeability transition

scientific article published on May 1995

Carbachol-stimulated Ca2+ increase in single neuroblastoma SH-SY5Y cells: effects of ethanol

scientific article published in May 1998

Cellular activation by Ca2+ release from stores in the endoplasmic reticulum but not by increased free Ca2+ in the cytosol

scientific article published in November 1999

Cellular adaptation to ethanol

scientific article published on July 1988

Cellular signaling mechanisms in alcohol-induced liver damage

scientific article published in August 2004

Chronic alcohol exposure alters transcription broadly in a key integrative brain nucleus for homeostasis: the nucleus tractus solitarius

scientific article published on 27 September 2005

Chronic alcohol feeding potentiates hormone-induced calcium signalling in hepatocytes

scientific article published on 20 February 2017

Chronic alcohol ingestion in rats alters lung metabolism, promotes lipid accumulation, and impairs alveolar macrophage functions.

scientific article

Chronic ethanol consumption causes alterations in the structural integrity of mitochondrial DNA in aged rats

scientific article published on October 1999

Chronic ethanol feeding alters miRNA expression dynamics during liver regeneration.

scientific article

Computational Modeling of Spatiotemporal Ca(2+) Signal Propagation Along Hepatocyte Cords

scientific article published on 4 April 2016

Computational modeling analysis of mitochondrial superoxide production under varying substrate conditions and upon inhibition of different segments of the electron transport chain.

scientific article

Coordinated dynamic gene expression changes in the central nucleus of the amygdala during alcohol withdrawal

scientific article

Decorin induces mitophagy in breast carcinoma cells via peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) and mitostatin

scientific article

Differential inhibition of epidermal growth factor signaling pathways in rat hepatocytes by long-term ethanol treatment

scientific article published on 01 June 1997

Diffusion control of protein phosphorylation in signal transduction pathways

scientific article

Direct influence of the p53 tumor suppressor on mitochondrial biogenesis and function

scientific article published on March 2001

Effect of chronic ethanol ingestion on pancreatic protein synthesis

scientific article published in September 1988

Effect of ethanol on amylase secretion and cellular calcium homeostasis in pancreatic acini from normal and ethanol-fed rats

scientific article published on January 1987

Elevated PTEN levels account for the increased sensitivity of ethanol-exposed cells to tumor necrosis factor-induced cytotoxicity.

scientific article

Emergence of bimodal cell population responses from the interplay between analog single-cell signaling and protein expression noise ⬇️

scientific article published on August 24, 2012

Endotoxin and alcoholic liver disease: tolerance and susceptibility

scientific article published on 01 May 1999

Epidermal growth factor-induced activation of the insulin-like growth factor I receptor in rat hepatocytes

scientific article

Epidermal growth factor-mediated activation of the ETS domain transcription factor Elk-1 requires nuclear calcium

scientific article

Ethanol does not stimulate guanine nucleotide-induced activation of phospholipase C in permeabilized hepatocytes

scientific article published on 01 July 1987

Ethanol inhibits the peak of muscarinic receptor-stimulated formation of inositol 1,4,5-trisphosphate in neuroblastoma SH-SY5Y cells

scientific article published on August 1995

Ethanol modulation of rat alveolar macrophage superoxide production

scientific article published in September 1988

Ethanol stimulates shape change in human platelets by activation of phosphoinositide-specific phospholipase C.

scientific article

Ethanol withdrawal stimulates protein synthesis in rat pancreatic lobules

scientific article published on 01 November 1990

Ethanol-induced stimulation of phosphoinositide turnover and calcium influx in isolated hepatocytes

scientific article published on 01 June 1988

Evidence for a lipid dependence of mitochondrial nicotinamide nucleotide transhydrogenase

scientific article published on 01 June 1976

Farewell to Drs. Ivan Diamond and T.-K. Li.

scientific article published on 3 March 2014

Functional consequences of the sustained or transient activation by Bax of the mitochondrial permeability transition pore

scientific article published on 01 October 1999

Glutamate transport and the trans-membrane pH gradient in isolated rat-liver mitochondria

scientific article published on December 1976

Hormonal stimulation, mitochondrial Ca2+ accumulation, and the control of the mitochondrial permeability transition in intact hepatocytes

scientific article published on September 1997

In Vivo Zonal Variation and Liver Cell-Type Specific NF-κB Localization after Chronic Adaptation to Ethanol and following Partial Hepatectomy

scientific article published on 9 October 2015

Increased oxidative damage to mitochondrial DNA following chronic ethanol consumption

scientific article published on 01 June 1997

Inhibition of ethanol-induced platelet activation by agents that elevate cAMP.

scientific article published on June 1990

Inhibition of insulin-like growth factor I receptor tyrosine kinase by ethanol

scientific article published in November 2004

Inhibition of miR-21 rescues liver regeneration after partial hepatectomy in ethanol-fed rats

scientific article published on 15 September 2016

Intracellular acidosis protects cultured hepatocytes from the toxic consequences of a loss of mitochondrial energization

scientific article published on 01 July 1989

Introduction to the Virtual Issue Alcohol and Epigenetic Regulation: Do the Products of Alcohol Metabolism Drive Epigenetic Control of Gene Expression in Alcohol-Related Disorders?

scientific article published on 06 April 2018

Kinetics and control of oxidative phosphorylation in rat liver mitochondria after chronic ethanol feeding

scientific article published on July 2000

Leupeptin inhibits phospholipases D and C activation in rat hepatocytes

scientific article published on 01 August 1994

Ligand-dependent responses of the ErbB signaling network: experimental and modeling analyses

scientific article

MICU1 regulation of mitochondrial Ca(2+) uptake dictates survival and tissue regeneration.

