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List of works by Hidenori Ichijō

A TNF- and c-Cbl-dependent FLIP(S)-degradation pathway and its function in Mycobacterium tuberculosis-induced macrophage apoptosis

scientific article

A novel monoclonal antibody reveals a conformational alteration shared by amyotrophic lateral sclerosis-linked SOD1 mutants

scientific article published on 01 November 2012

A systematic immunoprecipitation approach reinforces the concept of common conformational alterations in amyotrophic lateral sclerosis-linked SOD1 mutants.

scientific article published on 18 August 2015

ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1.

scientific article published on June 2008

ASK family proteins in stress response and disease

scientific article published on September 2007

ASK1 Signalosome: a Signaling Complex Essential for Cellular Stress Responses

article

ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis.

scientific article published on 12 February 2009

ASK1 deficiency attenuates neural cell death in GLAST-deficient mice, a model of normal tension glaucoma

scientific article published on 21 May 2010

ASK1 is activated by arsenic trioxide in leukemic cells through accumulation of reactive oxygen species and may play a negative role in induction of apoptosis

scientific article published on 22 February 2007

ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats

scientific article

ASK1 is involved in cognitive impairment caused by long-term high-fat diet feeding in mice

scientific article

ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis

scholarly article by K Tobiume published in March 2001

ASK1 mediates apoptotic cell death induced by genotoxic stress.

scientific article published on January 1999

ASK1 promotes apoptosis of normal and malignant plasma cells.

scientific article

ASK1 promotes the contact hypersensitivity response through IL-17 production

scientific article published on 16 April 2014

ASK1 promotes uterine inflammation leading to pathological preterm birth

scientific article published on 05 February 2020

ASK1 regulates influenza virus infection-induced apoptotic cell death

scientific article published in August 2003

ASK1 resistant neuroblastoma is deficient in activation of p38 kinase

scientific article

ASK1 restores the antiviral activity of APOBEC3G by disrupting HIV-1 Vif-mediated counteraction

scientific article published on 22 April 2015

ASK1 signalling regulates brown and beige adipocyte function.

scientific article published on 5 April 2016

ASK1-dependent recruitment and activation of macrophages induce hair growth in skin wounds

scientific article

ASK1-p38 MAPK-p47phox activation is essential for inflammatory responses during tuberculosis via TLR2-ROS signalling

scientific article published on 19 November 2007

ASK3 responds to osmotic stress and regulates blood pressure by suppressing WNK1-SPAK/OSR1 signaling in the kidney

scientific article published in Nature Communications

ASKA technology-based pull-down method reveals a suppressive effect of ASK1 on the inflammatory NOD-RIPK2 pathway in brown adipocytes

scientific article published on 10 November 2021

Activation mechanisms of ASK1 in response to various stresses and its significance in intracellular signaling

scientific article published on 13 September 2012

Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein Daxx

scientific article

Activation of apoptosis signal-regulating kinase 1 (ASK1) by tumor necrosis factor receptor-associated factor 2 requires prior dissociation of the ASK1 inhibitor thioredoxin.

scientific article

Activation of apoptosis signal-regulating kinase 1 by the stress-induced activating phosphorylation of pre-formed oligomer

scientific article

Activation of apoptosis signal-regulating kinase 1 in injured artery and its critical role in neointimal hyperplasia

scientific journal article

Amyloid beta induces neuronal cell death through ROS-mediated ASK1 activation

scientific article

Apoptosis Signal-Regulating Kinase 1 Regulates Colitis and Colitis-Associated Tumorigenesis by the Innate Immune Responses

article

Apoptosis Signal-Regulating Kinase-1 Is Involved in Vascular Endothelial and Cardiac Remodeling Caused by Nitric Oxide Deficiency

