List of works - Miguel A Valverde

A gain-of-function SNP in TRPC4 cation channel protects against myocardial infarction

scientific article

A loss-of-function nonsynonymous polymorphism in the osmoregulatory TRPV4 gene is associated with human hyponatremia

scientific article published on 04 August 2009

A mutation in the first intracellular loop of CACNA1A prevents P/Q channel modulation by SNARE proteins and lowers exocytosis.

scientific article

ADF/cofilin regulates secretory cargo sorting at the TGN via the Ca2+ ATPase SPCA1.

scientific article published in May 2011

Activation of Maxi Cl(-) channels by antiestrogens and phenothiazines in NIH3T3 fibroblasts

scientific article published on May 2002

Acute activation of Maxi-K channels (hSlo) by estradiol binding to the beta subunit

scientific article (publication date: 17 September 1999)

Amyloid-dependent triosephosphate isomerase nitrotyrosination induces glycation and tau fibrillation.

scientific article

BK channel activation by tungstate requires the β1 subunit extracellular loop residues essential to modulate voltage sensor function and channel gating.

scientific article published on 26 October 2013

Cab45 is required for Ca(2+)-dependent secretory cargo sorting at the trans-Golgi network

scientific article published on December 2012

Cell sensing and decision-making in confinement: The role of TRPM7 in a tug of war between hydraulic pressure and cross-sectional area

scientific article published on 24 July 2019

Cell volume regulation and swelling-activated chloride channels

scientific article published on December 2003

Chloride channels: a state of flux.

scientific article published on April 1995

Chloride secretion in a morphologically differentiated human colonic cell line that expresses the epithelial Na+ channel

scientific article published on 12 December 2003

Cl? currents of unstimulated T84 intestinal epithelial cells studied by intracellular recording

scientific article published on 01 February 1994

Classical and novel steroid actions: a unified but complex view

scientific article published on 01 April 2002

Confinement Sensing and Signal Optimization via Piezo1/PKA and Myosin II Pathways.

scientific article published on 4 May 2016

Contribution of the IsK (MinK) Potassium Channel Subunit to Regulatory Volume Decrease in Murine Tracheal Epithelial Cells

scientific article published in Journal of Biological Chemistry

DYRK1A Kinase Positively Regulates Angiogenic Responses in Endothelial Cells.

scientific article

Defective regulatory volume decrease in human cystic fibrosis tracheal cells because of altered regulation of intermediate conductance Ca2+-dependent potassium channels

scientific article published on 17 April 2001

Development of Na(+)- and K(+)-currents in the cochlear ganglion of the chick embryo

scientific article published in December 1992

Differential effects of tamoxifen and I? on three distinguishable chloride currents activated in T84 intestinal cells

scientific article published on 01 December 1993

Drug efflux mediated by the human multidrug resistance P-glycoprotein is inhibited by cell swelling.

scientific article published on December 1994

Endothelial Progenitor Cells Predict Cardiovascular Events after Atherothrombotic Stroke and Acute Myocardial Infarction. A PROCELL Substudy.

scientific article published on 2 September 2015

Environmental estrogenic pollutants induce acute vascular relaxation by inhibiting L-type Ca2+ channels in smooth muscle cells

scientific article published in May 1998

Extreme population differences in the human zinc transporter ZIP4 (SLC39A4) are explained by positive selection in Sub-Saharan Africa

scientific article

Fibrinogen nitrotyrosination after ischemic stroke impairs thrombolysis and promotes neuronal death

scientific article published on 12 December 2014

Functional coupling of GABAA/B receptors and the channel TRPV4 mediates rapid progesterone signaling in the oviduct

scientific article published on 14 August 2018

Functional coupling of TRPV4 cationic channel and large conductance, calcium-dependent potassium channel in human bronchial epithelial cell lines

scientific article

GEMC1 is a critical regulator of multiciliated cell differentiation

scientific article published on March 2016

Gain-of-function mutation in the KCNMB1 potassium channel subunit is associated with low prevalence of diastolic hypertension

scientific article

Genetic variation in the KCNMA1 potassium channel α subunit as risk factor for severe essential hypertension and myocardial infarction

scientific article published on 01 November 2008

Glutamatergic stimulation induces GluN2B translation by the nitric oxide-Heme-Regulated eIF2α kinase in cortical neurons.

scientific article published on 19 August 2016

Human ClC-3 is not the swelling-activated chloride channel involved in cell volume regulation

scientific article published on 22 February 2001

Human TRPV4 channel splice variants revealed a key role of ankyrin domains in multimerization and trafficking

scientific article

IP3 receptor binds to and sensitizes TRPV4 channel to osmotic stimuli via a calmodulin-binding site.

