List of works - Sander M. Houten

A Diet Rich in Unsaturated Fatty Acids Prevents Progression Toward Heart Failure in a Rabbit Model of Pressure and Volume Overload

scientific article published on 02 April 2012

A cholesterol-free, high-fat diet suppresses gene expression of cholesterol transporters in murine small intestine.

scientific article

A general introduction to the biochemistry of mitochondrial fatty acid β-oxidation

scientific article

A key role for the peroxisomal ABCD2 transporter in fatty acid homeostasis.

scientific article published on 14 October 2008

A liver revival featuring bile acids

scientific article published on 19 December 2006

A mitochondrial expatriate: nuclear pyruvate dehydrogenase

scientific article published on 01 July 2014

A mitochondrial long-chain fatty acid oxidation defect leads to transfer RNA uncharging and activation of the integrated stress response in the mouse heart

scientific article published in 2022

ACAD9, a complex I assembly factor with a moonlighting function in fatty acid oxidation deficiencies

scientific article published on 24 October 2013

Aberrant protein acylation is a common observation in inborn errors of acyl-CoA metabolism

scientific article published on 15 February 2014

Acyl-CoA dehydrogenase 9 is required for the biogenesis of oxidative phosphorylation complex I

scientific article

Acylcarnitines: reflecting or inflicting insulin resistance?

scientific article

Adaptive reciprocity of lipid and glucose metabolism in human short-term starvation

scientific article

Assessment of plasma acylcarnitines before and after weight loss in obese subjects.

scientific article

Bezafibrate lowers very long‐chain fatty acids in X‐linked adrenoleukodystrophy fibroblasts by inhibiting fatty acid elongation ⬇️

scientific article published on March 24, 2012

Bile acid binding resin improves metabolic control through the induction of energy expenditure

scientific article

Bile acids alter male fertility through G-protein-coupled bile acid receptor 1 signaling pathways in mice

scientific article published on September 2014

Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation

scientific article

Biochemical and genetic aspects of mevalonate kinase and its deficiency

scientific article (publication date: 15 December 2000)

Biochemical competition makes fatty-acid β-oxidation vulnerable to substrate overload

scientific article (publication date: 2013)

Carnitine palmitoyltransferase 2 and carnitine/acylcarnitine translocase are involved in the mitochondrial synthesis and export of acylcarnitines

scientific article published on 15 January 2013

Carnitine supplementation attenuates myocardial lipid accumulation in long-chain acyl-CoA dehydrogenase knockout mice

scientific article

Carnitine supplementation in high-fat diet-fed rats does not ameliorate lipid-induced skeletal muscle mitochondrial dysfunction in vivo.

scientific article published on 18 August 2015

Carrier frequency of the V377I (1129G>A) MVK mutation, associated with Hyper-IgD and periodic fever syndrome, in the Netherlands

scientific article published on February 2003

Changes in the Metabolome in Response to Low-Dose Exposure to Environmental Chemicals Used in Personal Care Products during Different Windows of Susceptibility

scientific article

Characterization of D-3-hydroxybutyrylcarnitine (ketocarnitine): an identified ketosis-induced metabolite

scientific article published on 29 December 2011

Characterization of L-aminocarnitine, an inhibitor of fatty acid oxidation

scientific article published on 20 February 2008

Cholesterol-induced hepatic inflammation does not underlie the predisposition to insulin resistance in dyslipidemic female LDL receptor knockout mice

scientific article

Compromised intestinal lipid absorption in mice with a liver-specific deficiency of liver receptor homolog 1.

scientific article

Critical assessment of human metabolic pathway databases: a stepping stone for future integration

scientific article

Deficiency of the Mitochondrial NAD Kinase Causes Stress-induced Hepatic Steatosis in Mice.

scientific article

Deletion of 2-aminoadipic semialdehyde synthase limits metabolite accumulation in cell and mouse models for glutaric aciduria type 1

scientific article published on 21 June 2020

Differential effects of short- and long-term high-fat diet feeding on hepatic fatty acid metabolism in rats.

scientific article published on 19 May 2011

Effect of statins on the viability of macrophages and smooth muscle cells

scientific article

Effects of insulin on ketogenesis following fasting in lean and obese men.

