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List of works by Danny Huylebroeck

A broken heart: a stretch too far: an overview of mouse models with mutations in stretch-sensor components

scientific article published on 20 August 2008

A mesoderm-inducing factor produced by WEHI-3 murine myelomonocytic leukemia cells is activin A.

scientific article published on October 1990

A novel expression cloning method to isolate mammalian transcription factors in Schizosaccharomyces pombe

scientific article published on November 1998

Active complex formation of type I and type II activin and TGF beta receptors in vivo as studied by overexpression in zebrafish embryos.

scientific article

Activin-like factor from a Xenopus laevis cell line responsible for mesoderm induction

scientific article published on June 1990

Alk3/Bmpr1a receptor is required for development of the atrioventricular canal into valves and annulus fibrosus

scientific journal article

Alzheimer's disease associated presenilin 1 interacts with HC5 and ZETA, subunits of the catalytic 20S proteasome

scientific article published on October 1999

Alzheimer-associated C allele of the promoter polymorphism -22C>T causes a critical neuron-specific decrease of presenilin 1 expression

scientific article

Amnion formation in the mouse embryo: the single amniochorionic fold model.

scientific article

Amniotic ectoderm expansion in mouse occurs via distinct modes and requires SMAD5-mediated signalling

scholarly article by Mariya P Dobreva published in July 2018

Amyloid precursor protein is not processed by furin, PACE 4, PC1/3, PC2, PC4 and PC5/6 of the furin family of proprotein processing enzymes

scientific article published in January 1995

Analysis of Schizosaccharomyces pombe mediator reveals a set of essential subunits conserved between yeast and metazoan cells

scientific article

Antagonism of Nodal signaling by BMP/Smad5 prevents ectopic primitive streak formation in the mouse amnion

scientific article published on September 2012

Antigenic drift between the haemagglutinin of the Hong Kong influenza strains A/Aichi/2/68 and A/Victoria/3/75.

scientific article published in August 1980

Aptamers and their potential to selectively target aspects of EGF, Wnt/β-catenin and TGFβ-smad family signaling

scientific article published on 26 March 2013

Atypical Mowat-Wilson patient confirms the importance of the novel association between ZFHX1B/SIP1 and NuRD corepressor complex

scientific article published on 8 January 2008

BMP-SMAD Signaling Regulates Lineage Priming, but Is Dispensable for Self-Renewal in Mouse Embryonic Stem Cells

scientific article

Bmp7 regulates the survival, proliferation, and neurogenic properties of neural progenitor cells during corticogenesis in the mouse

scientific article published in 2012

Cardiomyocytes stimulate angiogenesis after ischemic injury in a ZEB2-dependent manner

scientific article published on 04 January 2021

Complementary expression pattern of Zfhx1 genes Sip1 and deltaEF1 in the mouse embryo and their genetic interaction revealed by compound mutants

scientific journal article

Complete nucleotide sequence of a human influenza neuraminidase gene of subtype N2 (A/Victoria/3/75).

scientific article published in October 1982

Complete nucleotide sequence of the influenza B/Singapore/222/79 virus hemagglutinin gene and comparison with the B/Lee/40 hemagglutinin.

scientific article published on July 1983

Complete nucleotide sequence of the nucleoprotein gene from the human influenza strain A/PR/8/34 (HON1).

scientific article published in May 1981

Complete structure of A/duck/Ukraine/63 influenza hemagglutinin gene: animal virus as progenitor of human H3 Hong Kong 1968 influenza hemagglutinin

scientific article published in August 1981

Complete structure of the hemagglutinin gene from the human influenza A/Victoria/3/75 (H3N2) strain as determined from cloned DNA.

scientific article published in March 1980

Complex Smad-dependent transcriptional responses in vertebrate development and human disease

scientific article

Conditional deletion of Smad1 and Smad5 in somatic cells of male and female gonads leads to metastatic tumor development in mice

scientific article

Correlation between ALK-6 (BMPR-IB) distribution and responsiveness to osteogenic protein-1 (BMP-7) in embryonic mouse bone rudiments

scientific article

Deletion of MgcRacGAP in the male germ cells impairs spermatogenesis and causes male sterility in the mouse.

scientific article published on 16 December 2013

Differentiation of Mouse Enteric Nervous System Progenitor Cells Is Controlled by Endothelin 3 and Requires Regulation of Ednrb by SOX10 and ZEB2.

scientific article published on 4 January 2017

Differentiation of aggregated murine P19 embryonal carcinoma cells is induced by a novel visceral endoderm-specific FGF-like factor and inhibited by activin A.

