List of works - Sander M. Houten

Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation

scientific article

Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation

scientific article

Serum bile acids are higher in humans with prior gastric bypass: potential contribution to improved glucose and lipid metabolism

scientific article

A general introduction to the biochemistry of mitochondrial fatty acid β-oxidation

scientific article

Multilayered genetic and omics dissection of mitochondrial activity in a mouse reference population

scientific article

Acylcarnitines: reflecting or inflicting insulin resistance?

scientific article

The metabolic footprint of aging in mice

scientific article published on 31 October 2011

PARP-2 regulates SIRT1 expression and whole-body energy expenditure

scientific article

Lowering bile acid pool size with a synthetic farnesoid X receptor (FXR) agonist induces obesity and diabetes through reduced energy expenditure

scientific article

Acyl-CoA dehydrogenase 9 is required for the biogenesis of oxidative phosphorylation complex I

scientific article

Compromised intestinal lipid absorption in mice with a liver-specific deficiency of liver receptor homolog 1.

scientific article

Lack of isoprenoid products raises ex vivo interleukin-1beta secretion in hyperimmunoglobulinemia D and periodic fever syndrome

scientific article published on October 2002

The enzymology of mitochondrial fatty acid beta-oxidation and its application to follow-up analysis of positive neonatal screening results

scientific article published on 20 May 2010

Post-natal myogenic and adipogenic developmental: defects and metabolic impairment upon loss of A-type lamins.

scientific article

Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis

scientific article

Mitochondrial long chain fatty acid beta-oxidation in man and mouse

scientific article (publication date: August 2009)

Mitochondrial protein acetylation is driven by acetyl-CoA from fatty acid oxidation

scientific article

Poly(ADP-ribose) polymerase-2 [corrected] controls adipocyte differentiation and adipose tissue function through the regulation of the activity of the retinoid X receptor/peroxisome proliferator-activated receptor-gamma [corrected] heterodimer

scientific article

Overexpression of PLIN5 in skeletal muscle promotes oxidative gene expression and intramyocellular lipid content without compromising insulin sensitivity

scientific journal article

Increased intramyocellular lipid content but normal skeletal muscle mitochondrial oxidative capacity throughout the pathogenesis of type 2 diabetes

scientific article

Bile acid binding resin improves metabolic control through the induction of energy expenditure

scientific article

A key role for the peroxisomal ABCD2 transporter in fatty acid homeostasis.

scientific article published on 14 October 2008

Adaptive reciprocity of lipid and glucose metabolism in human short-term starvation

scientific article

Organization of the mevalonate kinase (MVK) gene and identification of novel mutations causing mevalonic aciduria and hyperimmunoglobulinaemia D and periodic fever syndrome

scientific article published on April 2001

Biochemical and genetic aspects of mevalonate kinase and its deficiency

scientific article (publication date: 15 December 2000)

Glutamine synthetase in muscle is required for glutamine production during fasting and extrahepatic ammonia detoxification.

scientific article

Critical assessment of human metabolic pathway databases: a stepping stone for future integration

scientific article

The small heterodimer partner is a gonadal gatekeeper of sexual maturation in male mice

scientific article

Aberrant protein acylation is a common observation in inborn errors of acyl-CoA metabolism

scientific article published on 15 February 2014

Pyruvate dehydrogenase kinase 4 expression is synergistically induced by AMP-activated protein kinase and fatty acids.

scientific article published in April 2009

Fasting serum taurine-conjugated bile acids are elevated in type 2 diabetes and do not change with intensification of insulin

scientific article

Carrier frequency of the V377I (1129G>A) MVK mutation, associated with Hyper-IgD and periodic fever syndrome, in the Netherlands

scientific article published on February 2003

Peroxisomal L-bifunctional enzyme (Ehhadh) is essential for the production of medium-chain dicarboxylic acids

scientific article

Peroxisomes contribute to the acylcarnitine production when the carnitine shuttle is deficient

scientific article published on 10 July 2013

Peroxisomes and bile acid biosynthesis.

scientific article published on 14 September 2006

Muscle acylcarnitines during short-term fasting in lean healthy men.

scientific article

Optimizing anesthetic regimen for surgery in mice through minimization of hemodynamic, metabolic, and inflammatory perturbations

scientific article published in June 2014

Differential effects of short- and long-term high-fat diet feeding on hepatic fatty acid metabolism in rats.

scientific article published on 19 May 2011

In VivoImaging of Farnesoid X Receptor Activity Reveals the Ileum as the Primary Bile Acid Signaling Tissue

scientific article published on 10 April 2007

Plasma acylcarnitines inadequately reflect tissue acylcarnitine metabolism

scientific article published on 18 April 2014

Carnitine palmitoyltransferase 2 and carnitine/acylcarnitine translocase are involved in the mitochondrial synthesis and export of acylcarnitines

scientific article published on 15 January 2013

Increased mitochondrial content rescues in vivo muscle oxidative capacity in long-term high-fat-diet-fed rats.

scientific article published on 29 December 2009

SUMOylation-dependent LRH-1/PROX1 interaction promotes atherosclerosis by decreasing hepatic reverse cholesterol transport

scientific article

Regulation of isoprenoid/cholesterol biosynthesis in cells from mevalonate kinase-deficient patients

scientific article published on 10 December 2002

Impaired amino acid metabolism contributes to fasting-induced hypoglycemia in fatty acid oxidation defects

scientific article published on 9 August 2013

A cholesterol-free, high-fat diet suppresses gene expression of cholesterol transporters in murine small intestine.

