List of works - Ling Qi

A CRISPR-Based Screen Identifies Genes Essential for West-Nile-Virus-Induced Cell Death

scientific article

A Phos-tag-based approach reveals the extent of physiological endoplasmic reticulum stress

scientific article

A conserved structural determinant located at the interdomain region of mammalian inositol-requiring enzyme 1alpha

scientific article

Activation of natural killer T cells promotes M2 Macrophage polarization in adipose tissue and improves systemic glucose tolerance via interleukin-4 (IL-4)/STAT6 protein signaling axis in obesity

scientific article published on 6 March 2012

Adipocyte CREB promotes insulin resistance in obesity

scientific article published in March 2009

Adipocyte spliced form of X-box-binding protein 1 promotes adiponectin multimerization and systemic glucose homeostasis

scientific article

Angptl4 protects against severe proinflammatory effects of saturated fat by inhibiting fatty acid uptake into mesenteric lymph node macrophages

scientific article

Chronic intake of high fish oil diet induces myeloid-derived suppressor cells to promote tumor growth.

scientific article

Deficiency of suppressor enhancer Lin12 1 like (SEL1L) in mice leads to systemic endoplasmic reticulum stress and embryonic lethality

scientific journal article

Designing a retrievable and scalable cell encapsulation device for potential treatment of type 1 diabetes

scientific article published on 26 December 2017

Detecting and quantitating physiological endoplasmic reticulum stress

scientific article published on January 2011

Developing robust, hydrogel-based, nanofiber-enabled encapsulation devices (NEEDs) for cell therapies

scientific article

Diet-induced alterations in gut microflora contribute to lethal pulmonary damage in TLR2/TLR4-deficient mice

scientific article

Direct control of hepatic glucose production by interleukin-13 in mice.

scientific article

ER-associated degradation in health and disease - from substrate to organism

scientific article published on 02 December 2019

ER-associated degradation is required for vasopressin prohormone processing and systemic water homeostasis.

scientific article

ER-stress-associated functional link between Parkin and DJ-1 via a transcriptional cascade involving the tumor suppressor p53 and the spliced X-box binding protein XBP-1.

scientific article published on 27 February 2013

Emerging roles for XBP1, a sUPeR transcription factor

scientific article published on January 2010

Endoplasmic reticulum quality control in cancer: Friend or foe.

scientific article published on 18 March 2015

Endoplasmic reticulum-associated degradation regulates mitochondrial dynamics in brown adipocytes

scientific article published on 19 March 2020

Epithelial Sel1L is required for the maintenance of intestinal homeostasis

scientific article published on 2 December 2015

Feeding Angptl4-/- mice trans fat promotes foam cell formation in mesenteric lymph nodes without leading to ascites

scientific article published on 15 April 2017

Fish Oil-Rich Diet Promotes Hematopoiesis and Alters Hematopoietic Niche.

scientific article published on 10 June 2015

Gr-1+ CD11b+ myeloid-derived suppressor cells suppress inflammation and promote insulin sensitivity in obesity

scientific article

H2-O inhibits presentation of bacterial superantigens, but not endogenous self antigens

scientific article published on 01 August 2001

Haploid insufficiency of suppressor enhancer Lin12 1-like (SEL1L) protein predisposes mice to high fat diet-induced hyperglycemia.

scientific article published on 2 May 2011

Hepatic Sel1L-Hrd1 ER-associated degradation (ERAD) manages FGF21 levels and systemic metabolism via CREBH

scientific article published on 02 November 2018

High-Resolution Metabolomics with Acyl-CoA Profiling Reveals Widespread Remodeling in Response to Diet

scientific article published on 20 March 2015

Hypothalamic ER-associated degradation regulates POMC maturation, feeding, and age-associated obesity.

scientific article published on 19 February 2018

Hypoxia-inducible lipid droplet-associated (HILPDA) is a novel peroxisome proliferator-activated receptor (PPAR) target involved in hepatic triglyceride secretion

scientific article

Hypoxia-inducible lipid droplet-associated (HILPDA) is not a direct physiological regulator of lipolysis in adipose tissue.

scientific article

IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradation

scientific article

Invariant chain and the MHC class II cytoplasmic domains regulate localization of MHC class II molecules to lipid rafts in tumor cell-based vaccines

scientific article published on January 2004

Mechanisms of inflammatory responses in obese adipose tissue

scientific article

Misfolded proinsulin in the endoplasmic reticulum during development of beta cell failure in diabetes.

scientific article

NOTCH3 is non-enzymatically fragmented in inherited cerebral small-vessel disease

scientific article published on 04 January 2020

New Insights into the Physiological Role of Endoplasmic Reticulum-Associated Degradation

scientific article published on 25 January 2017

Nonmuscle myosin IIB links cytoskeleton to IRE1α signaling during ER stress.

