List of works by Nigel Mark Hooper

A Greek Tragedy: The Growing Complexity of Alzheimer Amyloid Precursor Protein Proteolysis

scientific article

A Mutation in Aminopeptidase N (CD13) Isolated from a Patient Suffering from Leukemia Leads to an Arrest in the Endoplasmic Reticulum

scientific article published in Journal of Biological Chemistry

A Preliminary Evaluation of the Pro-Chondrogenic Potential of 3D-Bioprinted Poly(ester Urea) Scaffolds

scientific article published on 30 June 2020

A broad-spectrum fluorescence-based peptide library for the rapid identification of protease substrates

scientific article

A continuous fluorometric assay for leukotriene D4 hydrolase.

scientific article published in March 1999

A functional XPNPEP2 promoter haplotype leads to reduced plasma aminopeptidase P and increased risk of ACE inhibitor-induced angioedema.

scientific article published on 12 September 2011

A label-free electrical impedimetric biosensor for the specific detection of Alzheimer's amyloid-beta oligomers

scientific article published on 24 December 2013

A new take on prions: preventing Alzheimer's disease

scientific article published on 17 March 2008

A point mutation in the juxtamembrane stalk of human angiotensin I-converting enzyme invokes the action of a distinct secretase

scientific article published on 23 March 2001

A step-by-step translation of evidence into a psychosocial intervention for everyday activities in dementia: a focus group study

scientific article published on 12 December 2016

ACE2: from vasopeptidase to SARS virus receptor ⬇️

scientific article

ACEH/ACE2 is a novel mammalian metallocarboxypeptidase and a homologue of angiotensin-converting enzyme insensitive to ACE inhibitors

scientific article (publication date: April 2002)

ADAMs family members as amyloid precursor protein alpha-secretases

scientific article published on November 2003

Ablation of Prion Protein in Wild Type Human Amyloid Precursor Protein (APP) Transgenic Mice Does Not Alter The Proteolysis of APP, Levels of Amyloid-β or Pathologic Phenotype

scientific article published on 22 July 2016

Ablation of the metal ion-induced endocytosis of the prion protein by disease-associated mutation of the octarepeat region

scientific article published in April 2001

Alkaline phosphatase is increased in both brain and plasma in Alzheimer's disease.

scientific article published on 20 October 2011

Alzheimer's amyloid precursor protein alpha-secretase is inhibited by hydroxamic acid-based zinc metalloprotease inhibitors: similarities to the angiotensin converting enzyme secretase

scientific article published on February 1998

Amyloid precursor protein, although partially detergent-insoluble in mouse cerebral cortex, behaves as an atypical lipid raft protein

scientific article published on November 1999

Amyloid β synaptotoxicity is Wnt-PCP dependent and blocked by fasudil. ⬇️

scientific article

Amyloid-β Receptors: The Good, the Bad, and the Prion Protein

scientific article

An ACE structure

scientific article published on 01 March 2003

Angiotensin Converting Enzyme-2 (ACE2) and its Possible Roles in Hypertension, Diabetes and Cardiac Function

scientific article published on 01 January 2003

Angiotensin I-Converting Enzyme (ACE)

Angiotensin converting enzyme-2 (ACE2) and its possible roles in hypertension, diabetes and cardiac function

scientific article published on 01 January 2003

Angiotensin converting enzyme: Implications from molecular biology for its physiological functions ⬇️

scientific article published on January 1, 1991

Angiotensin-Converting Enzyme-2

Angiotensin-Converting Enzyme-2 (ACE2)

article from 2007

Angiotensin-converting enzyme 2

article from 2004

Angiotensin-converting enzyme 2 (ACE2), but not ACE, is preferentially localized to the apical surface of polarized kidney cells

scientific article published on 15 September 2005

Angiotensin-converting enzyme 2 and new insights into the renin-angiotensin system

scientific article published on 17 August 2007

Angiotensin-converting enzyme 2 is subject to post-transcriptional regulation by miR-421.

