List of works - Antony W. Oliver

A Hypomorphic PALB2 Allele Gives Rise to an Unusual Form of FA-N Associated with Lymphoid Tumour Development

scientific article

A first generation inhibitor of human Greatwall kinase, enabled by structural and functional characterisation of a minimal kinase domain construct

scientific article

APLF promotes the assembly and activity of non-homologous end joining protein complexes

scientific article

ATM Localization and Heterochromatin Repair Depend on Direct Interaction of the 53BP1-BRCT2 Domain with γH2AX.

scientific article published on 24 November 2015

Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites

scientific article

Activation segment exchange: a common mechanism of kinase autophosphorylation?

scientific article published on 12 July 2007

An Artemis polymorphic variant reduces Artemis activity and confers cellular radiosensitivity

Are SMC Complexes Loop Extruding Factors? Linking Theory With Fact

scientific article published on 03 December 2018

BRCT domains of the DNA damage checkpoint proteins TOPBP1/Rad4 display distinct specificities for phosphopeptide ligands

scientific article published on 08 October 2018

Binding of the TRF2 iDDR motif to RAD50 highlights a convergent evolutionary strategy to inactivate MRN at telomeres

scientific article published in 2024

CCRK is a novel signalling hub exploitable in cancer immunotherapy.

scientific article published on 19 January 2018

CCT241533 Is a Potent and Selective Inhibitor of CHK2 that Potentiates the Cytotoxicity of PARP Inhibitors ⬇️

scientific article published on January 15, 2011

Cancer and the bromodomains of BAF180.

scientific article published on April 2012

Chromatin association of the SMC5/6 complex is dependent on binding of its NSE3 subunit to DNA.

scientific article published on 7 October 2015

Crystal structure of the catalytic fragment of murine poly(ADP-ribose) polymerase-2

scientific article

Crystal structure of the proximal BAH domain of the polybromo protein.

scientific article published on August 2005

DIS3 isoforms vary in their endoribonuclease activity and are differentially expressed within haematological cancers.

scientific article published on 29 June 2018

Design and discovery of 3-aryl-5-substituted-isoquinolin-1-ones as potent tankyrase inhibitors

article

Destabilized SMC5/6 complex leads to chromosome breakage syndrome with severe lung disease

scientific journal article

Development of an oligonucleotide-based fluorescence assay for the identification of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors.

scientific article

Efficient Single-Strand Break Repair Requires Binding to Both Poly(ADP-Ribose) and DNA by the Central BRCT Domain of XRCC1

scientific article published on 01 January 2019

Fragment-based screening maps inhibitor interactions in the ATP-binding site of checkpoint kinase 2

scientific article

Identification and Characterization of a Novel Constitutional PIK3CA Mutation in a Child Lacking the Typical Segmental Overgrowth of "PIK3CA-Related Overgrowth Spectrum".

scientific article published on 23 November 2015

MDC1 Interacts with TOPBP1 to Maintain Chromosomal Stability during Mitosis

scientific article published on 18 March 2019

Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2.

scientific article published on 20 April 2016

Nse5/6 is a negative regulator of the ATPase activity of the Smc5/6 complex

scientific article published on 01 May 2021

PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2B(Glu2)

scientific article

PP2A/B55 and Fcp1 regulate Greatwall and Ensa dephosphorylation during mitotic exit

scientific article

Phosphorylation-Dependent Assembly and Coordination of the DNA Damage Checkpoint Apparatus by Rad4TopBP1

scientific article

Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint

scientific article published on 28 May 2019

Preferential binding of fd gene 5 protein to tetraplex nucleic acid structures.

scientific article

Regulation of DNA replication through Sld3-Dpb11 interaction is conserved from yeast to humans.

scientific article published on 23 June 2011

Specialized interfaces of Smc5/6 control hinge stability and DNA association.

scientific article published on 30 January 2017

Structural basis for recruitment of BRCA2 by PALB2

scientific article

Structural basis for recruitment of BRCA2 by PALB2.

scientific article published on July 2017

Structural basis for recruitment of the CHK1 DNA damage kinase by the CLASPIN scaffold protein

scientific article published on 30 March 2021

Structural characterization of DNA and RNA sequences recognized by the gene 5 protein of bacteriophage fd.

scientific article

Structure and function of the Rad9-binding region of the DNA-damage checkpoint adaptor TopBP1

Structure of an archaeal PCNA1-PCNA2-FEN1 complex: elucidating PCNA subunit and client enzyme specificity

scientific article published on 31 August 2006

The 3' to 5' Exoribonuclease DIS3: From Structure and Mechanisms to Biological Functions and Role in Human Disease

scientific article (publication date: 2015)

