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List of works by Jeffrey L. Curtis

"B" for Bad, Beneficial, or Both? Lung Lymphoid Neogenesis in Chronic Obstructive Pulmonary Disease

scientific article

A Hairline Crack in the Levee: Focal Secretory IgA Deficiency as a First Step toward Emphysema

scientific article published in April 2017

A combined pulmonary-radiology workshop for visual evaluation of COPD: study design, chest CT findings and concordance with quantitative evaluation

scientific article published on 19 March 2012

A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response

scientific article

Accumulation of CD11b+ lung dendritic cells in response to fungal infection results from the CCR2-mediated recruitment and differentiation of Ly-6Chigh monocytes

scientific article

Activation of protein kinase C beta II by the stereo-specific phosphatidylserine receptor is required for phagocytosis of apoptotic thymocytes by resident murine tissue macrophages

scientific article published on 11 July 2002

Acute Exacerbations and Lung Function Loss in Smokers with and without Chronic Obstructive Pulmonary Disease

scientific article published on 24 August 2016

Acute exacerbations of chronic obstructive pulmonary disease are associated with decreased CD4+ & CD8+ T cells and increased growth & differentiation factor-15 (GDF-15) in peripheral blood.

scientific article

Age and Small Airway Imaging Abnormalities in Subjects with and without Airflow Obstruction in SPIROMICS.

scientific article published on 26 August 2016

Age-Related Differences in Health-Related Quality of Life in COPD: An Analysis of the COPDGene and SPIROMICS Cohorts

scientific article published on 17 December 2015

Alignment of Inhaled Chronic Obstructive Pulmonary Disease Therapies with Published Strategies. Analysis of the Global Initiative for Chronic Obstructive Lung Disease Recommendations in SPIROMICS

scientific article published on 01 February 2019

Alveolar eosinophilia in current smokers with chronic obstructive pulmonary disease in the SPIROMICS cohort.

scientific article

An airway epithelial IL-17A response signature identifies a steroid-unresponsive COPD patient subgroup

article

Analysis of culture-dependent versus culture-independent techniques for identification of bacteria in clinically obtained bronchoalveolar lavage fluid

scientific article

Analysis of the lung microbiome in the "healthy" smoker and in COPD

scientific article published in 2011

Analysis of the upper respiratory tract microbiotas as the source of the lung and gastric microbiotas in healthy individuals

scientific article

Anxiety is associated with diminished exercise performance and quality of life in severe emphysema: a cross-sectional study

scientific article

Application of a neutral community model to assess structuring of the human lung microbiome

scientific article

Association between Emphysema and COPD Outcomes in COPDGene and SPIROMICS Cohorts.

scientific article published on 27 February 2018

Association between acute respiratory disease events and the MUC5B promoter polymorphism in smokers

scientific article published on 13 February 2018

Association of sputum and blood eosinophil concentrations with clinical measures of COPD severity: an analysis of the SPIROMICS cohort

scientific article published on 13 November 2017

Association of urine mitochondrial DNA with clinical measures of COPD in the SPIROMICS cohort

scientific article published on 13 February 2020

At the Checkpoint: Lung CD8(+) T Cells, Respiratory Viruses, and Chronic Obstructive Pulmonary Disease

scientific article published on March 2016

At the Root: Defining and Halting Progression of Early Chronic Obstructive Pulmonary Disease.

scientific article

Azithromycin for prevention of exacerbations of COPD.

scientific article published on August 2011

B Cells Caught in the Act: Class Switching to IgA in Lung Lymphoid Follicles in COPD

scientific article published on 01 March 2019

Bacterial Topography of the Healthy Human Lower Respiratory Tract

scientific article (publication date: 14 February 2017)

Basal gene expression by lung CD4+ T cells in chronic obstructive pulmonary disease identifies independent molecular correlates of airflow obstruction and emphysema extent

scientific article

Biomarkers Predictive of Exacerbations in the SPIROMICS and COPDGene Cohorts.

scientific article

CC chemokine receptor 5 and CXC chemokine receptor 6 expression by lung CD8+ cells correlates with chronic obstructive pulmonary disease severity

scientific article

CCR2 and CCR6, but not endothelial selectins, mediate the accumulation of immature dendritic cells within the lungs of mice in response to particulate antigen.