scientific article published in August 2014

Angiotensin-converting enzyme as a GPIase: a critical reevaluation

scientific article published in November 2005

Angiotensin-converting enzyme-2 (ACE2): comparative modeling of the active site, specificity requirements, and chloride dependence

scientific article published in November 2003

Antibody-mediated disruption of the interaction between PCSK9 and the low-density lipoprotein receptor

scientific article

Assigning functions to distinct regions of the N-terminus of the prion protein that are involved in its copper-stimulated, clathrin-dependent endocytosis

scientific article

Association of a GPI-anchored protein with detergent-resistant membranes facilitates its trafficking through the early secretory pathway

scientific article

Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

scientific article published on 01 September 2019

Author Correction: Proteolysis of the low density lipoprotein receptor by bone morphogenetic protein-1 regulates cellular cholesterol uptake

scientific article published on 11 February 2020

BIN1 is decreased in sporadic but not familial Alzheimer's disease or in aging ⬇️

scientific article

Blended alginate/collagen hydrogels promote neurogenesis and neuronal maturation

scientific article published on 18 June 2019

Calmodulin interacts with angiotensin-converting enzyme-2 (ACE2) and inhibits shedding of its ectodomain

scientific article published on 10 December 2007

Cellular prion protein expression is not regulated by the Alzheimer's amyloid precursor protein intracellular domain

scientific article

Cellular prion protein protects against reactive-oxygen-species-induced DNA damage

scientific article published on 13 June 2007

Cellular prion protein regulates beta-secretase cleavage of the Alzheimer's amyloid precursor protein

scientific article published on 15 June 2007

Changes of angiotensin-converting enzyme activity in the pancreas of chronic hypoxia and acute pancreatitis

scientific article published in June 2003

Characterization of a 150 kDa accessory receptor for TGF-beta 1 on keratinocytes: direct evidence for a GPI anchor and ligand binding of the released form

scientific article

Characterization of an antibody to the cross-reacting determinant of the glycosyl-phosphatidylinositol anchor of human membrane dipeptidase

scientific article

Characterization of detergent-insoluble complexes containing the familial Alzheimer's disease-associated presenilins

scientific article published in April 1999

Characterization of neuronal and endothelial forms of angiotensin converting enzyme in pig brain

scientific article

Circulating activities of angiotensin-converting enzyme, its homolog, angiotensin-converting enzyme 2, and neprilysin in a family study.

scientific article published on 25 September 2006

Cleavage of Alzheimer's amyloid precursor protein by alpha-secretase occurs at the surface of neuronal cells

scientific article published on July 1999

Cloning, expression, and characterization of human cytosolic aminopeptidase P: a single manganese(II)-dependent enzyme

scientific article

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

scientific article (publication date: May 2011)

Contamination of nuclear fractions with plasma membrane lipid rafts.

scientific article published on April 2007

Could inhibition of the proteasome cause mad cow disease?

scientific article published in April 2003

Detergent-insoluble glycosphingolipid/cholesterol-rich membrane domains, lipid rafts and caveolae (review).

scientific article

Determination of glycosyl-phosphatidylinositol membrane protein anchorage

scholarly article by Nigel Mark Hooper published in June 2001

Determination of mammalian membrane protein anchorage: Glycosyl-phosphatidylinositol (G-PI) or transmembrane polypeptide anchor

Development and Application of a Fluorometric Assay for Mammalian Membrane Dipeptidase

article

Directed mutagenesis of pig renal membrane dipeptidase. His219 is critical but the DHXXH motif is not essential for zinc binding or catalytic activity.