scientific article

Fasting serum taurine-conjugated bile acids are elevated in type 2 diabetes and do not change with intensification of insulin

scientific article

Fasting-induced myocardial lipid accumulation in long-chain acyl-CoA dehydrogenase knockout mice is accompanied by impaired left ventricular function

scientific article (publication date: September 2011)

Fiber-type-specific sensitivities and phenotypic adaptations to dietary fat overload differentially impact fast- versus slow-twitch muscle contractile function in C57BL/6J mice.

scientific article published on 25 October 2014

Food withdrawal lowers energy expenditure and induces inactivity in long-chain fatty acid oxidation-deficient mouse models

scientific article (publication date: July 2014)

Functional redundancy of mitochondrial enoyl-CoA isomerases in the oxidation of unsaturated fatty acids.

scientific article

Genetic basis of hyperlysinemia

scientific article published in 2013

Glutamine synthetase in muscle is required for glutamine production during fasting and extrahepatic ammonia detoxification.

scientific article

High-protein diets prevent steatosis and induce hepatic accumulation of monomethyl branched-chain fatty acids.

scientific article published on 16 September 2014

Homing in on bile acid physiology.

scientific article published on December 2006

Hyper IgD syndrome (HIDS) associated with in vitro evidence of defective monocyte TNFRSF1A shedding and partial response to TNF receptor blockade with etanercept

scientific article published on December 2002

Identification and characterization of Eci3, a murine kidney-specific Δ3,Δ2-enoyl-CoA isomerase

scientific journal article

Identification and characterization of three novel missense mutations in mevalonate kinase cDNA causing mevalonic aciduria, a disorder of isoprene biosynthesis

scientific article published in August 1999

Impaired amino acid metabolism contributes to fasting-induced hypoglycemia in fatty acid oxidation defects

scientific article published on 9 August 2013

Improving the description of metabolic networks: the TCA cycle as example.

scientific article published on June 2012

In VivoImaging of Farnesoid X Receptor Activity Reveals the Ileum as the Primary Bile Acid Signaling Tissue

scientific article published on 10 April 2007

In vivo mouse myocardial (31)P MRS using three-dimensional image-selected in vivo spectroscopy (3D ISIS): technical considerations and biochemical validations.

scientific article

In vivo proton T1 relaxation times of mouse myocardial metabolites at 9.4 T.

scientific article

Increased intramyocellular lipid content but normal skeletal muscle mitochondrial oxidative capacity throughout the pathogenesis of type 2 diabetes

scientific article

Increased mitochondrial content rescues in vivo muscle oxidative capacity in long-term high-fat-diet-fed rats.

scientific article published on 29 December 2009

Inhibition and Crystal Structure of the Human DHTKD1-Thiamin Diphosphate Complex

scientific article published on 09 July 2020

Lack of isoprenoid products raises ex vivo interleukin-1beta secretion in hyperimmunoglobulinemia D and periodic fever syndrome

scientific article published on October 2002

Lowering bile acid pool size with a synthetic farnesoid X receptor (FXR) agonist induces obesity and diabetes through reduced energy expenditure

scientific article

Manipulation of isoprenoid biosynthesis as a possible therapeutic option in mevalonate kinase deficiency

scientific article published on July 2006

Metabolomics: unraveling the chemical individuality of common human diseases

scientific article published on January 2009

Mevalonic aciduria in 12 unrelated patients with hyperimmunoglobulinaemia D and periodic fever syndrome

scientific article published on June 2000

Mitochondrial NADP(H) deficiency due to a mutation in NADK2 causes dienoyl-CoA reductase deficiency with hyperlysinemia

scientific article

Mitochondrial long chain fatty acid beta-oxidation in man and mouse

scientific article (publication date: August 2009)

Mitochondrial protein acetylation is driven by acetyl-CoA from fatty acid oxidation

scientific article

Molecular basis of classical mevalonic aciduria and the hyperimmunoglobulinaemia D and periodic fever syndrome: high frequency of 3 mutations in the mevalonate kinase gene

scientific article published on June 2000

Multilayered genetic and omics dissection of mitochondrial activity in a mouse reference population

scientific article

Muscle MRI in patients with long-chain fatty acid oxidation disorders

scientific article

Muscle acylcarnitines during short-term fasting in lean healthy men.

