List of works - Evan T Powers

A designed protein binding-pocket to control excited-state intramolecular proton transfer fluorescence

scientific article published on 01 January 2019

ALS mutants of human superoxide dismutase form fibrous aggregates via framework destabilization

scientific article

Adsorption of beta-hairpin peptides on the surface of water: a neutron reflection study

scientific article published in April 2003

Amyloid-β forms fibrils by nucleated conformational conversion of oligomers

scientific article published on 31 July 2011

An Adaptable Standard for Protein Export from the Endoplasmic Reticulum

article

Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue

scientific article published on 18 May 2016

Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss

scientific article

Backbone-Backbone H-Bonds Make Context-Dependent Contributions to Protein Folding Kinetics and Thermodynamics: Lessons from Amide-to-Ester Mutations.

scientific article

Benzoxazoles as transthyretin amyloid fibril inhibitors: synthesis, evaluation, and mechanism of action

scientific article

Binding of 3,4,5,6-Tetrahydroxyazepanes to the Acid-β-glucosidase Active Site: Implications for Pharmacological Chaperone Design for Gaucher Disease

scientific article

Blinded potency comparison of transthyretin kinetic stabilisers by subunit exchange in human plasma

scientific article published on 18 August 2020

Characterizing the altered cellular proteome induced by the stress-independent activation of heat shock factor 1.

scientific article

Context-dependent effects of asparagine glycosylation on Pin WW folding kinetics and thermodynamics.

scientific article

Controlling the morphology of cross beta-sheet assemblies by rational design

scientific article published in June 2005

Correction to Context-Dependent Effects of Asparagine Glycosylation on Pin WW Folding Kinetics and Thermodynamics

scientific article published on 27 February 2012

Costly Mistakes: Translational Infidelity and Protein Homeostasis

article

Current and future treatment of amyloid diseases

scientific article published on 10 May 2016

Design, synthesis, and evaluation of oxazole transthyretin amyloidogenesis inhibitors

scientific article

Diversity in the origins of proteostasis networks--a driver for protein function in evolution

scientific article published on 06 March 2013

Enhanced Aromatic Sequons Increase Oligosaccharyltransferase Glycosylation Efficiency and Glycan Homogeneity

scientific article

Evaluating beta-turn mimics as beta-sheet folding nucleators

scientific article

Fluorogenic small molecules requiring reaction with a specific protein to create a fluorescent conjugate for biological imaging-what we know and what we need to learn

scientific article

Heparin binds 8 kDa gelsolin cross-β-sheet oligomers and accelerates amyloidogenesis by hastening fibril extension

scientific article published on 15 March 2011

Incorporating beta-turns and a turn mimetic out of context in loop 1 of the WW domain affords cooperatively folded beta-sheets

scientific article published in June 2001

Influence of the N-terminal domain on the aggregation properties of the prion protein

scientific article published on August 2005

Kinetic versus thermodynamic control of mutational effects on protein homeostasis: A perspective from computational modeling and experiment

scientific article published on 24 May 2019

Ligand-promoted protein folding by biased kinetic partitioning

scientific article published on 20 February 2017

Localized thermodynamic coupling between hydrogen bonding and microenvironment polarity substantially stabilizes proteins

scientific article published on 14 June 2009

Medium-dependent self-assembly of an amphiphilic peptide: direct observation of peptide phase domains at the air-water interface

scientific article published in January 2001

Metabolite-initiated protein misfolding may trigger Alzheimer's disease

scholarly article

N-PEGylation of a reverse turn is stabilizing in multiple sequence contexts, unlike N-GlcNAcylation

scientific article

N-glycosylation of enhanced aromatic sequons to increase glycoprotein stability

scientific article published on 3 February 2012

Ordered Langmuir-Blodgett Films of Amphiphilic β-Hairpin Peptides Imaged by Atomic Force Microscopy

scientific article published on 01 January 2002

Oxidative metabolites accelerate Alzheimer's amyloidogenesis by a two-step mechanism, eliminating the requirement for nucleation

scientific article published in April 2005

Partitioning conformational intermediates between competing refolding and aggregation pathways: insights into transthyretin amyloid disease.

scientific article published on December 2005

Peptide probes detect misfolded transthyretin oligomers in plasma of hereditary amyloidosis patients.

