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List of works by Adrian Harris

177Lu-labeled-VG76e monoclonal antibody in tumor angiogenesis: A comparative study using DOTA and DTPA chelating systems

3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers

scientific article published on 26 November 2018

6-thioguanine selectively kills BRCA2-defective tumors and overcomes PARP inhibitor resistance

scientific article

8-Cl-adenosine is an active metabolite of 8-Cl-cAMP responsible for its in vitro antiproliferative effects on CHO mutants hypersensitive to cytostatic drugs

scientific article published in December 2001

A 26-gene hypoxia signature predicts benefit from hypoxia-modifying therapy in laryngeal cancer but not bladder cancer

scientific article published on 02 July 2013

A Gene Signature for Selecting Benefit from Hypoxia Modification of Radiotherapy for High-Risk Bladder Cancer Patients

scientific article published on 11 April 2017

A New Hydroxy Metabolite of 2-Oxoglutarate Regulates Metabolism in Hypoxia

scientific article published on 01 August 2015

A Novel Cyclic Adenosine Monophosphate Analog Induces Hypercalcemia via Production of 1,25-Dihydroxyvitamin D in Patients with Solid Tumors ⬇️

scientific article published on 01 December 1997

A Novel Metal-Based Imaging Probe for Targeted Dual-Modality SPECT/MR Imaging of Angiogenesis.

scientific article published on 20 June 2018

A Phase I First-in-Human Study of Enoticumab (REGN421), a Fully Human Delta-like Ligand 4 (Dll4) Monoclonal Antibody in Patients with Advanced Solid Tumors

scientific article published on 27 February 2015

A core human primary tumor angiogenesis signature identifies the endothelial orphan receptor ELTD1 as a key regulator of angiogenesis

scientific article published on 18 July 2013

A first-in-human phase I study to determine the maximum tolerated dose of the oral Src/ABL inhibitor AZD0424.

scientific article published on 13 February 2018

A first-in-man phase i and pharmacokinetic study on CHR-2797 (Tosedostat), an inhibitor of M1 aminopeptidases, in patients with advanced solid tumors

scientific article

A five-gene molecular grade index and HOXB13:IL17BR are complementary prognostic factors in early stage breast cancer

scientific article

A multicentre phase II trial of bryostatin-1 in patients with advanced renal cancer.

scientific article published on October 2003

A mycobacterial iron chelator, desferri-exochelin, induces hypoxia-inducible factors 1 and 2, NIP3, and vascular endothelial growth factor in cancer cell lines

scientific article published on December 2002

A pharmacokinetic study of granisetron (BRL 43694A), a selective 5-HT3 receptor antagonist: correlation with anti-emetic response

scientific article

A phase 1 study of tazarotene in adults with advanced cancer.

scientific article published on September 2003

A phase 1 trial of intravenous 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) in patients with advanced solid tumours

scientific article

A phase I study of immunostimulation and toxicity in patients with colorectal carcinoma using the immunomodulator 3,6-bis(2-piperidinoethoxy) acridine trihydrochloride (CL 246738).

scientific article

A phase I study on the reversal of multidrug resistance (MDR) in vivo: nifedipine plus etoposide ⬇️

scientific article published on February 1, 1992

A phase II study of epirubicin, cisplatin and raltitrexed combination chemotherapy (ECT) in patients with advanced oesophageal and gastric adenocarcinoma

scientific article published in October 2001

A phase II study of etanercept (Enbrel), a tumor necrosis factor alpha inhibitor in patients with metastatic breast cancer.

scientific article published on October 2004

A phase II study of high-dose hydroxyurea and dacarbazine (DTIC) in the treatment of metastatic malignant melanoma

scientific article published on 01 January 1994

A phase II study of ifosfamide/mesna with doxorubicin for adult soft tissue sarcoma

scientific article

A phase II study of mitomycin C and oral etoposide for advanced adenocarcinoma of the upper gastrointestinal tract

scientific article published on 01 March 1997

A phase II study of the modulation of 5-fluorouracil and folinic acid with high-dose infusional hydroxyurea in metastatic colorectal carcinoma

scientific article published on 01 August 1999

A phase II trial of goserelin (Zoladex) in relapsed epithelial ovarian cancer ⬇️

scientific article published on April 1, 1992

A phase II trial of ifosfamide/mesna with doxorubicin for malignant mesothelioma

scientific article published in May 1989

A prosurvival DNA damage-induced cytoplasmic interferon response is mediated by end resection factors and is limited by Trex1.

scientific article published on 9 March 2017

A protective role for HIF-1 in response to redox manipulation and glucose deprivation: implications for tumorigenesis

scientific article published on January 2002

A quantitative analysis of lymphatic vessels in human breast cancer, based on LYVE-1 immunoreactivity

scientific article published on November 2005

A reliable external control for ribonuclease protection assays

scientific article

A review of ELTD1, a pro-angiogenic adhesion GPCR.

scientific article

A small molecule targeting ALK1 prevents Notch cooperativity and inhibits functional angiogenesis

scientific article

A statistical approach for detecting genomic aberrations in heterogeneous tumor samples from single nucleotide polymorphism genotyping data

scientific article

A study of adhesion molecules as markers of progression in malignant melanoma

A two-part phase II study of cediranib in patients with advanced solid tumours: the effect of food on single-dose pharmacokinetics and an evaluation of safety, efficacy and imaging pharmacodynamics.

scientific article published in December 2010

ADAM10 mediates trastuzumab resistance and is correlated with survival in HER2 positive breast cancer

scientific article

ADGRL4/ELTD1 Silencing in Endothelial Cells Induces ACLY and SLC25A1 and Alters the Cellular Metabolic Profile

scientific article published on 25 November 2019

ATF4 orchestrates a program of BH3-only protein expression in severe hypoxia

scientific article

Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status

scientific article

Absence of lymphangiogenesis and intratumoural lymph vessels in human metastatic breast cancer

scientific article published in June 2003

Abstract P3-06-01: Nuclear β-catenin negativity predicts for late relapse in ER+, tamoxifen-treated breast cancer

Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress

scientific article

Acid-extrusion from tissue: the interplay between membrane transporters and pH buffers

scientific article published on January 2012

Activated VEGFR2/KDR pathway in tumour cells and tumour associated vessels of colorectal cancer

scientific article published on 20 September 2007

Activating transcription factor 4.

scientific article published on 28 January 2007

Activation of peroxisome proliferator-activated receptor delta stimulates the proliferation of human breast and prostate cancer cell lines.

scientific article published on May 2004

Adaptation to HIF-1 deficiency by upregulation of the AMP/ATP ratio and phosphofructokinase activation in hepatomas

scientific article

Adenosine-diphosphoribosyltransferase inhibitors can protect against or potentiate the cytotoxicity of S-phase acting drugs

scientific article published on 01 June 1988

Advanced breast cancer: a phase II trial with gemcitabine ⬇️

scientific article published on November 1, 1995

Advances in Hypoxia-Inducible Factor Biology

scientific article published on 8 November 2017

Amifostine Protects Mouse Liver Against Radiation-induced Autophagy Blockage.

