Search filters

List of works by Ian Spendlove

105Ad7 cancer vaccine stimulates anti-tumour helper and cytotoxic T-cell responses in colorectal cancer patients but repeated immunisations are required to maintain these responses

scientific article published in January 2000

A HIF-LIMD1 negative feedback mechanism mitigates the pro-tumorigenic effects of hypoxia

scientific article published on 01 August 2018

A neoadjuvant/adjuvant randomized trial of colorectal cancer patients vaccinated with an anti-idiotypic antibody, 105AD7, mimicking CD55

scientific article published on 22 November 2006

A novel CEA vaccine stimulates T cell proliferation, gammaIFN secretion and CEA specific CTL responses

scientific article published on September 2004

A prebiotic galactooligosaccharide mixture reduces severity of hyperpnoea-induced bronchoconstriction and markers of airway inflammation.

scientific article published in September 2016

Antibodies designed as effective cancer vaccines.

scientific article published on January 2009

Ballooned neurons in several neurodegenerative diseases and stroke contain alpha B crystallin

scientific article published on August 1992

CD55 costimulation induces differentiation of a discrete T regulatory type 1 cell population with a stable phenotype

scientific article published on 6 November 2013

CD55 is over-expressed in the tumour environment

scientific article published on January 2001

Cancer vaccines

scientific article published on 01 September 1996

Cancer vaccines entering Phase III clinical trials.

scientific article published on November 2003

Characterisation of a mouse monoclonal anti-idiotype reactive with a V region sequence commonly used by human immunoglobulins.

scientific article published on April 2000

Comparison of the immune response to a self antigen after DNA immunisation of HLA*A201/H-2Kb and HHD transgenic mice.

scientific article published on April 2004

Complement decay accelerating factor (DAF)/CD55 in cancer.

scientific article

Costimulation via CD55 on human CD4+ T cells mediated by CD97

scientific article

Cytoplasmic expression of p27(kip1) is associated with a favourable prognosis in colorectal cancer patients.

scientific article

Cytoplasmic p27 expression is an independent prognostic factor in ovarian cancer

scientific article published in January 2010

DNA vaccination with T-cell epitopes encoded within Ab molecules induces high-avidity anti-tumor CD8+ T cells

scientific article published on 01 March 2010

Decay accelerating factor (CD55): a target for cancer vaccines?

scientific article published on 01 May 1999

Dementia with beta-amyloid deposition: involvement of alpha B-crystallin supports two main diseases

scientific article published in August 1990

Differential subcellular localisation of the tumour suppressor protein LIMD1 in breast cancer correlates with patient survival

scientific article published on 01 November 2008

Do poor-prognosis breast tumours express membrane cofactor proteins (CD46)?

scientific article published on 16 September 2004

Elevation of alanine transaminase and markers of liver fibrosis after a mixed meal challenge in individuals with type 2 diabetes

scientific article published on 17 May 2012

Engineering the human Fc-region enables direct cell killing by cancer glycan-targeting antibodies without the need for immune effector cells or complement

scientific article published on 12 June 2020

Enhanced expression of the complement regulatory protein CD55 predicts a poor prognosis in colorectal cancer patients

scientific article published on 14 June 2003

Evidence that the p53 negative / Bcl-2 positive phenotype is an independent indicator of good prognosis in colorectal cancer: a tissue microarray study of 460 patients

scientific article

Expression of the membrane complement regulatory protein CD59 (protectin) is associated with reduced survival in colorectal cancer patients

scientific article

Expression of the stress-related MHC class I chain-related protein MICA is an indicator of good prognosis in colorectal cancer patients

scientific article published in March 2006

High expression of Lewis y/b antigens is associated with decreased survival in lymph node negative breast carcinomas

scientific article

Human anti-idiotypic antibodies can be good immunogens as they target FC receptors on antigen-presenting cells allowing efficient stimulation of both helper and cytotoxic T-cell responses

scientific article published on 01 May 2001

Human leukocyte antigen class I antigen expression is an independent prognostic factor in ovarian cancer

scientific article published on 01 June 2007

Identification of an HLA-A*0201 cytotoxic T lymphocyte epitope specific to the endothelial antigen Tie-2.

