List of works - Dinesh C. Soares

A cytogenetic abnormality and rare coding variants identify ABCA13 as a candidate gene in schizophrenia, bipolar disorder, and depression

scientific article

A recurrent de novo mutation in ACTG1 causes isolated ocular coloboma

scientific article

A structural organization for the Disrupted in Schizophrenia 1 protein, identified by high-throughput screening, reveals distinctly folded regions, which are bisected by mental illness-related mutations

scientific article published in March 2017

A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells.

scientific article published on 23 November 2017

A t(1;11) translocation linked to schizophrenia and affective disorders gives rise to aberrant chimeric DISC1 transcripts that encode structurally altered, deleterious mitochondrial proteins

scientific article

ACS Omega 2017: A Year-End Expression of Appreciation for the Fundamental Contributions of Our Reviewers

scientific article published on 18 January 2018

ARABIDOPSIS CRINKLY4 function, internalization, and turnover are dependent on the extracellular crinkly repeat domain

scientific article published in 2005

Ablation of EYS in zebrafish causes mislocalisation of outer segment proteins, F-actin disruption and cone-rod dystrophy

scientific article published on 05 April 2017

An interrupted beta-propeller and protein disorder: structural bioinformatics insights into the N-terminus of alsin

scientific article published on 21 November 2008

Atypical femoral fracture in osteoporosis pseudoglioma syndrome associated with two novel compound heterozygous mutations in LRP5

article

Characterization of a novel RP2-OSTF1 interaction and its implication for actin remodeling

scientific article published on 12 January 2018

Condensin II mutation causes T-cell lymphoma through tissue-specific genome instability

scientific article

DISC1 as a genetic risk factor for schizophrenia and related major mental illness: response to Sullivan

scientific article published in February 2014

DISC1 complexes with TRAK1 and Miro1 to modulate anterograde axonal mitochondrial trafficking

scientific article

DISC1 genetics, biology and psychiatric illness

scientific article published on February 2013

DISC1: Structure, Function, and Therapeutic Potential for Major Mental Illness ⬇️

scientific article published on August 5, 2011

Evolutionary Characterization of the Retinitis Pigmentosa GTPase Regulator Gene

scientific article published in October 2015

Functional insights from the structure of the multifunctional C345C domain of C5 of complement

scientific article

HIV-1 Uncoating and Reverse Transcription Require eEF1A Binding to Surface-Exposed Acidic Residues of the Reverse Transcriptase Thumb Domain.

scientific article published on 27 March 2018

Highly homologous eEF1A1 and eEF1A2 exhibit differential post-translational modification with significant enrichment around localised sites of sequence variation

scientific article published on 13 November 2013

HpARI Protein Secreted by a Helminth Parasite Suppresses Interleukin-33

scientific article published on October 2017

In silico structure-function analysis of pathological variation in the HSD11B2 gene sequence

scientific article

Large-scale modelling as a route to multiple surface comparisons of the CCP module family

article

Missense Mutations in the Human Nanophthalmos Gene TMEM98 Cause Retinal Defects in the Mouse

scientific article published on 01 July 2019

Molecular evolution of the human SRPX2 gene that causes brain disorders of the Rolandic and Sylvian speech areas

scientific article

Monoallelic and biallelic mutations in MAB21L2 cause a spectrum of major eye malformations

scientific article

NDE1 and NDEL1: multimerisation, alternate splicing and DISC1 interaction

scientific article

NDE1 and NDEL1: twin neurodevelopmental proteins with similar 'nature' but different 'nurture'.

scientific article published on October 2013

Novel de novo EEF1A2 missense mutations causing epilepsy and intellectual disability

scientific article published on 03 April 2016

Novel pathogenic mutations in C1QTNF5 support a dominant negative disease mechanism in late-onset retinal degeneration

scientific article published on 22 September 2017

Opportunities for new therapies based on the natural regulators of complement activation

scientific article

Oxovanadium(IV) cyclam and bicyclam complexes: potential CXCR4 receptor antagonists

scientific article

PKA phosphorylation of NDE1 is DISC1/PDE4 dependent and modulates its interaction with LIS1 and NDEL1

scientific article

PLAA Mutations Cause a Lethal Infantile Epileptic Encephalopathy by Disrupting Ubiquitin-Mediated Endolysosomal Degradation of Synaptic Proteins ⬇️

scientific article published on 10 April 2017

Pathogenic mutations in retinitis pigmentosa 2 predominantly result in loss of RP2 protein stability in humans and zebrafish

scientific article published on 16 February 2017

RPGR: Its role in photoreceptor physiology, human disease, and future therapies.