scientific article

Fasting-induced myocardial lipid accumulation in long-chain acyl-CoA dehydrogenase knockout mice is accompanied by impaired left ventricular function

scientific article (publication date: September 2011)

Hyper IgD syndrome (HIDS) associated with in vitro evidence of defective monocyte TNFRSF1A shedding and partial response to TNF receptor blockade with etanercept

scientific article published on December 2002

Genetic basis of hyperlysinemia

scientific article published in 2013

Biochemical competition makes fatty-acid β-oxidation vulnerable to substrate overload

scientific article (publication date: 2013)

List of works by Sander M. Houten

Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation

Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation

Serum bile acids are higher in humans with prior gastric bypass: potential contribution to improved glucose and lipid metabolism

A general introduction to the biochemistry of mitochondrial fatty acid β-oxidation

Multilayered genetic and omics dissection of mitochondrial activity in a mouse reference population

Acylcarnitines: reflecting or inflicting insulin resistance?

The metabolic footprint of aging in mice

PARP-2 regulates SIRT1 expression and whole-body energy expenditure

Lowering bile acid pool size with a synthetic farnesoid X receptor (FXR) agonist induces obesity and diabetes through reduced energy expenditure

Acyl-CoA dehydrogenase 9 is required for the biogenesis of oxidative phosphorylation complex I

Compromised intestinal lipid absorption in mice with a liver-specific deficiency of liver receptor homolog 1.

Lack of isoprenoid products raises ex vivo interleukin-1beta secretion in hyperimmunoglobulinemia D and periodic fever syndrome

The enzymology of mitochondrial fatty acid beta-oxidation and its application to follow-up analysis of positive neonatal screening results

Post-natal myogenic and adipogenic developmental: defects and metabolic impairment upon loss of A-type lamins.

Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis

Mitochondrial long chain fatty acid beta-oxidation in man and mouse

Mitochondrial protein acetylation is driven by acetyl-CoA from fatty acid oxidation

Poly(ADP-ribose) polymerase-2 [corrected] controls adipocyte differentiation and adipose tissue function through the regulation of the activity of the retinoid X receptor/peroxisome proliferator-activated receptor-gamma [corrected] heterodimer

Overexpression of PLIN5 in skeletal muscle promotes oxidative gene expression and intramyocellular lipid content without compromising insulin sensitivity

Increased intramyocellular lipid content but normal skeletal muscle mitochondrial oxidative capacity throughout the pathogenesis of type 2 diabetes

Bile acid binding resin improves metabolic control through the induction of energy expenditure

A key role for the peroxisomal ABCD2 transporter in fatty acid homeostasis.

Adaptive reciprocity of lipid and glucose metabolism in human short-term starvation

Organization of the mevalonate kinase (MVK) gene and identification of novel mutations causing mevalonic aciduria and hyperimmunoglobulinaemia D and periodic fever syndrome

Biochemical and genetic aspects of mevalonate kinase and its deficiency

Glutamine synthetase in muscle is required for glutamine production during fasting and extrahepatic ammonia detoxification.

Critical assessment of human metabolic pathway databases: a stepping stone for future integration

The small heterodimer partner is a gonadal gatekeeper of sexual maturation in male mice

Aberrant protein acylation is a common observation in inborn errors of acyl-CoA metabolism

Pyruvate dehydrogenase kinase 4 expression is synergistically induced by AMP-activated protein kinase and fatty acids.

Fasting serum taurine-conjugated bile acids are elevated in type 2 diabetes and do not change with intensification of insulin

Carrier frequency of the V377I (1129G>A) MVK mutation, associated with Hyper-IgD and periodic fever syndrome, in the Netherlands

Peroxisomal L-bifunctional enzyme (Ehhadh) is essential for the production of medium-chain dicarboxylic acids

Peroxisomes contribute to the acylcarnitine production when the carnitine shuttle is deficient

Peroxisomes and bile acid biosynthesis.

Muscle acylcarnitines during short-term fasting in lean healthy men.

Optimizing anesthetic regimen for surgery in mice through minimization of hemodynamic, metabolic, and inflammatory perturbations

Differential effects of short- and long-term high-fat diet feeding on hepatic fatty acid metabolism in rats.

In VivoImaging of Farnesoid X Receptor Activity Reveals the Ileum as the Primary Bile Acid Signaling Tissue

Plasma acylcarnitines inadequately reflect tissue acylcarnitine metabolism

Carnitine palmitoyltransferase 2 and carnitine/acylcarnitine translocase are involved in the mitochondrial synthesis and export of acylcarnitines

Increased mitochondrial content rescues in vivo muscle oxidative capacity in long-term high-fat-diet-fed rats.

SUMOylation-dependent LRH-1/PROX1 interaction promotes atherosclerosis by decreasing hepatic reverse cholesterol transport

Regulation of isoprenoid/cholesterol biosynthesis in cells from mevalonate kinase-deficient patients

Impaired amino acid metabolism contributes to fasting-induced hypoglycemia in fatty acid oxidation defects

A cholesterol-free, high-fat diet suppresses gene expression of cholesterol transporters in murine small intestine.

Fasting-induced myocardial lipid accumulation in long-chain acyl-CoA dehydrogenase knockout mice is accompanied by impaired left ventricular function

Hyper IgD syndrome (HIDS) associated with in vitro evidence of defective monocyte TNFRSF1A shedding and partial response to TNF receptor blockade with etanercept

Genetic basis of hyperlysinemia

Biochemical competition makes fatty-acid β-oxidation vulnerable to substrate overload