scientific article published on February 1991

Differentiation-dependent alternative splicing and expression of the extracellular matrix protein 1 gene in human keratinocytes.

scientific article

Direct regulation of the Nrarp gene promoter by the Notch signaling pathway

scientific article

Directed migration of cortical interneurons depends on the cell-autonomous action of Sip1.

scientific article

Distinct spatial and temporal expression patterns of two type I receptors for bone morphogenetic proteins during mouse embryogenesis

scientific article

Dlx1&2-dependent expression of Zfhx1b (Sip1, Zeb2) regulates the fate switch between cortical and striatal interneurons

scientific article published on January 2013

Dual-mode modulation of Smad signaling by Smad-interacting protein Sip1 is required for myelination in the central nervous system

scientific article published on February 2012

Dynamic regulation of Brachyury expression in the amphibian embryo by XSIP1.

scientific article published in February 2002

Endocardial cushion and myocardial defects after cardiac myocyte-specific conditional deletion of the bone morphogenetic protein receptor ALK3

scientific article

Epidermal differentiation does not involve the pro-apoptotic executioner caspases, but is associated with caspase-14 induction and processing

scientific article (publication date: December 2000)

Essential validation of gene trap mouse ES cell lines: a test case with the gene Ttrap

scientific article

Exposure to Ionizing Radiation Triggers Prolonged Changes in Circular RNA Abundance in the Embryonic Mouse Brain and Primary Neurons

scientific article published on 26 July 2019

Expression and processing of the activin-A/erythroid differentiation factor precursor: a member of the transforming growth factor-beta superfamily

scientific article published on August 1990

Expression of the follistatin/EGF-containing transmembrane protein M7365 (tomoregulin-1) during mouse development.

scientific article published in October 2000

Expression of the inhibitory Smad7 in early mouse development and upregulation during embryonic vasculogenesis

article

Expression of type I and type IB receptors for activin in midgestation mouse embryos suggests distinct functions in organogenesis

scientific journal article

Extracellular matrix protein 1 (ECM1) has angiogenic properties and is expressed by breast tumor cells

scientific article

Few Smad proteins and many Smad-interacting proteins yield multiple functions and action modes in TGFβ/BMP signaling in vivo

scientific article published on October 2011

Follistatins neutralize activin bioactivity by inhibition of activin binding to its type II receptors

scientific article published on January 1996

Foreign transmembrane peptides replacing the internal signal sequence of transferrin receptor allow its translocation and membrane binding

scientific article published on 01 January 1987

Four amino acids within a tandem QxVx repeat in a predicted extended α-helix of the Smad-binding domain of Sip1 are necessary for binding to activated Smad proteins

scientific article (publication date: 2013)

Functional redundancy of TGF-beta family type I receptors and receptor-Smads in mediating anti-Mullerian hormone-induced Mullerian duct regression in the mouse

scientific article

Functional redundancy of extracellular matrix protein 1 in epidermal differentiation.

scientific article

Generation of a floxed allele of Smad5 for cre-mediated conditional knockout in the mouse

scientific article published in September 2003

Generation of the floxed allele of the SIP1 (Smad-interacting protein 1) gene for Cre-mediated conditional knockout in the mouse

scientific article published in February 2002

Genetic interaction between Sox10 and Zfhx1b during enteric nervous system development.

scientific article published on 4 March 2010

Group 2 Innate Lymphoid Cells in Human Respiratory Disorders

scientific article published on 06 February 2019

Heterogeneity and clonal relationships of adaptive immune cells in ulcerative colitis revealed by single-cell analyses

scientific article published on 01 August 2020

Heteromeric MAPPIT: a novel strategy to study modification-dependent protein-protein interactions in mammalian cells

scientific article published on July 2003

Heterozygous missense mutations in SMARCA2 cause Nicolaides-Baraitser syndrome

scientific article

High-level transient expression of influenza virus proteins from a series of SV40 late and early replacement vectors

scientific article

IL-12 up-regulates CD40 ligand (CD154) expression on human T cells

scientific article published on February 1998

Identical cis-acting elements and related trans-acting factors control activity of nonviral promoter in Schizosaccharomyces pombe and mammalian cells

scientific article published on April 1998

Identification of a ZEB2-MITF-ZEB1 transcriptional network that controls melanogenesis and melanoma progression

scientific article

Identification of a potent Xenopus mesoderm-inducing factor as a homologue of activin A.