scientific article

IP3sensitizes TRPV4 channel to the mechano- and osmotransducing messenger 5′-6′-epoxyeicosatrienoic acid

scientific article published on 01 May 2008

Impaired cell volume regulation in intestinal crypt epithelia of cystic fibrosis mice

scientific article

In vitro and in vivo evidence for an inflammatory role of the calcium channel TRPV4 in lung epithelium: Potential involvement in cystic fibrosis.

scientific article published on 5 August 2016

Inactivation of the murine cftr gene abolishes cAMP-mediated but not Ca(2+)-mediated secretagogue-induced volume decrease in small-intestinal crypts

scientific article published in December 1993

Inhibition of ligand-gated cation-selective channels by tamoxifen

scientific article published in August 1998

Inhibition of voltage-gated cationic channels in rat embryonic hypothalamic neurones and C1300 neuroblastoma cells by triphenylethylene antioestrogens

scientific article published on September 1998

Interaction between the Linker, Pre-S1, and TRP Domains Determines Folding, Assembly, and Trafficking of TRPV Channels

scientific article

Ion channels in asthma.

scientific article published on 28 July 2011

KChIP3 coupled to Ca oscillations exerts a tonic brake on baseline mucin release in the colon

scientific article published on 01 October 2018

Late-onset episodic ataxia type 2 associated with a novel loss-of-function mutation in the CACNA1A gene.

scientific article

Lens opacification by antioestrogens: tamoxifen vs ICI 182,780.

scientific article published in August 1995

Loss of function of transient receptor potential vanilloid 1 (TRPV1) genetic variant is associated with lower risk of active childhood asthma

scientific article published on 18 July 2010

Maxi K+ channel mediates regulatory volume decrease response in a human bronchial epithelial cell line

scientific article

Membrane conductance and cell volume changes evoked by vasoactive intestinal polypeptide and carbachol in small intestinal crypts

scientific article published on 01 September 1992

Mobilization of endothelial progenitor cells in acute cardiovascular events in the PROCELL study: Time-course after acute myocardial infarction and stroke

article

Murine CFTR channel and its role in regulatory volume decrease of small intestine crypts

scientific article

Murine embryonic stem cell-derived pancreatic acinar cells recapitulate features of early pancreatic differentiation

scientific article published on 25 June 2008

Nitro-oxidative stress after neuronal ischemia induces protein nitrotyrosination and cell death

scientific article published on August 2013

Novel plasma membrane action of estrogen and antiestrogens revealed by their regulation of a large conductance chloride channel

scientific article published on July 1994

ORMDL3 modulates store-operated calcium entry and lymphocyte activation

scientific article published on 25 October 2012

Okadaic acid-sensitive activation of Maxi Cl(-) channels by triphenylethylene antioestrogens in C1300 mouse neuroblastoma cells

scientific article

Osmosensitive C1- currents and their relevance to regulatory volume decrease in human intestinal T84 cells: outwardly vs. inwardly rectifying currents

scientific article published on August 1998

Oxidative stress triggers the amyloidogenic pathway in human vascular smooth muscle cells.

scientific article published on 15 February 2007

Phosphatidylinositol-4,5-biphosphate-dependent rearrangement of TRPV4 cytosolic tails enables channel activation by physiological stimuli.

scientific article published on 20 May 2013

Piezo2 channel regulates RhoA and actin cytoskeleton to promote cell mechanobiological responses.

scientific article published on 5 February 2018

Plasma membrane voltage-dependent anion channel mediates antiestrogen-activated maxi Cl- currents in C1300 neuroblastoma cells.

scientific article

Posttranslational nitro-glycative modifications of albumin in Alzheimer's disease: implications in cytotoxicity and amyloid-β peptide aggregation

scientific article published in January 2014

Potassium currents of isolated Necturus enterocytes: a whole-cell patch-clamp study

scientific article

Protective effect of the KCNMB1 E65K genetic polymorphism against diastolic hypertension in aging women and its relevance to cardiovascular risk.

scientific article

Protein kinase C phosphorylation disengages human and mouse-1a P-glycoproteins from influencing the rate of activation of swelling-activated chloride currents

scientific article published on April 1998

Protein kinase C-mediated phosphorylation of the human multidrug resistance P-glycoprotein regulates cell volume-activated chloride channels

scientific journal article

RCAN1 (DSCR1) increases neuronal susceptibility to oxidative stress: a potential pathogenic process in neurodegeneration.