Apoptosis Signal-regulating Kinase 1 (ASK1)-p38 Pathway-dependent Cytoplasmic Translocation of the Orphan Nuclear Receptor NR4A2 Is Required for Oxidative Stress-induced Necrosis

scientific article published on 9 March 2015

Apoptosis of periodontal ligament cells induced by mechanical stress during tooth movement

scientific article published on 01 September 2001

Apoptosis signal regulating kinase-1 connects reactive oxygen species to p38 MAPK-induced mitochondrial apoptosis in UVB-irradiated human keratinocytes

article

Apoptosis signal-regulating kinase (ASK) 2 functions as a mitogen-activated protein kinase kinase kinase in a heteromeric complex with ASK1

scientific article

Apoptosis signal-regulating kinase (ASK)-1 mediates apoptosis through activation of JNK1 following engagement of membrane immunoglobulin.

scientific article published on 18 September 2009

Apoptosis signal-regulating kinase 1 (ASK1) induces neuronal differentiation and survival of PC12 cells

scientific article (publication date: 31 March 2000)

Apoptosis signal-regulating kinase 1 (ASK1) is an intracellular inducer of keratinocyte differentiation

scientific article

Apoptosis signal-regulating kinase 1 and cyclin D1 compose a positive feedback loop contributing to tumor growth in gastric cancer

scientific article

Apoptosis signal-regulating kinase 1 as a therapeutic target

scientific article published on 24 March 2014

Apoptosis signal-regulating kinase 1 deficiency accelerates hyperlipidemia-induced atheromatous plaques via suppression of macrophage apoptosis.

scientific article

Apoptosis signal-regulating kinase 1 deficiency attenuates vascular injury-induced neointimal hyperplasia by suppressing apoptosis in smooth muscle cells

scientific article published on 22 November 2012

Apoptosis signal-regulating kinase 1 deficiency eliminates cardiovascular injuries induced by high-salt diet.

scientific article

Apoptosis signal-regulating kinase 1 in leukotriene D(4)-induced activator protein-1 activation in airway smooth muscle cells

scientific article published on July 2005

Apoptosis signal-regulating kinase 1 in regulated necrosis.

scientific article published on 23 November 2017

Apoptosis signal-regulating kinase 1 in stress and immune response

scientific article published on January 2008

Apoptosis signal-regulating kinase 1 inhibits hepatocarcinogenesis by controlling the tumor-suppressing function of stress-activated mitogen-activated protein kinase.

scientific article

Apoptosis signal-regulating kinase 1 is a novel target molecule for cognitive impairment induced by chronic cerebral hypoperfusion

scientific article

Apoptosis signal-regulating kinase 1 is involved not only in apoptosis but also in non-apoptotic cardiomyocyte death.

scientific article

Apoptosis signal-regulating kinase 1 mediates MPTP toxicity and regulates glial activation

scientific article

Apoptosis signal-regulating kinase 1 mediates cellular senescence induced by high glucose in endothelial cells

scientific article published on June 2006

Apoptosis signal-regulating kinase 1 modulates the phenotype of α-synuclein transgenic mice

scientific article

Apoptosis signal-regulating kinase 1 plays a pivotal role in angiotensin II-induced cardiac hypertrophy and remodeling

scientific article published on 9 October 2003

Apoptosis signal-regulating kinase 1-mediated signaling pathway regulates hydrogen peroxide-induced apoptosis in human pulmonary vascular endothelial cells

scientific article published in December 2003

Apoptosis signal-regulating kinase 1-mediated signaling pathway regulates nitric oxide-induced activator protein-1 activation in human bronchial epithelial cells

scientific article published in March 2003

Apoptosis signal-regulating kinase 1/p38 signaling pathway negatively regulates physiological hypertrophy

scientific article

Apoptosis signal-regulating kinase-1 inhibitor as a potent therapeutic drug for the treatment of gastric cancer.

