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List of works by Ashley Mansell

A novel function of InIB from Listeria monocytogenes: activation of NF-kappaB in J774 macrophages.

scientific article

A type III effector antagonizes death receptor signalling during bacterial gut infection

scientific article published on September 2013

Adaptors in toll-like receptor signaling and their potential as therapeutic targets

scientific article published on October 2012

BTB-ZF transcriptional regulator PLZF modifies chromatin to restrain inflammatory signaling programs.

scientific article

Carbonylation caused by cigarette smoke extract is associated with defective macrophage immunity.

scientific article

Cloning, expression, purification, crystallization and preliminary X-ray crystallographic analysis of the TIR domain from the Brucella melitensis TIR-domain-containing protein TcpB.

scientific article published on 28 September 2013

Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection

scientific article

Crystallization and X-ray diffraction analysis of the N-terminal domain of the Toll-like receptor signalling adaptor protein TRIF/TICAM-1.

scientific article published on 28 June 2013

Dangerous liaisons between interleukin-6 cytokine and toll-like receptor families: a potent combination in inflammation and cancer

scientific article published on 03 May 2013

Different bacterial gene expression patterns and attenuated host immune responses are associated with the evolution of low-level vancomycin resistance during persistent methicillin-resistant Staphylococcus aureus bacteraemia

scientific article

Endogenous macrophage migration inhibitory factor modulates glucocorticoid sensitivity in macrophages via effects on MAP kinase phosphatase-1 and p38 MAP kinase.

scientific article published on 19 January 2006

HIV Blocks Interferon Induction in Human Dendritic Cells and Macrophages by Dysregulation of TBK1

scientific article published on 8 April 2015

Hero turned villain: NLRP3 inflammasome-induced inflammation during influenza A virus infection

scientific article

IL-1β and IL-18: inflammatory markers or mediators of hypertension?

scientific article

IL-6 trans-signaling modulates TLR4-dependent inflammatory responses via STAT3.

scientific article published on 10 December 2010

IRF7 in the Australian black flying fox, Pteropus alecto: evidence for a unique expression pattern and functional conservation

scientific article

In Vivo Infection Model of Severe Influenza A Virus

scientific article published in January 2018

Induction of memory cytotoxic T cells to influenza A virus and subsequent viral clearance is not modulated by PB1-F2-dependent inflammasome activation

scientific article published on 15 December 2015

Innate IL-17A-producing leukocytes promote acute kidney injury via inflammasome and Toll-like receptor activation

scientific article published on 14 March 2014

Internalin B activates nuclear factor-kappa B via Ras, phosphoinositide 3-kinase, and Akt.

scientific article

LPS hypersensitivity of gp130 mutant mice is independent of elevated haemopoietic TLR4 signaling.

scientific article

Life is so much easier for the sea urchin

scientific article published in August 2007

Lipid-containing mimetics of natural triggers of innate immunity as CTL-inducing influenza vaccines

scientific article published on 31 October 2006

Lipopolysaccharide-deficient Acinetobacter baumannii shows altered signaling through host Toll-like receptors and increased susceptibility to the host antimicrobial peptide LL-37.

scientific article published on 17 December 2012

Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

scientific article

Mal interacts with tumor necrosis factor receptor-associated factor (TRAF)-6 to mediate NF-kappaB activation by toll-like receptor (TLR)-2 and TLR4.

scientific article published on 9 July 2004

Mechanism of Bacterial Interference with TLR4 Signaling by Brucella Toll/Interleukin-1 Receptor Domain-containing Protein TcpB

scientific article

Mitochondrially localised MUL1 is a novel modulator of antiviral signaling

scientific article

MyD88 adapter-like (Mal)/TIRAP interaction with TRAF6 is critical for TLR2- and TLR4-mediated NF-kappaB proinflammatory responses.

scientific article published on 10 July 2009

MyD88 is a critical regulator of hematopoietic cell-mediated neuroprotection seen after stroke.

