List of works - Jianxing Song

A disalicylic acid-furanyl derivative inhibits ephrin binding to a subset of Eph receptors

scientific article

A gradual disruption of tight side-chain packing: 2D 1H-NMR characterization of acid-induced unfolding of CHABII.

scientific article published in February 1999

A model of dynamic side-chain--side-chain interactions in the alpha-lactalbumin molten globule

scientific article

A monoclonal antibody binds to threonine 49 in the non-structural 1 protein of influenza A virus and interferes with its ability to modulate viral replication.

scientific article

A novel SOD1-dependent mechanism for the iron-induced production of toxic SOD1 and oxidative stress that initiates ALS

article

A novel nucleolar transcriptional activator ApLLP for long-term memory formation is intrinsically unstructured but functionally active

scientific article published on 17 December 2007

A small molecule agonist of EphA2 receptor tyrosine kinase inhibits tumor cell migration in vitro and prostate cancer metastasis in vivo.

scientific article

A unified mechanism for LLPS of ALS/FTLD-causing FUS as well as its modulation by ATP and oligonucleic acids

scientific article published on 12 June 2019

A β-sheet structure interacting peptide for intracellular protein delivery into human pluripotent stem cells and their derivatives

scientific article published on 19 April 2012

ALS-Causing Mutations Significantly Perturb the Self-Assembly and Interaction with Nucleic Acid of the Intrinsically Disordered Prion-Like Domain of TDP-43.

scientific article published on 6 January 2016

ALS-causing P56S mutation and splicing variation on the hVAPB MSP domain transform its β-sandwich fold into lipid-interacting helical conformations

scientific article

ALS-causing cleavages of TDP-43 abolish its RRM2 structure and unlock CTD for enhanced aggregation and toxicity

scientific article published on 28 February 2017

C-Terminal Auto-Regulatory Motif of Hepatitis C Virus NS5B Interacts with Human VAPB-MSP to Form a Dynamic Replication Complex

scientific article

Contribution of individual residues to formation of the native-like tertiary topology in the alpha-lactalbumin molten globule

scientific article published in July 1998

Crystal Structure and NMR Binding Reveal That Two Small Molecule Antagonists Target the High Affinity Ephrin-binding Channel of the EphA4 Receptor

scientific article

Direct and Indirect Models for Protein Chemical Denaturation are Characteristic of Opposite Dynamic Properties

Disruption of FAT10-MAD2 binding inhibits tumor progression.

scientific article

Dissection study on the severe acute respiratory syndrome 3C-like protease reveals the critical role of the extra domain in dimerization of the enzyme: defining the extra domain as a new target for design of highly specific protease inhibitors

scientific article

Distinctive binding of three antagonistic peptides to the ephrin-binding pocket of the EphA4 receptor

scientific article published on July 2012

Dnd Is a Critical Specifier of Primordial Germ Cells in the Medaka Fish

scientific article published on 27 January 2016

Dynamic principle for designing antagonistic/agonistic molecules for EphA4 receptor, the only known ALS modifier.

scientific article published on 24 October 2014

Dynamically-driven enhancement of the catalytic machinery of the SARS 3C-like protease by the S284-T285-I286/A mutations on the extra domain

scientific article

Dynamically-driven inactivation of the catalytic machinery of the SARS 3C-like protease by the N214A mutation on the extra domain

scientific article

Elimination of the native structure and solubility of the hVAPB MSP domain by the Pro56Ser mutation that causes amyotrophic lateral sclerosis

scientific article

Fusion gene vectors allowing for simultaneous drug selection, cell labeling, and reporter assay in vitro and in vivo

scientific article published on 23 December 2011

Identification and structural mechanism for a novel interaction between a ubiquitin ligase WWP1 and Nogo-A, a key inhibitor for central nervous system regeneration

scientific article

Identification of a Zika NS2B-NS3pro pocket susceptible to allosteric inhibition by small molecules including qucertin rich in edible plants

article

Identification of a novel nonstructural protein, VP9, from white spot syndrome virus: its structure reveals a ferredoxin fold with specific metal binding sites

scientific article

Identification of quercetin from fruits to immediately fight Zika

scholarly article published 11 September 2016

Identification, recombinant production and structural characterization of four silk proteins from the Asiatic honeybee Apis cerana

scientific article published on 3 April 2008

Insight into "insoluble proteins" with pure water

scientific article

Insights into protein aggregation by NMR characterization of insoluble SH3 mutants solubilized in salt-free water

scientific article

Insoluble protein characterization by circular dichroism (CD) spectroscopy and nuclear magnetic resonance (NMR).