scientific article

Apoptosis signaling kinases: from stress response to health outcomes

scientific article published on 20 April 2011

Apoptosis-signal regulating kinase-1 is involved in the low potassium-induced activation of p38 mitogen-activated protein kinase and c-Jun in cultured cerebellar granule neurons

scientific article published in June 2003

Ask1 regulates murine platelet granule secretion, thromboxane A2 generation, and thrombus formation

scientific article

Biological effects and binding properties of transforming growth factor-beta on human oral squamous cell carcinoma cells

scientific article published on April 1990

CHIP-dependent termination of MEKK2 regulates temporal ERK activation required for proper hyperosmotic response

scientific article

Calcium signalingvia voltage-dependent L-type Ca2+ channels

scholarly article by Isao Naguro published in December 2004

Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis

scientific article published on October 2004

Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis

article

Cells recognize osmotic stress through liquid-liquid phase separation lubricated with poly(ADP-ribose)

scientific article published on 01 March 2021

Characterization of in Vivo Phosphorylation of Activin Type II Receptor

scientific article published on 01 August 1993

Characterization of the Interaction of FKBP12 with the Transforming Growth Factor-β Type I Receptorin Vivo

scientific article published in Journal of Biological Chemistry

Chk2 kinase is required for methylglyoxal-induced G2/M cell-cycle checkpoint arrest: implication of cell-cycle checkpoint regulation in diabetic oxidative stress signaling

scientific article

Cloning and characterization of p70(S6K beta) defines a novel family of p70 S6 kinases

scientific article

Cloning of a TGF beta type I receptor that forms a heteromeric complex with the TGF beta type II receptor

scientific journal article

Cold stress-induced ferroptosis involves the ASK1-p38 pathway

scientific article

Critical role for apoptosis signal-regulating kinase 1 in the development of inflammatory K/BxN serum-induced arthritis

scientific article published on 6 July 2010

Critical role of apoptosis signal-regulating kinase 1 in aldosterone/salt-induced cardiac inflammation and fibrosis.

scientific article

Cryo-EM structure of the volume-regulated anion channel LRRC8D isoform identifies features important for substrate permeation

scientific article published on 15 May 2020

Cryo-EM structures of the human volume-regulated anion channel LRRC8

scientific article published on 20 August 2018

Decreased level of transforming growth factor-beta in blood lymphocytes of patients with aplastic anemia

scientific article published on January 1992

Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-Jun N-terminal kinase activation

scientific article published on 9 July 2008

Deletion of apoptosis signal-regulating kinase-1 prevents ventilator-induced lung injury in mice

scientific article

Depletion of apoptosis signal-regulating kinase 1 prevents bile duct ligation-induced necroinflammation and subsequent peribiliary fibrosis

scientific article published on 9 January 2014

Direct interaction and reciprocal regulation between ASK1 and calcineurin-NFAT control cardiomyocyte death and growth

scientific article

ER stress activates the NLRP3 inflammasome via an UPR-independent pathway

scientific article published on 26 January 2012

Efficient association of an amino-terminally extended form of human latent transforming growth factor-beta binding protein with the extracellular matrix

scientific article

Enhanced TNF-alpha-induced apoptosis in Fanconi anemia type C-deficient cells is dependent on apoptosis signal-regulating kinase 1.

scientific article published on 18 August 2005

Erratum: ASK1 is involved in cognitive impairment caused by long-term high-fat diet feeding in mice

scientific article published on 8 October 2015

Essential role of E2-25K/Hip-2 in mediating amyloid-beta neurotoxicity

scientific article published in September 2003

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015.

scientific article

Execution of Apoptosis Signal-regulating Kinase 1 (ASK1)-induced Apoptosis by the Mitochondria-dependent Caspase Activation

scientific article published in Journal of Biological Chemistry

Fatty acids liberated from low-density lipoprotein trigger endothelial apoptosis via mitogen-activated protein kinases

scientific article published in August 2005

Fra-2 mediates oxygen-sensitive induction of transforming growth factor beta in cardiac fibroblasts

scientific article

GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease

scientific article

Glutathione S-transferase mu modulates the stress-activated signals by suppressing apoptosis signal-regulating kinase 1

scientific article (publication date: 20 April 2001)