scientific article published in September 2017

Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum proteins

scientific article published on 07 August 2018

Potent and selective structure-based dibenzofuran inhibitors of transthyretin amyloidogenesis: kinetic stabilization of the native state

scientific article published in May 2005

Prevention of transthyretin amyloid disease by changing protein misfolding energetics.

scientific article

Protein energetics in maturation of the early secretory pathway.

scientific article published on 7 August 2007

Protein folding: Protection from the outside.

scientific article published in March 2011

Protein native-state stabilization by placing aromatic side chains in N-glycosylated reverse turns

scientific article published on February 2011

Quantification of the thermodynamically linked quaternary and tertiary structural stabilities of transthyretin and its disease-associated variants: the relationship between stability and amyloidosis.

scientific article published on 07 June 2008

Quantification of transthyretin kinetic stability in human plasma using subunit exchange.

scientific article published on 24 March 2014

Site-specific modification of Alzheimer's peptides by cholesterol oxidation products enhances aggregation energetics and neurotoxicity

scholarly article

Small molecule oxidation products trigger disease-associated protein misfolding.

scientific article published on September 2006

Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation.

scientific article published on 20 July 2016

Stabilizing the CH2 Domain of an Antibody by Engineering in an Enhanced Aromatic Sequon

scientific article published on 29 April 2016

Structural and Energetic Basis of Carbohydrate–Aromatic Packing Interactions in Proteins

scientific article

Synthesis, structure, and activity of diclofenac analogues as transthyretin amyloid fibril formation inhibitors

scientific article published in January 2002

Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade

scientific article

Targeting protein aggregation for the treatment of degenerative diseases

scientific article

The 8 and 5 kDa fragments of plasma gelsolin form amyloid fibrils by a nucleated polymerization mechanism, while the 68 kDa fragment is not amyloidogenic

scientific article

The Dependence of Carbohydrate-Aromatic Interaction Strengths on the Structure of the Carbohydrate

scientific article published on June 2016

The kinetics of nucleated polymerizations at high concentrations: amyloid fibril formation near and above the "supercritical concentration".

scientific article published on 7 April 2006

The oxidative stress metabolite 4-hydroxynonenal promotes Alzheimer protofibril formation

scientific article

The proteostasis boundary in misfolding diseases of membrane traffic

scientific article published on August 2009

The transthyretin amyloidoses: from delineating the molecular mechanism of aggregation linked to pathology to a regulatory-agency-approved drug

scientific article published on 05 January 2012

The unfolded protein response regulator ATF6 promotes mesodermal differentiation.

scientific article published on 13 February 2018

Thermodynamic stability and denaturation kinetics of a benign natural transthyretin mutant identified in a Danish kindred.

scientific article published on 16 March 2011

Translation: An O-GlcNAc stamp of approval

scientific article published on 16 March 2015

Transthyretin aggregation under partially denaturing conditions is a downhill polymerization

scientific article

List of works by Evan T Powers

A designed protein binding-pocket to control excited-state intramolecular proton transfer fluorescence

ALS mutants of human superoxide dismutase form fibrous aggregates via framework destabilization

Adsorption of beta-hairpin peptides on the surface of water: a neutron reflection study

Amyloid-β forms fibrils by nucleated conformational conversion of oligomers

An Adaptable Standard for Protein Export from the Endoplasmic Reticulum

Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue

Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss

Backbone-Backbone H-Bonds Make Context-Dependent Contributions to Protein Folding Kinetics and Thermodynamics: Lessons from Amide-to-Ester Mutations.

Benzoxazoles as transthyretin amyloid fibril inhibitors: synthesis, evaluation, and mechanism of action

Binding of 3,4,5,6-Tetrahydroxyazepanes to the Acid-β-glucosidase Active Site: Implications for Pharmacological Chaperone Design for Gaucher Disease

Blinded potency comparison of transthyretin kinetic stabilisers by subunit exchange in human plasma

Characterizing the altered cellular proteome induced by the stress-independent activation of heat shock factor 1.

Context-dependent effects of asparagine glycosylation on Pin WW folding kinetics and thermodynamics.