scientific article

Rare variants in calcium homeostasis modulator 1 (CALHM1) found in early onset Alzheimer's disease patients alter calcium homeostasis

scientific article published on 17 September 2013

Regulation of volume activated chloride channels by protein kinase C-mediated phosphorylation of P-glycoprotein

scientific article published on 01 January 1994

Regulatory volume increase after hypertonicity- or vasoactive-intestinal-peptide-induced cell-volume decrease in small-intestinal crypts is dependent on Na+-K+-2Cl? cotransport

scientific article published on 01 April 1993

Screening of CACNA1A and ATP1A2 genes in hemiplegic migraine: clinical, genetic, and functional studies.

scientific article published on 02 July 2013

Screening of cacna1a and ATP1A2 genes in hemiplegic migraine: clinical, genetic and functional studies

article

Separation of drug transport and chloride channel functions of the human multidrug resistance P-glycoprotein

scientific article (publication date: 2 October 1992)

Silica nanoparticles inhibit the cation channel TRPV4 in airway epithelial cells.

scientific article published on 3 November 2017

Sodium channel TRPM4 and sodium/calcium exchangers (NCX) cooperate in the control of Ca2+-induced mucin secretion from goblet cells

scientific article published on 27 November 2018

Specific inhibitors distinguish the chloride channel and drug transporter functions associated with the human multidrug resistance P-glycoprotein.

scientific article published on January 1993

Structural determinants for functional coupling between the beta and alpha subunits in the Ca2+-activated K+ (BK) channel

scientific article

Structural determinants of 5',6'-epoxyeicosatrienoic acid binding to and activation of TRPV4 channel.

scientific article

Swelling-activated Ca2+ entry via TRPV4 channel is defective in cystic fibrosis airway epithelia.

scientific article

TRPM5-mediated calcium uptake regulates mucin secretion from human colon goblet cells.

scientific article published on 28 May 2013

TRPV1 polymorphisms influence capsaicin cough sensitivity in men.

scientific article published on March 2017

TRPV4 activation triggers protective responses to bacterial lipopolysaccharides in airway epithelial cells

scientific article

TRPV4 channel is involved in the coupling of fluid viscosity changes to epithelial ciliary activity

scientific article

TRPV4 channel participates in receptor-operated calcium entry and ciliary beat frequency regulation in mouse airway epithelial cells

scientific article

TRPV4 participates in the establishment of trailing adhesions and directional persistence of migrating cells

scientific article

TRPV4-Mediated Detection of Hyposmotic Stress by Skin Keratinocytes Activates Developmental Immunity.

scientific article published on 16 December 2015

Tamoxifen blocks chloride channels. A possible mechanism for cataract formation.

scientific article published on October 1994

The TRPV4 Channel in Ciliated Epithelia

The TRPV4 channel links calcium influx to DDX3X activity and viral infectivity.

scientific article published on 13 June 2018

The TRPV4 channel.

scientific article published on January 2014

The asthma-associated ORMDL3 gene product regulates endoplasmic reticulum-mediated calcium signaling and cellular stress

article

The estrogen trinity: membrane, cytosolic, and nuclear effects.

scientific article

The hemiplegic migraine-associated Y1245C mutation in CACNA1A results in a gain of channel function due to its effect on the voltage sensor and G-protein-mediated inhibition

scientific article

The mechanosensitive Piezo1 channel controls endosome trafficking for an efficient cytokinetic abscission

scientific article published on 29 October 2021

The nucleus measures shape changes for cellular proprioception to control dynamic cell behavior

scientific article

The progesterone receptor regulates the expression of TRPV4 channel.

scientific article

Transient outward currents in cochlear ganglion neurons of the chick embryo.

scientific article

Transient receptor potential genes, smoking, occupational exposures and cough in adults

scientific article published on 23 March 2012

Tungstate activates BK channels in a β subunit- and Mg2+-dependent manner: relevance for arterial vasodilatation

Tungstate-targeting of BKαβ1 channels tunes ERK phosphorylation and cell proliferation in human vascular smooth muscle.

scientific article published on 6 February 2015

Two types of potassium currents seen in isolated Necturus enterocytes with the single-electrode voltage-clamp technique

scientific article published in February 1991

Vitamin E but not 17beta-estradiol protects against vascular toxicity induced by beta-amyloid wild type and the Dutch amyloid variant.

scientific article

Voltage-dependent anion channel localises to the plasma membrane and peripheral but not perinuclear mitochondria

scientific article published on 16 April 2003

Volume-activated chloride channels in HeLa cells are blocked by verapamil and dideoxyforskolin

scientific article published in January 1993

Volume-regulated chloride channels associated with the human multidrug-resistance P-glycoprotein

scientific article (publication date: 27 February 1992)

List of works by Miguel A Valverde

A gain-of-function SNP in TRPC4 cation channel protects against myocardial infarction

A loss-of-function nonsynonymous polymorphism in the osmoregulatory TRPV4 gene is associated with human hyponatremia

A mutation in the first intracellular loop of CACNA1A prevents P/Q channel modulation by SNARE proteins and lowers exocytosis.