scientific article published in July 1994

Discovery and characterization of ACE2 - a 20-year journey of surprises from vasopeptidase to COVID-19

scientific article published on 01 September 2020

Discovery of biphenylacetamide-derived inhibitors of BACE1 using de novo structure-based molecular design. ⬇️

scientific article

Discovery of novel non-peptide inhibitors of BACE-1 using virtual high-throughput screening

scientific article published on 2 October 2009

Distance of sequons to the C-terminus influences the cellular N-glycosylation of the prion protein

scientific article published on February 2003

Dual mechanisms for shedding of the cellular prion protein

scientific article published on 7 January 2004

Ectodomain shedding of cystinyl aminopeptidase from human placental membranes

scientific article published in January 2002

Ectoenzymes of the kidney microvillar membrane Aminopeptidase P is anchored by a glycosyl-phosphatidylinositol moiety

scientific article published on 01 March 1988

Effect of hydrophobic mismatch on phase behavior of lipid membranes

scientific article

Effects of Alterations of Post-Mortem Delay and Other Tissue-Collection Variables on Metabolite Levels in Human and Rat Brain

scientific article published on 29 October 2020

Elevation of brain glucose and polyol-pathway intermediates with accompanying brain-copper deficiency in patients with Alzheimer's disease: metabolic basis for dementia.

scientific article published on 09 June 2016

Emerging and potential therapies for Alzheimer's disease

scholarly article by Heledd H Griffiths et al published 15 May 2008 in Expert Opinion on Therapeutic Targets

Emerging therapeutics for Alzheimer's disease

scientific article

Endopeptidase-24.11 is striosomally ordered in pig brain and, in contrast to aminopeptidase N and peptidyl dipeptidase A ('angiotensin converting enzyme'), is a marker for a set of striatal efferent fibres

scientific article published on December 1988

Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism

scientific article

Evidence that levels of nine essential metals in post-mortem human-Alzheimer's-brain and ex vivo rat-brain tissues are unaffected by differences in post-mortem delay, age, disease staging, and brain bank location

scientific article published on 06 May 2020

Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition up-regulates beta-site processing of the amyloid precursor protein

scientific article

Extracellular Vesicles Isolated from Human Induced Pluripotent Stem Cell-Derived Neurons Contain a Transcriptional Network

scientific article published on 02 May 2020

Families of zinc metalloproteases.

scientific article

Foreword: lipid rafts/biophysics, cell signalling, trafficking and processing.

scientific article published in January 2006

Gene Ontology Curation of Neuroinflammation Biology Improves the Interpretation of Alzheimer's Disease Gene Expression Data

scientific article published on 13 May 2020

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

scientific article published on 28 February 2019

Glycosyl-phosphatidylinositol (GPI)-anchored renal dipeptidase is released by a phospholipase C in vivo

scientific article published on January 2002

Glycosyl-phosphatidylinositol anchored membrane enzymes.

scientific article published in October 1997

Glycosylation and GPI anchorage of the prion protein.

scientific article published in January 2005

Glycosylation efficiency of Asn-Xaa-Thr sequons is independent of distance from the C-terminus in membrane dipeptidase

scientific article published on 28 May 2003

Glypican-1 mediates both prion protein lipid raft association and disease isoform formation

scientific article published in November 2009

Glypican‐1 facilitates prion conversion in lipid rafts ⬇️

scientific article published on March 1, 2011

Heme oxygenase-1 protects against Alzheimer's amyloid-β(1-42)-induced toxicity via carbon monoxide production ⬇️

scientific article published on 11 December 2014

Identification and characterisation of the angiotensin converting enzyme-3 (ACE3) gene: a novel mammalian homologue of ACE.

scientific article

Identification and validation of novel CSF biomarkers for early stages of Alzheimer's disease

article

Identification of critical active-site residues in angiotensin-converting enzyme-2 (ACE2) by site-directed mutagenesis

scientific article published on July 2005

Identification of critical residues in the active site of porcine membrane-bound aminopeptidase P.