scientific article published in January 2018

Amifostine induces anaerobic metabolism and hypoxia-inducible factor 1 alpha

scientific journal article

Amino Acid Sensing by mTORC1: Intracellular Transporters Mark the Spot

scientific article

An Immunohistochemical and Prognostic Evaluation of Cathepsin D Expression in 105 Bladder Carcinomas

article published in 1995

An Investigation Into the Prognostic Significance of Necrosis and Hypoxia in High Grade and Invasive Bladder Cancer

article

An immunohistochemical and prognostic evaluation of cathepsin D expression in 105 bladder carcinomas

scientific article published on 01 July 1995

An in vivo hypoxia metagene identifies the novel hypoxia inducible factor target gene SLCO1B3.

scientific article

An investigation into the performance of the Adjuvant! Online prognostic programme in early breast cancer for a cohort of patients in the United Kingdom

scientific article

An oncogenic role of eIF3e/INT6 in human breast cancer

scientific article published on 10 May 2010

An open study to assess the safety, tolerance and pharmacokinetics of an intravenous infusion of granisetron given at 3 mg over 30 s in patients receiving chemotherapy for malignant disease

scientific article published on 01 January 1995

Analysis of combination anti-angiogenesis therapy on markers of coagulation, platelet activation and angiogenesis in patients with advanced cancer

scientific article

Analysis of gene expression in ductal carcinoma in situ of the breast.

scientific article

Angiogenesis - still a worthwhile target for breast cancer therapy?

scientific article

Angiogenesis in Pituitary Adenomas and the Normal Pituitary Gland

scientific article published on 01 March 2000

Angiogenesis in bladder cancer--prognostic marker and target for future therapy.

scientific article

Angiogenesis in ductal breast carcinoma. Comparison of microvessel density between primary tumour and lymph node metastasis

scientific article published in April 1999

Angiogenesis in endocrine tumors.

scientific article published on October 2003

Angiogenesis in primary lung cancer and lung secondaries

scientific article published on December 1996

Angiogenesis vs. response after combined chemoradiotherapy of squamous cell head and neck cancer.

scientific article

Angiogenesis, assessed by platelet/endothelial cell adhesion molecule antibodies, as indicator of node metastases and survival in breast cancer

scientific article published in The Lancet

Angiogenic co-operation of VEGF and stromal cell TP in endometrial carcinomas

scientific article published in April 2002

Angiogenin is up-regulated in the nucleus and cytoplasm in human primary breast carcinoma and is associated with markers of hypoxia but not survival

scientific article

Anoxic induction of ATF-4 through HIF-1-independent pathways of protein stabilization in human cancer cells

scientific article published on 6 November 2003

Anti-Dll4 therapy: can we block tumour growth by increasing angiogenesis?

scientific article published on 06 September 2007

Anti-angiogenic effect of tamoxifen combined with epirubicin in breast cancer patients

scientific article published on 3 August 2010

Anti-angiogenic therapies in cancer clinical trials.

scientific article

Antiangiogenic Resistance and Cancer Metabolism: Opportunities for Synthetic Lethality

scientific article published on 7 March 2016

Antiangiogenic activity of a domain deletion mutant of tissue plasminogen activator containing kringle 2.

scientific article published on 3 February 2005

Antiangiogenic and tumour inhibitory effects of downregulating tumour endothelial FABP4.

scientific article published on 29 August 2016

Antiangiogenic therapy for von Hippel-Lindau disease

scientific article published in February 2004

Antiangiogenic therapy in oncology: current status and future directions

scientific article published on 4 February 2016

Antibody inhibiting enzymatic activity of tumour-associated carbonic anhydrase isoform IX.

scientific article

Are angiostatin and endostatin cures for cancer? ⬇️

scientific article published on May 30, 1998

Assessing early therapeutic response to bevacizumab in primary breast cancer using magnetic resonance imaging and gene expression profiles

scientific article published in January 2011

Assessing the clinical impact of prognostic factors: when is "statistically significant" clinically useful?

scientific article

Assessment of microvessel density and carbonic anhydrase-9 (CA-9) expression in rectal cancer.

scientific article published on 13 November 2008

Assessment of tumour hypoxia for prediction of response to therapy and cancer prognosis

scientific article published on 16 October 2009

Association of hypoxia-inducible factors 1alpha and 2alpha with activated angiogenic pathways and prognosis in patients with endometrial carcinoma

scientific article

Association of ovarian Malignancy With Expression of Paltelet-Derived Endothelial Cell Growth Factor

scientific article published on 01 August 1994

Automated uro-oncology data collection: the Cancer Research Uro-Oncology Database

scientific article

Autophagosome Proteins LC3A, LC3B and LC3C Have Distinct Subcellular Distribution Kinetics and Expression in Cancer Cell Lines.

scientific article published on 17 September 2015

Autophagy and hypoxia in colonic adenomas related to aggressive features

scientific article published in May 2013

Autophagy and lysosomal related protein expression patterns in human glioblastoma

scientific article

BDS Melanoma Guidelines

scientific article published on 01 May 2003

BHLHB2 controls Bdnf promoter 4 activity and neuronal excitability.

scientific article

BNIP3 as a Progression Marker in Primary Human Breast Cancer; Opposing Functions inIn situVersus Invasive Cancer

BNIP3 expression in endometrial cancer relates to active hypoxia inducible factor 1 pathway and prognosis

scientific article published on 18 May 2007

BNIP3 expression is linked with hypoxia-regulated protein expression and with poor prognosis in non-small cell lung cancer

scientific article

BRCA2 abrogation triggers innate immune responses potentiated by treatment with PARP inhibitors

scientific article published on 17 July 2019

Bcl-2 and p53 expression in node-negative breast carcinoma: A study with long-term follow-up

scientific article published on 01 November 1996

Bcl-2 protein expression: association with p53 and prognosis in colorectal cancer ⬇️

scientific article published on June 1, 1998

Beclin 1 over- and underexpression in colorectal cancer: distinct patterns relate to prognosis and tumour hypoxia

scientific article

Biological and Prognostic Significance of the Morphological Types and Vascular Patterns in Colorectal Liver Metastases (CRLM): Looking Beyond the Tumor Margin

scientific article published on February 2016

Biomarkers to predict the clinical efficacy of bevacizumab in cancer

scientific article published on December 2010

Bladder Cancer — Field versus Clonal Origin ⬇️

scientific article published on March 12, 1992

Bladder cancer angiogenesis, its role in recurrence, stage progression and as a therapeutic target

scientific article published on June 1996

Bleomycin and X-ray-hypersensitive Chinese hamster ovary cell mutants: genetic analysis and cross-resistance to neocarzinostatin.

scientific article

Blood vessel invasion and other variables as predictors of long-term survival in Japanese and British patients with primary invasive breast cancer.

scientific article

Blood vessels and cancer much more than just angiogenesis

scientific article

Bone morphogenetic protein 2 (BMP-2) and induction of tumor angiogenesis

scientific article published on November 2005

Bone morphogenetic protein 2 (BMP-2) induces in vitro invasion and in vivo hormone independent growth of breast carcinoma cells

scientific article published on August 2005

Breast adenocarcinoma liver metastases, in contrast to colorectal cancer liver metastases, display a non-angiogenic growth pattern that preserves the stroma and lacks hypoxia

scientific article published on April 2004

Breast cancer angiogenesis--new approaches to therapy via antiangiogenesis, hypoxic activated drugs, and vascular targeting

scientific article published on January 1996

Breast cancer angiogenesis: Therapy target and prognostic factor

scientific article published on 01 January 1995

Breast cancer classification and prognosis based on gene expression profiles from a population-based study

scientific article published on 13 August 2003

Breast screening remains a controversial issue ⬇️

scientific article published on June 6, 2013

Breast tumour angiogenesis

scientific article published in January 2007

C2028T polymorphism in exon 12 and dinucleotide repeat polymorphism in intron 13 of the HIF-1α gene define HIF-1α protein expression in non-small cell lung cancer

article

CARBOPLATIN OR CISPLATIN?