scientific article published on July 2005

CCR2 mediates conventional dendritic cell recruitment and the formation of bronchovascular mononuclear cell infiltrates in the lungs of mice infected with Cryptococcus neoformans.

scientific article published on July 2008

CD49d overexpression and T cell autoimmunity

scientific article published in July 2003

COPDGene® 2019: Redefining the Diagnosis of Chronic Obstructive Pulmonary Disease

scientific article published on 01 November 2019

CT-based Visual Classification of Emphysema: Association with Mortality in the COPDGene Study

scientific article published on 15 May 2018

Cell-associated bacteria in the human lung microbiome

scientific article published on 18 August 2014

Cell-mediated adaptive immune defense of the lungs

scientific article

Changes in the lung microbiome following lung transplantation include the emergence of two distinct Pseudomonas species with distinct clinical associations

scientific article

Chemokine receptor 2-mediated accumulation of fungicidal exudate macrophages in mice that clear cryptococcal lung infection

scientific article

Chronic Obstructive Pulmonary Disease Exacerbations in the COPDGene Study: Associated Radiologic Phenotypes ⬇️

scientific article published on July 25, 2011

Chronic obstructive pulmonary disease phenotypes: the future of COPD.

scientific article published on 3 June 2010

Cigarette smoke exposure impairs pulmonary bacterial clearance and alveolar macrophage complement-mediated phagocytosis of Streptococcus pneumoniae.

scientific article

Clinical Significance of Bronchodilator Responsiveness Evaluated by Forced Vital Capacity in COPD: SPIROMICS Cohort Analysis

scientific article published on 20 December 2019

Clinical Significance of Symptoms in Smokers with Preserved Pulmonary Function

scientific article published on May 2016

Clinical and Radiologic Disease in Smokers With Normal Spirometry

scientific article

Clinical significance of radiologic characterizations in COPD.

scientific article published on December 2009

Common Genetic Polymorphisms Influence Blood Biomarker Measurements in COPD.

scientific article

Comorbidities of COPD have a major impact on clinical outcomes, particularly in African Americans

scientific article

Comparison of serum, EDTA plasma and P100 plasma for luminex-based biomarker multiplex assays in patients with chronic obstructive pulmonary disease in the SPIROMICS study

scientific article published on 08 January 2014

Comparison of the respiratory microbiome in healthy nonsmokers and smokers

scientific article published on May 2013

Conserved nontypeable Haemophilus influenzae-derived TLR2-binding lipopeptides synergize with IFN-beta to increase cytokine production by resident murine and human alveolar macrophages.

scientific article published on July 2006

Critical Relevance of Stochastic Effects on Low-Bacterial-Biomass 16S rRNA Gene Analysis

scientific article published on 09 June 2020

Cryptococcal urease promotes the accumulation of immature dendritic cells and a non-protective T2 immune response within the lung

scientific article published on 13 February 2009

Cryptococcus neoformans-induced macrophage lysosome damage crucially contributes to fungal virulence

scientific article

Current smoking with or without chronic bronchitis is independently associated with goblet cell hyperplasia in healthy smokers and COPD subjects

scientific article published on 18 November 2020

Cytotoxic potential of lung CD8(+) T cells increases with chronic obstructive pulmonary disease severity and with in vitro stimulation by IL-18 or IL-15.

scientific article

Design of a multi-center immunophenotyping analysis of peripheral blood, sputum and bronchoalveolar lavage fluid in the Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS)

scientific article

Early or late IL-10 blockade enhances Th1 and Th17 effector responses and promotes fungal clearance in mice with cryptococcal lung infection

scientific article published on 15 September 2014

Efferocytosis and lung disease

scientific article

Elastase- and LPS-exposed mice display altered responses to rhinovirus infection

scientific article published on 11 September 2009

Elastase/LPS-exposed mice exhibit impaired innate immune responses to bacterial challenge: role of scavenger receptor A.

scientific article published on 8 November 2011

Elevated circulating MMP-9 is linked to increased COPD exacerbation risk in SPIROMICS and COPDGene.

scientific article published on 15 November 2018

Enhancing antitumor immunity perioperatively: a matter of timing, cooperation, and specificity

scientific article published in May 2003

Epidemiology, genetics, and subtyping of preserved ratio impaired spirometry (PRISm) in COPDGene

scientific article

Erratum for Xu et al., "Disruption of Early Tumor Necrosis Factor Alpha Signaling Prevents Classical Activation of Dendritic Cells in Lung-Associated Lymph Nodes and Development of Protective Immunity against Cryptococcal Infection".

scientific article published on 29 May 2018

Frequency of exacerbations in patients with chronic obstructive pulmonary disease: an analysis of the SPIROMICS cohort

scientific article

GDF-15 in Pulmonary and Critical Care Medicine

scientific article published on 01 June 2019

GDF-15 plasma levels in chronic obstructive pulmonary disease are associated with subclinical coronary artery disease

scientific article published on 28 February 2017

Gender and chronic obstructive pulmonary disease: why it matters

scientific article published on 2 August 2007

Gender differences in symptoms and care delivery for chronic obstructive pulmonary disease

scientific article

Glucocorticoid-Augmented Efferocytosis Inhibits Pulmonary Pneumococcal Clearance in Mice by Reducing Alveolar Macrophage Bactericidal Function

scientific article published on 18 May 2015

Glucocorticoids relieve collectin-driven suppression of apoptotic cell uptake in murine alveolar macrophages through downregulation of SIRPα.

scientific article published on 21 May 2012

Handgrip Strength in Chronic Obstructive Pulmonary Disease. Associations with Acute Exacerbations and Body Composition.

scientific article

Human CD56+ cytotoxic lung lymphocytes kill autologous lung cells in chronic obstructive pulmonary disease

scientific article

Identifying Smoking-Related Disease on Lung Cancer Screening CT Scans: Increasing the Value

scientific article published on 01 July 2019

Impact of self-reported gastroesophageal reflux disease in subjects from COPDGene cohort

scientific article

Improving the Quality and Reproducibility of Flow Cytometry in the Lung. An Official American Thoracic Society Workshop Report

scientific article published on 01 August 2019

In vivo depletion of murine CD8 positive T cells impairs survival during infection with a highly virulent strain of Cryptococcus neoformans

scientific article

Increased airway iron parameters and risk for exacerbation in COPD: an analysis from SPIROMICS

scientific article published on 29 June 2020

Increased cytokine response of rhinovirus-infected airway epithelial cells in chronic obstructive pulmonary disease

scientific article

Inference of Cellular Immune Environments in Sputum and Peripheral Blood Associated with Acute Exacerbations of COPD

scientific article published on 15 March 2019

Influence of Lightweight Ambulatory Oxygen on Oxygen Use and Activity Patterns of COPD Patients Receiving Long-Term Oxygen Therapy ⬇️

scientific article published on February 1, 2012

It's Complicated: Lung Dendritic Cells in Chronic Obstructive Pulmonary Disease

scientific article published on 14 April 2020

Long-term comparative immunogenicity of protein conjugate and free polysaccharide pneumococcal vaccines in chronic obstructive pulmonary disease

scientific article

Longitudinal change in the BODE index predicts mortality in severe emphysema

scientific article published on 5 June 2008

Lower serum IgA is associated with COPD exacerbation risk in SPIROMICS.

scientific article published on 12 April 2018

Lung CD8+ T cells in COPD have increased expression of bacterial TLRs

scientific article published on February 2013

Lung dendritic cell expression of maturation molecules increases with worsening chronic obstructive pulmonary disease

scientific article

Mannose-binding lectin deficiency and acute exacerbations of chronic obstructive pulmonary disease

scientific article

Metoprolol for the Prevention of Acute Exacerbations of COPD

scientific article published on 20 October 2019

MicroRNA-34a Negatively Regulates Efferocytosis by Tissue Macrophages in Part via SIRT1

scientific article

Monocytes recruited to the lungs of mice during immune inflammation ingest apoptotic cells poorly

scientific article

Mortality and Exacerbations by Global Initiative for Chronic Obstructive Lung Disease Groups ABCD: 2011 Versus 2017 in the COPDGene® Cohort

scientific article published on 10 January 2019

Multicenter Comparison of Lung and Oral Microbiomes of HIV-infected and HIV-uninfected Individuals

scientific article published on 6 August 2015

Murine alveolar macrophages limit replication of vaccinia virus

scientific article published on 27 February 2007

NT-proBNP in stable COPD and future exacerbation risk: Analysis of the SPIROMICS cohort

scientific article published on 05 June 2018

Neonatal rhinovirus infection induces mucous metaplasia and airways hyperresponsiveness.