scientific article published in December 2000

Improving the Gene Ontology Resource to Facilitate More Informative Analysis and Interpretation of Alzheimer’s Disease Data

article

In vitro cytocidal effects on Trypanosoma brucei and inhibition of Leishmania major GP63 by peptidomimetic metalloprotease inhibitors

scientific article published on 01 April 2001

Increased circulating insulin-like growth factor-1 in late-onset Alzheimer's disease. ⬇️

scientific article published in December 2007

Inhibition of aminopeptidases N, A and W

article

Isolation and characterization of glycosylphosphatidylinositol-anchored peptides by hydrophilic interaction chromatography and MALDI tandem mass spectrometry

scientific article

Ligand-stimulated VEGFR2 signaling is regulated by co-ordinated trafficking and proteolysis.

scientific article published on January 2010

Lipid Rafts: Linking Alzheimer's Amyloid-β Production, Aggregation, and Toxicity at Neuronal Membranes

scientific article published on 27 December 2010

Lipid rafts: linking prion protein to zinc transport and amyloid-β toxicity in Alzheimer's disease ⬇️

scientific article published on 20 August 2014

Mechanism of the metal-mediated endocytosis of the prion protein

scientific article published on December 2008

Membrane Dipeptidase

Membrane dipeptidase

Membrane dipeptidase

Membrane raft actin deficiency and altered Ca2+-induced vesiculation in stomatin-deficient overhydrated hereditary stomatocytosis

scientific article

Membrane topology influences N-glycosylation of the prion protein

scientific article published on February 2001

Membrane-associated zinc peptidase families: comparing ACE and ACE2.

scientific article

Metabolism of neuropeptides by cell-surface peptidases

doctoral thesis

Mild cognitive impairment: the Manchester consensus

scientific article published on 17 November 2020

Modelling Sporadic Alzheimer's Disease Using Induced Pluripotent Stem Cells

scientific article published on 01 November 2018

More than just a membrane anchor

scientific article published on 01 November 1992

Mosaic expression of membrane peptidases by confluent cultures of Caco-2 cells.

scientific article published in February 1993

Muscarine enhances soluble amyloid precursor protein secretion in human neuroblastoma SH-SY5Y by a pathway dependent on protein kinase C(alpha), src-tyrosine kinase and extracellular signal-regulated kinase but not phospholipase C.

scientific article published in June 2002

N-glycans as apical targeting signals in polarized epithelial cells

scientific article

N-glycans, not the GPI anchor, mediate the apical targeting of a naturally glycosylated, GPI-anchored protein in polarised epithelial cells

scientific article published on October 2004

Neprilysin, obesity and the metabolic syndrome

scientific article published on 2 November 2010

Neurokinin B is hydrolysed by synaptic membranes and by endopeptidase-24.11 (enkephalinase) but not by angiotensin converting enzyme

scientific article published in October 1985

Neuronal zinc regulation and the prion protein ⬇️

scientific article

Nitric oxide inhibits the shedding of the glycosylphosphatidylinositol-anchored dipeptidase from porcine renal proximal tubules

scientific article

Normalized proliferation of normal and psoriatic keratinocytes by suppression of sAPPalpha-release

scientific article

PCSK9: an emerging target for treatment of hypercholesterolemia

scientific article published on 05 January 2011

Plasma alkaline phosphatase is elevated in Alzheimer's disease and inversely correlates with cognitive function.

scientific article

Plasma angiotensin-converting enzyme in Alzheimer's disease.

scientific article published in January 2009

Plasma metals as potential biomarkers in dementia: a case-control study in patients with sporadic Alzheimer's disease.

scientific article published on 7 March 2018

Presenilin-1 mutations alter K+ currents in the human neuroblastoma cell line, SH-SY5Y.

scientific article published on August 2002

Prion disease: close encounters of the cellular kind

scientific article

Prion protein "gamma-cleavage": characterizing a novel endoproteolytic processing event.

