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List of works by Jiří Zavadil

A novel role of endothelin-1 in linking Toll-like receptor 7-mediated inflammation to fibrosis in congenital heart block.

scientific article

A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia.

scientific article

A spotlight on regulatory networks connecting EMT and cancer stem cells

scientific article published on 01 August 2010

Abstract 3884: Genome-wide analysis of somatic mutations shared by co-occurring ovarian high-grade serous carcinomas and serous tubal intraepithelial carcinomas

article published in 2015

Abstract 633: Inhibition of TGFβ as a strategy to convert the irradiated tumor into in situ individualized vaccine

Abstract LB-342: MicroRNA-130b contributes to mesenchymal differentiation and leiomyosarcomagenesis

Analysis and meta-analysis of transcriptional profiling in human epidermis

scientific article published in January 2014

Analysis of transcripts from 17p13.3 in medulloblastoma suggests ROX/MNT as a potential tumour suppressor gene.

scientific article published in November 2004

Applications for microarrays in renal biology and medicine

scientific article published in January 2002

Aristolochic acid-associated urothelial cancer in Taiwan

scientific article

Autosomal dominant distal renal tubular acidosis is associated in three families with heterozygosity for the R589H mutation in the AE1 (band 3) Cl-/HCO3- exchanger

scientific article published in March 1998

Base changes in tumour DNA have the power to reveal the causes and evolution of cancer

scientific article

Beta HPV38 oncoproteins act with a hit-and-run mechanism in ultraviolet radiation-induced skin carcinogenesis in mice.

scientific article published on 11 January 2018

CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia

scientific article published on June 2009

Cancer risk: role of chance overstated

scientific article published on 5 February 2015

Characterising Mutational Spectra of Carcinogens in the Tumour Suppressor Gene TP53 Using Human TP53 Knock-in (Hupki) Mouse Embryo Fibroblasts

scientific article published on 13 November 2019

Chromatin remodeling and SWI/SNF2 factors in human disease.

scientific article published on May 2008

Chromatin remodeling enzyme Brg1 is required for mouse lens fiber cell terminal differentiation and its denucleation

scientific journal article

Chromatin remodeling enzyme Snf2h regulates embryonic lens differentiation and denucleation

scientific article published on June 2016

Chromatin structure regulation in transforming growth factor-beta-directed epithelial-mesenchymal transition

scientific article published on January 2007

Circulating free DNA concentration is an independent prognostic biomarker in lung cancer.

scientific article published on 22 October 2015

Comparison of gene expression profiles in chromate transformed BEAS-2B cells

scientific article

Comparison of the miRNA expression profiles in fresh frozen and formalin-fixed paraffin-embedded tonsillar tumors

scientific article

Comparison of the miRNA profiles in HPV-positive and HPV-negative tonsillar tumors and a model system of human keratinocyte clones.

scientific article

Comprehensive transcriptional profiling of human epidermis, reconstituted epidermal equivalents, and cultured keratinocytes using DNA microarray chips

scientific article published on January 2010

Consistent loss of the D5S89 locus mapping telomeric to the interleukin gene cluster and centromeric to EGR-1 in patients with 5q- chromosome

scientific article published in January 1994

Control of cholesterol metabolism and plasma high-density lipoprotein levels by microRNA-144.

scientific article published on 21 March 2013

Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7

scientific article published on 12 May 2008

Corrigendum: Modelling mutational landscapes of human cancers in vitro.

scientific article published on 16 January 2017

DNA damage and eIF4G1 in breast cancer cells reprogram translation for survival and DNA repair mRNAs

scientific article

Differential regulation of catechol-O-methyltransferase expression in a mouse model of aggression.

scientific article

Distinct functions of Sox2 control self-renewal and differentiation in the osteoblast lineage.

scientific article

Drosophila H1 Regulates the Genetic Activity of Heterochromatin by Recruitment of Su(var)3-9 ⬇️

scientific article published on April 5, 2013

Efficient in vivo microRNA targeting of liver metastasis

scientific article published on 22 November 2010

Endemic (Balkan) nephropathy is aristolochic acid nephropathy

scientific article published on January 2014

Epigenetic silencing of the oncogenic miR-17-92 cluster during PU.1-directed macrophage differentiation.

