List of works by Xinzhuan Su

A Cas9 Transgenic Plasmodium yoelii parasite for efficient gene editing.

scientific article published on 20 April 2018

A class of tricyclic compounds blocking malaria parasite oocyst development and transmission

scientific article

A genetic map and recombination parameters of the human malaria parasite Plasmodium falciparum

scientific article (publication date: 12 November 1999)

A molecular marker for chloroquine-resistant falciparum malaria

scientific article

A specific inhibitor of PfCDPK4 blocks malaria transmission: chemical-genetic validation.

scientific article published on 10 October 2013

Actinoramide A Identified as a Potent Antimalarial from Titration-Based Screening of Marine Natural Product Extracts ⬇️

scientific article published on 14 October 2015

Allelic modifications of the cg2 and cg1 genes do not alter the chloroquine response of drug-resistant Plasmodium falciparum

scientific article published on September 2000

Alternative mutations at position 76 of the vacuolar transmembrane protein PfCRT are associated with chloroquine resistance and unique stereospecific quinine and quinidine responses in Plasmodium falciparum

scientific article published on January 2002

Ambient glucose concentration and gene expression in Plasmodium falciparum

scientific article

An open dataset of Plasmodium falciparum genome variation in 7,000 worldwide samples

An open dataset of Plasmodium falciparum genome variation in 7,000 worldwide samples

scientific article published on 24 February 2021

Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing

scientific article (publication date: 19 July 2012)

Angiogenesis inhibitors specific for methionine aminopeptidase 2 as drugs for malaria and leishmaniasis

scientific article published on January 2002

Anti-Pfs25 human plasma reduces transmission of Plasmodium falciparum isolates that have diverse genetic backgrounds

scientific article published on 18 March 2013

Artemisinin and its derivatives in treating helminthic infections beyond schistosomiasis.

scientific article

Artemisinin and its derivatives in treating protozoan infections beyond malaria

scientific article published on 17 November 2016

Artemisinin resistance phenotypes and K13 inheritance in a Plasmodium falciparum cross and Aotus model

scientific article published on 19 November 2018

Artemisinin-resistant Plasmodium falciparum in Pursat province, western Cambodia: a parasite clearance rate study

scientific article published on 30 August 2012

Artemisinin: discovery from the Chinese herbal garden

scientific article published on 16 September 2011

Blockage of Galectin-receptor Interactions by α-lactose Exacerbates Plasmodium berghei-induced Pulmonary Immunopathology

scientific article published on 24 August 2016

CD4+ T-cell response to mitochondrial cytochrome B in human melanoma

scientific article published on June 2006

CRISPR/Cas9 mediated sequential editing of genes critical for ookinete motility in Plasmodium yoelii

scientific article published on 26 December 2016

Canine thyrotropin beta-subunit gene: cloning and expression in Escherichia coli, generation of monoclonal antibodies, and transient expression in the Chinese hamster ovary cells

scientific article

Changes in the plasmodial surface anion channel reduce leupeptin uptake and can confer drug resistance in Plasmodium falciparum-infected erythrocytes.

scientific article published on 28 April 2008

Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets

scientific article

Chemical genomics for studying parasite gene function and interaction.

scientific article

Chromosome-wide SNPs reveal an ancient origin for Plasmodium falciparum

scientific article published in July 2002

Cloning and expression of complementary DNA encoding an antigen of Trichinella spiralis

scholarly article

Complex mutations in a high proportion of microsatellite loci from the protozoan parasite Plasmodium falciparum.

scientific article

Cross-Regulation of Two Type I Interferon Signaling Pathways in Plasmacytoid Dendritic Cells Controls Anti-malaria Immunity and Host Mortality.

scientific article

Current status of the Plasmodium falciparum genome project.

scientific article published on July 1996

Detection of genome-wide polymorphisms in the AT-rich Plasmodium falciparum genome using a high-density microarray

scientific article

Detection of host pathways universally inhibited after Plasmodium yoelii infection for immune intervention

scientific article published in Scientific Reports

Directional gene expression and antisense transcripts in sexual and asexual stages of Plasmodium falciparum

scientific article

Discovery, mechanisms of action and combination therapy of artemisinin

scientific article

Disruption of a Plasmodium falciparum Multidrug Resistance-associated Protein (PfMRP) Alters Its Fitness and Transport of Antimalarial Drugs and Glutathione

scientific article (publication date: 20 March 2009)