scientific article published on 23 August 2015

Prion protein and Alzheimer disease

scientific article published on 02 October 2009

Prion protein facilitates uptake of zinc into neuronal cells

scientific article

Prion protein in Alzheimer’s disease

article

Prion protein interacts with BACE1 protein and differentially regulates its activity toward wild type and Swedish mutant amyloid precursor protein.

scientific article

Prion protein is decreased in Alzheimer's brain and inversely correlates with BACE1 activity, amyloid-β levels and Braak stage

scientific article

Prion protein is reduced in aging and in sporadic but not in familial Alzheimer's disease.

scientific article published in January 2010

Prion protein-mediated toxicity of amyloid-β oligomers requires lipid rafts and the transmembrane LRP1

scientific journal article

Proteases: a primer

scientific article

Protective effect of prion protein via the N-terminal region in mediating a protective effect on paraquat-induced oxidative injury in neuronal cells

scientific article

Proteolysis of the low density lipoprotein receptor by bone morphogenetic protein-1 regulates cellular cholesterol uptake

scientific article published on 06 August 2019

Proteolytic fragmentation of the murine prion protein: role of Tyr-128 and His-177.

scientific article published in December 1999

Proteolytic fragmentation reveals the oligomeric and domain structure of porcine aminopeptidase A.

scientific article published on March 1997

Proteolytic mechanisms in amyloid-beta metabolism: therapeutic implications for Alzheimer's disease

scientific article

Proteolytic shedding of the prion protein via activation of metallopeptidase ADAM10 reduces cellular binding and toxicity of amyloid-β oligomers

article

Purification and characterization of a peptidyl dipeptidase resembling angiotensin converting enzyme from the electric organ of Torpedo marmorata

scientific article

Purification and characterization of smooth muscle cell caveolae

scientific article

Quantitative interaction proteomics reveals differences in the interactomes of amyloid precursor protein isoforms

scientific article published on 14 February 2019

Rab GTPase regulation of VEGFR2 trafficking and signaling in endothelial cells

scientific article published on 16 April 2009

Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease

scientific article

Reactive oxygen species (ROS)-mediated beta-cleavage of the prion protein in the mechanism of the cellular response to oxidative stress

scientific article published on November 2005

Reactive oxygen species-mediated beta-cleavage of the prion protein in the cellular response to oxidative stress

scientific article published on 24 August 2005

Regulation of amyloid-β production by the prion protein

scientific article published on July 2012

Release of renal dipeptidase from glycosylphosphatidylinositol anchor by insulin-triggered phospholipase C/intracellular Ca2+

scientific article published on 01 May 2007

Role of ADAMs in the ectodomain shedding and conformational conversion of the prion protein

scientific article

Role of lipid rafts in the processing of the pathogenic prion and Alzheimer's amyloid-beta proteins

scientific article published on 24 July 2007

Secretase-mediated cell surface shedding of the angiotensin-converting enzyme

scientific article

Secretases as Pharmacological Targets in Alzheimer's Disease

scholarly article published 2007

Shedding of somatic angiotensin-converting enzyme (ACE) is inefficient compared with testis ACE despite cleavage at identical stalk sites.

scientific article

Site-directed mutagenesis of conserved cysteine residues in porcine membrane dipeptidase. Cys 361 alone is involved in disulfide-linked dimerization.

scientific article published in September 1996

Soluble Amyloid Precursor Protein α: Friend or Foe?

scientific article published on 01 January 2018

Specificity of the Alzheimer's amyloid precursor protein α-secretase

scientific article published on 01 January 1995

Sphingomyelin chain length influences the distribution of GPI-anchored proteins in rafts in supported lipid bilayers

scientific article

Spontaneous release of glycosylphosphatidylinositol (GPI)-anchored renal dipeptidase from porcine renal proximal tubules

scientific article published on 01 February 2002

Structure-activity relationship of hydroxamate-based inhibitors on the secretases that cleave the amyloid precursor protein, angiotensin converting enzyme, CD23, and pro-tumor necrosis factor-alpha

scientific article published on April 2002

Subcellular fractionation studies indicate an intracellular localization for human monocyte specific esterase (MSE).

