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List of works by Jose Carlos Segovia

A comprehensive strategy for the subtyping of patients with Fanconi anaemia: conclusions from the Spanish Fanconi Anemia Research Network

scientific article

A cutaneous gene therapy approach to human leptin deficiencies: correction of the murine ob/ob phenotype using leptin-targeted keratinocyte grafts

scientific article published on July 2001

A simplified approach to improve the efficiency and safety of ex vivo hematopoietic gene therapy in fanconi anemia patients

scientific article published in February 2006

Altered T cell differentiation and Notch signaling induced by the ectopic expression of keratin K10 in the epithelial cells of the thymus

scientific article published in June 2005

Altered hematopoiesis in mice lacking DNA polymerase mu is due to inefficient double-strand break repair

scientific article

Bone marrow-derived cells promote liver regeneration in mice with erythropoietic protoporphyria

scientific article published in December 2009

Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosis

scientific article published on 9 June 2006

Brief report: reduced expression of CD18 leads to the in vivo expansion of hematopoietic stem cells in mouse bone marrow.

scientific article published in October 2014

Cardiac Bmi1(+) cells contribute to myocardial renewal in the murine adult heart

scientific article

Cell fusion reprogramming leads to a specific hepatic expression pattern during mouse bone marrow derived hepatocyte formation in vivo.

scientific article

Characteristics of lentiviral vectors harboring the proximal promoter of the vav proto-oncogene: a weak and efficient promoter for gene therapy

scientific article published on 29 May 2007

Constitutively active Akt induces ectodermal defects and impaired bone morphogenetic protein signaling

scientific article

Cytotoxic infection of hematopoietic stem and committed progenitor cells by the parvovirus minute virus of mice. Propagation of an acute myelosuppression in culture

scientific article published in January 1991

Development of lentiviral vectors with optimized transcriptional activity for the gene therapy of patients with Fanconi anemia

scientific article published in May 2010

Dissecting the role of epidermal growth factor receptor catalytic activity during liver regeneration and hepatocarcinogenesis.

scientific article published on 27 August 2015

Efficient engraftment of in utero transplanted mice with retrovirally transduced hematopoietic stem cells

scientific article

Engraftment and in vivo proliferation advantage of gene corrected mobilized CD34(+) cells from Fanconi anemia patients.

scientific article published on 11 August 2017

Enhanced anti-inflammatory effects of mesenchymal stromal cells mediated by the transient ectopic expression of CXCR4 and IL10

scientific article published on 12 February 2021

Evolution to pathogenicity of the parvovirus minute virus of mice in immunodeficient mice involves genetic heterogeneity at the capsid domain that determines tropism.

scientific article

Ex vivo expansion of umbilical cord blood (UCB) CD34(+) cells alters the expression and function of alpha 4 beta 1 and alpha 5 beta 1 integrins

scientific article published on 01 October 2001

Functional analysis of gammaretroviral vector transduction by quantitative PCR.

scientific article published on September 2006

Generation of iPSCs from genetically corrected Brca2 hypomorphic cells: implications in cell reprogramming and stem cell therapy

scientific article published in February 2014

Hematopoietic dysfunction in a mouse model for Fanconi anemia group D1

scientific journal article

Hematopoietic mobilization in mice increases the presence of bone marrow-derived hepatocytes via in vivo cell fusion

scientific article published in January 2006

Human Pluripotent Stem Cell-Derived Neurons Are Functionally Mature In Vitro and Integrate into the Mouse Striatum Following Transplantation

scientific article published on 30 April 2020

Hydroxytyrosol Administration Enhances Atherosclerotic Lesion Development in Apo E Deficient Mice

scientific article published on 27 July 2006

IGF-I mediates regeneration of endocrine pancreas by increasing beta cell replication through cell cycle protein modulation in mice.

scientific article

IKKβ overexpression together with a lack of tumour suppressor genes causes ameloblastic odontomas in mice

scientific article published on 02 January 2020

Immunoresponse against the transgene limits hematopoietic engraftment of mice transplanted in utero with virally transduced fetal liver.