Disruption of a Plasmodium falciparum gene linked to male sexual development causes early arrest in gametocytogenesis

scientific article (publication date: 15 November 2005)

Dissecting the loci of low-level quinine resistance in malaria parasites

scientific article published on May 2004

Drug resistance and genetic mapping in Plasmodium falciparum.

scientific article published on 18 September 2008

Efficient editing of malaria parasite genome using the CRISPR/Cas9 system

scientific article

Erythrocytic ferroportin reduces intracellular iron accumulation, hemolysis, and malaria risk.

scientific article published in March 2018

Evidence for different mechanisms of chloroquine resistance in 2 Plasmodium species that cause human malaria.

scientific article published on 27 April 2001

Ex vivo susceptibility of Plasmodium falciparum to antimalarial drugs in western, northern, and eastern Cambodia, 2011-2012: association with molecular markers

scientific article published on 12 August 2013

Expression of Tim-1 and Tim-3 in Plasmodium berghei ANKA infection.

scientific article published on 8 May 2013

FOSL1 Inhibits Type I Interferon Responses to Malaria and Viral Infections by Blocking TBK1 and TRAF3/TRIF Interactions

scientific article published on 03 January 2017

Five bovine dinucleotide repeat polymorphisms: RM040, RM044, RM096, RM153 and RM179

scientific article published on 01 February 1995

Gene structure and expression of a Plasmodium falciparum 220-kDa protein homologous to the Plasmodium vivax reticulocyte binding proteins

article

Generation and functional characterisation of Plasmodium yoelii csp deletion mutants using a microhomology-based CRISPR/Cas9 method

scientific article published on 13 June 2019

Genetic diversity and chloroquine selective sweeps in Plasmodium falciparum

scientific article (publication date: 18 July 2002)

Genetic diversity of Plasmodium vivax population in Anhui province of China

scientific article published on 08 January 2014

Genetic linkage and association analyses for trait mapping in Plasmodium falciparum

scientific article published on July 2007

Genetic loci associated with delayed clearance of Plasmodium falciparum following artemisinin treatment in Southeast Asia

scientific article published on 17 December 2012

Genetic mapping in the human malaria parasite Plasmodium falciparum.

scientific article published in September 2004

Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum

scientific article published on 06 September 2009

Genome Display and Typing of Plasmodium Parasites Using Anchored PolyA and PolyT Oligonucleotides

scientific article published on 01 April 2000

Genome projects, genetic analysis, and the changing landscape of malaria research

scientific article

Genome-wide Analysis of Host-Plasmodium yoelii Interactions Reveals Regulators of the Type I Interferon Response.

scientific article published on 16 July 2015

Genome-wide compensatory changes accompany drug- selected mutations in the Plasmodium falciparum crt gene

scientific article

Genome-wide polymorphisms and development of a microarray platform to detect genetic variations in Plasmodium yoelii

scientific article

Genome-wide profiling of chromosome interactions in Plasmodium falciparum characterizes nuclear architecture and reconfigurations associated with antigenic variation

scientific article published on 30 September 2013

Genome-wide variation and identification of vaccine targets in the Plasmodium falciparum genome.

scientific article

High recombination rates and hotspots in a Plasmodium falciparum genetic cross

scientific article published on 4 April 2011

High-throughput matrix screening identifies synergistic and antagonistic antimalarial drug combinations

scientific article

Histone acetyltransferase inhibitor anacardic acid causes changes in global gene expression during in vitro Plasmodium falciparum development

scientific article published on 16 May 2008

Host switch leads to emergence of Plasmodium vivax malaria in humans

scientific article

Human malaria parasites: are we ready for a new species?

scientific article published on May 2010

Hundreds of microsatellites for genotyping Plasmodium yoelii parasites

scientific article published on 09 April 2009

ISP1-Anchored Polarization of GCβ/CDC50A Complex Initiates Malaria Ookinete Gliding Motility

scientific article published on 23 August 2018

Identification of a subtelomeric gene family expressed during the asexual-sexual stage transition in Plasmodium falciparum

scientific article (publication date: September 2005)