scientific article published in The Lancet

CD31 angiogenesis and combined expression of HIF-1α and HIF-2α are prognostic in primary clear-cell renal cell carcinoma (CC-RCC), but HIFα transcriptional products are not: implications for antiangiogenic trials and HIFα biomarker studies in primar

scientific article published on 09 July 2012

CD70 (TNFSF7) is expressed at high prevalence in renal cell carcinomas and is rapidly internalised on antibody binding.

scientific article published on August 2006

CHOP-based Chemotherapy is as effective as alternating PEEC/CHOP chemotherapy in a randomised trial in high-grade non-Hodgkin's lymphoma

scientific article published on 01 July 1997

CITED4 inhibits hypoxia-activated transcription in cancer cells, and its cytoplasmic location in breast cancer is associated with elevated expression of tumor cell hypoxia-inducible factor 1alpha

scientific article published in September 2004

COVID-19 and cancer research

scientific article published on 26 June 2020

Cancer metabolism as a therapeutic target: metabolic synthetic lethality

scientific article published in May 2013

Cancer-associated, hypoxia-inducible carbonic anhydrase IX facilitates CO2 diffusion

scientific article

Carbonic Anhydrase Activity Monitored In Vivo by Hyperpolarized 13C-Magnetic Resonance Spectroscopy Demonstrates Its Importance for pH Regulation in Tumors

scientific article

Carbonic anhydrase 9 (CA9) expression in non-small-cell lung cancer: correlation with regulatory FOXP3+T-cell tumour stroma infiltration

scientific article published on 18 February 2020

Carbonic anhydrase IX expression, a novel surrogate marker of tumor hypoxia, is associated with a poor prognosis in non-small-cell lung cancer

scientific article (publication date: February 2003)

Carbonic anhydrase IX induction defines a heterogeneous cancer cell response to hypoxia and mediates stem cell-like properties and sensitivity to HDAC inhibition

scientific article

Carbonic anhydrase IX is a pH-stat that sets an acidic tumour extracellular pH in vivo

scientific article published on 01 August 2018

Carbonic anhydrase IX promotes tumor growth and necrosis in vivo and inhibition enhances anti-VEGF therapy

scientific article

Cathepsin D levels in primary breast cancers: Relationship with epidermal growth factor receptor, oestrogen receptor and axillary nodal status

scientific article published on 01 January 1993

Cellular mechanisms of bone resorption in breast carcinoma

scientific article

Changes of bone turnover markers and serum PTH after night or morning administration of zoledronic acid in breast cancer patients with bone metastases.

scientific article published on 27 May 2008

Changing prognosis of renal cell carcinoma: a single-centre experience over 25 years

Chemotherapy induced emesis may exacerbate the nephrotoxicity of combined ifosfamide/mesna and cisplatin chemotherapy

scientific article published on 01 May 1989

Cid1, a fission yeast protein required for S-M checkpoint control when DNA polymerase delta or epsilon is inactivated

scientific article

Circulating tumour cells demonstrate an altered response to hypoxia and an aggressive phenotype.

scientific article

Clinical and immunological responses in metastatic melanoma patients vaccinated with a high-dose poly-epitope vaccine

article

Clinical imaging of tumor angiogenesis.

scientific article

Clinical prognostic significance of tumour angiogenesis ⬇️

scientific article published on April 1, 1994

Close and Stable Relationship between Proliferation and a Hypoxia Metagene in Aromatase Inhibitor-Treated ER-Positive Breast Cancer

scientific article published on 15 February 2011

Combination antiangiogenesis therapy with marimastat, captopril and fragmin in patients with advanced cancer

scientific article (publication date: 5 July 2004)

Combination of letrozole, metronomic cyclophosphamide and sorafenib is well-tolerated and shows activity in patients with primary breast cancer

scientific article published on 2 December 2014

Combined role of tumor angiogenesis,bcl-2, and p53 expression in the prognosis of patients with colorectal carcinoma

scientific article published on 01 October 1999

Combining lapatinib and pertuzumab to overcome lapatinib resistance due to NRG1-mediated signalling in HER2-amplified breast cancer

scientific article published on March 2015

Combining virotherapy and angiotherapy for the treatment of breast cancer.

scientific article published on 12 July 2013

Comparison of hypoxia transcriptome in vitro with in vivo gene expression in human bladder cancer

scientific article

Comparison of metabolic pathways between cancer cells and stromal cells in colorectal carcinomas: a metabolic survival role for tumor-associated stroma

scientific article published in January 2006

Comparison of prognostic factors in patients in phase I trials of cytotoxic drugs vs new noncytotoxic agents.

scientific article published on October 2003

Comparison of short-term and continuous chemotherapy (mitozantrone) for advanced breast cancer

scientific article

Comprehensive proteomic analysis of breast cancer cell membranes reveals unique proteins with potential roles in clinical cancer

scientific article

Consensus guidelines for the use and interpretation of angiogenesis assays

article

Consensus statement: Expedition Inspiration 2004 Breast Cancer Symposium ?Breast Cancer ? the Development and Validation of New Therapeutics?

article

Continuous low-dose cyclophosphamide and methotrexate combined with celecoxib for patients with advanced cancer ⬇️

scientific article published on May 17, 2011

Continuous low-dose cyclophosphamide and methotrexate combined with celecoxib for patients with advanced cancer.

scientific article

Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.

scientific article

Contribution of granulocyte colony-stimulating factor to the acute mobilization of endothelial precursor cells by vascular disrupting agents.

scientific article published on 08 September 2009

Cooling of burns: Mechanisms and models

scientific article published on 25 March 2015

Cooperative stimulation of vascular endothelial growth factor expression by hypoxia and reactive oxygen species: the effect of targeting vascular endothelial growth factor and oxidative stress in an orthotopic xenograft model of bladder carcinoma

scientific article

Copper chelator ATN-224 inhibits endothelial function by multiple mechanisms

scientific article

Correction to: Disruption of hypoxia-inducible fatty acid binding protein 7 induces beige fat-like differentiation and thermogenesis in breast cancer cells

scientific article published on 10 August 2020

Correction: HER2 Phosphorylation Is Maintained by a PKB Negative Feedback Loop in Response to Anti-HER2 Herceptin in Breast Cancer

scientific article

Corrigendum

scholarly article published in Histopathology

Current approaches to targeting cancer using antiangiogenesis therapies

scientific article

Cutaneous breast cancer deposits show distinct growth patterns with different degrees of angiogenesis, hypoxia and fibrin deposition

scientific article published in June 2003

Cyclooxygenase-2 expression and angiogenesis in squamous cell carcinoma of the skin and its precursors: a paired immunohistochemical study of 35 cases

scientific article published in October 2004

Cyclophosphamide, methotrexate and infusional 5-fluorouracil (infusional CMF) in metastatic breast cancer ⬇️

scientific article published on June 1, 1998

Cytokine networks in solid human tumors: regulation of angiogenesis ⬇️

scientific article published on October 1, 1994

Cytoplasmic location of factor-inhibiting hypoxia-inducible factor is associated with an enhanced hypoxic response and a shorter survival in invasive breast cancer

scientific article

Cytoplasmic p21WAF1/CIP1 expression is correlated with HER-2/ neu in breast cancer and is an independent predictor of prognosis

scientific article

DEC1 (STRA13) protein expression relates to hypoxia- inducible factor 1-alpha and carbonic anhydrase-9 overexpression in non-small cell lung cancer

scientific article (publication date: June 2003)