scientific article published on 9 March 2016

Metabolic design: How to engineer a living cell to desired metabolite concentrations and fluxes

scientific article published on 01 July 1998

Metformin and the fate of fat

scientific article published on 01 June 2006

Mitochondria-targeted cytochrome P450 2E1 induces oxidative damage and augments alcohol-mediated oxidative stress

scientific article

Mitochondrial Ca2+ and regulation of the permeability transition pore

scientific article

Mitochondrial binding of hexokinase II inhibits Bax-induced cytochrome c release and apoptosis.

scientific article

Mitochondrial fusion dynamics is robust in the heart and depends on calcium oscillations and contractile activity

scientific article published on 17 January 2017

Mitochondrial morphology and dynamics in hepatocytes from normal and ethanol-fed rats

scientific article

Modular response analysis of cellular regulatory networks.

scientific article

Multistrip Western blotting to increase quantitative data output

scientific article

Multistrip Western blotting: a tool for comparative quantitative analysis of multiple proteins

scientific article published on January 2015

On the oxidation of reduced nicotinamide dinucleotide phosphate by submitochondrial particles from beef heart

scientific article published in June 1973

On the use of N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)phosphatidylethanolamine in the study of lipid polymorphism

scientific article published in November 1989

PI3K/Akt-sensitive MEK-independent compensatory circuit of ERK activation in ER-positive PI3K-mutant T47D breast cancer cells

scientific article

Pattern analysis uncovers a chronic ethanol-induced disruption of the switch-like dynamics of C/EBP-β and C/EBP-α genome-wide binding during liver regeneration

scientific article

Pharmacological ceramide reduction alleviates alcohol-induced steatosis and hepatomegaly in adiponectin knockout mice

scientific article published on 17 April 2014

Phosphate transport in rat-liver mitochondria

scientific article published on 01 March 1971

Potentiation by chronic ethanol treatment of the mitochondrial permeability transition.

scientific article

Prolactin-stimulated activation of ERK1/2 mitogen-activated protein kinases is controlled by PI3-kinase/Rac/PAK signaling pathway in breast cancer cells

scientific article

Quantification of Short Term Signaling by the Epidermal Growth Factor Receptor

scientific article published in Journal of Biological Chemistry

Quantification of information transfer via cellular signal transduction pathways ⬇️

scientific article published on September 8, 1997

RSA 2004: combined basic research satellite symposium - session three: alcohol and mitochondrial metabolism: at the crossroads of life and death

scientific article

RSA 2004: combined basic research satellite symposium-mechanisms of alcohol-mediated organ and tissue damage: inflammation and immunity and alcohol and mitochondrial metabolism: at the crossroads of life and death session one: alcohol, cellular and

scientific article published on 01 September 2005

Rapid temporal changes in the expression of a set of neuromodulatory genes during alcohol withdrawal in the dorsal vagal complex: molecular evidence of homeostatic disturbance

scientific article

Role of calcium in the hormonal regulation of liver metabolism

scientific article published on 01 December 1981

Secretion of prostaglandins elicited by lipopolysaccharide and ethanol in cultured rat Kupffer cells

scientific article published on 01 October 1995

Selective solubilization of nicotinamide nucleotide transhydrogenase from the mitochondrial inner membrane.

scientific article

Signal processing at the Ras circuit: what shapes Ras activation patterns?

scientific article published in June 2004

Signaling through receptors and scaffolds: independent interactions reduce combinatorial complexity

scientific article

Silence on the relevant literature and errors in implementation

scientific article published in April 2015

Stimulation of protein synthesis in isolated pancreatic acini from chronically ethanol-fed rats is due to alterations in post-transcriptional regulation

scientific article published on 01 October 1993

Systems-level interactions between insulin-EGF networks amplify mitogenic signaling.

scientific article published on 07 April 2009

TGF-beta1 calcium signaling in osteoblasts

scientific article published on 01 May 2007

TGF-beta1 calcium signaling increases alpha5 integrin expression in osteoblasts

scientific article published in September 2002

Temperature dependence of the epidermal growth factor receptor signaling network can be accounted for by a kinetic model

scientific article published in January 2002

Temporal and functional profile of the transcriptional regulatory network in the early regenerative response to partial hepatectomy in the rat

scientific journal article

The NAD-linked isocitrate dehydrogenase activity in rat-liver mitochondria

scientific article published on 01 June 1973

The effect of inhibitors of glutamate transport on the pathway of glutamate oxidation in rat liver mitochondria

scientific article published on 01 February 1983

The nicotinamide nucleotide specificity of glutamate dehydrogenase in intact rat-liver mitochondria.

scientific article published in March 1974

The oxidoreduction state of free NAD(P) and mass-action ratio of total nicotinamide nucleotides in isolated rat-liver mitochondria

scientific article published on 01 November 1973

The path from mitochondrial ROS to aging runs through the mitochondrial permeability transition pore.

scientific article published on 31 July 2017

Trading the micro-world of combinatorial complexity for the macro-world of protein interaction domains.

scientific article

Transport of glutamate in rat-liver mitochondria

scientific article published in December 1972

Tyr-317 phosphorylation increases Shc structural rigidity and reduces coupling of domain motions remote from the phosphorylation site as revealed by molecular dynamics simulations.

scientific article published on 12 November 2003

Unilateral nephrectomy selectively stimulates phospholipase D in the remaining kidney

scientific article

Untangling the wires: a strategy to trace functional interactions in signaling and gene networks

scientific article

Use of CYP2E1-transfected human liver cell lines in elucidating the actions of ethanol

scientific article published on September 2005

Why cytoplasmic signalling proteins should be recruited to cell membranes.

scientific article

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