List of works - Gunnar K. Gouras

ADAM10 and BACE1 are localized to synaptic vesicles

scientific article

APP depletion alters selective pre- and post-synaptic proteins

scientific article published on 11 February 2019

Accumulation of cellular prion protein within dystrophic neurites of amyloid plaques in the Alzheimer's disease brain.

scientific article published on 9 November 2010

Accumulation of intraneuronal β-amyloid 42 peptides is associated with early changes in microtubule-associated protein 2 in neurites and synapses

scientific article

Activity-independent release of the amyloid β-peptide from rat brain nerve terminals

scientific article

Aging, Metabolism, Synaptic Activity, and Aβ in Alzheimer's Disease

scientific article published on 23 July 2019

Alzheimer beta-amyloid peptides: normal and abnormal localization

scientific article

Amyloid-beta oligomers are inefficiently measured by enzyme-linked immunosorbent assay

scientific article published on July 2005

Analysis of vesicular trafficking in primary neurons by live imaging

scientific article published in January 2011

Apolipoprotein E, A beta-amyloid, and the molecular pathology of Alzheimer's disease. Therapeutic implications.

scientific article published in December 1996

Aβ accumulation causes MVB enlargement and is modelled by dominant negative VPS4A.

scientific article published on 23 August 2017

Beta-amyloid accumulation impairs multivesicular body sorting by inhibiting the ubiquitin-proteasome system.

scientific article

Beta-amyloid accumulation in APP mutant neurons reduces PSD-95 and GluR1 in synapses

scientific article published in November 2005

Beta-amyloid modulation of synaptic transmission and plasticity

scientific article published on October 2007

Brain activity and Alzheimer's disease: a complex relationship

scientific article published in August 2016

Cellular and molecular basis of beta-amyloid precursor protein metabolism

scientific article

Cellular and molecular basis of beta-amyloid precursor protein metabolism

scientific article published on 26 March 1998

Chaperones increase association of tau protein with microtubules

scientific article

Co-occurrence of Alzheimer's disease ß-amyloid and τ pathologies at synapses.

scientific article

Coenzyme Q10 decreases amyloid pathology and improves behavior in a transgenic mouse model of Alzheimer's disease

scientific article published on January 2011

Conditional inactivation of presenilin 1 prevents amyloid accumulation and temporarily rescues contextual and spatial working memory impairments in amyloid precursor protein transgenic mice.

scientific article published in July 2005

Convergence of synapses, endosomes, and prions in the biology of neurodegenerative diseases

scientific article

Critical role of intraneuronal Aβ in Alzheimer's disease: technical challenges in studying intracellular Aβ.

scientific article

Current theories for the molecular and cellular pathogenesis of Alzheimer's disease

scientific article published on 31 May 2001

Decreased senile plaque density in Alzheimer neocortex adjacent to an omental transposition

scientific article published in August 1996

Degradation of Alzheimer's amyloid fibrils by microglia requires delivery of ClC-7 to lysosomes

scientific article

Direct High Affinity Interaction between Aβ42 and GSK3α Stimulates Hyperphosphorylation of Tau. A New Molecular Link in Alzheimer's Disease?

scientific article

Dysregulation of Elongation Factor 1A Expression is Correlated with Synaptic Plasticity Impairments in Alzheimer's Disease

scientific article

Dysregulation of the mTOR pathway mediates impairment of synaptic plasticity in a mouse model of Alzheimer's disease

scientific article

ESCRTs regulate amyloid precursor protein sorting in multivesicular bodies and intracellular amyloid-β accumulation

scientific article published on 22 May 2015

Effects of synaptic modulation on beta-amyloid, synaptophysin, and memory performance in Alzheimer's disease transgenic mice.

scientific article

Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides

scientific article

Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides

scientific article

Evidence for phosphorylation and oligomeric assembly of presenilin 1.