scientific article published on 6 September 2011

Epithelial-Mesenchymal Transition

article from 2008

Experimental Delineation of Mutational Signatures Is an Essential Tool in Cancer Epidemiology and Prevention

scientific article published on 11 September 2019

Experimental and pan-cancer genome analyses reveal widespread contribution of acrylamide exposure to carcinogenesis in humans

scientific article published on 07 March 2019

Experimental identification of cancer driver alterations in the era of pan-cancer genomics

scientific article published on 31 October 2019

Factor VIII gene deletions in haemophilia A patients in Czechoslovakia

scientific article

Functional genomic analysis identifies indoxyl sulfate as a major, poorly dialyzable uremic toxin in end-stage renal disease

scientific article

Gene expression pattern in hepatic stem/progenitor cells during rat fetal development using complementary DNA microarrays.

scholarly article

Genome-scale mutational signatures of aflatoxin in cells, mice, and human tumors

scientific article

Genotoxicity of industrial effluents, river waters, and their fractions using the Ames test and in vitro cytogenetic assay

scientific article published in November 1996

Global Reprogramming of the Cellular Translational Landscape Facilitates Cytomegalovirus Replication

scientific article published on 27 March 2014

Global reprogramming of the cellular translational landscape facilitates cytomegalovirus replication

scientific article

Hedgehog pathway blockade inhibits melanoma cell growth in vitro and in vivo

scientific article

Hierarchical model of gene regulation by transforming growth factor beta

scientific article published on 20 August 2003

Histology-Specific MicroRNA Alterations in Melanoma ⬇️

scientific article published on May 3, 2012

Hypoxia induces trimethylated H3 lysine 4 by inhibition of JARID1A demethylase

scientific article

Identification and characterization of FGF2-dependent mRNA: microRNA networks during lens fiber cell differentiation

scientific journal article

Identification of pax6-dependent gene regulatory networks in the mouse lens

scientific article

Immune profile and mitotic index of metastatic melanoma lesions enhance clinical staging in predicting patient survival

scientific article

In TCR-stimulated T-cells, N-ras regulates specific genes and signal transduction pathways

scientific article

Influence of optical fibers on the spectrum of transmitted light-emitting-diode radiation

scientific article published on 01 July 1995

Inhibition of Smad5 in human hematopoietic progenitors blocks erythroid differentiation induced by BMP4.

scientific article

Inhibition of nonsense-mediated RNA decay by the tumor microenvironment promotes tumorigenesis

scientific article

Insulin acts through FOXO3a to activate transcription of plasminogen activator inhibitor type 1.

scientific article published on 16 July 2009

Integrative genomics identifies molecular alterations that challenge the linear model of melanoma progression

scientific article

Knock down of HIF-1alpha in glioma cells reduces migration in vitro and invasion in vivo and impairs their ability to form tumor spheres.

scientific article

Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development

scientific article published on 19 September 2006

Long chain fatty Acyl-CoA synthetase 4 is a biomarker for and mediator of hormone resistance in human breast cancer

scientific article published in 2013

Low-Coverage Exome Sequencing Screen in Formalin-Fixed Paraffin-Embedded Tumors Reveals Evidence of Exposure to Carcinogenic Aristolochic Acid.

scientific article published on 17 September 2015

MYB transcriptionally regulates the miR-155 host gene in chronic lymphocytic leukemia

scientific article

MicroRNA-21 in glomerular injury

scientific article

Mir-17-3p controls spinal neural progenitor patterning by regulating Olig2/Irx3 cross-repressive loop

scientific journal article

Mitral valve prolapse is associated with altered extracellular matrix gene expression patterns.

scientific article published on 05 April 2016

Modeling cancer driver events in vitro using barrier bypass-clonal expansion assays and massively parallel sequencing

scientific article published on 10 July 2017

Modelling Mutation Spectra of Human Carcinogens Using Experimental Systems

scientific article

Modelling mutational landscapes of human cancers in vitro.

scientific article

Molecular characterization of hybridoma subclones spontaneously switching at high frequencies in vitro

scientific article published on 17 July 2009

Molecular signatures of prostate stem cells reveal novel signaling pathways and provide insights into prostate cancer

scientific article

Molecular signatures of the primitive prostate stem cell niche reveal novel mesenchymal-epithelial signaling pathways

scientific article (publication date: 30 September 2010)

MutSpec: a Galaxy toolbox for streamlined analyses of somatic mutation spectra in human and mouse cancer genomes.