scientific article

Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis

scientific article

Myocardial energy shortage and unmet anaplerotic needs in the fasted long-chain acyl-CoA dehydrogenase knockout mouse

scientific article

New driver for lipid synthesis

scientific article published on 01 November 2011

Nonorthologous gene displacement of phosphomevalonate kinase.

scientific article

Novel, compound heterozygous, single-nucleotide variants in MARS2 associated with developmental delay, poor growth, and sensorineural hearing loss

scientific article

Optimizing anesthetic regimen for surgery in mice through minimization of hemodynamic, metabolic, and inflammatory perturbations

scientific article published in June 2014

Organization of the mevalonate kinase (MVK) gene and identification of novel mutations causing mevalonic aciduria and hyperimmunoglobulinaemia D and periodic fever syndrome

scientific article published on April 2001

Overexpression of PLIN5 in skeletal muscle promotes oxidative gene expression and intramyocellular lipid content without compromising insulin sensitivity

scientific journal article

PARP-2 regulates SIRT1 expression and whole-body energy expenditure

scientific article

Peroxisomal L-bifunctional enzyme (Ehhadh) is essential for the production of medium-chain dicarboxylic acids

scientific article

Peroxisomal L-bifunctional protein (EHHADH) deficiency causes male-specific kidney hypertrophy and proximal tubular injury in mice

scientific article published on 30 September 2021

Peroxisomes and bile acid biosynthesis.

scientific article published on 14 September 2006

Peroxisomes contribute to the acylcarnitine production when the carnitine shuttle is deficient

scientific article published on 10 July 2013

Pioglitazone treatment restores in vivo muscle oxidative capacity in a rat model of diabetes.

scientific article

Plasma acylcarnitines inadequately reflect tissue acylcarnitine metabolism

scientific article published on 18 April 2014

Poly(ADP-ribose) polymerase-2 [corrected] controls adipocyte differentiation and adipose tissue function through the regulation of the activity of the retinoid X receptor/peroxisome proliferator-activated receptor-gamma [corrected] heterodimer

scientific article

Post-natal myogenic and adipogenic developmental: defects and metabolic impairment upon loss of A-type lamins.

scientific article

Prevention and reversal of hepatic steatosis with a high-protein diet in mice.

scientific article

Pyruvate dehydrogenase kinase 4 expression is synergistically induced by AMP-activated protein kinase and fatty acids.

scientific article published in April 2009

Regulation of isoprenoid/cholesterol biosynthesis in cells from mevalonate kinase-deficient patients

scientific article published on 10 December 2002

Role of medium- and short-chain L-3-hydroxyacyl-CoA dehydrogenase in the regulation of body weight and thermogenesis.

scientific article published on 11 October 2011

SUMOylation-dependent LRH-1/PROX1 interaction promotes atherosclerosis by decreasing hepatic reverse cholesterol transport

scientific article

Saccharopine, a lysine degradation intermediate, is a mitochondrial toxin

scientific article published on 16 January 2019

Serum bile acids are higher in humans with prior gastric bypass: potential contribution to improved glucose and lipid metabolism

scientific article

Slc22a5 haploinsufficiency does not aggravate the phenotype of the long-chain acyl-CoA dehydrogenase KO mouse

scientific article published on 17 December 2019

Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation

scientific article

Structure-function analyses of the G729R 2-oxoadipate dehydrogenase genetic variant associated with L-lysine metabolism disorder

scientific article published on 17 April 2020

Substrate specificity of human carnitine acetyltransferase: Implications for fatty acid and branched-chain amino acid metabolism.

scientific article

The Effects of Long- or Medium-Chain Fat Diets on Glucose Tolerance and Myocellular Content of Lipid Intermediates in Rats

scientific article published on 01 July 2010

The enzymology of mitochondrial fatty acid beta-oxidation and its application to follow-up analysis of positive neonatal screening results

scientific article published on 20 May 2010

The glucosylceramide synthase inhibitor N-(5-adamantane-1-yl-methoxy-pentyl)-deoxynojirimycin induces sterol regulatory element-binding protein-regulated gene expression and cholesterol synthesis in HepG2 cells.

scientific article

The impact of altered carnitine availability on acylcarnitine metabolism, energy expenditure and glucose tolerance in diet-induced obese mice.