The ASCIZ-DYNLL1 axis promotes 53BP1-dependent non-homologous end joining and PARP inhibitor sensitivity

scientific article published in Nature Communications

The BAH domain of Rsc2 is a histone H3 binding domain

scientific article

The Ku-binding motif is a conserved module for recruitment and stimulation of non-homologous end-joining proteins

scientific article published on 11 April 2016

The Structural Basis for Substrate Recognition by Mammalian Polynucleotide Kinase 3′ Phosphatase

scientific article

The XRCC1 phosphate-binding pocket binds poly (ADP-ribose) and is required for XRCC1 function

scientific article published on 29 June 2015

The conserved Fanconi anemia nuclease Fan1 and the SUMO E3 ligase Pli1 act in two novel Pso2-independent pathways of DNA interstrand crosslink repair in yeast

scientific article published on 2 November 2013

The zinc-finger domains of PARP1 cooperate to recognize DNA strand breaks

scientific article

TopBP1 utilises a bipartite GINS binding mode to support genome replication

scientific article published in 2024

TopBP1: A BRCT-scaffold protein functioning in multiple cellular pathways

scientific article published on 30 July 2014

Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchange

scientific article

List of works by Antony W. Oliver

A Hypomorphic PALB2 Allele Gives Rise to an Unusual Form of FA-N Associated with Lymphoid Tumour Development

A first generation inhibitor of human Greatwall kinase, enabled by structural and functional characterisation of a minimal kinase domain construct

APLF promotes the assembly and activity of non-homologous end joining protein complexes

ATM Localization and Heterochromatin Repair Depend on Direct Interaction of the 53BP1-BRCT2 Domain with γH2AX.

Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites

Activation segment exchange: a common mechanism of kinase autophosphorylation?

An Artemis polymorphic variant reduces Artemis activity and confers cellular radiosensitivity

Are SMC Complexes Loop Extruding Factors? Linking Theory With Fact

BRCT domains of the DNA damage checkpoint proteins TOPBP1/Rad4 display distinct specificities for phosphopeptide ligands

Binding of the TRF2 iDDR motif to RAD50 highlights a convergent evolutionary strategy to inactivate MRN at telomeres

CCRK is a novel signalling hub exploitable in cancer immunotherapy.

CCT241533 Is a Potent and Selective Inhibitor of CHK2 that Potentiates the Cytotoxicity of PARP Inhibitors ⬇️

Cancer and the bromodomains of BAF180.

Chromatin association of the SMC5/6 complex is dependent on binding of its NSE3 subunit to DNA.

Crystal structure of the catalytic fragment of murine poly(ADP-ribose) polymerase-2

Crystal structure of the proximal BAH domain of the polybromo protein.

DIS3 isoforms vary in their endoribonuclease activity and are differentially expressed within haematological cancers.

Design and discovery of 3-aryl-5-substituted-isoquinolin-1-ones as potent tankyrase inhibitors

Destabilized SMC5/6 complex leads to chromosome breakage syndrome with severe lung disease

Development of an oligonucleotide-based fluorescence assay for the identification of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors.

Efficient Single-Strand Break Repair Requires Binding to Both Poly(ADP-Ribose) and DNA by the Central BRCT Domain of XRCC1

Fragment-based screening maps inhibitor interactions in the ATP-binding site of checkpoint kinase 2

Identification and Characterization of a Novel Constitutional PIK3CA Mutation in a Child Lacking the Typical Segmental Overgrowth of "PIK3CA-Related Overgrowth Spectrum".

MDC1 Interacts with TOPBP1 to Maintain Chromosomal Stability during Mitosis

Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2.

Nse5/6 is a negative regulator of the ATPase activity of the Smc5/6 complex

PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2B(Glu2)

PP2A/B55 and Fcp1 regulate Greatwall and Ensa dephosphorylation during mitotic exit

Phosphorylation-Dependent Assembly and Coordination of the DNA Damage Checkpoint Apparatus by Rad4TopBP1

Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint

Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint

Preferential binding of fd gene 5 protein to tetraplex nucleic acid structures.

Regulation of DNA replication through Sld3-Dpb11 interaction is conserved from yeast to humans.

Specialized interfaces of Smc5/6 control hinge stability and DNA association.

Structural basis for recruitment of BRCA2 by PALB2

Structural basis for recruitment of BRCA2 by PALB2.

Structural basis for recruitment of the CHK1 DNA damage kinase by the CLASPIN scaffold protein

Structural characterization of DNA and RNA sequences recognized by the gene 5 protein of bacteriophage fd.

Structure and function of the Rad9-binding region of the DNA-damage checkpoint adaptor TopBP1

Structure of an archaeal PCNA1-PCNA2-FEN1 complex: elucidating PCNA subunit and client enzyme specificity

The 3' to 5' Exoribonuclease DIS3: From Structure and Mechanisms to Biological Functions and Role in Human Disease

The ASCIZ-DYNLL1 axis promotes 53BP1-dependent non-homologous end joining and PARP inhibitor sensitivity

The BAH domain of Rsc2 is a histone H3 binding domain

The Ku-binding motif is a conserved module for recruitment and stimulation of non-homologous end-joining proteins

The Structural Basis for Substrate Recognition by Mammalian Polynucleotide Kinase 3′ Phosphatase

The XRCC1 phosphate-binding pocket binds poly (ADP-ribose) and is required for XRCC1 function

The conserved Fanconi anemia nuclease Fan1 and the SUMO E3 ligase Pli1 act in two novel Pso2-independent pathways of DNA interstrand crosslink repair in yeast

The zinc-finger domains of PARP1 cooperate to recognize DNA strand breaks

TopBP1 utilises a bipartite GINS binding mode to support genome replication

TopBP1: A BRCT-scaffold protein functioning in multiple cellular pathways

Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchange