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List of works by John S. Spencer

A bispecific antibody based assay shows potential for detecting tuberculosis in resource constrained laboratory settings

scientific article

A modified synthesis and serological evaluation of neoglycoproteins containing the natural disaccharide of PGL-I from Mycobacterium leprae

scientific article

A new Mycobacterium species causing diffuse lepromatous leprosy

scientific article

Analysis of antibody responses to Mycobacterium leprae phenolic glycolipid I, lipoarabinomannan, and recombinant proteins to define disease subtype-specific antigenic profiles in leprosy.

scientific article

Antigenic specificity of the Mycobacterium leprae homologue of ESAT-6

scientific article published in February 2002

Boosting BCG-primed responses with a subunit Apa vaccine during the waning phase improves immunity and imparts protection against Mycobacterium tuberculosis

scientific article

Cell-mediated immune response to tuberculosis antigens: comparison of skin testing and measurement of in vitro gamma interferon production in whole-blood culture

scientific article

Characterization of defective I-A surface expression in a mixed isotype expressing murine B cell lymphoma: continued expression of E alpha d A beta d despite competition from restored A alpha d A beta d pairs

scientific article

Characterization of the Antigenic Heterogeneity of Lipoarabinomannan, the Major Surface Glycolipid of Mycobacterium tuberculosis, and Complexity of Antibody Specificities toward This Antigen

scientific article published on 2 April 2018

Characterization of the secreted MPT53 antigen of Mycobacterium tuberculosis

scientific article

Comparative analysis of B- and T-cell epitopes of Mycobacterium leprae and Mycobacterium tuberculosis culture filtrate protein 10.

scientific article

Comparative genomic and phylogeographic analysis of Mycobacterium leprae

article

Continued proteomic analysis of Mycobacterium leprae subcellular fractions

article

Deciphering the proteomic profile of Mycobacterium leprae cell envelope

scientific article published on June 2008

Detection of lipoarabinomannan in urine and serum of HIV-positive and HIV-negative TB suspects using an improved capture-enzyme linked immuno absorbent assay and gas chromatography/mass spectrometry

article

Detection of the tuberculosis antigenic marker mannose-capped lipoarabinomannan in pretreated serum by surface-enhanced Raman scattering

scientific article published on 07 December 2016

Diguanylate cyclase activity of the Mycobacterium leprae T cell antigen ML1419c

scientific article published on 22 July 2016

Erratum: Corrigendum: Comparative genomic and phylogeographic analysis of Mycobacterium leprae

scholarly article published in Nature Genetics

Evaluation of Immunodiagnostic Tests for Leprosy in Brazil, China and Ethiopia

scientific article published in Scientific Reports

Evidence of hidden leprosy in a supposedly low endemic area of Brazil

scientific article published in December 2017

Evidence of zoonotic leprosy in Pará, Brazilian Amazon, and risks associated with human contact or consumption of armadillos.

scientific article published on 28 June 2018

Expression and characterization of recombinant interferon gamma (IFN-gamma) from the nine-banded armadillo (Dasypus novemcinctus) and its effect on Mycobacterium leprae-infected macrophages.

scientific article published on 16 June 2008

Field-evaluation of a new lateral flow assay for detection of cellular and humoral immunity against Mycobacterium leprae. ⬇️

scientific article

From genome-based in silico predictions to ex vivo verification of leprosy diagnosis

scientific article published on 28 January 2009

Further biochemical characterization of Mycobacterium leprae laminin-binding proteins

scientific article

Gene expression profile and immunological evaluation of unique hypothetical unknown proteins of Mycobacterium leprae by using quantitative real-time PCR.

scientific article published on 12 December 2012

Gene set signature of reversal reaction type I in leprosy patients

scientific article

Glycolytic and Non-glycolytic Functions of Mycobacterium tuberculosis Fructose-1,6-bisphosphate Aldolase, an Essential Enzyme Produced by Replicating and Non-replicating Bacilli

scientific article

IL-10 and NOS2 modulate antigen-specific reactivity and nerve infiltration by T cells in experimental leprosy

scientific article

Identification of amino acids and domains required for catalytic activity of DPPR synthase, a cell wall biosynthetic enzyme of Mycobacterium tuberculosis

scientific article

Identification of an Immunomodulating Agent from Mycobacterium leprae

scientific article

Immunization against full-length protein and peptides from the Lutzomyia longipalpis sand fly salivary component maxadilan protects against Leishmania major infection in a murine model

scientific article published on 24 October 2017

Immunological Characterization of Antigens Encoded by the RD1 Region of the Mycobacterium tuberculosis Genome

scientific article published on 01 November 2001

Immunological characterization of novel secreted antigens of Mycobacterium tuberculosis.