scientific article

Rare disruptive variants in the DISC1 Interactome and Regulome: association with cognitive ability and schizophrenia

scientific article published on 20 June 2017

SAF-A Regulates Interphase Chromosome Structure through Oligomerization with Chromatin-Associated RNAs

scientific article published on June 2017

Solution Structure of CCP Modules 10–12 Illuminates Functional Architecture of the Complement Regulator, Factor H

scientific article

Solution Structure of Factor I-like Modules from Complement C7 Reveals a Pair of Follistatin Domains in Compact Pseudosymmetric Arrangement

scientific article

Specific Interaction between eEF1A and HIV RT Is Critical for HIV-1 Reverse Transcription and a Potential Anti-HIV Target

scientific article (publication date: December 2015)

Structural analysis of the C-terminal region (modules 18-20) of complement regulator factor H (FH)

scientific article published in 2012

Structural models of human eEF1A1 and eEF1A2 reveal two distinct surface clusters of sequence variation and potential differences in phosphorylation

scientific article

Structure of the N-terminal region of complement factor H and conformational implications of disease-linked sequence variations

scientific article

Structure-based Mapping of DAF Active Site Residues That Accelerate the Decay of C3 Convertases

scientific article published in Journal of Biological Chemistry

Targeted sequencing of the Paget's disease associated 14q32 locus identifies several missense coding variants in RIN3 that predispose to Paget's disease of bone.

scientific article published on 20 February 2015

The central portion of factor H (modules 10-15) is compact and contains a structurally deviant CCP module

scientific article

The evolution of TEP1, an exceptionally polymorphic immunity gene in Anopheles gambiae

scientific article

The intermediate filament protein, vimentin, is a regulator of NOD2 activity

scientific article

The mitosis and neurodevelopment proteins NDE1 and NDEL1 form dimers, tetramers, and polymers with a folded back structure in solution.

scientific article

The structure of the KlcA and ArdB proteins reveals a novel fold and antirestriction activity against Type I DNA restriction systems in vivo but not in vitro

scientific article

Translation elongation factor 1A2 is encoded by one of four closely related eef1a genes and is dispensable for survival in zebrafish

scientific article published on 01 January 2020

eEF1A2 and neuronal degeneration

scientific article published on 01 December 2009

List of works by Dinesh C. Soares

A cytogenetic abnormality and rare coding variants identify ABCA13 as a candidate gene in schizophrenia, bipolar disorder, and depression

A recurrent de novo mutation in ACTG1 causes isolated ocular coloboma

A structural organization for the Disrupted in Schizophrenia 1 protein, identified by high-throughput screening, reveals distinctly folded regions, which are bisected by mental illness-related mutations

A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells.

A t(1;11) translocation linked to schizophrenia and affective disorders gives rise to aberrant chimeric DISC1 transcripts that encode structurally altered, deleterious mitochondrial proteins

ACS Omega 2017: A Year-End Expression of Appreciation for the Fundamental Contributions of Our Reviewers

ARABIDOPSIS CRINKLY4 function, internalization, and turnover are dependent on the extracellular crinkly repeat domain

Ablation of EYS in zebrafish causes mislocalisation of outer segment proteins, F-actin disruption and cone-rod dystrophy

An interrupted beta-propeller and protein disorder: structural bioinformatics insights into the N-terminus of alsin

Atypical femoral fracture in osteoporosis pseudoglioma syndrome associated with two novel compound heterozygous mutations in LRP5

Characterization of a novel RP2-OSTF1 interaction and its implication for actin remodeling

Condensin II mutation causes T-cell lymphoma through tissue-specific genome instability

DISC1 as a genetic risk factor for schizophrenia and related major mental illness: response to Sullivan

DISC1 complexes with TRAK1 and Miro1 to modulate anterograde axonal mitochondrial trafficking

DISC1 genetics, biology and psychiatric illness

DISC1: Structure, Function, and Therapeutic Potential for Major Mental Illness ⬇️

Evolutionary Characterization of the Retinitis Pigmentosa GTPase Regulator Gene

Functional insights from the structure of the multifunctional C345C domain of C5 of complement

HIV-1 Uncoating and Reverse Transcription Require eEF1A Binding to Surface-Exposed Acidic Residues of the Reverse Transcriptase Thumb Domain.

