List of works by Stefan T Arold

1H-Imidazole-2,5-Dicarboxamides as NS4A Peptidomimetics: Identification of a New Approach to Inhibit HCV-NS3 Protease

scientific article published on 21 March 2020

A Biochemical/Biophysical Assay Dyad for HTS-Compatible Triaging of Inhibitors of the HIV-1 Nef/Hck SH3 Interaction

scientific article published on 26 July 2013

A Children's Oncology Group and TARGET initiative exploring the genetic landscape of Wilms tumor.

scientific article published on 21 August 2017

A Critical SUMO1 Modification of LKB1 Regulates AMPK Activity during Energy Stress.

scientific article published on 23 July 2015

A Novel TBX1 Variant Causing Hypoparathyroidism and Deafness

scientific article published on 29 November 2019

A genetic barcode of SARS-CoV-2 for monitoring global distribution of different clades during the COVID-19 pandemic

scientific article published on 22 August 2020

A landscape of driver mutations in melanoma

scientific article

A mutant impaired in SNARE complex dissociation identifies the plasma membrane as first target of synaptobrevin 2.

scientific article published in May 2004

A noncanonical mu-1A-binding motif in the N terminus of HIV-1 Nef determines its ability to downregulate major histocompatibility complex class I in T lymphocytes

scientific article published in February 2012

A specific protein disorder catalyzer of HIV-1 Nef

article

A two-stage biological gas to liquid transfer process to convert carbon dioxide into bioplastic

Alternative splicing modulates autoinhibition and SH3 accessibility in the Src kinase Fyn.

scientific article

An integrated structure- and system-based framework to identify new targets of metabolites and known drugs.

scientific article published on 18 August 2015

Anti-apoptotic ARC protein confers chemoresistance by controlling leukemia-microenvironment interactions through a NFκB/IL1β signaling network

scientific article published on 04 March 2016

Autozygosity reveals recessive mutations and novel mechanisms in dominant genes: implications in variant interpretation

scientific article published on 6 April 2017

Beyond initiation-limited translational bursting: the effects of burst size distributions on the stability of gene expression

scientific article published on 13 November 2015

Bi-allelic variants in HOPS complex subunit VPS41 cause cerebellar ataxia and abnormal membrane trafficking

publication published on 01 April 2021

Biallelic UFM1 and UFC1 mutations expand the essential role of ufmylation in brain development.

scientific article published in July 2018

CRISPR directed evolution of the spliceosome for resistance to splicing inhibitors

scientific article published on 30 April 2019

Catalytic protein modification with dirhodium metallopeptides: specificity in designed and natural systems

scientific article published on 7 June 2012

Characterization and molecular basis of the oligomeric structure of HIV-1 nef protein

scientific article published on June 2000

Chromatin phosphoproteomics unravels a function for AT-hook motif nuclear localized protein AHL13 in PAMP-triggered immunity

scientific article published on 01 January 2021

Clinical and Genetic Characterization of Craniosynostosis in Saudi Arabia

scientific article published on 16 April 2021

Conformational dynamics of the focal adhesion targeting domain control specific functions of focal adhesion kinase in cells.

scientific article

ContaMiner and ContaBase: a webserver and database for early identification of unwantedly crystallized protein contaminants.

scientific article published on 2 November 2016

Crystal Structure of PKG I:cGMP Complex Reveals a cGMP-Mediated Dimeric Interface that Facilitates cGMP-Induced Activation

scientific article published on 5 April 2016

Crystal structure of the N-terminal dimerisation domain of VicH, the H-NS-like protein of Vibrio cholerae

scientific article

DNA Sequencing of Small Bowel Adenocarcinomas Identifies Targetable Recurrent Mutations in the ERBB2 Signaling Pathway

scientific article published on 23 October 2018

De Novo Variants Disrupting the HX Repeat Motif of ATN1 Cause a Recognizable Non-Progressive Neurocognitive Syndrome

scientific article published on 28 February 2019

Discriminative SKP2 Interactions with CDK-Cyclin Complexes Support a Cyclin A-Specific Role in p27KIP1 Degradation

scientific article published on 07 January 2021

Dynamic Nef and Nef dynamics: how structure could explain the complex activities of this small HIV protein

scientific article

Endogenous Control Mechanisms of FAK and PYK2 and Their Relevance to Cancer Development and Therapy

article

Energetics of Src homology domain interactions in receptor tyrosine kinase-mediated signaling

scientific article

Essential role of the CD docking motif of MPK4 in plant immunity, growth, and development

scientific article published in 2023

Established and candidate transthyretin amyloidosis variants identified in the Saudi population by data mining

scientific article published on 11 August 2021

Expanding the genetic heterogeneity of intellectual disability

scientific article published on 22 September 2017

FAK dimerization controls its kinase-dependent functions at focal adhesions

scientific article

Familial non-syndromic macular pseudocoloboma secondary to homozygous CLDN19 mutation

scientific article published on 01 August 2018

Female Infertility Caused by Mutations in the Oocyte-Specific Translational Repressor PATL2.