scientific article

Mycotoxin exposure and human cancer risk: A systematic review of epidemiological studies

scientific article published on 20 May 2020

Nephritogenic anti-DNA antibodies regulate gene expression in MRL/lpr mouse glomerular mesangial cells.

scientific article

New TGF-beta and Ras crosstalk in EMT.

scientific article published in January 2009

Nicotine-induced sensitization in mice: changes in locomotor activity and mesencephalic gene expression

scientific article published in August 2005

PU.1 activation relieves GATA-1-mediated repression of Cebpa and Cbfb during leukemia differentiation.

scientific article

Palladium nanoparticles on InP for hydrogen detection

scientific article published on 2 June 2011

Pax6 interactions with chromatin and identification of its novel direct target genes in lens and forebrain

scientific article

Peroperative optical autofluorescence biopsy—verification of its diagnostic potential ⬇️

scientific article published on November 4, 2010

Pocket proteins critically regulate cell cycle exit of the trabecular myocardium and the ventricular conduction system

scientific article published on 31 July 2013

Profiling and functional analyses of microRNAs and their target gene products in human uterine leiomyomas

scientific article

Quantitative analysis of miRNA expression in epithelial cells and tissues.

scientific article published on January 2012

RNA Labeling and Hybridization of DNA Microarrays

scientific article published on 01 January 2003

Regulation of androgen receptor-mediated transcription by RPB5 binding protein URI/RMP

scientific article

Regulation of hematopoietic stem cell differentiation by a single ubiquitin ligase-substrate complex

scientific article

Relapse-specific mutations in NT5C2 in childhood acute lymphoblastic leukemia

scientific article published on 3 February 2013

Renal cell carcinomas of chronic kidney disease patients harbor the mutational signature of carcinogenic aristolochic acid.

scientific article

Revealing the Molecular Portrait of Triple Negative Breast Tumors in an Understudied Population through Omics Analysis of Formalin-Fixed and Paraffin-Embedded Tissues.

scientific article published on 11 May 2015

Role of hypoxia and cAMP in the transdifferentiation of human fetal cardiac fibroblasts: implications for progression to scarring in autoimmune-associated congenital heart block.

scientific article published in December 2007

Single cell behavior in metastatic primary mammary tumors correlated with gene expression patterns revealed by molecular profiling

article

Smad5, a tumor suppressor candidate at 5q31.1, is hemizygously lost and not mutated in the retained allele in human leukemia cell line HL60.

scientific article published on August 1997

Spectrum and Range of Oxidative Stress Responses of Human Lens Epithelial Cells to H2O2 Insult ⬇️

scientific article published on May 1, 2003

TGF-beta and epithelial-to-mesenchymal transitions

scientific article (publication date: 29 August 2005)

TGFβ Is a Master Regulator of Radiation Therapy-Induced Antitumor Immunity

scientific article published on 9 April 2015

TP53 Variations in Human Cancers: New Lessons from the IARC TP53 Database and Genomics Data.

scientific article

Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation

scientific journal article

The IARC Monographs: Updated Procedures for Modern and Transparent Evidence Synthesis in Cancer Hazard Identification

scientific article published on 01 January 2020

The inducible deletion of Drosha and microRNAs in mature podocytes results in a collapsing glomerulopathy ⬇️

scientific article published on May 4, 2011

The molecular and functional phenotype of glomerular podocytes reveals key features of contractile smooth muscle cells

scientific article

Transforming growth factor-beta and microRNA:mRNA regulatory networks in epithelial plasticity

scientific article published on January 2007

Two subunits specific to the PBAP chromatin remodeling complex have distinct and redundant functions during drosophila development.

scientific article published on 23 June 2008

Variation in genomic landscape of clear cell renal cell carcinoma across Europe

scientific article published on 29 October 2014

Ventral tegmental transcriptome response to intermittent nicotine treatment and withdrawal in BALB/cJ, C57BL/6ByJ, and quasi-congenic RQI mice

scientific article

Vreteno, a gonad-specific protein, is essential for germline development and primary piRNA biogenesis in Drosophila

scientific article

Wild type N-ras displays anti-malignant properties, in part by downregulating decorin

scientific article published on June 2012

Withdrawal of BDNF from hippocampal cultures leads to changes in genes involved in synaptic function

scientific article published on 25 August 2014

chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila

scientific article

miR-30b/30d regulation of GalNAc transferases enhances invasion and immunosuppression during metastasis.

scientific article published on July 2011

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