DLL4-Notch signaling mediates tumor resistance to anti-VEGF therapy in vivo

scientific article

Defective repair of DNA single- and double-strand breaks in the bleomycin- and X-ray-sensitive Chinese hamster ovary cell mutant, BLM-2.

scientific article

Definition of clinically distinct molecular subtypes in estrogen receptor-positive breast carcinomas through genomic grade

scientific article

Delta-like 4 Notch ligand regulates tumor angiogenesis, improves tumor vascular function, and promotes tumor growth in vivo.

scientific article published in December 2007

Delta-like ligand 4-notch blockade and tumor radiation response

scientific article

Detection of Mammaglobin mRNA in the Plasma of Breast Cancer Patients ⬇️

scientific article published on 01 September 2001

Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large B-cell lymphoma

scientific article (publication date: May 2008)

Development of Therapeutic Anti-JAGGED1 Antibodies for Cancer Therapy

scientific article published on 08 August 2019

Development of a new bimodal imaging methodology: a combination of fluorescence microscopy and high-resolution secondary ion mass spectrometry.

scientific article

Dichloroacetate reverses the hypoxic adaptation to bevacizumab and enhances its antitumor effects in mouse xenografts.

scientific article published on 30 January 2013

Different patterns of stromal and cancer cell thymidine phosphorylase reactivity in non-small-cell lung cancer: impact on tumour neoangiogenesis and survival ⬇️

scientific article published on May 1, 1998

Differential assessment of angiogenic activity and of vascular survival ability (VSA) in breast cancer

scientific article published on 01 January 2002

Differential expression of vascular endothelial growth factor mRNA vs protein isoform expression in human breast cancer and relationship to eIF-4E ⬇️

scientific article published on June 1, 1998

Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor

scientific article

Differential gene expression patterns in HER2/neu-positive and -negative breast cancer cell lines and tissues

scientific article published on October 2002

Differential modulation of doxorubicin toxicity to multidrug and intrinsically drug resistant cell lines by anti-oestrogens and their major metabolites ⬇️

scientific article published on June 1, 1993

Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization

scientific article

Disrupting Hypoxia-Induced Bicarbonate Transport Acidifies Tumor Cells and Suppresses Tumor Growth.

scientific article published on 17 May 2016

Disruption of hypoxia-inducible fatty acid binding protein 7 induces beige fat-like differentiation and thermogenesis in breast cancer cells

scientific article published on 06 July 2020

Distinct angiogenic patterns are associated with high-grade in situ ductal carcinomas of the breast

scientific article published in February 1997

Distinct microRNA alterations characterize high- and low-grade bladder cancer

scientific article published on 20 October 2009

Distinct molecular signature of inflammatory breast cancer by cDNA microarray analysis

scientific article published in October 2005

Does amifostine reduce metabolic rate? Effect of the drug on gas exchange and acute ventilatory hypoxic response in humans.

scientific article published on 16 April 2015

Does improved control of tumour growth require an anti-cancer therapy targeting both neoplastic and intratumoral endothelial cells?

scientific article

Dose Seeking Evaluation of a Novel Heterologous Primeboost Immunotherapy in Stage III and IV Metastatic Melanoma Patients

Down-regulation of phosphatidylinositol 3'-kinase/AKT/molecular target of rapamycin metabolic pathway by primary letrozole-based therapy in human breast cancer

scientific article published on May 2008

EFNA3 long noncoding RNAs induced by hypoxia promote metastatic dissemination

scientific article

EGFR mutations in exons 18-21 in sporadic breast cancer

scientific article published on 01 January 2007

ER and HER2 expression are positively correlated in HER2 non-overexpressing breast cancer ⬇️

scientific article

Early expression of bcl-2 protein in the adenoma-carcinoma sequence of colorectal neoplasia

scientific article

Editorial

Effect of Primary Letrozole Treatment on Tumor Expression of mTOR and HIF-1α and Relation to Clinical Response

scientific article

Effect of ascorbate on the activity of hypoxia-inducible factor in cancer cells

scientific article (publication date: 15 April 2003)

Effects of HIF-1alpha and HIF2alpha on Growth and Metabolism of Clear-Cell Renal Cell Carcinoma 786-0 Xenografts

scientific article published on 27 June 2010

Effects of acute versus chronic hypoxia on DNA damage responses and genomic instability

scientific article

Effects of transferrin receptor blockade on cancer cell proliferation and hypoxia-inducible factor function and their differential regulation by ascorbate

scientific article published on March 2006

Efficacy and toxicity of the angiogenesis inhibitor SU5416 as a single agent in patients with advanced renal cell carcinoma, melanoma, and soft tissue sarcoma.

scientific article published in May 2003

Elevated serum vascular endothelial growth factor in patients with hormone-escaped prostate cancer

scientific article published on 01 February 2000

Endocrinology of Zoladex in postmenopausal women

scientific article published in January 1989

Endogenous markers of hypoxia/anaerobic metabolism and anemia in primary colorectal cancer

scientific article

Endogenous markers of two separate hypoxia response pathways (hypoxia inducible factor 2 alpha and carbonic anhydrase 9) are associated with radiotherapy failure in head and neck cancer patients recruited in the CHART randomized trial.

scientific article published on 17 January 2006

Endogenous miRNA sponges mediate the generation of oscillatory dynamics for a non-coding RNA network

Endothelial Cell-Specific Expression of Tumor Necrosis Factor-αfrom the KDR or E-Selectin Promoters Following Retroviral Delivery ⬇️

scientific article published on December 10, 1997

Endothelial alpha3beta1-integrin represses pathological angiogenesis and sustains endothelial-VEGF.

scientific article

Endothelial cell metabolism and implications for cancer therapy.

scientific article published on October 2012

Enhanced expression of SPARC/osteonectin in the tumor-associated stroma of non-small cell lung cancer is correlated with markers of hypoxia/acidity and with poor prognosis of patients ⬇️

scientific article published on September 1, 2003

Enhanced response to radiotherapy in tumours deficient in the function of hypoxia-inducible factor-1

scientific article

Enhancement of Adriamycin cytotoxicity in a multidrug resistant Chinese hamster ovary (CHO) subline, CHO-Adrr, by toremifene and its modulation by alpha 1 acid glycoprotein

scientific article published on April 1990

Enhancement of tumor growth and vascular density by transfection of vascular endothelial cell growth factor into MCF-7 human breast carcinoma cells

scientific article published on February 1995

Epidermal growth factor receptor (EGFr) as a marker for poor prognosis in node-negative breast cancer patients: Neu and tamoxifen failure

article

Epidermal growth factor receptor (EGFr); results of a 6 year follow-up study in operable breast cancer with emphasis on the node negative subgroup ⬇️

scientific article published on January 1, 1991

Epidermal growth factor receptors in breast cancer: Association with early relapse and death, poor response to hormones and interactions with neu

article

Epigenetic downregulation of human disabled homolog 2 switches TGF-beta from a tumor suppressor to a tumor promoter.