Controlling the morphology of cross beta-sheet assemblies by rational design

Correction to Context-Dependent Effects of Asparagine Glycosylation on Pin WW Folding Kinetics and Thermodynamics

Costly Mistakes: Translational Infidelity and Protein Homeostasis

Current and future treatment of amyloid diseases

Design, synthesis, and evaluation of oxazole transthyretin amyloidogenesis inhibitors

Diversity in the origins of proteostasis networks--a driver for protein function in evolution

Enhanced Aromatic Sequons Increase Oligosaccharyltransferase Glycosylation Efficiency and Glycan Homogeneity

Evaluating beta-turn mimics as beta-sheet folding nucleators

Fluorogenic small molecules requiring reaction with a specific protein to create a fluorescent conjugate for biological imaging-what we know and what we need to learn

Heparin binds 8 kDa gelsolin cross-β-sheet oligomers and accelerates amyloidogenesis by hastening fibril extension

Incorporating beta-turns and a turn mimetic out of context in loop 1 of the WW domain affords cooperatively folded beta-sheets

Influence of the N-terminal domain on the aggregation properties of the prion protein

Kinetic versus thermodynamic control of mutational effects on protein homeostasis: A perspective from computational modeling and experiment

Ligand-promoted protein folding by biased kinetic partitioning

Localized thermodynamic coupling between hydrogen bonding and microenvironment polarity substantially stabilizes proteins

Medium-dependent self-assembly of an amphiphilic peptide: direct observation of peptide phase domains at the air-water interface

Metabolite-initiated protein misfolding may trigger Alzheimer's disease

N-PEGylation of a reverse turn is stabilizing in multiple sequence contexts, unlike N-GlcNAcylation

N-glycosylation of enhanced aromatic sequons to increase glycoprotein stability

Ordered Langmuir-Blodgett Films of Amphiphilic β-Hairpin Peptides Imaged by Atomic Force Microscopy

Oxidative metabolites accelerate Alzheimer's amyloidogenesis by a two-step mechanism, eliminating the requirement for nucleation

Partitioning conformational intermediates between competing refolding and aggregation pathways: insights into transthyretin amyloid disease.

Peptide probes detect misfolded transthyretin oligomers in plasma of hereditary amyloidosis patients.

Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum proteins

Potent and selective structure-based dibenzofuran inhibitors of transthyretin amyloidogenesis: kinetic stabilization of the native state

Prevention of transthyretin amyloid disease by changing protein misfolding energetics.

Protein energetics in maturation of the early secretory pathway.

Protein folding: Protection from the outside.

Protein native-state stabilization by placing aromatic side chains in N-glycosylated reverse turns

Quantification of the thermodynamically linked quaternary and tertiary structural stabilities of transthyretin and its disease-associated variants: the relationship between stability and amyloidosis.

Quantification of transthyretin kinetic stability in human plasma using subunit exchange.

Site-specific modification of Alzheimer's peptides by cholesterol oxidation products enhances aggregation energetics and neurotoxicity

Small molecule oxidation products trigger disease-associated protein misfolding.

Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation.

Stabilizing the CH2 Domain of an Antibody by Engineering in an Enhanced Aromatic Sequon

Structural and Energetic Basis of Carbohydrate–Aromatic Packing Interactions in Proteins

Synthesis, structure, and activity of diclofenac analogues as transthyretin amyloid fibril formation inhibitors

Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade

Targeting protein aggregation for the treatment of degenerative diseases

The 8 and 5 kDa fragments of plasma gelsolin form amyloid fibrils by a nucleated polymerization mechanism, while the 68 kDa fragment is not amyloidogenic

The Dependence of Carbohydrate-Aromatic Interaction Strengths on the Structure of the Carbohydrate

The kinetics of nucleated polymerizations at high concentrations: amyloid fibril formation near and above the "supercritical concentration".

The oxidative stress metabolite 4-hydroxynonenal promotes Alzheimer protofibril formation

The proteostasis boundary in misfolding diseases of membrane traffic

The transthyretin amyloidoses: from delineating the molecular mechanism of aggregation linked to pathology to a regulatory-agency-approved drug

The unfolded protein response regulator ATF6 promotes mesodermal differentiation.

Thermodynamic stability and denaturation kinetics of a benign natural transthyretin mutant identified in a Danish kindred.

Translation: An O-GlcNAc stamp of approval

Transthyretin aggregation under partially denaturing conditions is a downhill polymerization