In vitro sensitivity of Plasmodium falciparum clinical isolates from the China-Myanmar border area to quinine and association with polymorphism in the Na+/H+ exchanger

scientific article

Increased tolerance to artemisinin in Plasmodium falciparum is mediated by a quiescence mechanism

scientific article

Indels, structural variation, and recombination drive genomic diversity in Plasmodium falciparum

scientific article published on 16 August 2016

Inflammasome activation negatively regulates MyD88-IRF7 type I IFN signaling and anti-malaria immunity

scientific article published in Nature Communications

Isolation of Trichinella-Specific Antigens for Diagnosis by Gradient Monoclonal Antibody Affinity Chromatography

scientific article published on 01 December 1990

Lack of allele-specific efficacy of a bivalent AMA1 malaria vaccine

scientific article

Lack of association of the S769N mutation in Plasmodium falciparum SERCA (PfATP6) with resistance to artemisinins

scientific article

Large-scale Artemisinin-Piperaquine Mass Drug Administration With or Without Primaquine Dramatically Reduces Malaria in a Highly Endemic Region of Africa

scientific article published on 01 November 2018

Large-scale genotyping and genetic mapping in Plasmodium parasites.

scientific article published on 26 May 2009

Leveraging crowdsourcing to accelerate global health solutions

scientific article published on 01 August 2019

Local adaptation and vector-mediated population structure in Plasmodium vivax malaria.

scientific article published on 2 April 2008

ML238: An Antimalarial Small Molecule of a Unique Structural Class

Macrophage migration inhibitory factor homolog from Plasmodium yoelii modulates monocyte recruitment and activation in spleen during infection

scientific article

Malaria: therapy, genes and vaccines

scientific article published in May 2006

Mechanism of splenic cell death and host mortality in a Plasmodium yoelii malaria model

scientific article published on 5 September 2017

Microsatellite markers and genetic mapping in Plasmodium falciparum

scientific article published in July 2000

Molecular and epidemiological characterization of Plasmodium vivax recurrent infections in southern Mexico

scientific article published on 18 April 2013

Molecular characterization of Plasmodium falciparum S-adenosylmethionine synthetase

scientific article (publication date: December 1999)

Molecular surveillance of pvdhfr, pvdhps, and pvmdr-1 mutations in Plasmodium vivax isolates from Yunnan and Anhui provinces of China

scientific article

Monitoring the Prevalence of Leucocytozoon sabrazesi in Southern China and Testing Tricyclic Compounds against Gametocytes.

scientific article

Monoclonal Antibodies to Porcine Tumor Necrosis Factor Alpha: Development of an Enzyme-Linked Immunosorbent Assay

scientific article published on 01 January 1992

Multi-strain infections and 'relapse' of Leucocytozoon sabrazesi gametocytes in domestic chickens in southern China

scientific article

Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia

scientific article published on 28 April 2013

Multiple transporters associated with malaria parasite responses to chloroquine and quinine

scientific article published on August 2003

Mutations in transmembrane domains 1, 4 and 9 of the Plasmodium falciparum chloroquine resistance transporter alter susceptibility to chloroquine, quinine and quinidine

scientific article published on 5 December 2006

Mutations in transmembrane domains 1, 4 and 9 of the Plasmodium falciparum chloroquine resistance transporter alter susceptibility to chloroquine, quinine and quinidine

scientific article published in 2007

Optimized protocols for improving the likelihood of cloning recombinant progeny from Plasmodium yoelii genetic crosses.

scientific article

Oral administration with attenuated Salmonella encoding a Trichinella cystatin-like protein elicited host immunity

scientific article

P. falciparum CG2, linked to chloroquine resistance, does not resemble Na+/H+ exchangers

scientific article published on August 1998

PfCRT and PfMDR1 modulate interactions of artemisinin derivatives and ion channel blockers

scientific article (publication date: 5 May 2016)

PfGCN5-mediated histone H3 acetylation plays a key role in gene expression in Plasmodium falciparum

scientific article

Plasmodium Genomics and Genetics: New Insights into Malaria Pathogenesis, Drug Resistance, Epidemiology, and Evolution

scientific article published on 31 July 2019

Plasmodium falciparum: a rapid DNA fingerprinting method using microsatellite sequences within var clusters

scientific article published in July 1997

Plasmodium falciparum: isolation of large numbers of parasite clones from infected blood samples

scientific article published in June 1996

Plasmodium falciparum:Assignment of Microsatellite Markers to Chromosomes by PFG–PCR