scientific article

Erratum to “Microvessel networks pre-formed in artificial clinical grade dermal substitutes in vitro using cells from haematopoietic tissues” [Burns 38 (2012) 691–701]

scholarly article published in Burns

Erratum: Corrigendum: How cancer metabolism is tuned for proliferation and vulnerable to disruption

scientific article published in Nature

Estimation and external validation of a new prognostic model for predicting recurrence-free survival for early breast cancer patients in the UK.

scientific article

Estrogen receptor-α directly regulates the hypoxia-inducible factor 1 pathway associated with antiestrogen response in breast cancer

scientific article

Evaluation of the current knowledge limitations in breast cancer research: a gap analysis

scientific article published on 27 March 2008

Ex vivo cytotoxic drug evaluation by DiSC assay to expedite identification of clinical targets: results with 8-chloro-cAMP ⬇️

scientific article published on January 1, 1997

Exon array analysis of head and neck cancers identifies a hypoxia related splice variant of LAMA3 associated with a poor prognosis

scientific article

Expression and subcellular localization of human AP endonuclease 1 (HAP1/Ref-1) protein: a basis for its role in human disease

scientific article

Expression of BNIP3 correlates with hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha and the androgen receptor in prostate cancer and is regulated directly by hypoxia but not androgens in cell lines

scientific article published on February 2008

Expression of Hypoxia-related Tissue Factors Correlates with Diminished Survival of Adjuvantly Treated Patients with Chromosome 1p Aberrant Oligodendroglial Neoplasms and Therapeutic Implications

scientific article published on 01 October 2004

Expression of VEGF in routinely fixed material using a new monoclonal

Expression of VEGF in routinely fixed material using a new monoclonal antibody VG1

scientific article published on 01 November 1998

Expression of Wnt5a is downregulated by extracellular matrix and mutated c-Ha-ras in the human mammary epithelial cell line MCF-10A.

scientific article

Expression of angiogenic factors and hypoxia inducible factors HIF 1, HIF 2 and CA IX in non-Hodgkin's lymphoma

scientific article published on March 2002

Expression of bone morphogenetic protein 2 in breast cancer cells inhibits hypoxic cell death

scientific article

Expression of carbonic anhydrase IX in breast is associated with malignant tissues and is related to overexpression of c-erbB2.

scientific article published in July 2002

Expression of delta-like ligand 4 (Dll4) and markers of hypoxia in colon cancer

scientific article published on 20 October 2009

Expression of hypoxia-associated proteins in sporadic medullary thyroid cancer is associated with desmoplastic stroma reaction and lymph node metastasis and may indicate somatic mutations in the VHL gene

article

Expression of hypoxia-inducible factors is correlated with the presence of a fibrotic focus and angiogenesis in pancreatic ductal adenocarcinomas

scientific article published on 01 June 2005

Expression of key hypoxia sensing prolyl-hydroxylases PHD1, -2 and -3 in pancreaticobiliary cancer

scientific article published on 15 May 2010

Expression of messenger RNA for amphiregulin, heregulin, and cripto-1, three new members of the epidermal growth factor family, in human breast carcinomas

scientific article published on 01 September 1995

Expression of miR-210 in relation to other measures of hypoxia and prediction of benefit from hypoxia modification in patients with bladder cancer

scientific article published on 21 July 2016

Expression of prolyl-hydroxylases PHD-1, 2 and 3 and of the asparagine hydroxylase FIH in non-small cell lung cancer relates to an activated HIF pathway.

scientific article

Expression of the angiopoietins and their receptor Tie2 in human renal clear cell carcinomas; regulation by the von Hippel-Lindau gene and hypoxia

scientific article published in December 2002

Expression of the cell death genes BNip3 and NIX in ductal carcinoma in situ of the breast; correlation of BNip3 levels with necrosis and grade

scientific article published in December 2003

Expression of the forkhead transcription factor FOXP1 is associated both with hypoxia inducible factors (HIFs) and the androgen receptor in prostate cancer but is not directly regulated by androgens or hypoxia

scientific article published on July 2007

Expression of the forkhead transcription factor FOXP1 is associated with estrogen receptor alpha and improved survival in primary human breast carcinomas

scientific article

Expression of the forkhead transcription factor FOXP1 is associated with that of estrogen receptor-beta in primary invasive breast carcinomas

scientific article published on 17 November 2007

Expression of vascular Notch ligands Delta-like 4 and Jagged-1 in glioblastoma

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Recruitment of regulatory T cells is correlated with hypoxia-induced CXCR4 expression, and is associated with poor prognosis in basal-like breast cancers.

scientific article published on 26 April 2011

Recurrent PTPRB and PLCG1 mutations in angiosarcoma

scientific article

Reduced topoisomerase II and elevated alpha class glutathione S-transferase expression in a multidrug resistant CHO cell line highly cross-resistant to mitomycin C.

scientific article published on February 1992

Reduction in angiogenesis after neoadjuvant chemoendocrine therapy in patients with operable breast carcinoma

scientific article published on 01 May 1999

Regulation of CXCR4 by the Notch ligand delta-like 4 in endothelial cells

scientific article

Regulation of Wnt5a expression in human mammary cells by protein kinase C activity and the cytoskeleton ⬇️

scientific article published on August 1, 1998

Regulation of Wnt5a mRNA expression in human mammary epithelial cells by cell shape, confluence, and hepatocyte growth factor

scientific article published on May 1995

Regulation of a rat VL30 element in human breast cancer cells in hypoxia and anoxia: role of HIF-1

scientific article published on November 2002

Regulation of angiogenesis by homotypic and heterotypic notch signalling in endothelial cells and pericytes: from basic research to potential therapies

scientific article published on 07 February 2008

Regulation of autophagy by ATF4 in response to severe hypoxia.

scientific article published on 31 May 2010

Regulation of hepatocyte growth factor activator inhibitor 2 by hypoxia in breast cancer

scientific article published on January 2007

Regulation of intracellular pH in cancer cell lines under normoxia and hypoxia

scientific article published on April 2013

Regulation of multiple angiogenic pathways by Dll4 and Notch in human umbilical vein endothelial cells

scientific article published on 29 June 2007

Regulation of the human topoisomerase IIalpha gene promoter in confluence-arrested cells

scientific article

Regulation of the tumour suppressor PDCD4 by miR-499 and miR-21 in oropharyngeal cancers.

scientific article published in January 2015

Regulation of tumor pH and the role of carbonic anhydrase 9.

scientific article published on June 2007

Relation of Erythropoietin and Erythropoietin Receptor Expression to Hypoxia and Anemia in Head and Neck Squamous Cell Carcinoma

article

Relation of a Hypoxia Metagene Derived from Head and Neck Cancer to Prognosis of Multiple Cancers

article

Relation of hypoxia inducible factor 1 alpha and 2 alpha in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survival

scientific article

Relation of hypoxia-inducible factor-2 alpha (HIF-2 alpha) expression in tumor-infiltrative macrophages to tumor angiogenesis and the oxidative thymidine phosphorylase pathway in Human breast cancer

scientific article published on March 2002

Relationship of elevated tumour thymidine phosphorylase in node-positive breast carcinomas to the effects of adjuvant CMF

scientific article published on 01 March 1997

Repair of cisplatin-DNA adducts by protein extracts from human ovarian carcinoma

scientific article published on 01 November 1994

Reply: Metronomic chemotherapy with cyclophosphamide and dexamethasone in patients with metastatic carcinoma of the prostate.