scientific article published on May 1997

FRET-Based Screening Identifies p38 MAPK and PKC Inhibition as Targets for Prevention of Seeded α-Synuclein Aggregation

scientific article published on 13 July 2021

Generation and regulation of beta-amyloid peptide variants by neurons

scientific article published in November 1998

Heterogeneous Association of Alzheimer's Disease-Linked Amyloid-β and Amyloid-β Protein Precursor with Synapses

scientific article published on 30 August 2017

High-resolution 3D reconstruction reveals intra-synaptic amyloid fibrils.

scientific article

Highly selective effects of nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 on intact and injured basal forebrain magnocellular neurons.

scientific article

Immunotherapy for Alzheimer disease

scientific article published on 11 March 2009

Impaired β-amyloid secretion in Alzheimer's disease pathogenesis

scientific article published on October 2011

Increased apolipoprotein E epsilon 4 in epilepsy with senile plaques

scientific article

Increased plaque burden in brains of APP mutant MnSOD heterozygous knockout mice.

scientific article published in June 2004

Internalized antibodies to the Abeta domain of APP reduce neuronal Abeta and protect against synaptic alterations.

scientific article published on 27 April 2007

Intraneuronal -Amyloid Expression Downregulates the Akt Survival Pathway and Blunts the Stress Response

article

Intraneuronal Abeta accumulation and origin of plaques in Alzheimer's disease

scientific article

Intraneuronal Abeta42 accumulation in human brain.

scientific article published on January 2000

Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology

scientific article published on November 2002

Intraneuronal Aβ accumulation, amyloid plaques, and synapse pathology in Alzheimer's disease.

scientific article published on 21 January 2012

Intraneuronal beta-amyloid accumulation and synapse pathology in Alzheimer's disease

scientific article

Lesion of the subiculum reduces the spread of amyloid beta pathology to interconnected brain regions in a mouse model of Alzheimer's disease

scientific article published in 2014

Live discussion. From here to there: AbetaPP as an axonal transport receptor--how could this explain neurodegeneration in AD. 15 July 2002.

scientific article published in December 2003

Mesencephalic clefts with associated eye movement disorders

scientific article published in April 1996

Metal chelator decreases Alzheimer beta-amyloid plaques

scientific article

Myotonia in colchicine myoneuropathy

scientific article published on July 1996

Neurogenesis as a therapeutic strategy for cognitive aging and Alzheimer's disease

scientific article

Nonsteroidal selective androgen receptor modulators and selective estrogen receptor β agonists moderate cognitive deficits and amyloid-β levels in a mouse model of Alzheimer's disease

scientific article

Oligomerization of Alzheimer's beta-amyloid within processes and synapses of cultured neurons and brain.

scientific article

Parkinson's disease and multiple system atrophy patient iPSC-derived oligodendrocytes exhibit alpha-synuclein-induced changes in maturation and immune reactive properties

scientific article published on 16 March 2022

Pathology of synapses and dendritic spines

scientific article published on 23 September 2012

Plaque formation and the intraneuronal accumulation of β-amyloid in Alzheimer's disease

scientific article published on 5 March 2017

Poly(propylene imine) dendrimers with histidine-maltose shell as novel type of nanoparticles for synapse and memory protection

scientific article from 2019

Pre-plaque conformational changes in Alzheimer's disease-linked Aβ and APP.

scientific article published on 13 March 2017

Prion-like seeding and nucleation of intracellular amyloid-β.

scientific article published on 29 January 2018

Regulation of NMDA receptor trafficking by amyloid-beta

scientific journal article

S100A9-Driven Amyloid-Neuroinflammatory Cascade in Traumatic Brain Injury as a Precursor State for Alzheimer's Disease

scientific article published in Scientific Reports

Super-Resolution Infrared Imaging of Polymorphic Amyloid Aggregates Directly in Neurons

scientific article published on 07 February 2020

Synapses, synaptic activity and intraneuronal abeta in Alzheimer's disease

scientific article

Synaptic activity reduces intraneuronal Abeta, promotes APP transport to synapses, and protects against Abeta-related synaptic alterations