scientific article published on June 1990

Identification of two amino acids in activin A that are important for biological activity and binding to the activin type II receptors

scientific article

Inactivation of Smad5 in endothelial cells and smooth muscle cells demonstrates that Smad5 is required for cardiac homeostasis

scientific journal article

Integrative and perturbation-based analysis of the transcriptional dynamics of TGFβ/BMP system components in transition from embryonic stem cells to neural progenitors

scientific article published on 13 December 2019

Interaction between Smad-interacting protein-1 and the corepressor C-terminal binding protein is dispensable for transcriptional repression of E-cadherin

scientific article published on 24 April 2003

Involvement of SIP1 in positioning of somite boundaries in the mouse embryo

scientific article published in October 2005

Loss-of-function mutations in LEMD3 result in osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis

scientific article

Mice lacking ZFHX1B, the gene that codes for Smad-interacting protein-1, reveal a role for multiple neural crest cell defects in the etiology of Hirschsprung disease-mental retardation syndrome

scientific journal article

Mice with a homozygous gene trap vector insertion in mgcRacGAP die during pre-implantation development

scientific journal article

MicroRNAs promote skeletal muscle differentiation of mesodermal iPSC-derived progenitors.

scientific article published on November 2017

Modulation of activin expression by type beta transforming growth factors

scientific article published on August 1993

Modulation of furin-mediated proprotein processing activity by site-directed mutagenesis.

scientific article published on October 1993

NF-kappaB is involved in the regulation of CD154 (CD40 ligand) expression in primary human T cells

scientific article

NLS-tagging: an alternative strategy to tag nuclear proteins

scientific article published on 26 September 2014

Nematode chromosomal proteins--I. Isolation of chromatin and preliminary characterization of the chromosomal proteins of Caenorhabditis elegans

scientific article published on January 1979

Neural crest-specific removal of Zfhx1b in mouse leads to a wide range of neurocristopathies reminiscent of Mowat-Wilson syndrome

scientific article published on 3 May 2007

New intracellular components of bone morphogenetic protein/Smad signaling cascades

scientific article

New mode of DNA binding of multi-zinc finger transcription factors: deltaEF1 family members bind with two hands to two target sites

scientific article

Oct-1 is involved in the transcriptional repression of the von willebrand factor gene promoter.

scientific article published in August 1998

Onecut transcription factors act upstream of Isl1 to regulate spinal motoneuron diversification

scientific article

Organization of the mouse Zfhx1b gene encoding the two-handed zinc finger repressor Smad-interacting protein-1.

scientific article

Overexpression of activin A in the skin of transgenic mice reveals new activities of activin in epidermal morphogenesis, dermal fibrosis and wound repair

scientific article published on October 1999

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

scientific journal article

Region-specific activation of the Xenopus brachyury promoter involves active repression in ectoderm and endoderm: a study using transgenic frog embryos.

scientific article published in June 2000

Remarkable versatility of Smad proteins in the nucleus of transforming growth factor-beta activated cells

scientific article

Robustness in angiogenesis: notch and BMP shaping waves

scientific article published on 30 December 2012

Sesn1 is a novel gene for left-right asymmetry and mediating nodal signaling

scientific article published on 12 October 2006

Sip1 regulates sequential fate decisions by feedback signaling from postmitotic neurons to progenitors

scientific article published on 18 October 2009

Sip1 regulates the generation of the inner nuclear layer retinal cell lineages in mammals

scientific article published on 6 July 2016

Slowed conduction and thin myelination of peripheral nerves associated with mutant rho Guanine-nucleotide exchange factor 10

scientific article

Smad-interacting protein 1 affects acute and tonic, but not chronic pain

scientific article published on 17 July 2013

Smad-interacting protein 1 is a repressor of liver/bone/kidney alkaline phosphatase transcription in bone morphogenetic protein-induced osteogenic differentiation of C2C12 cells

scientific article published on 26 October 2001

Smad-interacting protein-1 (Zfhx1b) acts upstream of Wnt signaling in the mouse hippocampus and controls its formation

scientific journal article

Smad1/5/8 are myogenic regulators of murine and human mesoangioblasts

scientific article

Smad3 is a key nonredundant mediator of transforming growth factor beta signaling in Nme mouse mammary epithelial cells

scientific article published on 11 August 2009

Smad5 determines murine amnion fate through the control of bone morphogenetic protein expression and signalling levels

scientific article published on 3 August 2006

Smad5 is essential for left-right asymmetry in mice.

scientific article published in March 2000

Smad5 knockout mice die at mid-gestation due to multiple embryonic and extraembryonic defects

scientific article published in April 1999

Smads and chromatin modulation

scientific article

Smicl is a novel Smad interacting protein and cleavage and polyadenylation specificity factor associated protein

scientific article

Stalk cell phenotype depends on integration of Notch and Smad1/5 signaling cascades

scientific article published on 23 February 2012

Synaptopodin and 4 novel genes identified in primary sensory neurons

scientific article published in September 2005

TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1.