scientific article published on 13 March 2012

Resistance to Diverse Drugs and Ultraviolet Light Conferred by Overexpression of a Novel Human 26 S Proteasome Subunit ⬇️

scientific article published on November 28, 1997

Reversal of P-glycoprotein-mediated multidrug resistance by pure anti-oestrogens and novel tamoxifen derivatives

scientific article published on July 1994

Reversible p53 expression in lung cancer

scientific article published in The Lancet

Robust prognostic value of a knowledge-based proliferation signature across large patient microarray studies spanning different cancer types

scientific article published on 4 November 2008

Role of ATF4 in regulation of autophagy and resistance to drugs and hypoxia

scientific article published on 15 December 2009

Role of Delta-like 4 in Jagged1-induced tumour angiogenesis and tumour growth

scientific article published on 8 April 2017

Role of carbonic anhydrase IX expression in prediction of the efficacy and outcome of primary epirubicin/tamoxifen therapy for breast cancer

scientific article published on 01 September 2006

Role of carbonic anhydrase IX in human tumor cell growth, survival, and invasion

scientific article published on September 2004

Role of gene signatures combined with pathology in classification of oropharynx head and neck cancer

scientific article published on 23 June 2020

Role of hypoxia-inducible factor-1alpha as a cancer therapy target

scientific article published on December 2006

Role of hypoxia-inducible factors in epigenetic regulation via histone demethylases

scientific article published on October 2009

Role of matrix metalloproteinase 9 in pituitary tumor behavior

scientific article published on August 2000

Role of the hypoxia sensing system, acidity and reproductive hormones in the variability of vascular endothelial growth factor induction in human breast carcinoma cell lines

scientific article

Role of thymidine phosphorylase in an in vitro model of human bladder cancer invasion

scientific article published on March 2002

Roles of tetrahydrobiopterin in promoting tumor angiogenesis

scientific article

SMER28 is a mTOR-independent small molecule enhancer of autophagy that protects mouse bone morrow and liver against radiotherapy.

scientific article published on 31 January 2018

SREBP maintains lipid biosynthesis and viability of cancer cells under lipid- and oxygen-deprived conditions and defines a gene signature associated with poor survival in glioblastoma multiforme

scientific article published on 26 January 2015

Scarring, stem cells, scaffolds and skin repair

scientific article published on 29 October 2013

Secretion of epidermal growth factor by macrophages associated with breast carcinoma

scientific article published in The Lancet

Selective silencing of the hypoxia-inducible factor 1 target gene BNIP3 by histone deacetylation and methylation in colorectal cancer

scientific article published on 26 June 2006

Sentinel lymph node surgery after neoadjuvant chemotherapy in patients with T2 to T4, N0 and N1 breast cancer.

scientific article published on 15 July 2016

Seven In Absentia Homolog 2 (SIAH2) downregulation is associated with tamoxifen resistance in MCF-7 breast cancer cells.

scientific article

Short course intermediate dose intravenous melphalan therapy in myeloma--relation to early emergence of drug resistance (phase II study).

scientific article

Single-cell heterogeneity in ductal carcinoma in situ of breast.

scientific article published on 17 November 2017

Sizing and phenotyping of cellular vesicles using Nanoparticle Tracking Analysis.

scientific article

Small-molecule inhibitors of the HIF pathway and synthetic lethal interactions

scientific article published on 18 April 2012

Specific inhibition of carbonic anhydrase IX activity enhances the in vivo therapeutic effect of tumor irradiation.

scientific article published on 14 June 2011

Spectral clustering of microarray data elucidates the roles of microenvironment remodeling and immune responses in survival of head and neck squamous cell carcinoma

scientific article

Stable isotope imaging of biological samples with high resolution secondary ion mass spectrometry and complementary techniques.

scientific article

Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth.

scientific article published on 23 January 2013

Strong time dependence of the 76-gene prognostic signature for node-negative breast cancer patients in the TRANSBIG multicenter independent validation series

scientific article published in June 2007

Synchronised phosphorylation of BNIP3, Bcl-2 and Bcl-xL in response to microtubule-active drugs is JNK-independent and requires a mitotic kinase

scientific article

Synergistic activity of letrozole and sorafenib on breast cancer cells

scientific article

Synergistic effect of metronomic dosing of cyclophosphamide combined with specific antitumor immunotherapy in a murine melanoma model.

scientific article published in December 2003

TRAP1 regulates proliferation, mitochondrial function, and has prognostic significance in NSCLC.

scientific article

TUMOUR ANGIOGENESIS

scientific article published on 01 July 1996

Taking advantage of tumor cell adaptations to hypoxia for developing new tumor markers and treatment strategies

scientific article published on April 2009

Targeting DLL4 in tumors shows preclinical activity but potentially significant toxicity

scientific article published on July 2010

Targeting glycogen metabolism: a novel strategy to inhibit cancer cell growth?

scientific article published in January 2013

Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells

scientific article

Targeting the ATF4 pathway in cancer therapy

scientific article published on 26 September 2012

Targeting the hypoxia-inducible factor (HIF) pathway in cancer.

scientific article published on 27 August 2009

Targeting tumour hypoxia in breast cancer

scientific article

Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium

scientific article

Targeting vascular endothelial growth factor in renal cell carcinoma

scientific article

Telling changes of base

scientific article published in Nature

Temozolomide pharmacodynamics in patients with metastatic melanoma: dna damage and activity of repair enzymes O6-alkylguanine alkyltransferase and poly(ADP-ribose) polymerase-1.

scientific article

The BET inhibitor JQ1 selectively impairs tumour response to hypoxia and downregulates CA9 and angiogenesis in triple negative breast cancer

scientific article published on 13 June 2016

The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages

scientific article (publication date: August 2000)

The G-protein-coupled receptor CLR is upregulated in an autocrine loop with adrenomedullin in clear cell renal cell carcinoma and associated with poor prognosis

scientific article published on 22 August 2013

The Role of Oxygen in Avascular Tumor Growth

scientific article

The Role of pH Regulation in Cancer Progression.

scientific article

The actions of GR32191B, a thromboxane receptor antagonist, on the effects of inhaled PAF on human airways

scientific article published in May 1990

The androgen receptor is significantly associated with vascular endothelial growth factor and hypoxia sensing via hypoxia-inducible factors HIF-1a, HIF-2a, and the prolyl hydroxylases in human prostate cancer

scientific article published on November 2005

The angiogenic "vascular endothelial growth factor/flk-1(KDR) receptor" pathway in patients with endometrial carcinoma: prognostic and therapeutic implications

scientific article published on 01 November 2001

The angiogenic ?vascular endothelial growth factor/flk-1(KDR) receptor? pathway in patients with endometrial carcinoma

The angiogenic pathway ?vascular endothelial growth factor/flk-1(KDR)-receptor? in rheumatoid arthritis and osteoarthritis

scholarly article by Alexandra Giatromanolaki et al published 2001 in Journal of Pathology

The angiogenic process as a therapeutic target in cancer

scientific article published on 04 March 2011

The angiogenic receptor KDR is widely distributed in human tissues and tumours and relocates intracellularly on phosphorylation. An immunohistochemical study

scientific article published on 01 July 2003

The cardiovascular safety of high-dose intravenous granisetron in cancer patients receiving highly emetogenic chemotherapy

scientific article published on 22 November 2003

The chemistry, physiology and pathology of pH in cancer

scientific article published on 03 February 2014

The cost-effectiveness of adjuvant chemotherapy for early breast cancer: A comparison of no chemotherapy and first, second, and third generation regimens for patients with differing prognoses

scientific article

The distribution of trace elements Ca, Fe, Cu and Zn and the determination of copper oxidation state in breast tumour tissue using μSRXRF and μXANES

scientific article published on 19 May 2008

The effect of GR32191 (a thromboxane receptor antagonist) on airway responsiveness in asthma

scientific article published on 01 September 1992

The effect of different etiologies of hepatic impairment on the pharmacokinetics of gefitinib