scientific article published on 13 February 2012

Noninvasive Imaging Biomarker Identifies Small Airway Damage in Severe Chronic Obstructive Pulmonary Disease

scientific article published on 01 September 2019

Novel Respiratory Disability Score Predicts COPD Exacerbations and Mortality in the SPIROMICS Cohort

scientific article published on 04 August 2020

Overexpression of sICAM-1 in the alveolar epithelial space results in an exaggerated inflammatory response and early death in Gram negative pneumonia

scientific article published on 19 January 2011

PGE2 accounts for bidirectional changes in alveolar macrophage self-renewal with aging and smoking

scientific article published on 20 August 2020

Persistent and Newly Developed Chronic Bronchitis Are Associated with Worse Outcomes in Chronic Obstructive Pulmonary Disease

scientific article published on 09 May 2016

Pneumocystis murina infection and cigarette smoke exposure interact to cause increased organism burden, development of airspace enlargement, and pulmonary inflammation in mice

scientific article published on 19 May 2008

Predictors of mortality in patients with emphysema and severe airflow obstruction

scientific article published on 16 March 2006

Prevalence and clinical correlates of bronchoreversibility in severe emphysema

scientific article published on 19 November 2009

Primary pulmonary hypertension and human immunodeficiency virus infection in a non-hemophiliac man.

scientific article published in February 1992

Procalcitonin-Guided Antibiotic Therapy in COPD Exacerbations

Protective effect of Toll-like receptor 4 in pulmonary vaccinia infection

scientific article

Pulmonary Arterial Enlargement and Acute Exacerbations of COPD ⬇️

scientific article published on 03 September 2012

Queens beat one-eyed jacks, but nobody's played the ace yet. Adipokines as chronic obstructive pulmonary disease biomarkers

scientific article published in July 2015

Quercetin prevents progression of disease in elastase/LPS-exposed mice by negatively regulating MMP expression

scientific article

Radiographic lung volumes predict progression to COPD in smokers with preserved spirometry in SPIROMICS

scientific article published on 31 October 2019

Randomized trial of zileuton for treatment of COPD exacerbations requiring hospitalization

scientific article published on February 2011

Relationship between quantitative CT metrics and health status and BODE in chronic obstructive pulmonary disease ⬇️

scientific article published on May 1, 2012

Reply to Janssen and Wouters: Loss of Alveolar Attachments as a Pathomechanistic Link between Small Airway Disease and Emphysema

scientific article published on 01 April 2020

Reprint of: Voxel-Wise Longitudinal Parametric Response Mapping Analysis of Chest Computed Tomography in Smokers

scientific article published on 18 February 2019

Resident murine alveolar and peritoneal macrophages differ in adhesion of apoptotic thymocytes

scientific article

Respiratory Symptoms Items from the COPD Assessment Test Identify Ever-Smokers with Preserved Lung Function at Higher Risk for Poor Respiratory Outcomes. An Analysis of the Subpopulations and Intermediate Outcome Measures in COPD Study Cohort

scientific article published on May 2017

Reversible Airflow Obstruction Predicts Future Chronic Obstructive Pulmonary Disease Development in the SPIROMICS Cohort: An Observational Cohort Study

scientific article published in 2022

Role of CC chemokine receptor 4 in natural killer cell activation during acute cigarette smoke exposure

scientific article published on 09 December 2013

Role of infection and antimicrobial therapy in acute exacerbations of chronic obstructive pulmonary disease

scientific article

Safety and Tolerability of Comprehensive Research Bronchoscopy in Chronic Obstructive Pulmonary Disease. Results from the SPIROMICS Bronchoscopy Substudy

scientific article published on 01 April 2019

Scavenger Receptor MARCO Orchestrates Early Defenses and Contributes to Fungal Containment during Cryptococcal Infection.

scientific article published on 15 March 2017

Scavenger receptor A modulates the immune response to pulmonary Cryptococcus neoformans infection

scientific article

Semiquantification and classification of local pulmonary function by V/Q single photon emission computed tomography in patients with non-small cell lung cancer: potential indication for radiotherapy planning

scientific article

Serum amino acid concentrations and clinical outcomes in smokers: SPIROMICS metabolomics study

scientific article published on 06 August 2019

Sex differences in severe pulmonary emphysema

scientific article

Sex, Depression, and Risk of Hospitalization and Mortality in Chronic Obstructive Pulmonary Disease

scientific article published on 01 November 2007

Sex-specific features of emphysema among current and former smokers with COPD.