ADF/cofilin regulates secretory cargo sorting at the TGN via the Ca2+ ATPase SPCA1.

Activation of Maxi Cl(-) channels by antiestrogens and phenothiazines in NIH3T3 fibroblasts

Acute activation of Maxi-K channels (hSlo) by estradiol binding to the beta subunit

Amyloid-dependent triosephosphate isomerase nitrotyrosination induces glycation and tau fibrillation.

BK channel activation by tungstate requires the β1 subunit extracellular loop residues essential to modulate voltage sensor function and channel gating.

Cab45 is required for Ca(2+)-dependent secretory cargo sorting at the trans-Golgi network

Cell sensing and decision-making in confinement: The role of TRPM7 in a tug of war between hydraulic pressure and cross-sectional area

Cell volume regulation and swelling-activated chloride channels

Chloride channels: a state of flux.

Chloride secretion in a morphologically differentiated human colonic cell line that expresses the epithelial Na+ channel

Cl? currents of unstimulated T84 intestinal epithelial cells studied by intracellular recording

Classical and novel steroid actions: a unified but complex view

Confinement Sensing and Signal Optimization via Piezo1/PKA and Myosin II Pathways.

Contribution of the IsK (MinK) Potassium Channel Subunit to Regulatory Volume Decrease in Murine Tracheal Epithelial Cells

DYRK1A Kinase Positively Regulates Angiogenic Responses in Endothelial Cells.

Defective regulatory volume decrease in human cystic fibrosis tracheal cells because of altered regulation of intermediate conductance Ca2+-dependent potassium channels

Development of Na(+)- and K(+)-currents in the cochlear ganglion of the chick embryo

Differential effects of tamoxifen and I? on three distinguishable chloride currents activated in T84 intestinal cells

Drug efflux mediated by the human multidrug resistance P-glycoprotein is inhibited by cell swelling.

Endothelial Progenitor Cells Predict Cardiovascular Events after Atherothrombotic Stroke and Acute Myocardial Infarction. A PROCELL Substudy.

Environmental estrogenic pollutants induce acute vascular relaxation by inhibiting L-type Ca2+ channels in smooth muscle cells

Extreme population differences in the human zinc transporter ZIP4 (SLC39A4) are explained by positive selection in Sub-Saharan Africa

Fibrinogen nitrotyrosination after ischemic stroke impairs thrombolysis and promotes neuronal death

Functional coupling of GABAA/B receptors and the channel TRPV4 mediates rapid progesterone signaling in the oviduct

Functional coupling of TRPV4 cationic channel and large conductance, calcium-dependent potassium channel in human bronchial epithelial cell lines

GEMC1 is a critical regulator of multiciliated cell differentiation

Gain-of-function mutation in the KCNMB1 potassium channel subunit is associated with low prevalence of diastolic hypertension

Genetic variation in the KCNMA1 potassium channel α subunit as risk factor for severe essential hypertension and myocardial infarction

Glutamatergic stimulation induces GluN2B translation by the nitric oxide-Heme-Regulated eIF2α kinase in cortical neurons.

Human ClC-3 is not the swelling-activated chloride channel involved in cell volume regulation

Human TRPV4 channel splice variants revealed a key role of ankyrin domains in multimerization and trafficking

IP3 receptor binds to and sensitizes TRPV4 channel to osmotic stimuli via a calmodulin-binding site.

IP3sensitizes TRPV4 channel to the mechano- and osmotransducing messenger 5′-6′-epoxyeicosatrienoic acid

Impaired cell volume regulation in intestinal crypt epithelia of cystic fibrosis mice

In vitro and in vivo evidence for an inflammatory role of the calcium channel TRPV4 in lung epithelium: Potential involvement in cystic fibrosis.