The epidermal growth factor receptor as a prognostic marker: results of 370 patients and review of 3009 patients

scientific article published on January 1994

The expression and cellular localization of phosphorylated VEGFR2 in lymphoma and non-neoplastic lymphadenopathy: an immunohistochemical study

scientific article published on February 2005

The glycerol backbone of phospholipids derives from noncarbohydrate precursors in starved lung cancer cells.

scientific article published on 29 May 2018

The hematopoietic chemokine CXCL12 promotes integration of human endothelial colony forming cell-derived cells into immature vessel networks

scientific article

The heparan sulfate editing enzyme Sulf1 plays a novel role in zebrafish VegfA mediated arterial venous identity

scientific article published in January 2014

The histone demethylase JMJD2B is regulated by estrogen receptor alpha and hypoxia, and is a key mediator of estrogen induced growth

scientific article

The hypoxia-inducible genes VEGF and CA9 are differentially regulated in superficial vs invasive bladder cancer

scientific article

The hypoxia-regulated transcription factor DEC1 (Stra13, SHARP-2) and its expression in human tissues and tumours

scientific article published in July 2004

The increased expression of adhesion molecules ICAM-3, E- and P-selectins on breast cancer endothelium

scientific article published on 01 December 1995

The key hypoxia regulated gene CAIX is upregulated in basal-like breast tumours and is associated with resistance to chemotherapy.

scientific article published on January 2009

The localisation and micro-mapping of copper and other trace elements in breast tumours using a synchrotron micro-XRF system

scientific article published on 18 October 2006

The molecular basis of the hypoxia response pathway: tumour hypoxia as a therapy target

scientific article published in June 1998

The multidrug resistant phenotype in clinical practice; evaluation of cross resistance to ifosfamide and mesna after VP16-213, doxorubicin and vincristine (VPAV) for small cell lung cancer.

scientific article

The notch ligand JAGGED1 as a target for anti-tumor therapy

scientific article published on 25 September 2014

The number of regulatory T cells in prostate cancer is associated with the androgen receptor and hypoxia-inducible factor (HIF)-2α but not HIF-1α

scientific article published on 01 May 2007

The pH low insertion peptide pHLIP Variant 3 as a novel marker of acidic malignant lesions

scientific article

The potential of new tumor endothelium-specific markers for the development of antivascular therapy

scientific article published in June 2007

The presence of a fibrotic focus in invasive breast carcinoma correlates with the expression of carbonic anhydrase IX and is a marker of hypoxia and poor prognosis

scientific article

The presence of tumor-infiltrating FOXP3+ lymphocytes correlates with intratumoral angiogenesis in endometrial cancer

scientific article published on 3 June 2008

The prognostic value of quantitative angiogenesis in breast cancer and role of adhesion molecule expression in tumor endothelium

scientific article published on 01 January 1995

The prolyl hydroxylase enzymes are positively associated with hypoxia-inducible factor-1α and vascular endothelial growth factor in human breast cancer and alter in response to primary systemic treatment with epirubicin and tamoxifen

scientific article

The quantitation by radioimmunoassay of 2′-deoxyuridine 5′-triphosphate in extracts of thymidylate synthase-inhibited cells

scientific article published on 01 March 1989

The relation between hypoxia-inducible factor (HIF)-1α and HIF-2α expression with anemia and outcome in surgically treated head and neck cancer

article

The relationship between angiogenesis and the immune response in carcinogenesis and the progression of malignant disease.

scientific article

The relative importance of NADPH: cytochrome c (P450) reductase for determining the sensitivity of human tumour cells to the indolequinone EO9 and related analogues lacking functionality at the C-2 and C-3 positions

scientific article published on 01 April 2000

The role of ATF4 stabilization and autophagy in resistance of breast cancer cells treated with Bortezomib

scientific article published on 5 May 2009

The role of DT-diaphorase in determining the sensitivity of human tumor cells to tirapazamine (SR 4233).

scientific article published in May 1994

The role of carbonic anhydrase 9 in regulating extracellular and intracellular ph in three-dimensional tumor cell growths

scientific article

The role of cell-free DNA size distribution in the management of prostate cancer

scientific article

The role of histone demethylase KDM4B in Myc signaling in neuroblastoma

scientific article

The role of hypoxia regulated microRNAs in cancer

scientific article published on January 2010

The role of hypoxia-inducible factor-1 in three-dimensional tumor growth, apoptosis, and regulation by the insulin-signaling pathway

scientific article

The role of oxygen in avascular tumor growth

The role of the hypoxia-inducible BH3-only proteins BNIP3 and BNIP3L in cancer

scientific article published on December 2007

The role of topoisomerase II alpha and beta in drug resistance

scientific article published on April 1993

The transcription factor DEC1 (stra13, SHARP2) is associated with the hypoxic response and high tumour grade in human breast cancers

scientific article published on August 2004

The tumour hypoxia induced non-coding transcriptome.

scientific article

The ubiquitin-proteasome pathway in cancer ⬇️

scientific article published on January 1, 1998

The unfolded protein response and integrated stress response to anoxia

scientific article published on May 2007

The unfolded protein response controls induction and activation of ADAM17/TACE by severe hypoxia and ER stress

scientific article

Thymidine phosphorylase expression in endometrial carcinomas

scientific article published on 01 July 1999

Thymidine phosphorylase expression in gallbladder adenocarcinomas

scientific article published in July 2002

Thymidine phosphorylase expression in normal and hyperplastic endometrium

scientific article

Thymidine phosphorylase expression in normal, hyperplastic and neoplastic prostates: correlation with tumour associated macrophages, infiltrating lymphocytes, and angiogenesis

scientific article

Thymidine phosphorylase is angiogenic and promotes tumor growth.

scientific article

Thymidine phosphorylase moderates thymidine-dependent rescue after exposure to the thymidylate synthase inhibitor ZD1694 (Tomudex) in vitro ⬇️

scientific article published on 01 July 1998

To branch or to expand?

scientific article published on 6 June 2016

Towards a biological staging model for operable non-small cell lung cancer ⬇️

scientific article published on December 1, 2001

Transcriptional profiling of human cord blood CD133+ and cultured bone marrow mesenchymal stem cells in response to hypoxia

scientific article

Transcriptional up-regulation of ULK1 by ATF4 contributes to cancer cell survival.

scientific article

Transcriptomic analysis of human primary breast cancer identifies fatty acid oxidation as a target for metformin

scientific article published on 10 December 2019

Tumor Infiltrating Lymphocytes in Multi-National Cohorts of Ductal Carcinoma In Situ (DCIS) of Breast

scientific article published in 2022

Tumor angiogenesis in node-negative breast carcinomas ? relationship with epidermal growth factor receptor, estrogen receptor, and survival

scientific article published on 01 January 1994

Tumor hypoxia induces nuclear paraspeckle formation through HIF-2α dependent transcriptional activation of NEAT1 leading to cancer cell survival

scientific article published in August 2015

Tumor hypoxia induces nuclear paraspeckle formation through HIF-2α dependent transcriptional activation of NEAT1 leading to cancer cell survival.