scientific article published on December 2012

Overexpression of TRB3 in muscle alters muscle fiber type and improves exercise capacity in mice

scientific article

PERK and XBP1 differentially regulate CXCL10 and CCL2 production

scientific article published on 5 January 2017

Phenformin activates the unfolded protein response in an AMP-activated protein kinase (AMPK)-dependent manner.

scientific article published on 2 April 2013

Quality Control in the Endoplasmic Reticulum: Crosstalk between ERAD and UPR pathways.

scientific article published on 29 June 2018

Requirement for translocon-associated protein (TRAP) α in insulin biogenesis

scientific article published on 04 December 2019

SEL1L-HRD1 interaction is required to form a functional HRD1 ERAD complex

scientific article published in 2024

SUMO modification regulates the transcriptional activity of XBP1

scientific article

Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival

scientific article published on 22 January 2014

Short telomeres and ataxia-telangiectasia mutated deficiency cooperatively increase telomere dysfunction and suppress tumorigenesis.

scientific article

Short term high fat diet challenge promotes alternative macrophage polarization in adipose tissue via natural killer T cells and interleukin-4.

scientific article

Stressed out about obesity: IRE1α-XBP1 in metabolic disorders

scientific article published on 22 June 2011

TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism

scientific article

Telomere fusion to chromosome breaks reduces oncogenic translocations and tumour formation

scientific article

The ATP-P2X7 signaling axis is dispensable for obesity-associated inflammasome activation in adipose tissue

scientific article

The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism

scientific journal article

The ER-associated degradation adaptor protein Sel1L regulates LPL secretion and lipid metabolism

scientific journal article

The IRE1alpha-XBP1 pathway of the unfolded protein response is required for adipogenesis

scientific article

The Sel1L-Hrd1 Endoplasmic Reticulum-Associated Degradation Complex Manages a Key Checkpoint in B Cell Development

scientific article

The full capacity of AICAR to reduce obesity-induced inflammation and insulin resistance requires myeloid SIRT1

scientific article

The obesity-induced adipokine sST2 exacerbates adipose Treg and ILC2 depletion and promotes insulin resistance

scientific article published on 13 May 2020

The pseudokinase tribbles homolog 3 interacts with ATF4 to negatively regulate insulin exocytosis in human and mouse beta cells.

scientific article

The roles of ATF3, an adaptive-response gene, in high-fat-diet-induced diabetes and pancreatic beta-cell dysfunction.

scientific article

The transcriptional co-regulator HCF-1 is required for INS-1 β-cell glucose-stimulated insulin secretion

scientific article

Tipping the balance in metabolic regulation: regulating regulatory T cells by costimulation

scientific article published on April 2014

Toll-like receptors TLR2 and TLR4 block the replication of pancreatic β cells in diet-induced obesity

scientific article published on 20 May 2019

Tumor cells present MHC class II-restricted nuclear and mitochondrial antigens and are the predominant antigen presenting cells in vivo

scientific article published on 01 November 2000

XBP-1 couples endoplasmic reticulum stress to augmented IFN-beta induction via a cis-acting enhancer in macrophages.

scientific article

List of works by Ling Qi

A CRISPR-Based Screen Identifies Genes Essential for West-Nile-Virus-Induced Cell Death

A Phos-tag-based approach reveals the extent of physiological endoplasmic reticulum stress

A conserved structural determinant located at the interdomain region of mammalian inositol-requiring enzyme 1alpha

Activation of natural killer T cells promotes M2 Macrophage polarization in adipose tissue and improves systemic glucose tolerance via interleukin-4 (IL-4)/STAT6 protein signaling axis in obesity

Adipocyte CREB promotes insulin resistance in obesity

Adipocyte spliced form of X-box-binding protein 1 promotes adiponectin multimerization and systemic glucose homeostasis

Angptl4 protects against severe proinflammatory effects of saturated fat by inhibiting fatty acid uptake into mesenteric lymph node macrophages

Chronic intake of high fish oil diet induces myeloid-derived suppressor cells to promote tumor growth.

Deficiency of suppressor enhancer Lin12 1 like (SEL1L) in mice leads to systemic endoplasmic reticulum stress and embryonic lethality

Designing a retrievable and scalable cell encapsulation device for potential treatment of type 1 diabetes

Detecting and quantitating physiological endoplasmic reticulum stress

Developing robust, hydrogel-based, nanofiber-enabled encapsulation devices (NEEDs) for cell therapies

Diet-induced alterations in gut microflora contribute to lethal pulmonary damage in TLR2/TLR4-deficient mice

Direct control of hepatic glucose production by interleukin-13 in mice.

ER-associated degradation in health and disease - from substrate to organism

ER-associated degradation is required for vasopressin prohormone processing and systemic water homeostasis.