scientific article

Findings from the Peutz-Jeghers syndrome registry of uruguay

scientific article

Functional pangenome analysis suggests inhibition of the protein E as a readily available therapy for COVID-2019

scientific article

GIT1 utilizes a focal adhesion targeting-homology domain to bind paxillin

scientific article

Genetic and functional analysis of the human immunodeficiency virus (HIV) type 1-inhibiting F12-HIVnef allele.

scientific article

Genome-wide functional analysis of Plasmodium protein phosphatases reveals key regulators of parasite development and differentiation

scientific article (publication date: 9 July 2014)

Genomic and phenotypic delineation of congenital microcephaly

scientific article published on 14 September 2018

H-NS forms a superhelical protein scaffold for DNA condensation

scientific article

H-NS uses an autoinhibitory conformational switch for environment-controlled gene silencing ⬇️

article

HER family kinase domain mutations promote tumor progression and can predict response to treatment in human breast cancer ⬇️

scientific article published on 11 November 2014

HIV-1 Nef protein: purification, crystallizations, and preliminary X-ray diffraction studies.

scientific article published in December 1997

How focal adhesion kinase achieves regulation by linking ligand binding, localization and action

scientific article published on 24 October 2011

How to awaken your nanomachines: Site-specific activation of focal adhesion kinases through ligand interactions

scientific article published on 17 June 2015

How to find a leucine in a haystack? Structure, ligand recognition and regulation of leucine-aspartic acid (LD) motifs

scientific article published on June 2014

Identification and Experimental Characterization of an Extremophilic Brine Pool Alcohol Dehydrogenase from Single Amplified Genomes.

scientific article

Identification and biophysical assessment of the molecular recognition mechanisms between the human haemopoietic cell kinase Src homology domain 3 and ALG-2-interacting protein X

scientific article

In silico exploration of Red Sea Bacillus genomes for natural product biosynthetic gene clusters.

scientific article published on 22 May 2018

In silico screening for candidate chassis strains of free fatty acid-producing cyanobacteria.

scientific article

Increased activity of the vesicular soluble N-ethylmaleimide-sensitive factor attachment protein receptor TI-VAMP/VAMP7 by tyrosine phosphorylation in the Longin domain

scientific article published on 7 March 2013

Inhibition of basal FGF receptor signaling by dimeric Grb2

scientific article

Interaction with Shc prevents aberrant Erk activation in the absence of extracellular stimuli ⬇️

scientific article

Interleukin-26 activates macrophages and facilitates killing of Mycobacterium tuberculosis

scientific article published on 14 October 2020

Intrinsic negative feedback as a limiting factor for the evolution of higher forms of intelligence

scientific article published on 13 October 2020

KDF1, encoding keratinocyte differentiation factor 1, is mutated in a multigenerational family with ectodermal dysplasia

scientific article published on 12 November 2016

KIF16B is a candidate gene for a novel autosomal-recessive intellectual disability syndrome

scientific article published on 07 May 2018

Loss of tubulin deglutamylase CCP1 causes infantile-onset neurodegeneration

scientific article published on 12 November 2018

MLLT1 YEATS domain mutations in clinically distinctive Favourable Histology Wilms tumours.

scientific article

Methods for the recombinant expression of active tyrosine kinase domains: Guidelines and pitfalls

scientific article published on 26 March 2019

Methylation at the C-3' in D-Ring of Strigolactone Analogs Reduces Biological Activity in Root Parasitic Plants and Rice

article

Mg2+ Is a Missing Link in Plant Cell Ca2+ Signalling and Homeostasis-A Study on Vicia faba Guard Cells

scientific article published on 27 May 2020

Molecular basis for group-specific activation of the virulence regulator PlcR by PapR heptapeptides

scientific article

Molecular basis for the adaptive evolution of environment sensing by H-NS proteins

scientific article published on 07 January 2021

Molecular mechanism by which the nucleoid occlusion factor, SlmA, keeps cytokinesis in check

scientific article

Molecular recognition of paxillin LD motifs by the focal adhesion targeting domain

scientific article

Mutations of PTPN23 in developmental and epileptic encephalopathy

scientific article published on 31 October 2017

NAD kinases use substrate-assisted catalysis for specific recognition of NAD

scientific article

Nef-induced major histocompatibility complex class I down-regulation is functionally dissociated from its virion incorporation, enhancement of viral infectivity, and CD4 down-regulation

scientific article

Noise in cellular signaling pathways: causes and effects

scientific article

Nuclear localization of cytoplasmic poly(A)-binding protein upon rotavirus infection involves the interaction of NSP3 with eIF4G and RoXaN.

scientific article

PRMT1-mediated methylation of the EGF receptor regulates signaling and cetuximab response

scientific article published on 16 November 2015

PTK2B/Pyk2 overexpression improves a mouse model of Alzheimer's disease.