scientific article

In comparison with palm oil, dietary nut supplementation delays the progression of atherosclerotic lesions in female apoE-deficient mice

scientific article published on 12 December 2012

In vitro and in vivo expression of human erythrocyte pyruvate kinase in erythroid cells: a gene therapy approach.

scientific article

In vitro and in vivo susceptibility of mouse megakaryocytic progenitors to strain i of parvovirus minute virus of mice.

scientific article

In vitro myelosuppressive effects of the parvovirus minute virus of mice (MVMi) on hematopoietic stem and committed progenitor cells ⬇️

scientific article published on March 1, 1991

In vivo CRISPR/Cas9 targeting of fusion oncogenes for selective elimination of cancer cells

scientific article published on 08 October 2020

In vivo proliferation advantage of genetically corrected hematopoietic stem cells in a mouse model of Fanconi anemia FA-D1.

scientific article published on 23 September 2008

Latent hematopoietic stem cell toxicity associated with protracted drug administration

scientific article

Lentiviral-mediated genetic correction of hematopoietic and mesenchymal progenitor cells from Fanconi anemia patients

scientific article published on 10 March 2009

Mesenchymal stromal cells enhance the engraftment of hematopoietic stem cells in an autologous mouse transplantation model

scientific article published on 7 September 2015

New frontier in regenerative medicine: site-specific gene correction in patient-specific induced pluripotent stem cells

scientific article published on June 2013

Non-homologous end-joining defect in fanconi anemia hematopoietic cells exposed to ionizing radiation

scientific article

Nonviral transfer of genes to pig primary keratinocytes. Induction of angiogenesis by composite grafts of modified keratinocytes overexpressing VEGF driven by a keratin promoter

scientific article published in October 1999

Olive oil preparation determines the atherosclerotic protection in apolipoprotein E knockout mice

scientific article published on 17 October 2006

Optimising stable retroviral transduction of primary human synovial fibroblasts.

scientific article published on 12 July 2006

Parvovirus infection suppresses long-term repopulating hematopoietic stem cells

scientific article

Peritoneal repairing cells: a type of bone marrow derived progenitor cells involved in mesothelial regeneration

scientific article published on 14 May 2010

Preserved long-term repopulation and differentiation properties of hematopoietic grafts subjected to ex vivo expansion with stem cell factor and interleukin 11

scientific article published on 01 May 1999

Purging of leukemia-contaminated bone marrow grafts using suicide adenoviral vectors: an in vivo murine experimental model.

scientific article published in August 2003

Regulatory elements of the vav gene drive transgene expression in hematopoietic stem cells from adult mice

scientific article published in April 2004

Reprogramming human B cells into induced pluripotent stem cells and its enhancement by C/EBPα.

scientific article

Rescue of pyruvate kinase deficiency in mice by gene therapy using the human isoenzyme

scientific article

Resistance to chemotherapy via Stat3-dependent overexpression of Bcl-2 in metastatic breast cancer cells

scientific article published on October 2002

Reticulocyte-prone malaria parasites predominantly invade CD71hi immature cells: implications for the development of an in vitro culture for Plasmodium vivax.

scientific article

Squalene in a sex-dependent manner modulates atherosclerotic lesion which correlates with hepatic fat content in apoE-knockout male mice

scientific article published on 12 September 2007

Targeted gene therapy into a safe harbor site in human hematopoietic progenitor cells

scientific article published on 26 March 2020

The NFKB Inducing Kinase Modulates Hematopoiesis During Stress

scientific article published on 2 June 2015

The role of the vav promoter in gene therapy: Safer vectors with weaker and stable expression

article

Transplantation of syngenic bone marrow contaminated with NGFr-marked WEHI-3B cells: an improved model of leukemia relapse in mice

scientific article

Yohimbine prevents the effect of morphine on the redox status of neuroblastomaxglioma NG108-15 cells

scientific article

p73 plays a role in erythroid differentiation through GATA1 induction.

scientific article published on 9 June 2009

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