scientific article

TDP2-dependent non-homologous end-joining protects against topoisomerase II-induced DNA breaks and genome instability in cells and in vivo

scientific article

TGFβ1-induced Baf60c regulates both smooth muscle cell commitment and quiescence

scientific journal article

TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation

scientific article

Terminal NK cell maturation is controlled by concerted actions of T-bet and Zeb2 and is essential for melanoma rejection

scientific article

The C-terminal domain of Mad-like signal transducers is sufficient for biological activity in the Xenopus embryo and transcriptional activation

scientific article published in January 1997

The EMT regulator Zeb2/Sip1 is essential for murine embryonic hematopoietic stem/progenitor cell differentiation and mobilization

scientific article published on 25 February 2011

The EMT transcription factor ZEB2 promotes proliferation of primary and metastatic melanoma while suppressing an invasive, mesenchymal-like phenotype

scientific article published on 05 June 2020

The EMT transcription factor Zeb2 controls adult murine hematopoietic differentiation by regulating cytokine signaling

scientific article published on 28 September 2016

The Notch intracellular domain integrates signals from Wnt, Hedgehog, TGFβ/BMP and hypoxia pathways

scientific article

The bone morphogenetic protein 2 signaling mediator Smad1 participates predominantly in osteogenic and not in chondrogenic differentiation in mesenchymal progenitors C3H10T1/2.

scientific article published in October 2000

The mammalian gene function resource: the International Knockout Mouse Consortium

scientific article

The novel Smad-interacting protein Smicl regulates Chordin expression in the Xenopus embryo

scientific article

The transcription factor Smad-interacting protein 1 controls pain sensitivity via modulation of DRG neuron excitability

The transcription factor Zeb2 regulates development of conventional and plasmacytoid DCs by repressing Id2

scientific article published on 16 May 2016

The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion

scientific article (publication date: June 2001)

Three classes of mammalian transcription activation domain stimulate transcription in Schizosaccharomyces pombe

scientific article published on September 1997

Transcriptional repressor ZEB2 promotes terminal differentiation of CD8+ effector and memory T cell populations during infection

scientific article

Transforming Growth Factor type beta and Smad family signaling in stem cell function

scientific article published on October 2009

Transforming growth factor beta signalling in vitro and in vivo: activin ligand-receptor interaction, Smad5 in vasculogenesis, and repression of target genes by the deltaEF1/ZEB-related SIP1 in the vertebrate embryo.

scientific article

Transforming growth factor-beta signalling in extraembryonic mesoderm is required for yolk sac vasculogenesis in mice

scientific article published in August 1999

Transforming growth factor-beta-activated kinase-1 (TAK1), a MAP3K, interacts with Smad proteins and interferes with osteogenesis in murine mesenchymal progenitors

scientific article

Truncated activin type II receptors inhibit bioactivity by the formation of heteromeric complexes with activin type I. receptors

scientific article

Ttrap is an essential modulator of Smad3-dependent Nodal signaling during zebrafish gastrulation and left-right axis determination

scientific article

XSIP1, a Xenopus zinc finger/homeodomain encoding gene highly expressed during early neural development

scientific article published in June 2000

XSip1 neuralizing activity involves the co-repressor CtBP and occurs through BMP dependent and independent mechanisms

scientific article published on 20 March 2007

ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling.

scientific article

ZEB2-transgene expression in the epidermis compromises the integrity of the epidermal barrier through the repression of different tight junction proteins

scientific article published on 27 February 2014

Zeb2 Regulates Cell Fate at the Exit from Epiblast State in Mouse Embryonic Stem Cells

scientific article

Zeb2 Regulates Myogenic Differentiation in Pluripotent Stem Cells

scientific article published on 05 April 2020

Zeb2 is a negative regulator of midbrain dopaminergic axon growth and target innervation

scientific article

Zeb2 recruits HDAC-NuRD to inhibit Notch and controls Schwann cell differentiation and remyelination

scientific article published on 13 June 2016

deltaEF1 and SIP1 are differentially expressed and have overlapping activities during Xenopus embryogenesis

scientific article published in June 2006

miR-200 family controls late steps of postnatal forebrain neurogenesis via Zeb2 inhibition

scientific article published on 21 October 2016

p120 Catenin-Mediated Stabilization of E-Cadherin Is Essential for Primitive Endoderm Specification

scientific article

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