Growth/Differentiation Factor-5 Induces Angiogenesisin Vivo

scientific article published on 01 August 1997

Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes.

scientific article published on 17 April 2009

HIV-1 Nef inhibits ASK1-dependent death signalling providing a potential mechanism for protecting the infected host cell

scientific article

HSV infection induces production of ROS, which potentiate signaling from pattern recognition receptors: role for S-glutathionylation of TRAF3 and 6

scientific article

Hyperactivity in novel environment with increased dopamine and impaired novelty preference in apoptosis signal-regulating kinase 1 (ASK1)-deficient mice.

scientific article published on 16 December 2009

Identification and characterization of autocrine-motility-factor-like activity in oral squamous-cell-carcinoma cells

scientific article published on December 1994

Identification of Op18/stathmin as a potential target of ASK1-p38 MAP kinase cascade

scientific article published in February 2006

Identification of a novel antiapoptotic protein that antagonizes ASK1 and CAD activities

scientific article

Identification of a novel bone morphogenetic protein-responsive gene that may function as a noncoding RNA.

scientific article

Identification of important regions in the cytoplasmic juxtamembrane domain of type I receptor that separate signaling pathways of transforming growth factor-beta

scientific article

Identification of novel ASK1 inhibitors using virtual screening

scientific article

Identification of type I and type II serine/threonine kinase receptors for growth/differentiation factor-5

scientific article

Impact of mitochondrial reactive oxygen species and apoptosis signal-regulating kinase 1 on insulin signaling

scientific article published on May 2006

Important Role of Apoptosis Signal-Regulating Kinase 1 in Ischemia-Induced Angiogenesis

Important role of apoptosis signal-regulating kinase 1 in ischemic acute kidney injury

scientific article published on 29 October 2007

In vivo gene manipulation reveals the impact of stress-responsive MAPK pathways on tumor progression

scientific article published on 25 May 2015

Induction of Smad6 mRNA by bone morphogenetic proteins

scientific article

Induction of a ribotoxic stress response that stimulates stress-activated protein kinases by 13-deoxytedanolide, an antitumor marine macrolide

scientific article published on January 2006

Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways

scientific article

Inhibition of ASK1-p38 pathway prevents neural cell death following optic nerve injury.

scientific article published on 14 September 2012

Inhibition of Cytohesins Protects against Genetic Models of Motor Neuron Disease.

scientific article published on June 2015

Inhibition of apoptosis signal-regulating kinase 1 enhances endochondral bone formation by increasing chondrocyte survival

scientific article published on 13 November 2014

Inhibition of mammalian target of rapamycin activates apoptosis signal-regulating kinase 1 signaling by suppressing protein phosphatase 5 activity

scientific article published on 24 June 2004

Integration of apoptosis signal-regulating kinase 1-mediated stress signaling with the Akt/protein kinase B-IκB kinase cascade

scientific article published on 25 March 2013

Interaction of ASK1 and the beta-amyloid precursor protein in a stress-signaling complex

scientific article

Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death

scientific article

Interaction of apoptosis signal-regulating kinase 1 with isoforms of 14-3-3 proteins

scientific article

Involvement of ASK1 in Ca2+-induced p38 MAP kinase activation

scientific article published on 16 January 2004

Involvement of ASK1-p38 pathway in the pathogenesis of diabetes triggered by pancreatic ß cell exhaustion

scientific article published on 15 February 2013

Involvement of apoptosis signal-regulating kinase-1 in house dust mite-induced allergic asthma in mice

scientific article published on 14 June 2017

Involvement of apoptosis signal-regulating kinase-1 on angiotensin II-induced monocyte chemoattractant protein-1 expression

