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List of works by Xavier Morelli

15N-labelling and preliminary heteronuclear NMR study of Desulfovibrio vulgaris Hildenborough cytochrome c553

scientific article published on 01 April 1999

2P2I HUNTER: a tool for filtering orthosteric protein-protein interaction modulators via a dedicated support vector machine.

scientific article

2P2Ichem: focused chemical libraries dedicated to orthosteric modulation of protein–protein interactions

article

2P2Idb v2: update of a structural database dedicated to orthosteric modulation of protein-protein interactions.

scientific article published on 15 March 2016

2P2Idb: a structural database dedicated to orthosteric modulation of protein-protein interactions.

scientific article

A Biochemical/Biophysical Assay Dyad for HTS-Compatible Triaging of Inhibitors of the HIV-1 Nef/Hck SH3 Interaction

scientific article published on 26 July 2013

A novel approach for assessing macromolecular complexes combining soft-docking calculations with NMR data.

scientific article

A peptide mimic of an antigenic loop of alpha-human chorionic gonadotropin hormone: solution structure and interaction with a llama V(HH) domain

scientific article published on September 2002

A specific protein disorder catalyzer of HIV-1 Nef

article

Acceleration of the Drug Discovery Process: A Combinatorial Approach Using NMR Spectroscopy and Virtual Screening

Alteration of a single tryptophan residue of the cellulose-binding domain blocks secretion of the Erwinia chrysanthemi Cel5 cellulase (ex-EGZ) via the type II system.

scientific article published in October 2000

Aminoacylase 1-catalysed deacetylation of bioactives epoxides mycotoxin-derived mercapturates; 3,4-epoxyprecocenes as models of cytotoxic epoxides

scientific article published on 11 February 2012

An integrative in silico methodology for the identification of modulators of macrophage migration inhibitory factor (MIF) tautomerase activity

scientific article

Atomic analysis of protein-protein interfaces with known inhibitors: the 2P2I database

scientific article

Chemical and structural lessons from recent successes in protein-protein interaction inhibition (2P2I).

scientific article

Chemical libraries dedicated to protein-protein interactions

scientific article

Chemistry-driven Hit-to-lead Optimization Guided by Structure-based Approaches

scientific article published on 27 July 2018

Comparative Virtual and Experimental Medium Throughput Screening for Hepatitis C Virus Polymerase Inhibitors

article published in 2008

Conotoxins and structural biology: a prospective paradigm for drug discovery.

scientific article published in August 2004

Coronavirus Nsp10, a critical co-factor for activation of multiple replicative enzymes

scientific article

CovaDOTS: In Silico Chemistry-Driven Tool to Design Covalent Inhibitors Using a Linking Strategy

scientific article published on 05 April 2019

Crystal structure of the vaccinia virus DNA polymerase holoenzyme subunit D4 in complex with the A20 N-terminal domain

scientific article

Dual protein kinase and nucleoside kinase modulators for rationally designed polypharmacology.

scientific article published on 10 November 2017

Editorial

scholarly article by Francoise Ochsenbein published in October 2015

Exploring Selective Inhibition of the First Bromodomain of the Human Bromodomain and Extra-terminal Domain (BET) Proteins

scientific article

Focused chemical libraries--design and enrichment: an example of protein-protein interaction chemical space

scientific article

GFscore: a general nonlinear consensus scoring function for high-throughput docking

scientific article published in July 2006

Genetic, structural, and chemical insights into the dual function of GRASP55 in germ cell Golgi remodeling and JAM-C polarized localization during spermatogenesis.

scientific article

Heteronuclear NMR and soft docking: an experimental approach for a structural model of the cytochrome c553-ferredoxin complex

scientific article

Identification and biophysical assessment of the molecular recognition mechanisms between the human haemopoietic cell kinase Src homology domain 3 and ALG-2-interacting protein X

scientific article

Identification of a Src kinase SH3 binding site in the C-terminal domain of the human ErbB2 receptor tyrosine kinase

scientific article

Identification of allosteric inhibitors blocking the hepatitis C virus polymerase NS5B in the RNA synthesis initiation step

scientific article

Integrated Strategy for Lead Optimization Based on Fragment Growing: The Diversity-Oriented-Target-Focused-Synthesis Approach

scientific article published on 22 June 2018

Interaction between the C-terminal domains of N and P proteins of measles virus investigated by NMR

scientific article

Mapping the cytochrome c 553 interacting site using 1 H and 15 N NMR

scientific article published on 01 October 1999

Modified cap group suberoylanilide hydroxamic acid histone deacetylase inhibitor derivatives reveal improved selective antileukemic activity.

scientific article published on April 2010

Molecular mapping of the RNA Cap 2'-O-methyltransferase activation interface between severe acute respiratory syndrome coronavirus nsp10 and nsp16.

scientific article

Multiple orientations in a physiological complex: the pyruvate-ferredoxin oxidoreductase-ferredoxin system

scientific article

Mutational analysis of the DOK2 haploinsufficient tumor suppressor gene in chronic myelomonocytic leukemia (CMML)

article

Optimization of a fragment linking hit toward Dengue and Zika virus NS5 methyltransferases inhibitors

scientific article published on 23 October 2018

Prevalence, specificity and determinants of lipid-interacting PDZ domains from an in-cell screen and in vitro binding experiments

scientific article

Protein protein interaction inhibition (2P2I) combining high throughput and virtual screening: Application to the HIV-1 Nef protein

scientific article

Protein-Protein Interaction Inhibition (2P2I)-Oriented Chemical Library Accelerates Hit Discovery

scientific article

Protein-protein interaction inhibition (2P2I): fewer and fewer undruggable targets.

scientific article

Searching for the Holy Grail; protein-protein interaction analysis and modulation

scientific article published on 18 September 2012

Sequential NMR assignment of the ferri-cytochrome c3 from Desulfovibrio vulgaris Hildenborough

scientific article published on 01 May 2002

Solution structure of HndAc: a thioredoxin-like domain involved in the NADP-reducing hydrogenase complex

scientific article published on June 2006

Stereoselective synthesis of original spirolactams displaying promising folded structures.

scientific article published on 13 June 2013

Structural Basis for the Interaction between Golgi Reassembly-stacking Protein GRASP55 and Golgin45.

scientific article

Structural and genetic analyses reveal a key role in prophage excision for the TorI response regulator inhibitor

scientific article published on 2 August 2005

Structural basis for the interaction between the Golgi reassembly-stacking protein GRASP65 and the Golgi matrix protein GM130.

scientific article

Structural basis of membrane binding by Gla domains of vitamin K-dependent proteins

scientific article

Structural model of the Fe-hydrogenase/cytochrome c553 complex combining transverse relaxation-optimized spectroscopy experiments and soft docking calculations

scientific article

Structural recognition mechanisms between human Src homology domain 3 (SH3) and ALG-2-interacting protein X (Alix)

scientific article

Synergy and allostery in ligand binding by HIV-1 Nef

scientific article published on 01 April 2021

The crystal structure of the hexadeca-heme cytochrome Hmc and a structural model of its complex with cytochrome c(3)

scientific article

The cytochrome c3-[Fe]-hydrogenase electron-transfer complex: structural model by NMR restrained docking

scientific article

The type I/type II cytochrome c3 complex: an electron transfer link in the hydrogen-sulfate reduction pathway

scientific article published on 29 September 2005

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