scientific article published on 01 April 1999

Plasmodium falciparum:Parasite Typing by Using a Multicopy Microsatellite Marker, PfRRM

scientific article published on 01 June 1998

Plasmodium genetic loci linked to host cytokine and chemokine responses

scientific article published on 23 January 2014

Polymorphism in a Plasmodium falciparum erythrocyte-binding ligand changes its receptor specificity

scientific article

Polymorphisms of the artemisinin resistant marker (K13) in Plasmodium falciparum parasite populations of Grande Comore Island 10 years after artemisinin combination therapy

scientific article

Population genetic analysis of Plasmodium falciparum parasites using a customized Illumina GoldenGate genotyping assay

scientific article

Population structure of the genes encoding the polymorphic Plasmodium falciparum apical membrane antigen 1: implications for vaccine design

scholarly article

Prevalence of crt and mdr-1 mutations in Plasmodium falciparum isolates from Grande Comore island after withdrawal of chloroquine

scientific article published on 15 August 2016

Protocol for production of a genetic cross of the rodent malaria parasites

scientific article

RTP4 inhibits IFN-I response and enhances experimental cerebral malaria and neuropathology

scientific article published on 24 July 2020

Recent Progress in Functional Genomic Research in Plasmodium falciparum

scientific article

Recombination hotspots and population structure in Plasmodium falciparum

scientific article

Reduced extension temperatures required for PCR amplification of extremely A+T-rich DNA.

scientific article

Regulation of Plasmodium yoelii oocyst development by strain- and stage-specific small-subunit rRNA

scientific article published on 10 March 2015

Sequence, transcript characterization and polymorphisms of a Plasmodium falciparum gene belonging to the heat-shock protein (HSP) 90 family

scientific article published on December 1994

Single-nucleotide polymorphisms and genome diversity in Plasmodium vivax.

scientific article

Six bovine dinucleotide repeat polymorphisms: RM041, RM051, RM066, RM088, RM103 and RM113

scientific article published on 01 February 1995

Strain-specific innate immune signaling pathways determine malaria parasitemia dynamics and host mortality

scientific article published on 13 January 2014

Structural polymorphism and diversifying selection on the pregnancy malaria vaccine candidate VAR2CSA.

scientific article

Systematic CRISPR-Cas9-Mediated Modifications of Plasmodium yoelii ApiAP2 Genes Reveal Functional Insights into Parasite Development

scientific article published on 12 December 2017

Temporal changes in genetic diversity of msp-1, msp-2, and msp-3 in Plasmodium falciparum isolates from Grande Comore Island after introduction of ACT.

scientific article published on 20 February 2018

The "Malaria's Eve" hypothesis and the debate concerning the origin of the human malaria parasite Plasmodium falciparum.

scientific article

The E3 ubiquitin ligase MARCH1 regulates antimalaria immunity through interferon signaling and T cell activation

scientific article published on 30 June 2020

The Gametocytes of Leucocytozoon sabrazesi Infect Chicken Thrombocytes, Not Other Blood Cells

scientific article

The large diverse gene family var encodes proteins involved in cytoadherence and antigenic variation of plasmodium falciparum-infected erythrocytes

scientific article (publication date: July 1995)

The roles of galectins in parasitic infections.

scientific article published on 3 October 2017

Toward a high-resolution Plasmodium falciparum linkage map: polymorphic markers from hundreds of simple sequence repeats.

scientific article published on May 1996

Toward quantitative genetic analysis of host and parasite traits in the manifestations of Plasmodium falciparum malaria

scientific article

Tracing the geographic origins of Plasmodium falciparum malaria parasites

scientific article

Translating Basic Research into Clinical Applications: Malaria Research at an NIH Lab

scientific article

Twelve microsatellite markers for characterization of Plasmodium falciparum from finger-prick blood samples.

scientific article published in August 1999

UTR introns, antisense RNA and differentially spliced transcripts between Plasmodium yoelii subspecies.

scientific article published on 20 January 2016

Upregulation of expression of the reticulocyte homology gene 4 in the Plasmodium falciparum clone Dd2 is associated with a switch in the erythrocyte invasion pathway

scientific article

cDNA sequences reveal considerable gene prediction inaccuracy in the Plasmodium falciparum genome.

scientific article

pfcrt Polymorphism and the spread of chloroquine resistance in Plasmodium falciparum populations across the Amazon Basin

scientific article published on 18 June 2004

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