scientific article

Inter-domain interactions of TDP-43 as decoded by NMR.

scientific article published on 31 March 2016

Interordinal chimera formation between medaka and zebrafish for analyzing stem cell differentiation

scientific article

Intrinsically unstructured domain 3 of hepatitis C Virus NS5A forms a "fuzzy complex" with VAPB-MSP domain which carries ALS-causing mutations

scientific article

Mechanism for Controlling the Dimer-Monomer Switch and Coupling Dimerization to Catalysis of the Severe Acute Respiratory Syndrome Coronavirus 3C-Like Protease

scientific article

Mechanism for transforming cytosolic SOD1 into integral membrane proteins of organelles by ALS-causing mutations

scientific article

Mechanisms of self-assembly and fibrillization of the prion-like domains

Microfibers fabricated by non-covalent assembly of peptide and DNA for viral vector encapsulation and cancer therapy

scientific article published on 25 May 2012

Mitf is a transcriptional activator of medaka germ genes in culture

scientific article published on 22 November 2011

Molecular Mechanism Underlying the Thermal Stability and pH-induced Unfolding of CHABII

Molecular interactions of the Gbeta binding domain of the Ste20p/PAK family of protein kinases. An isolated but fully functional Gbeta binding domain from Ste20p is only partially folded as shown by heteronuclear NMR spectroscopy.

scientific article

Myricetin Allosterically Inhibits the Dengue NS2B-NS3 Protease by Disrupting the Active and Locking the Inactive Conformations

scientific article published on 11 January 2022

NMR Assignment of the Human EphrinB2 Ectodomain

NMR and MD Studies Reveal That the Isolated Dengue NS3 Protease Is an Intrinsically Disordered Chymotrypsin Fold Which Absolutely Requests NS2B for Correct Folding and Functional Dynamics

scientific article

NMR binding and crystal structure reveal that intrinsically-unstructured regulatory domain auto-inhibits PAK4 by a mechanism different from that of PAK1

scientific article

NMR evidence for forming highly populated helical conformations in the partially folded hNck2 SH3 domain

scientific article

NMR for the design of functional mimetics of protein-protein interactions: one key is in the building of bridges

article published in 1998

NMR for the design of functional mimetics of protein-protein interactions: one key is in the building of bridges

article

NMR solution structure of a two-disulfide derivative of charybdotoxin: structural evidence for conservation of scorpion toxin alpha/beta motif and its hydrophobic side chain packing

scientific article

NMR structure and dynamics of human ephrin-B2 ectodomain: the functionally critical C-D and G-H loops are highly dynamic in solution

scientific article

NMR studies reveal a novel mode for hFADD to bind with the unstructured hRTN3 which initiates the ER-stress activated apoptosis

scientific article published on 11 April 2009

Nogo goes in the pure water: solution structure of Nogo-60 and design of the structured and buffer-soluble Nogo-54 for enhancing CNS regeneration

scientific article

Nogo-B receptor possesses an intrinsically unstructured ectodomain and a partially folded cytoplasmic domain

scientific article

On the convergent evolution of animal toxins. Conservation of a diad of functional residues in potassium channel-blocking toxins with unrelated structures

scientific article

Protein dynamics at Eph receptor-ligand interfaces as revealed by crystallography, NMR and MD simulations

scientific article

RRM domain of ALS/FTD-causing FUS characteristic of irreversible unfolding spontaneously self-assembles into amyloid fibrils

scientific article

RRM domain of ALS/FTD-causing FUS interacts with membrane: an anchor of membraneless organelles to membranes?