scientific article published in February 2005

Importance of specimen pretreatment for the low-level detection of mycobacterial lipoarabinomannan in human serum

scientific article

Insight toward early diagnosis of leprosy through analysis of the developing antibody responses of Mycobacterium leprae-infected armadillos.

scientific article

Lateral flow assay for simultaneous detection of cellular- and humoral immune responses.

scientific article

Leprosy in Children

scientific article

Leprosy in a prison population: A new active search strategy and a prospective clinical analysis

scientific article published on 10 December 2020

Long-term survival and virulence of Mycobacterium leprae in amoebal cysts

scientific article (publication date: December 2014)

Longitudinal immune profiles in type 1 leprosy reactions in Bangladesh, Brazil, Ethiopia and Nepal

scientific article published on 28 October 2015

ML0405 and ML2331 are antigens of Mycobacterium leprae with potential for diagnosis of leprosy

scientific article published on March 2006

ML1419c peptide immunization induces Mycobacterium leprae-specific HLA-A*0201-restricted CTL in vivo with potential to kill live mycobacteria

scientific article published on 24 June 2011

MTSA-10, the product of the Rv3874 gene of Mycobacterium tuberculosis, elicits tuberculosis-specific, delayed-type hypersensitivity in guinea pigs

scientific article

Monoclonal Antibodies Specific for Antigens Expressed by Rat Type II Alveolar Epithelial and Nonciliated Bronchiolar Cells

scientific article published on 01 July 1989

Multiple M. tuberculosis phenotypes in mouse and guinea pig lung tissue revealed by a dual-staining approach

scientific article published in 2010

New biomarkers with relevance to leprosy diagnosis applicable in areas hyperendemic for leprosy

scientific article

O-mannosylation of the Mycobacterium tuberculosis adhesin Apa is crucial for T cell antigenicity during infection but is expendable for protection

scientific article

PARK2 mediates interleukin 6 and monocyte chemoattractant protein 1 production by human macrophages

scientific article

Pathogen-specific epitopes as epidemiological tools for defining the magnitude of Mycobacterium leprae transmission in areas endemic for leprosy

scientific article

Phylogenomics and antimicrobial resistance of the leprosy bacillus Mycobacterium leprae

scientific article

Postgenomic approach to identify novel Mycobacterium leprae antigens with potential to improve immunodiagnosis of infection

scientific article

Serodiagnostic potential of culture filtrate antigens of Mycobacterium tuberculosis

scientific article

Spatial analysis spotlighting early childhood leprosy transmission in a hyperendemic municipality of the Brazilian Amazon region

scientific article

Spatial epidemiology and serologic cohorts increase the early detection of leprosy

scientific article published on 16 November 2015

The Carboxy Terminus of EmbC from Mycobacterium smegmatis Mediates Chain Length Extension of the Arabinan in Lipoarabinomannan

scientific article published on 10 May 2006

The effects of prednisolone treatment on serological responses and lipid profiles in Ethiopian leprosy patients with Erythema Nodosum Leprosum reactions

article

The level of PPD-specific IFN-gamma-producing CD4+ T cells in the blood predicts the in vivo response to PPD.

scientific article published on 13 October 2006

The presence of a galactosamine substituent on the arabinogalactan of Mycobacterium tuberculosis abrogates full maturation of human peripheral blood monocyte-derived dendritic cells and increases secretion of IL-10.

scientific article published on 14 May 2015

Unexpectedly high leprosy seroprevalence detected using a random surveillance strategy in midwestern Brazil: A comparison of ELISA and a rapid diagnostic test

scientific article published on 23 February 2017

Use of protein microarrays to define the humoral immune response in leprosy patients and identification of disease-state-specific antigenic profiles

scientific article

XCL1 (lymphotactin) chemokine produced by activated CD8 T cells during the chronic stage of infection with Mycobacterium tuberculosis negatively affects production of IFN-γ by CD4 T cells and participates in granuloma stability

scientific article published on 15 August 2007

miRNome Expression Analysis Reveals New Players on Leprosy Immune Physiopathology

scientific article published on 9 March 2018

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