scientific article

Testosterone reduces neuronal secretion of Alzheimer's beta-amyloid peptides

scientific article

The Arctic Alzheimer mutation favors intracellular amyloid-beta production by making amyloid precursor protein less available to alpha-secretase

scientific article published on May 2007

The immune system, amyloid-beta peptide, and Alzheimer's disease

scientific article

The inside-out amyloid hypothesis and synapse pathology in Alzheimer's disease

scientific article published on 24 September 2013

Triterpenoid CDDO-methylamide improves memory and decreases amyloid plaques in a transgenic mouse model of Alzheimer's disease

scientific article

Tyrosine-hydroxylase-containing neurons in the primate basal forebrain magnocellular complex

scientific article published on July 1992

mTOR: at the crossroads of aging, chaperones, and Alzheimer's disease ⬇️

scientific article published on December 26, 2012

β-Amyloid peptides and amyloid plaques in Alzheimer's disease

scientific article

List of works by Gunnar K. Gouras

ADAM10 and BACE1 are localized to synaptic vesicles

APP depletion alters selective pre- and post-synaptic proteins

Accumulation of cellular prion protein within dystrophic neurites of amyloid plaques in the Alzheimer's disease brain.

Accumulation of intraneuronal β-amyloid 42 peptides is associated with early changes in microtubule-associated protein 2 in neurites and synapses

Activity-independent release of the amyloid β-peptide from rat brain nerve terminals

Aging, Metabolism, Synaptic Activity, and Aβ in Alzheimer's Disease

Alzheimer beta-amyloid peptides: normal and abnormal localization

Amyloid-beta oligomers are inefficiently measured by enzyme-linked immunosorbent assay

Analysis of vesicular trafficking in primary neurons by live imaging

Apolipoprotein E, A beta-amyloid, and the molecular pathology of Alzheimer's disease. Therapeutic implications.

Aβ accumulation causes MVB enlargement and is modelled by dominant negative VPS4A.

Beta-amyloid accumulation impairs multivesicular body sorting by inhibiting the ubiquitin-proteasome system.

Beta-amyloid accumulation in APP mutant neurons reduces PSD-95 and GluR1 in synapses

Beta-amyloid modulation of synaptic transmission and plasticity

Brain activity and Alzheimer's disease: a complex relationship

Cellular and molecular basis of beta-amyloid precursor protein metabolism

Cellular and molecular basis of beta-amyloid precursor protein metabolism

Chaperones increase association of tau protein with microtubules

Co-occurrence of Alzheimer's disease ß-amyloid and τ pathologies at synapses.

Coenzyme Q10 decreases amyloid pathology and improves behavior in a transgenic mouse model of Alzheimer's disease

Conditional inactivation of presenilin 1 prevents amyloid accumulation and temporarily rescues contextual and spatial working memory impairments in amyloid precursor protein transgenic mice.

Convergence of synapses, endosomes, and prions in the biology of neurodegenerative diseases

Critical role of intraneuronal Aβ in Alzheimer's disease: technical challenges in studying intracellular Aβ.

Current theories for the molecular and cellular pathogenesis of Alzheimer's disease

Decreased senile plaque density in Alzheimer neocortex adjacent to an omental transposition

Degradation of Alzheimer's amyloid fibrils by microglia requires delivery of ClC-7 to lysosomes

Direct High Affinity Interaction between Aβ42 and GSK3α Stimulates Hyperphosphorylation of Tau. A New Molecular Link in Alzheimer's Disease?

Dysregulation of Elongation Factor 1A Expression is Correlated with Synaptic Plasticity Impairments in Alzheimer's Disease

Dysregulation of the mTOR pathway mediates impairment of synaptic plasticity in a mouse model of Alzheimer's disease

ESCRTs regulate amyloid precursor protein sorting in multivesicular bodies and intracellular amyloid-β accumulation

Effects of synaptic modulation on beta-amyloid, synaptophysin, and memory performance in Alzheimer's disease transgenic mice.

Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides

Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides

Evidence for phosphorylation and oligomeric assembly of presenilin 1.

