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List of works by Andrew F. Hill

A cell line infectible by prion strains from different species

scientific article published on January 2008

A clinical study of kuru patients with long incubation periods at the end of the epidemic in Papua New Guinea

scientific article

A domain level interaction network of amyloid precursor protein and Abeta of Alzheimer's disease

scientific article published on June 2010

A rigorous method to enrich for exosomes from brain tissue

scientific article published on 26 July 2017

A standardized method to determine the concentration of extracellular vesicles using tunable resistive pulse sensing

scientific article published on 27 September 2016

A truncated fragment of Src protein kinase generated by calpain-mediated cleavage is a mediator of neuronal death in excitotoxicity

scientific article published on 11 February 2013

APP involvement in retinogenesis of mice

scientific article published on 27 October 2010

Activation of epidermal growth factor receptor by metal-ligand complexes decreases levels of extracellular amyloid beta peptide

scientific article

An Escherichia coli cell-free system for recombinant protein synthesis on a milligram scale.

scientific article

An antibody raised against a conserved sequence of the prion protein recognizes pathological isoforms in human and animal prion diseases, including Creutzfeldt-Jakob disease and bovine spongiform encephalopathy ⬇️

scientific article published on June 1, 1998

An intact membrane is essential for small extracellular vesicle-induced modulation of α-synuclein fibrillization

scientific article published on 10 December 2020

Analysis of miRNA Signatures in Neurodegenerative Prion Disease.

scientific article

Anionic phospholipid interactions of the prion protein N terminus are minimally perturbing and not driven solely by the octapeptide repeat domain

scientific article published on 2 August 2010

Announcing the ISEV2019 special achievement award recipients: Takahiro Ochiya and Marca Wauben

scientific article published on 22 May 2019

Applying extracellular vesicles based therapeutics in clinical trials - an ISEV position paper.

scientific article

Arl5b is a Golgi-localised small G protein involved in the regulation of retrograde transport.

scientific article published on 5 January 2012

Australian sporadic CJD analysis supports endogenous determinants of molecular-clinical profiles

scientific article published in July 2005

BRAFV600 inhibition alters the microRNA cargo in the vesicular secretome of malignant melanoma cells

scientific article published on 6 July 2017

BSE prions propagate as either variant CJD-like or sporadic CJD-like prion strains in transgenic mice expressing human prion protein

scientific article published on December 2002

Both IFN-γ and IL-17 are required for the development of severe autoimmune gastritis

scientific article published on 15 August 2012

C-terminal peptides modelling constitutive PrPC processing demonstrate ameliorated toxicity predisposition consequent to α-cleavage

scientific article

C-terminal truncation and Parkinson's disease-associated mutations down-regulate the protein serine/threonine kinase activity of PTEN-induced kinase-1.

scientific article published on 25 September 2006

Cell-cell communication between malaria-infected red blood cells via exosome-like vesicles

scientific article (publication date: 23 May 2013)

Changing the solvent accessibility of the prion protein disulfide bond markedly influences its trafficking and effect on cell function

scientific article published on 13 May 2010

Characterization and deep sequencing analysis of exosomal and non-exosomal miRNA in human urine.

scientific article

Chronic methamphetamine interacts with BDNF Val66Met to remodel psychosis pathways in the mesocorticolimbic proteome

scientific article published on 10 December 2019

Conformational detection of prion protein with biarsenical labeling and FlAsH fluorescence

scientific article published on 25 January 2009

Conservation of a glycine-rich region in the prion protein is required for uptake of prion infectivity

scientific article

Correlative studies support lipid peroxidation is linked to PrPres propagation as an early primary pathogenic event in prion disease

scientific article published on 05 October 2005

Creutzfeldt-Jakob disease cluster in an Australian rural city

article

Decreased expression of GGA3 Protein in Alzheimer's disease frontal cortex and increased co-distribution of BACE with the amyloid precursor protein

scientific article published on 03 April 2011

Defining mesenchymal stromal cell (MSC)-derived small extracellular vesicles for therapeutic applications

scientific article published on 29 April 2019

Defining the purity of exosomes required for diagnostic profiling of small RNA suitable for biomarker discovery.