scientific article published on 18 December 2003

KLHDC10 Deficiency Protects Mice against TNFα-Induced Systemic Inflammation

scientific article

Key roles of Phe1112 and Ser1115 in the pore-forming IIIS5-S6 linker of L-type Ca2+ channel alpha1C subunit (CaV 1.2) in binding of dihydropyridines and action of Ca2+ channel agonists

scientific article published in August 2003

L-type Ca2+ channels serve as a sensor of the SR Ca2+ for tuning the efficacy of Ca2+-induced Ca2+ release in rat ventricular myocytes

scientific article published in October 2003

Latent form of transforming growth factor-beta 1 acts as a potent growth inhibitor on a human erythroleukemia cell line

scientific article published on February 1990

Liver protection from apoptosis requires both blockage of initiator caspase activities and inhibition of ASK1/JNK pathway via glutathione S-transferase regulation.

scientific article published on 4 October 2002

Localization of Transforming Growth Factor-β Type I and Type II Receptors in Mouse Development

article

Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1.

scientific article

Microtubule dysfunction induced by paclitaxel initiates apoptosis through both c-Jun N-terminal kinase (JNK)-dependent and -independent pathways in ovarian cancer cells

scientific article

Microtubule-interfering Agents Activate c-Jun N-terminal Kinase/Stress-activated Protein Kinase through Both Ras and Apoptosis Signal-regulating Kinase Pathways

scientific article published in Journal of Biological Chemistry

Mitochondrial phosphoglycerate mutase 5 uses alternate catalytic activity as a protein serine/threonine phosphatase to activate ASK1

scientific article

Mitochondrial proteolysis: its emerging roles in stress responses

scientific article published on 23 October 2014

Mitogen-activated protein kinases as key players in osmotic stress signaling

scientific article published on 31 May 2016

Mitogen-activated protein kinases in mammalian oxidative stress responses

scientific article published on 08 April 2011

Modulation of responses to TGF-beta by 1, 25 dihydroxyvitamin D3 in MG-63 osteoblastic cells: possible involvement of regulation of TGF-beta type II receptor

scientific article published on October 1994

Molecular cloning and characterization of the human and porcine transforming growth factor-beta type III receptors

scientific article

Molecular cloning and characterization of the mouse apoptosis signal-regulating kinase 1.

scientific article

Molecular cloning of rat bone morphogenetic protein (BMP) type IA receptor and its expression during ectopic bone formation induced by BMP.

scientific article published on October 1994

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

scientific article

NAMPT-dependent NAD<sup>+</sup> salvage is crucial for the decision between apoptotic and necrotic cell death under oxidative stress

scientific article published on 11 April 2022

Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress

scientific article

New mechanisms of skin innate immunity: ASK1-mediated keratinocyte differentiation regulates the expression of β-defensins, LL37, and TLR2

Novel mechanism and role of angiotensin II induced vascular endothelial injury in hypertensive diastolic heart failure

scientific journal article

Novel mechanism of angiotensin II-induced cardiac injury in hypertensive rats: the critical role of ASK1 and VEGF.

scientific article

Olmesartan prevents cardiovascular injury and hepatic steatosis in obesity and diabetes, accompanied by apoptosis signal regulating kinase-1 inhibition

scientific article

Osmotic stress induces the phosphorylation of WNK4 Ser575 via the p38MAPK-MK pathway

scientific article

Oxidation-triggered c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein (MAP) kinase pathways for apoptosis in human leukaemic cells stimulated by epigallocatechin-3-gallate (EGCG): a distinct pathway from those of chemically induced and

scientific article published on December 2002

Oxidative Stress-Induced Diseases via the ASK1 Signaling Pathway

scientific article published on 13 May 2012

Oxidizable residues mediating protein stability and cytoprotective interaction of DJ-1 with apoptosis signal-regulating kinase 1

scientific article published on 16 March 2009

Phosphorylation and inactivation of myeloid cell leukemia 1 by JNK in response to oxidative stress

scientific article published on 9 September 2002

Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway. A new mode of regulation of the MAP kinase cascade

scientific article (publication date: 25 October 2002)