scientific article

The metabolic footprint of aging in mice

scientific article published on 31 October 2011

The small heterodimer partner is a gonadal gatekeeper of sexual maturation in male mice

scientific article

Transorgan fluxes in a porcine model reveal a central role for liver in acylcarnitine metabolism

scientific article published on 2 June 2015

Treatment of genetically obese mice with the iminosugar N-(5-adamantane-1-yl-methoxy-pentyl)-deoxynojirimycin reduces body weight by decreasing food intake and increasing fat oxidation

scientific article published on 3 August 2011

List of works by Sander M. Houten

A Diet Rich in Unsaturated Fatty Acids Prevents Progression Toward Heart Failure in a Rabbit Model of Pressure and Volume Overload

A cholesterol-free, high-fat diet suppresses gene expression of cholesterol transporters in murine small intestine.

A general introduction to the biochemistry of mitochondrial fatty acid β-oxidation

A key role for the peroxisomal ABCD2 transporter in fatty acid homeostasis.

A liver revival featuring bile acids

A mitochondrial expatriate: nuclear pyruvate dehydrogenase

A mitochondrial long-chain fatty acid oxidation defect leads to transfer RNA uncharging and activation of the integrated stress response in the mouse heart

ACAD9, a complex I assembly factor with a moonlighting function in fatty acid oxidation deficiencies

Aberrant protein acylation is a common observation in inborn errors of acyl-CoA metabolism

Acyl-CoA dehydrogenase 9 is required for the biogenesis of oxidative phosphorylation complex I

Acylcarnitines: reflecting or inflicting insulin resistance?

Adaptive reciprocity of lipid and glucose metabolism in human short-term starvation

Assessment of plasma acylcarnitines before and after weight loss in obese subjects.

Bezafibrate lowers very long‐chain fatty acids in X‐linked adrenoleukodystrophy fibroblasts by inhibiting fatty acid elongation ⬇️

Bile acid binding resin improves metabolic control through the induction of energy expenditure

Bile acids alter male fertility through G-protein-coupled bile acid receptor 1 signaling pathways in mice

Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation

Biochemical and genetic aspects of mevalonate kinase and its deficiency

Biochemical competition makes fatty-acid β-oxidation vulnerable to substrate overload

Carnitine palmitoyltransferase 2 and carnitine/acylcarnitine translocase are involved in the mitochondrial synthesis and export of acylcarnitines

Carnitine supplementation attenuates myocardial lipid accumulation in long-chain acyl-CoA dehydrogenase knockout mice

Carnitine supplementation in high-fat diet-fed rats does not ameliorate lipid-induced skeletal muscle mitochondrial dysfunction in vivo.

Carrier frequency of the V377I (1129G>A) MVK mutation, associated with Hyper-IgD and periodic fever syndrome, in the Netherlands

Changes in the Metabolome in Response to Low-Dose Exposure to Environmental Chemicals Used in Personal Care Products during Different Windows of Susceptibility

Characterization of D-3-hydroxybutyrylcarnitine (ketocarnitine): an identified ketosis-induced metabolite

Characterization of L-aminocarnitine, an inhibitor of fatty acid oxidation

Cholesterol-induced hepatic inflammation does not underlie the predisposition to insulin resistance in dyslipidemic female LDL receptor knockout mice

Compromised intestinal lipid absorption in mice with a liver-specific deficiency of liver receptor homolog 1.

Critical assessment of human metabolic pathway databases: a stepping stone for future integration

Deficiency of the Mitochondrial NAD Kinase Causes Stress-induced Hepatic Steatosis in Mice.

Deletion of 2-aminoadipic semialdehyde synthase limits metabolite accumulation in cell and mouse models for glutaric aciduria type 1

Differential effects of short- and long-term high-fat diet feeding on hepatic fatty acid metabolism in rats.

Effect of statins on the viability of macrophages and smooth muscle cells

Effects of insulin on ketogenesis following fasting in lean and obese men.

Fasting serum taurine-conjugated bile acids are elevated in type 2 diabetes and do not change with intensification of insulin

Fasting-induced myocardial lipid accumulation in long-chain acyl-CoA dehydrogenase knockout mice is accompanied by impaired left ventricular function

Fiber-type-specific sensitivities and phenotypic adaptations to dietary fat overload differentially impact fast- versus slow-twitch muscle contractile function in C57BL/6J mice.

