List of works by Wayne Patrick

A large-scale whole-genome comparison shows that experimental evolution in response to antibiotics predicts changes in naturally evolved clinical Pseudomonas aeruginosa

scientific article published on 30 September 2019

A second-generation system for unbiased reading frame selection

scientific article

A study in molecular contingency: glutamine phosphoribosylpyrophosphate amidotransferase is a promiscuous and evolvable phosphoribosylanthranilate isomerase

scientific article

An Engineered Glycerol Dehydratase With Improved Activity for the Conversion of meso-2,3-butanediol to Butanone.

scientific article published on 7 September 2017

Archaeal Nucleic Acid Ligases and Their Potential in Biotechnology

scientific article

Artificial gene amplification reveals an abundance of promiscuous resistance determinants in Escherichia coli

scientific article

Assessment of Phenotype Microarray plates for rapid and high-throughput analysis of collateral sensitivity networks

scientific article published on 18 December 2019

Bacterial methionine biosynthesis

scientific article (publication date: August 2014)

Carbohydrate binding sites in Candida albicans exo-β-1,3-glucanase and the role of the Phe-Phe 'clamp' at the active site entrance

scientific article

Characterization of the indole-3-glycerol phosphate synthase from Pseudomonas aeruginosa PAO1

scientific journal article

Construction and analysis of randomized protein-encoding libraries using error-prone PCR.

scientific article

Desalting DNA by drop dialysis increases library size upon transformation

scientific article

Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues

scientific article published on 19 June 2020

Engineered DNA ligases with improved activities in vitro

scientific article

Enzyme evolution: innovation is easy, optimization is complicated.

scientific article published on 2 December 2017

Enzyme promiscuity in natural environments: alkaline phosphatase in the ocean

scientific article published on 28 May 2021

Error-prone PCR and effective generation of gene variant libraries for directed evolution

scientific article

GLUE-IT and PEDEL-AA: new programmes for analyzing protein diversity in randomized libraries

scientific article published on 28 April 2008

Genetic Code Evolution Started with the Incorporation of Glycine, Followed by Other Small Hydrophilic Amino Acids

scientific article published on 12 June 2014

Genomic and phenotypic comparison of environmental and patient-derived isolates of Pseudomonas aeruginosa suggest that antimicrobial resistance is rare within the environment

scientific article published on 01 November 2019

High-Throughput Chemical Screening Identifies Compounds that Inhibit Different Stages of the Phytophthora agathidicida and Phytophthora cinnamomi Life Cycles.

scientific article

ITCHY: Incremental Truncation for the Creation of Hybrid enzYmes

scientific article

In vitro selection and characterization of a stable subdomain of phosphoribosylanthranilate isomerase

scientific article

Intracellular complexities of acquiring a new enzymatic function revealed by mass-randomisation of active site residues

scientific article published on 13 November 2020

Mechanisms of ciprofloxacin resistance in Pseudomonas aeruginosa: new approaches to an old problem

scientific article published on 01 January 2019

Mechanistic and Evolutionary Insights from the Reciprocal Promiscuity of Two Pyridoxal Phosphate-dependent Enzymes.

scientific article

Methods for competitive enrichment and evaluation of superior DNA ligases

scientific article published on 20 May 2020

Multicopy suppression underpins metabolic evolvability

scientific article

Natural history as a predictor of protein evolvability

scientific article

New rRNA gene-based phylogenies of the Alphaproteobacteria provide perspective on major groups, mitochondrial ancestry and phylogenetic instability

scientific article published on 11 December 2013

Novel methods for directed evolution of enzymes: quality, not quantity

scientific article

Primordial-like enzymes from bacteria with reduced genomes

scientific article

Rapid bursts and slow declines: on the possible evolutionary trajectories of enzymes

scientific article

Reconstruction of an acetogenic 2,3-butanediol pathway involving a novel NADPH-dependent primary-secondary alcohol dehydrogenase

scientific article (publication date: June 2014)

Site-directed mutagenesis of Tyr354 in Geobacillus stearothermophilus alanine racemase identifies a role in controlling substrate specificity and a possible role in the evolution of antibiotic resistance

scientific article published in August 2002

Statistics of protein library construction

scientific article

Strategies and computational tools for improving randomized protein libraries

scientific article

Structural and functional innovations in the real-time evolution of new (βα)8 barrel enzymes

scientific article

Structure and kinetics of indole-3-glycerol phosphate synthase from Pseudomonas aeruginosa - decarboxylation is not essential for indole formation

scientific article published on 14 September 2020

Substitutions at the cofactor phosphate-binding site of a clostridial alcohol dehydrogenase lead to unexpected changes in substrate specificity

scientific article published on June 2015

The BRD3 ET domain recognizes a short peptide motif through a mechanism that is conserved across chromatin remodelers and transcriptional regulators.

scientific article published on 22 March 2018

The in vitro and in vivo effects of constitutive light expression on a bioluminescent strain of the mouse enteropathogen Citrobacter rodentium

scientific article published on 22 June 2016

The structure of a truncated phosphoribosylanthranilate isomerase suggests a unified model for evolution of the (βα)8 barrel fold

scientific article

The uncharacterized bacterial protein YejG has the same architecture as domain III of elongation factor G

scientific article published on 22 April 2019

Two-step Ligand Binding in a (βα)8 Barrel Enzyme: SUBSTRATE-BOUND STRUCTURES SHED NEW LIGHT ON THE CATALYTIC CYCLE OF HisA

scientific article (publication date: 20 August 2015)

User-friendly algorithms for estimating completeness and diversity in randomized protein-encoding libraries

scientific article

Whither life? Conjectures on the future evolution of biochemistry

scientific article

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