Inactivation of the murine cftr gene abolishes cAMP-mediated but not Ca(2+)-mediated secretagogue-induced volume decrease in small-intestinal crypts

Inhibition of ligand-gated cation-selective channels by tamoxifen

Inhibition of voltage-gated cationic channels in rat embryonic hypothalamic neurones and C1300 neuroblastoma cells by triphenylethylene antioestrogens

Interaction between the Linker, Pre-S1, and TRP Domains Determines Folding, Assembly, and Trafficking of TRPV Channels

Ion channels in asthma.

KChIP3 coupled to Ca oscillations exerts a tonic brake on baseline mucin release in the colon

Late-onset episodic ataxia type 2 associated with a novel loss-of-function mutation in the CACNA1A gene.

Lens opacification by antioestrogens: tamoxifen vs ICI 182,780.

Loss of function of transient receptor potential vanilloid 1 (TRPV1) genetic variant is associated with lower risk of active childhood asthma

Maxi K+ channel mediates regulatory volume decrease response in a human bronchial epithelial cell line

Membrane conductance and cell volume changes evoked by vasoactive intestinal polypeptide and carbachol in small intestinal crypts

Mobilization of endothelial progenitor cells in acute cardiovascular events in the PROCELL study: Time-course after acute myocardial infarction and stroke

Murine CFTR channel and its role in regulatory volume decrease of small intestine crypts

Murine embryonic stem cell-derived pancreatic acinar cells recapitulate features of early pancreatic differentiation

Nitro-oxidative stress after neuronal ischemia induces protein nitrotyrosination and cell death

Novel plasma membrane action of estrogen and antiestrogens revealed by their regulation of a large conductance chloride channel

ORMDL3 modulates store-operated calcium entry and lymphocyte activation

Okadaic acid-sensitive activation of Maxi Cl(-) channels by triphenylethylene antioestrogens in C1300 mouse neuroblastoma cells

Osmosensitive C1- currents and their relevance to regulatory volume decrease in human intestinal T84 cells: outwardly vs. inwardly rectifying currents

Oxidative stress triggers the amyloidogenic pathway in human vascular smooth muscle cells.

Phosphatidylinositol-4,5-biphosphate-dependent rearrangement of TRPV4 cytosolic tails enables channel activation by physiological stimuli.

Piezo2 channel regulates RhoA and actin cytoskeleton to promote cell mechanobiological responses.

Plasma membrane voltage-dependent anion channel mediates antiestrogen-activated maxi Cl- currents in C1300 neuroblastoma cells.

Posttranslational nitro-glycative modifications of albumin in Alzheimer's disease: implications in cytotoxicity and amyloid-β peptide aggregation

Potassium currents of isolated Necturus enterocytes: a whole-cell patch-clamp study

Protective effect of the KCNMB1 E65K genetic polymorphism against diastolic hypertension in aging women and its relevance to cardiovascular risk.

Protein kinase C phosphorylation disengages human and mouse-1a P-glycoproteins from influencing the rate of activation of swelling-activated chloride currents

Protein kinase C-mediated phosphorylation of the human multidrug resistance P-glycoprotein regulates cell volume-activated chloride channels

RCAN1 (DSCR1) increases neuronal susceptibility to oxidative stress: a potential pathogenic process in neurodegeneration.

Rare variants in calcium homeostasis modulator 1 (CALHM1) found in early onset Alzheimer's disease patients alter calcium homeostasis

Regulation of volume activated chloride channels by protein kinase C-mediated phosphorylation of P-glycoprotein

Regulatory volume increase after hypertonicity- or vasoactive-intestinal-peptide-induced cell-volume decrease in small-intestinal crypts is dependent on Na+-K+-2Cl? cotransport

Screening of CACNA1A and ATP1A2 genes in hemiplegic migraine: clinical, genetic, and functional studies.

Screening of cacna1a and ATP1A2 genes in hemiplegic migraine: clinical, genetic and functional studies

Separation of drug transport and chloride channel functions of the human multidrug resistance P-glycoprotein

Silica nanoparticles inhibit the cation channel TRPV4 in airway epithelial cells.

Sodium channel TRPM4 and sodium/calcium exchangers (NCX) cooperate in the control of Ca2+-induced mucin secretion from goblet cells

Specific inhibitors distinguish the chloride channel and drug transporter functions associated with the human multidrug resistance P-glycoprotein.

Structural determinants for functional coupling between the beta and alpha subunits in the Ca2+-activated K+ (BK) channel

Structural determinants of 5',6'-epoxyeicosatrienoic acid binding to and activation of TRPV4 channel.

Swelling-activated Ca2+ entry via TRPV4 channel is defective in cystic fibrosis airway epithelia.