scientific article

Porphyromonas gingivalis lipopolysaccharide weakly activates M1 and M2 polarized mouse macrophages but induces inflammatory cytokines.

scientific article

Porphyromonas gulae Activates Unprimed and Gamma Interferon-Primed Macrophages via the Pattern Recognition Receptors Toll-Like Receptor 2 (TLR2), TLR4, and NOD2.

scientific article published on 19 June 2017

Potential contribution of NF-kappaB in neuronal cell death in the glutathione peroxidase-1 knockout mouse in response to ischemia-reperfusion injury

scientific article

Pressor response to angiotensin II is enhanced in aged mice and associated with inflammation, vasoconstriction and oxidative stress

scientific article published on 28 June 2017

Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation

scientific article

Reassessing the role of the NLRP3 inflammasome during pathogenic influenza A virus infection via temporal inhibition

scientific article published on 10 June 2016

Recombinant production of functional full-length and truncated human TRAM/TICAM-2 adaptor protein involved in Toll-like receptor and interferon signaling

scientific article published on 13 October 2014

Rotavirus NSP4 Triggers Secretion of Proinflammatory Cytokines from Macrophages via Toll-Like Receptor 2.

scientific article published on 7 August 2013

STAT1 plays a role in TLR signal transduction and inflammatory responses.

scientific article published on 15 July 2014

STAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1β expression

scientific article published on 30 July 2020

Sculpting the immune response to infection ⬇️

scientific article published on June 20, 2011

Stimulation of the interleukin-1 receptor and Toll-like receptor 2 inhibits hepatitis B virus replication in hepatoma cell lines in vitro

scientific article published on January 2009

Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling

scientific article

Suppressor of Cytokine Signaling (SOCS) 1 Inhibits Type I Interferon (IFN) Signaling via the Interferon α Receptor (IFNAR1)-associated Tyrosine Kinase Tyk2 ⬇️

scientific article published on July 13, 2011

Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation

scientific article published on 15 January 2006

TIR-containing adaptors in Toll-like receptor signalling

scientific article published on 04 March 2009

TLR ligands of ryegrass pollen microbial contaminants enhance Th1 and Th2 responses and decrease induction of Foxp3(hi) regulatory T cells

scientific article published on 18 January 2013

TRIF-dependent TLR signaling, its functions in host defense and inflammation, and its potential as a therapeutic target

scientific article published on 9 May 2016

The Australian Toll-way gets the Nod--meeting report of TLROZ 2007: pattern recognition receptors in immunity and disease, Melbourne, Australia, 16-18th May 2007.

scientific article published on 17 July 2007

The Single Nucleotide Polymorphism Mal-D96N Mice Provide New Insights into Functionality of Mal in TLR Immune Responses

scientific article published on 20 February 2019

The TLR signaling adaptor TRAM interacts with TRAF6 to mediate activation of the inflammatory response by TLR4.

scientific article

The TLR signalling adaptor TRIF/TICAM-1 has an N-terminal helical domain with structural similarity to IFIT proteins

scientific article

The acetyltransferase HAT1 moderates the NF-κB response by regulating the transcription factor PLZF.

scientific article published on 13 April 2015

The hepatitis B e antigen (HBeAg) targets and suppresses activation of the toll-like receptor signaling pathway

scientific article

The serine protease inhibitor antithrombin III inhibits LPS-mediated NF-kappaB activation by TLR-4.

scientific article

Toll-IL1 receptor-mediated innate immune responses vary across HBV genotype and predict treatment response to pegylated-IFN in HBeAg-positive CHB patients.

scientific article published on 5 October 2015

Toll-Like Receptors as Interferon-Regulated Genes and Their Role in Disease ⬇️

scientific article published on 03 January 2011

Toll-like receptors: the swiss army knife of immunity and vaccine development

scientific article

Toll/IL-1 signaling is critical for house dust mite-specific helper T cell type 2 and type 17 [corrected] responses.

scientific article published on 26 February 2009

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