FRET-Based Screening Identifies p38 MAPK and PKC Inhibition as Targets for Prevention of Seeded α-Synuclein Aggregation

Generation and regulation of beta-amyloid peptide variants by neurons

Heterogeneous Association of Alzheimer's Disease-Linked Amyloid-β and Amyloid-β Protein Precursor with Synapses

High-resolution 3D reconstruction reveals intra-synaptic amyloid fibrils.

Highly selective effects of nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 on intact and injured basal forebrain magnocellular neurons.

Immunotherapy for Alzheimer disease

Impaired β-amyloid secretion in Alzheimer's disease pathogenesis

Increased apolipoprotein E epsilon 4 in epilepsy with senile plaques

Increased plaque burden in brains of APP mutant MnSOD heterozygous knockout mice.

Internalized antibodies to the Abeta domain of APP reduce neuronal Abeta and protect against synaptic alterations.

Intraneuronal -Amyloid Expression Downregulates the Akt Survival Pathway and Blunts the Stress Response

Intraneuronal Abeta accumulation and origin of plaques in Alzheimer's disease

Intraneuronal Abeta42 accumulation in human brain.

Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology

Intraneuronal Aβ accumulation, amyloid plaques, and synapse pathology in Alzheimer's disease.

Intraneuronal beta-amyloid accumulation and synapse pathology in Alzheimer's disease

Lesion of the subiculum reduces the spread of amyloid beta pathology to interconnected brain regions in a mouse model of Alzheimer's disease

Live discussion. From here to there: AbetaPP as an axonal transport receptor--how could this explain neurodegeneration in AD. 15 July 2002.

Mesencephalic clefts with associated eye movement disorders

Metal chelator decreases Alzheimer beta-amyloid plaques

Myotonia in colchicine myoneuropathy

Neurogenesis as a therapeutic strategy for cognitive aging and Alzheimer's disease

Nonsteroidal selective androgen receptor modulators and selective estrogen receptor β agonists moderate cognitive deficits and amyloid-β levels in a mouse model of Alzheimer's disease

Oligomerization of Alzheimer's beta-amyloid within processes and synapses of cultured neurons and brain.

Parkinson's disease and multiple system atrophy patient iPSC-derived oligodendrocytes exhibit alpha-synuclein-induced changes in maturation and immune reactive properties

Pathology of synapses and dendritic spines

Plaque formation and the intraneuronal accumulation of β-amyloid in Alzheimer's disease

Poly(propylene imine) dendrimers with histidine-maltose shell as novel type of nanoparticles for synapse and memory protection

Pre-plaque conformational changes in Alzheimer's disease-linked Aβ and APP.

Prion-like seeding and nucleation of intracellular amyloid-β.

Regulation of NMDA receptor trafficking by amyloid-beta

S100A9-Driven Amyloid-Neuroinflammatory Cascade in Traumatic Brain Injury as a Precursor State for Alzheimer's Disease

Super-Resolution Infrared Imaging of Polymorphic Amyloid Aggregates Directly in Neurons

Synapses, synaptic activity and intraneuronal abeta in Alzheimer's disease

Synaptic activity reduces intraneuronal Abeta, promotes APP transport to synapses, and protects against Abeta-related synaptic alterations

Testosterone reduces neuronal secretion of Alzheimer's beta-amyloid peptides

The Arctic Alzheimer mutation favors intracellular amyloid-beta production by making amyloid precursor protein less available to alpha-secretase

The immune system, amyloid-beta peptide, and Alzheimer's disease

The inside-out amyloid hypothesis and synapse pathology in Alzheimer's disease

Triterpenoid CDDO-methylamide improves memory and decreases amyloid plaques in a transgenic mouse model of Alzheimer's disease

Tyrosine-hydroxylase-containing neurons in the primate basal forebrain magnocellular complex

mTOR: at the crossroads of aging, chaperones, and Alzheimer's disease ⬇️

β-Amyloid peptides and amyloid plaques in Alzheimer's disease