scientific article

Immune responses to the 105AD7 human anti-idiotypic vaccine after intensive chemotherapy, for osteosarcoma.

scientific article published on April 2005

Immunization against tumor cell surface complement-regulatory proteins.

scientific article

Immunology in the clinic review series; focus on cancer: glycolipids as targets for tumour immunotherapy

scientific article published on February 2012

Immunosurveillance is active in colorectal cancer as downregulation but not complete loss of MHC class I expression correlates with a poor prognosis.

scientific article published in January 2006

International conference: progress in vaccination against cancer (PIVAC) 2002, Nottingham, UK.

scientific article published on 9 April 2003

Loss of CD55 is associated with aggressive breast tumors

scientific article published on April 2004

Loss of IFN gamma receptor is an independent prognostic factor in ovarian cancer

scientific article published on 01 July 2007

Low doses of 105AD7 cancer vaccine preferentially stimulate anti-tumor T-cell immunity

scientific article published on 01 February 1997

Monoclonal Antibodies Targeting LecLex-Related Glycans with Potent Antitumor Activity.

scientific article

Production and characterization of a polyclonal antibody to the c-erbB-3 protein: examination of c-erbB-3 protein expression in adenocarcinomas

scientific article published on November 1992

Randomized, placebo-controlled trial of pioglitazone in nondiabetic subjects with nonalcoholic steatohepatitis

scientific article

Single shot tetanus vaccine manufactured by a supercritical fluid encapsulation technology

scientific article published on 28 April 2011

Stromal fibroblasts support dendritic cells to maintain IL-23/Th17 responses after exposure to ionizing radiation.

scientific article published on 05 April 2016

Structural and functional characterization of a novel T cell receptor co-regulatory protein complex, CD97-CD55

scientific article

Structural biology of antibody recognition of carbohydrate epitopes and potential uses for targeted cancer immunotherapies

scientific article

T-cell responses in osteosarcoma patients vaccinated with an anti-idiotypic antibody, 105AD7, mimicking CD55

scientific article published on 27 May 2008

The ataxia telangiectasia mutated kinase pathway regulates IL-23 expression by human dendritic cells

scientific article published on 4 March 2013

The chemokine, CXCL12, is an independent predictor of poor survival in ovarian cancer ⬇️

scientific article published on March 13, 2012

The chromosome 3p21.3-encoded gene, LIMD1, is a critical tumor suppressor involved in human lung cancer development

scholarly article

The p53 positive Bcl-2 negative phenotype is an independent marker of prognosis in breast cancer

scientific article published on 01 March 2007

The role of CD55 in protecting the tumour environment from complement attack

scientific article published on September 2002

The role of CD97 in regulating adaptive T-cell responses.

scientific article published on January 2010

The ubiquitin-binding protein p62 is expressed in breast cancers showing features of aggressive disease

scientific article

The use of reverse immunology to identify HLA-A2 binding epitopes in Tie-2.

scientific article

Therapeutic targeting of Lewis(y) and Lewis(b) with a novel monoclonal antibody 692/29.

scientific article

Total loss of MHC class I is an independent indicator of good prognosis in breast cancer

scientific article published on 01 November 2005

Using monoclonal antibodies to stimulate antitumor cellular immunity

scientific article published on July 2011

Vaccines as early therapeutic interventions for cancer therapy: neutralising the immunosuppressive tumour environment and increasing T cell avidity may lead to improved responses

scientific article published on May 2010

Vascular endothelial growth factor expression in ovarian cancer: a model for targeted use of novel therapies?

scientific article published in May 2008

alpha B crystallin expression in non-lenticular tissues and selective presence in ubiquitinated inclusion bodies in human disease

scientific article published in January 1992

Paulina is supported by:

About Paulina

Help