Highly homologous eEF1A1 and eEF1A2 exhibit differential post-translational modification with significant enrichment around localised sites of sequence variation

HpARI Protein Secreted by a Helminth Parasite Suppresses Interleukin-33

In silico structure-function analysis of pathological variation in the HSD11B2 gene sequence

Large-scale modelling as a route to multiple surface comparisons of the CCP module family

Missense Mutations in the Human Nanophthalmos Gene TMEM98 Cause Retinal Defects in the Mouse

Molecular evolution of the human SRPX2 gene that causes brain disorders of the Rolandic and Sylvian speech areas

Monoallelic and biallelic mutations in MAB21L2 cause a spectrum of major eye malformations

NDE1 and NDEL1: multimerisation, alternate splicing and DISC1 interaction

NDE1 and NDEL1: twin neurodevelopmental proteins with similar 'nature' but different 'nurture'.

Novel de novo EEF1A2 missense mutations causing epilepsy and intellectual disability

Novel pathogenic mutations in C1QTNF5 support a dominant negative disease mechanism in late-onset retinal degeneration

Opportunities for new therapies based on the natural regulators of complement activation

Oxovanadium(IV) cyclam and bicyclam complexes: potential CXCR4 receptor antagonists

PKA phosphorylation of NDE1 is DISC1/PDE4 dependent and modulates its interaction with LIS1 and NDEL1

PLAA Mutations Cause a Lethal Infantile Epileptic Encephalopathy by Disrupting Ubiquitin-Mediated Endolysosomal Degradation of Synaptic Proteins ⬇️

Pathogenic mutations in retinitis pigmentosa 2 predominantly result in loss of RP2 protein stability in humans and zebrafish

RPGR: Its role in photoreceptor physiology, human disease, and future therapies.

Rare disruptive variants in the DISC1 Interactome and Regulome: association with cognitive ability and schizophrenia

SAF-A Regulates Interphase Chromosome Structure through Oligomerization with Chromatin-Associated RNAs

Solution Structure of CCP Modules 10–12 Illuminates Functional Architecture of the Complement Regulator, Factor H

Solution Structure of Factor I-like Modules from Complement C7 Reveals a Pair of Follistatin Domains in Compact Pseudosymmetric Arrangement

Specific Interaction between eEF1A and HIV RT Is Critical for HIV-1 Reverse Transcription and a Potential Anti-HIV Target

Structural analysis of the C-terminal region (modules 18-20) of complement regulator factor H (FH)

Structural models of human eEF1A1 and eEF1A2 reveal two distinct surface clusters of sequence variation and potential differences in phosphorylation

Structure of the N-terminal region of complement factor H and conformational implications of disease-linked sequence variations

Structure-based Mapping of DAF Active Site Residues That Accelerate the Decay of C3 Convertases

Targeted sequencing of the Paget's disease associated 14q32 locus identifies several missense coding variants in RIN3 that predispose to Paget's disease of bone.

The central portion of factor H (modules 10-15) is compact and contains a structurally deviant CCP module

The evolution of TEP1, an exceptionally polymorphic immunity gene in Anopheles gambiae

The intermediate filament protein, vimentin, is a regulator of NOD2 activity

The mitosis and neurodevelopment proteins NDE1 and NDEL1 form dimers, tetramers, and polymers with a folded back structure in solution.

The structure of the KlcA and ArdB proteins reveals a novel fold and antirestriction activity against Type I DNA restriction systems in vivo but not in vitro

Translation elongation factor 1A2 is encoded by one of four closely related eef1a genes and is dispensable for survival in zebrafish

eEF1A2 and neuronal degeneration