scientific article

Passenger sequences can promote interlaced dimers in a common variant of the maltose-binding protein

scientific article published on 31 December 2019

Phosphatidylinositol 4,5-Bisphosphate-Induced Conformational Change of Ezrin and Formation of Ezrin Oligomers

article by Kevin Carvalho et al published 2 November 2010 in Biochemistry

Phosphatidylinositol-(4,5)-bisphosphate enables efficient secretion of HIV-1 Tat by infected T-cells

scientific article

Phosphorylation of threonine residues on Shc promotes ligand binding and mediates crosstalk between MAPK and Akt pathways in breast cancer cells. ⬇️

scientific article published on 2 December 2017

Pre-mRNA splicing repression triggers abiotic stress signaling in plants

scientific article published on 24 September 2016

Protein protein interaction inhibition (2P2I) combining high throughput and virtual screening: Application to the HIV-1 Nef protein

scientific article

Proteobacterial Origin of Protein Arginine Methylation and Regulation of Complex I Assembly by MidA

scientific article published on 01 August 2018

Proteome-level assessment of origin, prevalence and function of Leucine-Aspartic Acid (LD) motifs

Proteome-level assessment of origin, prevalence and function of leucine-aspartic acid (LD) motifs

scientific article published on 01 February 2020

ROP18 is a rhoptry kinase controlling the intracellular proliferation of Toxoplasma gondii

scientific article

ROP2 from Toxoplasma gondii: a virulence factor with a protein-kinase fold and no enzymatic activity

scientific article

RT loop flexibility enhances the specificity of Src family SH3 domains for HIV-1 Nef

scientific article

Rapid Evolution of Plastic-degrading Enzymes Prevalent in the Global Ocean

scientific article

Rational design of Striga hermonthica-specific seed germination inhibitors

scientific article published on 01 February 2022

Recessive VARS2 mutation underlies a novel syndrome with epilepsy, mental retardation, short stature, growth hormone deficiency, and hypogonadism

scientific article published on 14 November 2017

Regulation of the PI3K pathway through a p85α monomer-homodimer equilibrium

scientific article published on 29 July 2015

Solution structure of the tandem acyl carrier protein domains from a polyunsaturated fatty acid synthase reveals beads-on-a-string configuration

scientific article

Structural basis for specific inhibition of the highly sensitive ShHTL7 receptor

scientific article published on 18 July 2018

Structural basis for the co-activation of protein kinase B by T-cell leukemia-1 (TCL1) family proto-oncoproteins.

scientific article published on 28 May 2004

Structural basis for the interaction between focal adhesion kinase and CD4

scientific article

Structural insights into the association between BCAR3 and Cas family members, an atypical complex implicated in anti-oestrogen resistance

scientific article

Structural recognition mechanisms between human Src homology domain 3 (SH3) and ALG-2-interacting protein X (Alix)

scientific article

Structure of PlcR: Insights into virulence regulation and evolution of quorum sensing in Gram-positive bacteria

scientific article

T(H)17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26

scientific article

The H-NS dimerization domain defines a new fold contributing to DNA recognition

scientific article (publication date: March 2003)

The TCL1A oncoprotein interacts directly with the NF-kappaB inhibitor IkappaB.

scientific article

The ancestral retinoic acid receptor was a low-affinity sensor triggering neuronal differentiation.

scientific article published on 21 February 2018

The genome of Chenopodium quinoa.

scientific article published on 8 February 2017

The genome sequence of the wild tomatoSolanum pimpinellifoliumprovides insights into salinity tolerance

The role of the Src homology 3-Src homology 2 interface in the regulation of Src kinases

scientific article

The solution structure of the adhesion protein Bd37 from Babesia divergens reveals structural homology with eukaryotic proteins involved in membrane trafficking

scientific article

The structural basis of localization and signaling by the focal adhesion targeting domain

scientific article

Truncating PREX2 mutations activate its GEF activity and alter gene expression regulation in NRAS-mutant melanoma

scientific article published on 16 February 2016

Truncating biallelic variant in DNAJA1, encoding the co-chaperone Hsp40, is associated with intellectual disability and seizures

scientific article published on 10 April 2019

Truncating mutations in YIF1B cause a progressive encephalopathy with various degrees of mixed movement disorder, microcephaly, and epilepsy

scientific article published on 31 January 2020

Understanding High-Salt and Cold Adaptation of a Polyextremophilic Enzyme

scientific article published on 16 October 2020

Unraveling the differential impact of PAHs and dioxin-like compounds on AKR1C3 reveals the EGFR extracellular domain as a critical determinant of the AHR response

scientific article published on 20 November 2021

Vemurafenib acts as an aryl hydrocarbon receptor antagonist: Implications for inflammatory cutaneous adverse events

scientific article published on 03 September 2019

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