scientific article published on 22 December 2016

Degradation of the Alzheimer disease amyloid beta-peptide by metal-dependent up-regulation of metalloprotease activity

scientific article published on 28 April 2006

Deletions in the prion protein gene are not associated with CJD.

scientific article

Detection of prion epitopes on PrP and PrP of transmissible spongiform encephalopathies using specific monoclonal antibodies to PrP.

scientific article published in December 2005

Diagnosis of new variant Creutzfeldt-Jakob disease by tonsil biopsy

scientific article published in The Lancet

Differential modulation of Alzheimer's disease amyloid beta-peptide accumulation by diverse classes of metal ligands.

scientific article published on November 2007

Disease Mechanisms in ALS: Misfolded SOD1 Transferred Through Exosome-Dependent and Exosome-Independent Pathways.

scientific article published on 23 February 2016

Disruption of prion protein-HOP engagement impairs glioblastoma growth and cognitive decline and improves overall survival

scientific article published on 25 August 2014

Dissociation of ERK signalling inhibition from the anti-amyloidogenic action of synthetic ceramide analogues

scientific article published on May 2012

Distinct glycoform ratios of protease resistant prion protein associated with PRNP point mutations.

scientific article published on 16 January 2006

Dopamine and the dopamine oxidation product 5,6-dihydroxylindole promote distinct on-pathway and off-pathway aggregation of alpha-synuclein in a pH-dependent manner

scientific article

Dopamine promotes alpha-synuclein aggregation into SDS-resistant soluble oligomers via a distinct folding pathway

scientific article published on 9 June 2005

Dual role of Src kinase in governing neuronal survival

scientific article published on 31 October 2014

EV-TRACK: transparent reporting and centralizing knowledge in extracellular vesicle research.

scientific article published on February 2017

EVpedia: a community web portal for extracellular vesicles research

scientific article

Elevation in sphingomyelin synthase activity is associated with increases in amyloid-beta peptide generation

scientific article

Enrichment of extracellular vesicles from human synovial fluid using size exclusion chromatography.

scientific article

Enrichment of prion protein in exosomes derived from ovine cerebral spinal fluid

scientific article published on 16 April 2008

Evidence for prion protein expression in enteroglial cells of the myenteric plexus of mouse intestine

article

Exosomes in the Pathology of Neurodegenerative Diseases

scientific article published on 16 November 2016

Exosomes provide a protective and enriched source of miRNA for biomarker profiling compared to intracellular and cell-free blood.

scientific article published on 26 March 2014

Exosomes: vehicles for the transfer of toxic proteins associated with neurodegenerative diseases?

scientific article published in 2012

Extended period of asymptomatic prion disease after low dose inoculation: assessment of detection methods and implications for infection control

scientific article published in November 2005

Extending gene ontology in the context of extracellular RNA and vesicle communication

scientific article published on 12 April 2016

Extracellular Vesicles Isolated from the Brains of rTg4510 Mice Seed Tau Protein Aggregation in a Threshold-dependent Manner

scientific article published on 30 March 2016

Extracellular vesicles - propagators of neuropathology and sources of potential biomarkers and therapeutics for neurodegenerative diseases

scientific article published on 11 December 2020

Extracellular vesicles--Their role in the packaging and spread of misfolded proteins associated with neurodegenerative diseases

scientific article

Extracellular vesicles: interneural shuttles of complex messages

scientific article published on 13 May 2016

Focus on Extracellular Vesicles: Exosomes and Their Role in Protein Trafficking and Biomarker Potential in Alzheimer's and Parkinson's Disease

scientific article

Formation of a High Affinity Lipid-Binding Intermediate during the Early Aggregation Phase of α-Synuclein†

scientific article published on 08 January 2008

Formation of dopamine-mediated alpha-synuclein-soluble oligomers requires methionine oxidation

scientific article

FunRich: An open access standalone functional enrichment and interaction network analysis tool

scientific article

Gene dysregulation is restored in the Parkinson's disease MPTP neurotoxic mice model upon treatment of the therapeutic drug Cu(II)(atsm).