scientific article published in August 1993

Surface coat remodeling during differentiation of Trypanosoma brucei

scientific article published on 25 April 2003

Tau Diagnostics and Clinical Studies.

scientific article published on 30 October 2017

Tau Proteolysis in the Pathogenesis of Tauopathies: Neurotoxic Fragments and Novel Biomarkers.

scientific article published on 30 March 2018

Tethering the N-terminus of the prion protein compromises the cellular response to oxidative stress

scientific article

The C-terminal domain, but not the interchain disulphide, is required for the activity and intracellular trafficking of aminopeptidase A.

scientific article published in February 2002

The Caenorhabditis elegans orthologue of mammalian puromycin-sensitive aminopeptidase has roles in embryogenesis and reproduction

scientific article

The N-terminal region of the prion protein ectodomain contains a lipid raft targeting determinant

scientific article

The Role of Tissue Non-specific Alkaline Phosphatase (TNAP) in Neurodegenerative Diseases: Alzheimer's Disease in the Focus

scientific article published on January 2015

The angiotensin-converting enzyme gene family: genomics and pharmacology

scientific article

The bradykinin-degrading aminopeptidase P is increased in women taking the oral contraceptive pill

scientific article

The carboxyl terminus of Dictyostelium discoideum protein 1I encodes a functional glycosyl-phosphatidylinositol signal sequence

scientific article

The cellular expression and proteolytic processing of the amyloid precursor protein is independent of TDP-43

scientific article published on 17 April 2020

The ectodomain shedding of angiotensin-converting enzyme is independent of its localisation in lipid rafts

scientific article

The effects of the cellular and infectious prion protein on the neuronal adaptor protein X11α.

scientific article published on 19 August 2015

The involvement of lipid rafts in Alzheimer's disease

scientific article

The kinetics of phase separation in asymmetric membranes

scientific article published on 18 March 2005

The low-density lipoprotein receptor-related protein 1 (LRP1) mediates the endocytosis of the cellular prion protein

scientific article published on February 2007

The molecular biology of GPI-anchored border hydrolases ⬇️

scientific article published on November 1, 1991

The prion protein and lipid rafts

scientific article

The prion protein and neuronal zinc homeostasis

scientific article

The response of neurones and glial cells to elevated copper

scientific article published in May 2001

The role of ADAM10 and ADAM17 in the ectodomain shedding of angiotensin converting enzyme and the amyloid precursor protein

scientific article published on June 2004

The role of lipid rafts in prion protein biology

scientific article published on January 2011

The role of zinc in Alzheimer's disease

scientific article published on 20 December 2010

The secretases that cleave angiotensin converting enzyme and the amyloid precursor protein are distinct from tumour necrosis factor-alpha convertase

scientific article

The transcriptionally active amyloid precursor protein (APP) intracellular domain is preferentially produced from the 695 isoform of APP in a {beta}-secretase-dependent pathway

scientific article published on 20 October 2010

Tissue Engineering 3D Neurovascular Units: A Biomaterials and Bioprinting Perspective.

scientific article published on 5 February 2018

Tumor necrosis factor-alpha convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome-coronavirus (SARS-CoV) receptor, angiotensin-converting enzyme-2 (ACE2).

scientific article published on 27 June 2005

Visualization of detergent solubilization of membranes: implications for the isolation of rafts

scientific article

Why Is Research on Amyloid-β Failing to Give New Drugs for Alzheimer's Disease?

scientific article published on 6 June 2017

X-Trp aminopeptidase

Xaa-Trp Aminopeptidase

alpha-cleavage of the prion protein occurs in a late compartment of the secretory pathway and is independent of lipid rafts

scientific article

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