Physiological roles of stress-activated protein kinases in skin

Pleiotropic properties of ASK1.

scientific article

Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide

scientific article published on 26 September 2004

Pre-emptive Quality Control Protects the ER from Protein Overload via the Proximity of ERAD Components and SRP

scientific journal article

Prevention of apoptosis by mitochondrial phosphatase PGAM5 in the mushroom body is crucial for heat shock resistance in Drosophila melanogaster

scientific article

ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity.

scientific article

Reaper-mediated inhibition of DIAP1-induced DTRAF1 degradation results in activation of JNK in Drosophila

scientific article published in September 2002

Reciprocal negative regulation of PDK1 and ASK1 signaling by direct interaction and phosphorylation

scientific article

Recruitment of tumor necrosis factor receptor-associated factor family proteins to apoptosis signal-regulating kinase 1 signalosome is essential for oxidative stress-induced cell death

scientific article

Redox control of cell fate by MAP kinase: physiological roles of ASK1-MAP kinase pathway in stress signaling

scientific article published on 16 January 2008

Regulation of Apoptosis by α-Subunits of G12 and G13 Proteins via Apoptosis Signal-regulating Kinase-1

scientific article published in Journal of Biological Chemistry

Regulation of anoxic death in Caenorhabditis elegans by mammalian apoptosis signal-regulating kinase (ASK) family proteins

scientific article

Regulation of apoptosis signal-regulating kinase 1 by protein phosphatase 2Cepsilon

scientific article published on August 2007

Regulation of the severity of neuroinflammation and demyelination by TLR-ASK1-p38 pathway

scientific article

Release of RASSF1C from the nucleus by Daxx degradation links DNA damage and SAPK/JNK activation

scientific article

Requirement of apoptosis-inducing kinase 1 for the induction of bronchial asthma following stimulation with ovalbumin

scientific article published on 31 July 2013

Requirement of reactive oxygen species-dependent activation of ASK1-p38 MAPK pathway for extracellular ATP-induced apoptosis in macrophage.

scientific article published on 22 January 2008

Rhomboid protease PARL mediates the mitochondrial membrane potential loss-induced cleavage of PGAM5

scientific article published on 22 August 2012

Role of ADP-ribosylation factor 6 (ARF6) in gastric acid secretion

scientific article

Role of Rho in rabbit parietal cell

scientific article published in December 2003

Role of apoptosis signal-regulating kinase 1 (ASK1) as an activator of the GAPDH-Siah1 stress-signaling cascade

scientific article

Role of apoptosis signal-regulating kinase 1 in stress-induced neural cell apoptosis in vivo

scientific article published on January 2006

Role of c-Jun NH2-terminal kinase in G-protein-coupled receptor agonist-induced cardiac plasminogen activator inhibitor-1 expression

scientific article

Roquin-2 promotes ubiquitin-mediated degradation of ASK1 to regulate stress responses

scientific article

SOD1 as a molecular switch for initiating the homeostatic ER stress response under zinc deficiency

scientific article published on 26 September 2013

SOD1 in neurotoxicity and its controversial roles in SOD1 mutation-negative ALS.

scientific article published on 31 October 2015

Selective activation of the p38 MAPK pathway by synthetic monophosphoryl lipid A.

scientific article

Serine 58 of 14-3-3zeta is a molecular switch regulating ASK1 and oxidant stress-induced cell death

scientific journal article

Signaling pathways from membrane lipid rafts to JNK1 activation in reactive nitrogen species-induced non-apoptotic cell death

scientific journal article

Stress signaling in cancer.

scientific article published on 23 July 2007

Stress-activated MAP kinase cascades in cellular senescence.