scientific article published on 24 November 2014

Tumor necrosis factor receptor-associated protein 1(TRAP1) regulates genes involved in cell cycle and metastases

scientific article published on 14 May 2010

Tumor specific activation of the VEGF/KDR angiogenic pathway in a subset of locally advanced squamous cell head and neck carcinomas

scientific article published on 01 January 2000

Tumor-associated carbonic anhydrase 9 spatially coordinates intracellular pH in three-dimensional multicellular growths

scientific article

Tumor-associated macrophages in breast cancer.

scientific article

URINARY VASCULAR ENDOTHELIAL GROWTH FACTOR AND ITS CORRELATION WITH BLADDER CANCER RECURRENCE RATES

scientific article published on 01 March 1999

Unlocking the complexity of hypoxia non-coding transcriptome landscape of breast cancer

scientific article

Unlocking the complexity of hypoxia non-coding transcriptome landscape of breast cancer

Up-regulation of delta-like 4 ligand in human tumor vasculature and the role of basal expression in endothelial cell function

scientific article

Up-regulation of endothelial delta-like 4 expression correlates with vessel maturation in bladder cancer

scientific article

Up-regulation of macrophage wnt gene expression in adenoma-carcinoma progression of human colorectal cancer

scientific article published in October 1999

Up-regulation of the Notch ligand Delta-like 4 inhibits VEGF-induced endothelial cell function

scientific article

Up-regulation of thymidine phosphorylase expression is associated with a discrete pattern of angiogenesis in ductal carcinomasin situ of the breast

scientific article published on 01 August 1997

Upregulated hypoxia inducible factor-1alpha and -2alpha pathway in rheumatoid arthritis and osteoarthritis

scientific article

Upregulation of basic fibroblast growth factor in breast carcinoma and its relationship to vascular density, oestrogen receptor, epidermal growth factor receptor and survival

scientific article published on 01 June 1999

Urinary protein and enzyme excretion in patients receiving chemotherapy with the cis-platinum analogs carboplatin (CBDCA, JM8) and iproplatin (CHIP, JM9).

scientific article published in January 1988

Use of novel monoclonal antibodies to determine the expression and distribution of the hypoxia regulatory factors PHD-1, PHD-2, PHD-3 and FIH in normal and neoplastic human tissues.

scientific article published on December 2005

Use of positron emission tomography in pharmacokinetic studies to investigate therapeutic advantage in a phase I study of 120-hour intravenous infusion XR5000.

scientific article published in January 2003

Utility of osteopontin as a biomarker in recurrent epithelial ovarian cancer

scientific article published in May 2004

Utilizing the adjuvant properties of CD1d-dependent NK T cells in T cell-mediated immunotherapy

scientific article published on December 2004

VEGF sticky-trap: the first report of a non-systemically acting angiogenesis inhibitor.

scientific article published in May 2014

VEGF-B expression in human primary breast cancers is associated with lymph node metastasis but not angiogenesis.

scientific article

Validation and clinical utility of a 70-gene prognostic signature for women with node-negative breast cancer

scientific article

Validation of a tissue microarray to study differential protein expression in inflammatory and non-inflammatory breast cancer

scientific article published in May 2004

Validation of anti-vascular endothelial growth factor (anti-VEGF) antibodies for immunohistochemical localization of VEGF in tissue sections: expression of VEGF in the human endometrium

scientific article published on 01 August 1998

Vascular density analysis in colorectal cancer patients treated with vatalanib (PTK787/ZK222584) in the randomised CONFIRM trials ⬇️

scientific article published on August 21, 2012

Vascular patterns in glioblastoma influence clinical outcome and associate with variable expression of angiogenic proteins: evidence for distinct angiogenic subtypes.

scientific article published in April 2003

Vascular patterns in reactive lymphoid tissue and in non-Hodgkin's lymphoma

scientific article published on February 2003

Vascular phenotype in angiogenic and non-angiogenic lung non-small cell carcinomas

scientific article

Vascular-promoting therapy reduced tumor growth and progression by improving chemotherapy efficacy

scientific article

Vascularization and expression of hypoxia-related tissue factors in intracranial ependymoma and their impact on patient survival

scientific article

Vessel co-option in primary human tumors and metastases: an obstacle to effective anti-angiogenic treatment?

scientific article published on 08 July 2013

Ways of escape: are all tumours angiogenic?

scientific article published on 01 December 2001

What is the biological, prognostic, and therapeutic role of the EGF receptor in human breast cancer?

scientific article published on 01 January 1994

When cancer co-opts the vasculature

scientific article published in May 2014

Why some tumours trigger neovascularisation and others don't: the story thus far.

scientific article published on 12 February 2016

Zinc presence in invasive ductal carcinoma of the breast and its correlation with oestrogen receptor status

scientific article published on 12 June 2009

bcl-2 and c-erbB-2 proteins are involved in the regulation of VEGF and of thymidine phosphorylase angiogenic activity in non-small-cell lung cancer

scientific article published in January 1999

c-Myc interacts with hypoxia to induce angiogenesis in vivo by a vascular endothelial growth factor-dependent mechanism

scientific article published in September 2004

c-erbB-2 and episialin challenge host immune response by HLA class I expression in human non-small-cell lung cancer

scientific article published in January 2000

c-erbB-2 protein overexpression in breast cancer is a risk factor in patients with involved and uninvolved lymph nodes ⬇️

scientific article published on March 1, 1991

c-erbB-2 related aggressiveness in breast cancer is hypoxia inducible factor-1alpha dependent

scientific article published in December 2004

cDNA Cloning of a Humandishevelled DVL-3Gene, Mapping to 3q27, and Expression in Human Breast and Colon Carcinomas ⬇️

scientific article published on October 20, 1997

hsa-miR-210 Is induced by hypoxia and is an independent prognostic factor in breast cancer

scientific article

hsa-mir-210 is a marker of tumor hypoxia and a prognostic factor in head and neck cancer

scientific article

miR-139-5p modulates radiotherapy resistance in breast cancer by repressing multiple gene networks of DNA repair and ROS defense

scientific article

miR-182-Mediated Downregulation of BRCA1 Impacts DNA Repair and Sensitivity to PARP Inhibitors

scholarly article by Patryk Moskwa published in January 2014

miR-182-mediated downregulation of BRCA1 impacts DNA repair and sensitivity to PARP inhibitors

scientific article

miR-193a-3p interaction with HMGB1 downregulates human endothelial cell proliferation and migration

scientific article published on 09 March 2017

miR-210 is a target of hypoxia-inducible factors 1 and 2 in renal cancer, regulates ISCU and correlates with good prognosis.

scientific article published on 28 February 2013

microRNA-Associated Progression Pathways and Potential Therapeutic Targets Identified by Integrated mRNA and microRNA Expression Profiling in Breast Cancer

scientific article published on 07 July 2011

p21-activated kinase 1: PAK'ed with potential

scientific article published on June 2011

p21WAF1 and p53 immunohistochemical expression in breast carcinoma may predict therapeutic response to adjuvant treatment

article

p53 regulates Cdc2 independently of inhibitory phosphorylation to reinforce radiation-induced G2 arrest in human cells ⬇️

scientific article published on August 13, 1998

‘Invading edge vs. inner’ (edvin) patterns of vascularization: an interplay between angiogenic and vascular survival factors defines the clinical behaviour of non-small cell lung cancer

scientific article published on 01 October 2000

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