ER-stress-associated functional link between Parkin and DJ-1 via a transcriptional cascade involving the tumor suppressor p53 and the spliced X-box binding protein XBP-1.

Emerging roles for XBP1, a sUPeR transcription factor

Endoplasmic reticulum quality control in cancer: Friend or foe.

Endoplasmic reticulum-associated degradation regulates mitochondrial dynamics in brown adipocytes

Epithelial Sel1L is required for the maintenance of intestinal homeostasis

Feeding Angptl4-/- mice trans fat promotes foam cell formation in mesenteric lymph nodes without leading to ascites

Fish Oil-Rich Diet Promotes Hematopoiesis and Alters Hematopoietic Niche.

Gr-1+ CD11b+ myeloid-derived suppressor cells suppress inflammation and promote insulin sensitivity in obesity

H2-O inhibits presentation of bacterial superantigens, but not endogenous self antigens

Haploid insufficiency of suppressor enhancer Lin12 1-like (SEL1L) protein predisposes mice to high fat diet-induced hyperglycemia.

Hepatic Sel1L-Hrd1 ER-associated degradation (ERAD) manages FGF21 levels and systemic metabolism via CREBH

High-Resolution Metabolomics with Acyl-CoA Profiling Reveals Widespread Remodeling in Response to Diet

Hypothalamic ER-associated degradation regulates POMC maturation, feeding, and age-associated obesity.

Hypoxia-inducible lipid droplet-associated (HILPDA) is a novel peroxisome proliferator-activated receptor (PPAR) target involved in hepatic triglyceride secretion

Hypoxia-inducible lipid droplet-associated (HILPDA) is not a direct physiological regulator of lipolysis in adipose tissue.

IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradation

Invariant chain and the MHC class II cytoplasmic domains regulate localization of MHC class II molecules to lipid rafts in tumor cell-based vaccines

Mechanisms of inflammatory responses in obese adipose tissue

Misfolded proinsulin in the endoplasmic reticulum during development of beta cell failure in diabetes.

NOTCH3 is non-enzymatically fragmented in inherited cerebral small-vessel disease

New Insights into the Physiological Role of Endoplasmic Reticulum-Associated Degradation

Nonmuscle myosin IIB links cytoskeleton to IRE1α signaling during ER stress.

Overexpression of TRB3 in muscle alters muscle fiber type and improves exercise capacity in mice

PERK and XBP1 differentially regulate CXCL10 and CCL2 production

Phenformin activates the unfolded protein response in an AMP-activated protein kinase (AMPK)-dependent manner.

Quality Control in the Endoplasmic Reticulum: Crosstalk between ERAD and UPR pathways.

Requirement for translocon-associated protein (TRAP) α in insulin biogenesis

SEL1L-HRD1 interaction is required to form a functional HRD1 ERAD complex

SUMO modification regulates the transcriptional activity of XBP1

Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival

Short telomeres and ataxia-telangiectasia mutated deficiency cooperatively increase telomere dysfunction and suppress tumorigenesis.

Short term high fat diet challenge promotes alternative macrophage polarization in adipose tissue via natural killer T cells and interleukin-4.

Stressed out about obesity: IRE1α-XBP1 in metabolic disorders

TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism

Telomere fusion to chromosome breaks reduces oncogenic translocations and tumour formation

The ATP-P2X7 signaling axis is dispensable for obesity-associated inflammasome activation in adipose tissue

The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism

The ER-associated degradation adaptor protein Sel1L regulates LPL secretion and lipid metabolism

The IRE1alpha-XBP1 pathway of the unfolded protein response is required for adipogenesis

The Sel1L-Hrd1 Endoplasmic Reticulum-Associated Degradation Complex Manages a Key Checkpoint in B Cell Development

The full capacity of AICAR to reduce obesity-induced inflammation and insulin resistance requires myeloid SIRT1

The obesity-induced adipokine sST2 exacerbates adipose Treg and ILC2 depletion and promotes insulin resistance

The pseudokinase tribbles homolog 3 interacts with ATF4 to negatively regulate insulin exocytosis in human and mouse beta cells.

The roles of ATF3, an adaptive-response gene, in high-fat-diet-induced diabetes and pancreatic beta-cell dysfunction.

The transcriptional co-regulator HCF-1 is required for INS-1 β-cell glucose-stimulated insulin secretion

Tipping the balance in metabolic regulation: regulating regulatory T cells by costimulation

Toll-like receptors TLR2 and TLR4 block the replication of pancreatic β cells in diet-induced obesity

Tumor cells present MHC class II-restricted nuclear and mitochondrial antigens and are the predominant antigen presenting cells in vivo

XBP-1 couples endoplasmic reticulum stress to augmented IFN-beta induction via a cis-acting enhancer in macrophages.