Rational design, solution conformation and identification of functional residues of the soluble and structured Nogo-54, which mimics Nogo-66 in inhibiting the CNS neurite outgrowth

scientific article published in 2008

Resolving the paradox for protein aggregation diseases: NMR structure and dynamics of the membrane-embedded P56S-MSP causing ALS imply a common mechanism for aggregation-prone proteins to attack membranes

scientific article

Resurrecting abandoned proteins with pure water: CD and NMR studies of protein fragments solubilized in salt-free water

scientific article

SALS-linked WT-SOD1 adopts a highly similar helical conformation as FALS-causing L126Z-SOD1 in a membrane environment

scientific article

Selective and specific ion binding on proteins at physiologically-relevant concentrations

scientific article

Solution conformations of Zika NS2B-NS3pro and its inhibition by natural products from edible plants

scientific article

Solution structure and backbone dynamics of the functional cytoplasmic subdomain of human ephrin B2, a cell-surface ligand with bidirectional signaling properties

scientific article (publication date: 10 September 2002)

Stability of protein-bound conformations of bioactive peptides: The folded conformation of an epidermal growth factor-like thrombomodulin fragment is similar to that recognized by thrombin

scientific article published in 2002

Structural Characterization of the EphA4-Ephrin-B2 Complex Reveals New Features Enabling Eph-Ephrin Binding Promiscuity

scientific article

Structural characterization of the human Nogo-A functional domains. Solution structure of Nogo-40, a Nogo-66 receptor antagonist enhancing injured spinal cord regeneration

scientific article

Structural characterization reveals that viperin is a radical S-adenosyl-L-methionine (SAM) enzyme

scientific article

Structural insight into the binding diversity between the Tyr-phosphorylated human ephrinBs and Nck2 SH2 domain

scientific article

Structural insight into the binding diversity between the human Nck2 SH3 domains and proline-rich proteins

scientific article

Structural study of hNck2 SH3 domain protein in solution by circular dichroism and X-ray solution scattering

scientific article published on 26 February 2013

Structural, stability, dynamic and binding properties of the ALS-causing T46I mutant of the hVAPB MSP domain as revealed by NMR and MD simulations

scientific article

Structure of the Arabidopsis thaliana DCL4 DUF283 domain reveals a noncanonical double-stranded RNA-binding fold for protein-protein interaction

scientific article

TDP-43 N terminus encodes a novel ubiquitin-like fold and its unfolded form in equilibrium that can be shifted by binding to ssDNA

scientific article

TMEM106B, a risk factor for FTLD and aging, has an intrinsically disordered cytoplasmic domain

scientific article published in PLoS ONE

The N- and C-termini of the human Nogo molecules are intrinsically unstructured: bioinformatics, CD, NMR characterization, and functional implications

scientific article

The active-site residue Cys-29 is responsible for the neutral-pH inactivation and the refolding barrier of human cathepsin B.

scientific article

The catalysis of the SARS 3C-like protease is under extensive regulation by its extra domain

scientific article published in March 2006

The variable N-terminal region of DDX5 contains structural elements and auto-inhibits its interaction with NS5B of hepatitis C virus

scientific article

Transforming Cytosolic Proteins into "Insoluble" and Membrane-toxic Forms by Genetic, Pathological or Environmental Factors

scientific article

Tyrosine phosphorylation of the well packed ephrinB cytoplasmic beta-hairpin for reverse signaling. Structural consequences and binding properties

scientific article

Unique properties of Zika NS2B-NS3pro complexes as decoded by experiments and MD simulations

scholarly article published 28 September 2016

Unique structure and dynamics of the EphA5 ligand binding domain mediate its binding specificity as revealed by X-ray crystallography, NMR and MD simulations

scientific article

Unlocked capacity of proteins to attack membranes characteristic of aggregation: the evil for diseases and aging from Pandora's box

article

VAPC, an human endogenous inhibitor for hepatitis C virus (HCV) infection, is intrinsically unstructured but forms a "fuzzy complex" with HCV NS5B.

scientific article

Why do proteins aggregate? "Intrinsically insoluble proteins" and "dark mediators" revealed by studies on "insoluble proteins" solubilized in pure water

scientific article published on 22 March 2013

List of works by Jianxing Song

A disalicylic acid-furanyl derivative inhibits ephrin binding to a subset of Eph receptors

A gradual disruption of tight side-chain packing: 2D 1H-NMR characterization of acid-induced unfolding of CHABII.

A model of dynamic side-chain--side-chain interactions in the alpha-lactalbumin molten globule

A monoclonal antibody binds to threonine 49 in the non-structural 1 protein of influenza A virus and interferes with its ability to modulate viral replication.

A novel SOD1-dependent mechanism for the iron-induced production of toxic SOD1 and oxidative stress that initiates ALS

A novel nucleolar transcriptional activator ApLLP for long-term memory formation is intrinsically unstructured but functionally active

A small molecule agonist of EphA2 receptor tyrosine kinase inhibits tumor cell migration in vitro and prostate cancer metastasis in vivo.