scientific article published on January 2009

Stress-responsive protein kinases in redox-regulated apoptosis signaling

scientific article

Survival and apoptosis signals in ER stress: the role of protein kinases.

scientific article published in September 2004

Sustained activation of the JNK cascade and rapamycin-induced apoptosis are suppressed by p53/p21(Cip1)

scientific article (publication date: June 2003)

Targeted deletion of apoptosis signal-regulating kinase 1 attenuates left ventricular remodeling

scientific article

Targeting ASK1 in ER stress-related neurodegenerative diseases.

scientific article published on June 2009

The ASK family kinases differentially mediate induction of type I interferon and apoptosis during the antiviral response

scientific article

The ASK1-MAP kinase cascades in mammalian stress response

scientific article

The ASK1-MAP kinase pathways in immune and stress responses

scientific article

The ASK1-MAP kinase signaling in ER stress and neurodegenerative diseases

scientific article

The ASK1-specific inhibitors K811 and K812 prolong survival in a mouse model of amyotrophic lateral sclerosis.

scientific article published on 24 November 2015

The Ablation of Mitochondrial Protein Phosphatase Pgam5 Confers Resistance Against Metabolic Stress

scientific article published on 29 January 2016

The CCR4-NOT deadenylase complex safeguards thymic positive selection by down-regulating aberrant pro-apoptotic gene expression

scientific article published on 02 December 2020

The DEAH-box RNA helicase DHX15 activates NF-κB and MAPK signaling downstream of MAVS during antiviral responses

scientific article published on 29 April 2014

The Kelch repeat protein KLHDC10 regulates oxidative stress-induced ASK1 activation by suppressing PP5.

scientific article

The Src/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis.

scientific article

The aspartyl protease DDI2 activates Nrf1 to compensate for proteasome dysfunction

scientific article published on 16 August 2016

The cell cycle-regulatory CDC25A phosphatase inhibits apoptosis signal-regulating kinase 1

scientific article

The cytoplasmic domain of Alzheimer's amyloid-beta protein precursor causes sustained apoptosis signal-regulating kinase 1/c-Jun NH2-terminal kinase-mediated neurotoxic signal via dimerization.

scientific article

The expression of Fn14 via mechanical stress-activated JNK contributes to apoptosis induction in osteoblasts.

scientific article published on 20 January 2014

The loss of PGAM5 suppresses the mitochondrial degeneration caused by inactivation of PINK1 in Drosophila

scientific article

The lysosome rupture-activated TAK1-JNK pathway regulates NLRP3 inflammasome activation

scientific article

The mitochondrial Ca<sup>2+</sup> uptake regulator, MICU1, is involved in cold stress-induced ferroptosis

scientific article published on 06 April 2021

The roles of ASK family proteins in stress responses and diseases

scientific article

Therapeutic targets in the ASK1-dependent stress signaling pathways

scientific article

Thioredoxin and TRAF family proteins regulate reactive oxygen species-dependent activation of ASK1 through reciprocal modulation of the N-terminal homophilic interaction of ASK1

scientific article

Thioredoxin and protein kinases in redox signaling.

scientific article published on 26 September 2006

Transforming growth factor-beta: latent forms, binding proteins and receptors

scientific article

Type 1 insulin-like growth factor receptor (IGF-IR) signaling inhibits apoptosis signal-regulating kinase 1 (ASK1)

scientific article

USP14 inhibits ER-associated degradation via interaction with IRE1alpha

scientific article

Ubiquitin-like sequence in ASK1 plays critical roles in the recognition and stabilization by USP9X and oxidative stress-induced cell death.

scientific article

Variant sublines with different metastatic potentials selected in nude mice from human oral squamous cell carcinomas

scientific article published on August 1989

[ASK family proteins in stress and disease--"how cells sense stress"].

scientific article published in February 2007

p38 MAPKs regulate the expression of genes in the dopamine synthesis pathway through phosphorylation of NR4A nuclear receptors.

scientific article published in September 2011

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