scientific article

Short-term and Long-term Outcomes After Bilateral Lung Volume Reduction Surgery

scientific article published on 01 May 2001

Significance of the microbiome in obstructive lung disease

scientific article published on 8 February 2012

Simvastatin for the prevention of exacerbations in moderate-to-severe COPD

scientific article

Smoking decreases the response of human lung macrophages to double-stranded RNA by reducing TLR3 expression

scientific article published on 9 March 2013

Socioeconomic Characteristics Are Major Contributors to Ethnic Differences in Health Status in Obstructive Lung Disease: An Analysis of the National Health and Nutrition Examination Survey 2007-2010.

scientific article published in July 2015

Spatial Variation in the Healthy Human Lung Microbiome and the Adapted Island Model of Lung Biogeography

scientific article published on June 2015

Specific engagement of TLR4 or TLR3 does not lead to IFN-beta-mediated innate signal amplification and STAT1 phosphorylation in resident murine alveolar macrophages

scientific article published on July 2004

Syk activation is a leukotriene B4-regulated event involved in macrophage phagocytosis of IgG-coated targets but not apoptotic cells

scientific article published in May 2003

Systemic Markers of Inflammation in Smokers With Symptoms Despite Preserved Spirometry in SPIROMICS

scientific article published on 23 January 2019

TLR3 increases disease morbidity and mortality from vaccinia infection

scientific article published on January 2008

The ABCs of Granulomatous Lung Diseases: Age-associated B Cells

scientific article published on 30 June 2020

The Association of Aging Biomarkers, Interstitial Lung Abnormalities, and Mortality

scientific article published on 20 October 2020

The class A scavenger receptor, macrophage receptor with collagenous structure, is the major phagocytic receptor for Clostridium sordellii expressed by human decidual macrophages.

scientific article published in September 2010

The clinical impact of non-obstructive chronic bronchitis in current and former smokers

scientific article

The immunopathogenesis of chronic obstructive pulmonary disease: insights from recent research

scientific article published on October 2007

The impact of panic disorder on interoception and dyspnea reports in chronic obstructive pulmonary disease

scientific article

The predictive role of plasma TGF-beta1 during radiation therapy for radiation-induced lung toxicity deserves further study in patients with non-small cell lung cancer

scientific article

The receptor tyrosine kinase MerTK activates phospholipase C gamma2 during recognition of apoptotic thymocytes by murine macrophages

scientific article published on 2 January 2004

The respiratory microbiome: an underappreciated player in the human response to inhaled pollutants?

scientific article

The scavenger receptor SR-A I/II (CD204) signals via the receptor tyrosine kinase Mertk during apoptotic cell uptake by murine macrophages

scientific article published on 29 May 2008

Time to treatment in patients with stage III non-small cell lung cancer.

scientific article

Transcellular delivery of vesicular SOCS proteins from macrophages to epithelial cells blunts inflammatory signaling

scientific article published on 6 April 2015

Transforming growth factor-β induces microRNA-29b to promote murine alveolar macrophage dysfunction after bone marrow transplantation

scientific article

Tumour necrosis factor receptor-75 and risk of COPD exacerbation in the azithromycin trial

scientific article

Tyro3 receptor tyrosine kinases in the heterogeneity of apoptotic cell uptake

scientific article

Understanding the role of the microbiome in chronic obstructive pulmonary disease: principles, challenges, and future directions

scientific article published on 23 June 2016

Undiagnosed Obstructive Lung Disease in the United States. Associated Factors and Long-term Mortality

scientific article

Use of bronchoalveolar lavage to assess the respiratory microbiome: signal in the noise

scientific article

Use of direct gradient analysis to uncover biological hypotheses in 16s survey data and beyond

scientific article

Variability in objective and subjective measures affects baseline values in studies of patients with COPD.

scientific article published on 21 September 2017

Voxel-Wise Longitudinal Parametric Response Mapping Analysis of Chest Computed Tomography in Smokers

scientific article published on 26 July 2018

Why do we need a nonhuman primate model of smoking-induced COPD?

scientific article

Widespread colonization of the lung by Tropheryma whipplei in HIV infection

scientific article published on May 2013

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