A unified mechanism for LLPS of ALS/FTLD-causing FUS as well as its modulation by ATP and oligonucleic acids

A β-sheet structure interacting peptide for intracellular protein delivery into human pluripotent stem cells and their derivatives

ALS-Causing Mutations Significantly Perturb the Self-Assembly and Interaction with Nucleic Acid of the Intrinsically Disordered Prion-Like Domain of TDP-43.

ALS-causing P56S mutation and splicing variation on the hVAPB MSP domain transform its β-sandwich fold into lipid-interacting helical conformations

ALS-causing cleavages of TDP-43 abolish its RRM2 structure and unlock CTD for enhanced aggregation and toxicity

C-Terminal Auto-Regulatory Motif of Hepatitis C Virus NS5B Interacts with Human VAPB-MSP to Form a Dynamic Replication Complex

Contribution of individual residues to formation of the native-like tertiary topology in the alpha-lactalbumin molten globule

Crystal Structure and NMR Binding Reveal That Two Small Molecule Antagonists Target the High Affinity Ephrin-binding Channel of the EphA4 Receptor

Direct and Indirect Models for Protein Chemical Denaturation are Characteristic of Opposite Dynamic Properties

Disruption of FAT10-MAD2 binding inhibits tumor progression.

Dissection study on the severe acute respiratory syndrome 3C-like protease reveals the critical role of the extra domain in dimerization of the enzyme: defining the extra domain as a new target for design of highly specific protease inhibitors

Distinctive binding of three antagonistic peptides to the ephrin-binding pocket of the EphA4 receptor

Dnd Is a Critical Specifier of Primordial Germ Cells in the Medaka Fish

Dynamic principle for designing antagonistic/agonistic molecules for EphA4 receptor, the only known ALS modifier.

Dynamically-driven enhancement of the catalytic machinery of the SARS 3C-like protease by the S284-T285-I286/A mutations on the extra domain

Dynamically-driven inactivation of the catalytic machinery of the SARS 3C-like protease by the N214A mutation on the extra domain

Elimination of the native structure and solubility of the hVAPB MSP domain by the Pro56Ser mutation that causes amyotrophic lateral sclerosis

Fusion gene vectors allowing for simultaneous drug selection, cell labeling, and reporter assay in vitro and in vivo

Identification and structural mechanism for a novel interaction between a ubiquitin ligase WWP1 and Nogo-A, a key inhibitor for central nervous system regeneration

Identification of a Zika NS2B-NS3pro pocket susceptible to allosteric inhibition by small molecules including qucertin rich in edible plants

Identification of a novel nonstructural protein, VP9, from white spot syndrome virus: its structure reveals a ferredoxin fold with specific metal binding sites

Identification of quercetin from fruits to immediately fight Zika

Identification, recombinant production and structural characterization of four silk proteins from the Asiatic honeybee Apis cerana

Insight into "insoluble proteins" with pure water

Insights into protein aggregation by NMR characterization of insoluble SH3 mutants solubilized in salt-free water

Insoluble protein characterization by circular dichroism (CD) spectroscopy and nuclear magnetic resonance (NMR).

Inter-domain interactions of TDP-43 as decoded by NMR.

Interordinal chimera formation between medaka and zebrafish for analyzing stem cell differentiation

Intrinsically unstructured domain 3 of hepatitis C Virus NS5A forms a "fuzzy complex" with VAPB-MSP domain which carries ALS-causing mutations

Mechanism for Controlling the Dimer-Monomer Switch and Coupling Dimerization to Catalysis of the Severe Acute Respiratory Syndrome Coronavirus 3C-Like Protease

Mechanism for transforming cytosolic SOD1 into integral membrane proteins of organelles by ALS-causing mutations

Mechanisms of self-assembly and fibrillization of the prion-like domains

Microfibers fabricated by non-covalent assembly of peptide and DNA for viral vector encapsulation and cancer therapy

Mitf is a transcriptional activator of medaka germ genes in culture

Molecular Mechanism Underlying the Thermal Stability and pH-induced Unfolding of CHABII

Molecular interactions of the Gbeta binding domain of the Ste20p/PAK family of protein kinases. An isolated but fully functional Gbeta binding domain from Ste20p is only partially folded as shown by heteronuclear NMR spectroscopy.