Food withdrawal lowers energy expenditure and induces inactivity in long-chain fatty acid oxidation-deficient mouse models

Functional redundancy of mitochondrial enoyl-CoA isomerases in the oxidation of unsaturated fatty acids.

Genetic basis of hyperlysinemia

Glutamine synthetase in muscle is required for glutamine production during fasting and extrahepatic ammonia detoxification.

High-protein diets prevent steatosis and induce hepatic accumulation of monomethyl branched-chain fatty acids.

Homing in on bile acid physiology.

Hyper IgD syndrome (HIDS) associated with in vitro evidence of defective monocyte TNFRSF1A shedding and partial response to TNF receptor blockade with etanercept

Identification and characterization of Eci3, a murine kidney-specific Δ3,Δ2-enoyl-CoA isomerase

Identification and characterization of three novel missense mutations in mevalonate kinase cDNA causing mevalonic aciduria, a disorder of isoprene biosynthesis

Impaired amino acid metabolism contributes to fasting-induced hypoglycemia in fatty acid oxidation defects

Improving the description of metabolic networks: the TCA cycle as example.

In VivoImaging of Farnesoid X Receptor Activity Reveals the Ileum as the Primary Bile Acid Signaling Tissue

In vivo mouse myocardial (31)P MRS using three-dimensional image-selected in vivo spectroscopy (3D ISIS): technical considerations and biochemical validations.

In vivo proton T1 relaxation times of mouse myocardial metabolites at 9.4 T.

Increased intramyocellular lipid content but normal skeletal muscle mitochondrial oxidative capacity throughout the pathogenesis of type 2 diabetes

Increased mitochondrial content rescues in vivo muscle oxidative capacity in long-term high-fat-diet-fed rats.

Inhibition and Crystal Structure of the Human DHTKD1-Thiamin Diphosphate Complex

Lack of isoprenoid products raises ex vivo interleukin-1beta secretion in hyperimmunoglobulinemia D and periodic fever syndrome

Lowering bile acid pool size with a synthetic farnesoid X receptor (FXR) agonist induces obesity and diabetes through reduced energy expenditure

Manipulation of isoprenoid biosynthesis as a possible therapeutic option in mevalonate kinase deficiency

Metabolomics: unraveling the chemical individuality of common human diseases

Mevalonic aciduria in 12 unrelated patients with hyperimmunoglobulinaemia D and periodic fever syndrome

Mitochondrial NADP(H) deficiency due to a mutation in NADK2 causes dienoyl-CoA reductase deficiency with hyperlysinemia

Mitochondrial long chain fatty acid beta-oxidation in man and mouse

Mitochondrial protein acetylation is driven by acetyl-CoA from fatty acid oxidation

Molecular basis of classical mevalonic aciduria and the hyperimmunoglobulinaemia D and periodic fever syndrome: high frequency of 3 mutations in the mevalonate kinase gene

Multilayered genetic and omics dissection of mitochondrial activity in a mouse reference population

Muscle MRI in patients with long-chain fatty acid oxidation disorders

Muscle acylcarnitines during short-term fasting in lean healthy men.

Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis

Myocardial energy shortage and unmet anaplerotic needs in the fasted long-chain acyl-CoA dehydrogenase knockout mouse

New driver for lipid synthesis

Nonorthologous gene displacement of phosphomevalonate kinase.

Novel, compound heterozygous, single-nucleotide variants in MARS2 associated with developmental delay, poor growth, and sensorineural hearing loss

Optimizing anesthetic regimen for surgery in mice through minimization of hemodynamic, metabolic, and inflammatory perturbations

Organization of the mevalonate kinase (MVK) gene and identification of novel mutations causing mevalonic aciduria and hyperimmunoglobulinaemia D and periodic fever syndrome

Overexpression of PLIN5 in skeletal muscle promotes oxidative gene expression and intramyocellular lipid content without compromising insulin sensitivity

PARP-2 regulates SIRT1 expression and whole-body energy expenditure

Peroxisomal L-bifunctional enzyme (Ehhadh) is essential for the production of medium-chain dicarboxylic acids

Peroxisomal L-bifunctional protein (EHHADH) deficiency causes male-specific kidney hypertrophy and proximal tubular injury in mice

Peroxisomes and bile acid biosynthesis.

Peroxisomes contribute to the acylcarnitine production when the carnitine shuttle is deficient