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List of works by Alexandre R Gingras

A mechanism of Rap1-induced stabilization of endothelial cell--cell junctions

scientific article

A vinculin binding domain from the talin rod unfolds to form a complex with the vinculin head.

scientific article published on January 2005

Activation of a vinculin-binding site in the talin rod involves rearrangement of a five-helix bundle

scientific article

Biochemical and functional characterization of the interaction between pentraxin 3 and C1q.

scientific article

Central Region of Talin Has a Unique Fold That Binds Vinculin and Actin

scientific article

Control of high affinity interactions in the talin C terminus: how talin domains coordinate protein dynamics in cell adhesions.

scientific article published on 11 March 2009

Crystal structure of the Ca(2+)-form and Ca(2+)-binding kinetics of metastasis-associated protein, S100A4

scientific article

Direct binding of C1q to apoptotic cells and cell blebs induces complement activation

scientific article published on 01 June 2002

Heart of glass anchors Rasip1 at endothelial cell-cell junctions to support vascular integrity

scientific article published on 19 January 2016

Inhibition of the HEG1-KRIT1 interaction increases KLF4 and KLF2 expression in endothelial cells

scientific article published on 18 February 2021

Integrins protect cardiomyocytes from ischemia/reperfusion injury.

scientific article published on 16 September 2013

Mapping and consensus sequence identification for multiple vinculin binding sites within the talin rod.

scientific article published on 30 August 2005

Molecular basis of sugar recognition by collectin-K1 and the effects of mutations associated with 3MC syndrome

scientific article published on 17 April 2015

NMR assignment of the C-terminal actin-binding domain of talin.

scientific article published on 22 December 2007

RIAM and Vinculin Binding to Talin Are Mutually Exclusive and Regulate Adhesion Assembly and Turnover

scientific article

Rap1 binding and a lipid-dependent helix in talin F1 domain promote integrin activation in tandem

scientific article published on 15 April 2019

Rap1 binding to the talin 1 F0 domain makes a minimal contribution to murine platelet GPIIb-IIIa activation

scientific article published on 01 September 2018

Reconstructing integrin activation in vitro

scientific article published on January 2013

Structural Basis of Dimeric Rasip1 RA Domain Recognition of the Ras Subfamily of GTP-Binding Proteins

scientific article published on 8 November 2016

Structural Determinants of Integrin Binding to the Talin Rod

scientific article

Structural and dynamic characterization of a vinculin binding site in the talin rod

scientific article

Structural basis of mannan-binding lectin recognition by its associated serine protease MASP-1: implications for complement activation

scientific article

Structural basis of the C1q/C1s interaction and its central role in assembly of the C1 complex of complement activation

scientific article

Structural basis of the junctional anchorage of the cerebral cavernous malformations complex

scientific article

Structural studies on full-length talin1 reveal a compact auto-inhibited dimer: implications for talin activation

scientific article published on 30 May 2013

Structure of a double ubiquitin-like domain in the talin head: a role in integrin activation

scientific article

Studies on the morphology and spreading of human endothelial cells define key inter- and intramolecular interactions for talin1.

scientific article

Talin at a glance

scientific article published in May 2008

Talin contains a C-terminal calpain2 cleavage site important in focal adhesion dynamics

scientific article published on 4 April 2012

Talin1 is the Principal Platelet Rap1 Effector of Integrin Activation

scientific article published on 09 June 2020

The Crystal Structure of Pneumolysin at 2.0 Å Resolution Reveals the Molecular Packing of the Pre-pore Complex

scientific article published on 3 September 2015

The Structure of an Interdomain Complex That Regulates Talin Activity

scientific article

The Structure of the Ternary Complex of Krev Interaction Trapped 1 (KRIT1) Bound to Both the Rap1 GTPase and the Heart of Glass (HEG1) Cytoplasmic Tail

scientific article

The activity of the vinculin binding sites in talin is influenced by the stability of the helical bundles that make up the talin rod.

scientific article published on 9 January 2006

The classical activation pathway of the human complement system is specifically inhibited by calreticulin from Trypanosoma cruzi

scientific article published in March 2004

The domain structure of talin: Residues 1815-1973 form a five-helix bundle containing a cryptic vinculin-binding site

scientific article

The methyltransferase Ezh2 controls cell adhesion and migration through direct methylation of the extranuclear regulatory protein talin

scientific article

The structure of the C-terminal actin-binding domain of talin

scientific article

Transmission of integrin β7 transmembrane domain topology enables gut lymphoid tissue development

scientific article published on 13 March 2018

Trypanosoma cruzi calreticulin: a possible role in Chagas' disease autoimmunity.

scientific article published on 23 December 2008

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