Myricetin Allosterically Inhibits the Dengue NS2B-NS3 Protease by Disrupting the Active and Locking the Inactive Conformations

NMR Assignment of the Human EphrinB2 Ectodomain

NMR and MD Studies Reveal That the Isolated Dengue NS3 Protease Is an Intrinsically Disordered Chymotrypsin Fold Which Absolutely Requests NS2B for Correct Folding and Functional Dynamics

NMR binding and crystal structure reveal that intrinsically-unstructured regulatory domain auto-inhibits PAK4 by a mechanism different from that of PAK1

NMR evidence for forming highly populated helical conformations in the partially folded hNck2 SH3 domain

NMR for the design of functional mimetics of protein-protein interactions: one key is in the building of bridges

NMR for the design of functional mimetics of protein-protein interactions: one key is in the building of bridges

NMR solution structure of a two-disulfide derivative of charybdotoxin: structural evidence for conservation of scorpion toxin alpha/beta motif and its hydrophobic side chain packing

NMR structure and dynamics of human ephrin-B2 ectodomain: the functionally critical C-D and G-H loops are highly dynamic in solution

NMR studies reveal a novel mode for hFADD to bind with the unstructured hRTN3 which initiates the ER-stress activated apoptosis

Nogo goes in the pure water: solution structure of Nogo-60 and design of the structured and buffer-soluble Nogo-54 for enhancing CNS regeneration

Nogo-B receptor possesses an intrinsically unstructured ectodomain and a partially folded cytoplasmic domain

On the convergent evolution of animal toxins. Conservation of a diad of functional residues in potassium channel-blocking toxins with unrelated structures

Protein dynamics at Eph receptor-ligand interfaces as revealed by crystallography, NMR and MD simulations

RRM domain of ALS/FTD-causing FUS characteristic of irreversible unfolding spontaneously self-assembles into amyloid fibrils

RRM domain of ALS/FTD-causing FUS interacts with membrane: an anchor of membraneless organelles to membranes?

Rational design, solution conformation and identification of functional residues of the soluble and structured Nogo-54, which mimics Nogo-66 in inhibiting the CNS neurite outgrowth

Resolving the paradox for protein aggregation diseases: NMR structure and dynamics of the membrane-embedded P56S-MSP causing ALS imply a common mechanism for aggregation-prone proteins to attack membranes

Resurrecting abandoned proteins with pure water: CD and NMR studies of protein fragments solubilized in salt-free water

SALS-linked WT-SOD1 adopts a highly similar helical conformation as FALS-causing L126Z-SOD1 in a membrane environment

Selective and specific ion binding on proteins at physiologically-relevant concentrations

Solution conformations of Zika NS2B-NS3pro and its inhibition by natural products from edible plants

Solution structure and backbone dynamics of the functional cytoplasmic subdomain of human ephrin B2, a cell-surface ligand with bidirectional signaling properties

Stability of protein-bound conformations of bioactive peptides: The folded conformation of an epidermal growth factor-like thrombomodulin fragment is similar to that recognized by thrombin

Structural Characterization of the EphA4-Ephrin-B2 Complex Reveals New Features Enabling Eph-Ephrin Binding Promiscuity

Structural characterization of the human Nogo-A functional domains. Solution structure of Nogo-40, a Nogo-66 receptor antagonist enhancing injured spinal cord regeneration

Structural characterization reveals that viperin is a radical S-adenosyl-L-methionine (SAM) enzyme

Structural insight into the binding diversity between the Tyr-phosphorylated human ephrinBs and Nck2 SH2 domain

Structural insight into the binding diversity between the human Nck2 SH3 domains and proline-rich proteins

Structural study of hNck2 SH3 domain protein in solution by circular dichroism and X-ray solution scattering

Structural, stability, dynamic and binding properties of the ALS-causing T46I mutant of the hVAPB MSP domain as revealed by NMR and MD simulations

Structure of the Arabidopsis thaliana DCL4 DUF283 domain reveals a noncanonical double-stranded RNA-binding fold for protein-protein interaction

TDP-43 N terminus encodes a novel ubiquitin-like fold and its unfolded form in equilibrium that can be shifted by binding to ssDNA

TMEM106B, a risk factor for FTLD and aging, has an intrinsically disordered cytoplasmic domain

The N- and C-termini of the human Nogo molecules are intrinsically unstructured: bioinformatics, CD, NMR characterization, and functional implications

The active-site residue Cys-29 is responsible for the neutral-pH inactivation and the refolding barrier of human cathepsin B.