scientific article published on March 2016

Generating recombinant C-terminal prion protein fragments of exact native sequence

scientific article

Generation of Infectious Prions and Detection with the Prion-Infected Cell Assay

scientific article

Generation of cell lines propagating infectious prions and the isolation and characterization of cell-derived exosomes

scientific article

Glycosaminoglycan sulfation determines the biochemical properties of prion protein aggregates

scientific article published on 20 February 2015

Glycosaminoglycan sulphation affects the seeded misfolding of a mutant prion protein

scientific article

High Content, Multi-Parameter Analyses in Buccal Cells to Identify Alzheimer's Disease.

scientific article

High density lipoproteins bind Aβ and apolipoprotein C-II amyloid fibrils

article

Human prion protein with valine 129 prevents expression of variant CJD phenotype

scientific article published on 11 November 2004

ISEV position paper: extracellular vesicle RNA analysis and bioinformatics.

scientific article

Identification of a new prion strain in cattle--is there more than one form of BSE?

scientific article published in May 2004

Impact of 27-hydroxycholesterol on amyloid-beta peptide production and ATP-binding cassette transporter expression in primary human neurons

scientific article

Impaired extracellular secretion of mutant superoxide dismutase 1 associates with neurotoxicity in familial amyotrophic lateral sclerosis

scientific journal article

Increased proportions of C1 truncated prion protein protect against cellular M1000 prion infection

scientific article published on October 2009

Influence of species and processing parameters on recovery and content of brain tissue-derived extracellular vesicles

scientific article published on 30 June 2020

Inhibition of gamma-secretase causes increased secretion of amyloid precursor protein C-terminal fragments in association with exosomes

scientific article published on 2 January 2008

Intercellular Resistance to BRAF Inhibition Can Be Mediated by Extracellular Vesicle-Associated PDGFRβ.

scientific article published on 27 September 2017

Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms

scientific article published on 18 February 2014

Intracellular itinerary of internalised β-secretase, BACE1, and its potential impact on β-amyloid peptide biogenesis.

scientific article published on 8 July 2013

Investigation of variant Creutzfeldt-Jakob disease and other human prion diseases with tonsil biopsy samples.

scientific article

Kuru prions and sporadic Creutzfeldt-Jakob disease prions have equivalent transmission properties in transgenic and wild-type mice

scientific article

Lipid metabolism in patients infected with Nef-deficient HIV-1 strain

scientific article

MYRF is a membrane-associated transcription factor that autoproteolytically cleaves to directly activate myelin genes

scientific article published on 13 August 2013

Malaria parasite DNA-harbouring vesicles activate cytosolic immune sensors

scientific article

Manganese chelation therapy extends survival in a mouse model of M1000 prion disease

scientific article published on 23 April 2010

Markers of A1 astrocytes stratify to molecular sub-types in sporadic Creutzfeldt-Jakob disease brain

scientific article published on 17 March 2020

Methodological Guidelines to Study Extracellular Vesicles

scientific article

Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the International Society for Extracellular Vesicles

scientific article

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

scientific article published on 23 November 2018

Misfolded polyglutamine, polyalanine, and superoxide dismutase 1 aggregate via distinct pathways in the cell

scientific article published on 14 January 2014

Misfolded α-synuclein causes hyperactive respiration without functional deficit in live neuroblastoma cells

scientific article published on 17 January 2020

Modification of lipid rafts by extracellular vesicles carrying HIV-1 protein Nef induces redistribution of APP and Tau causing neuronal dysfunction

scientific article published on 30 July 2020

Modulation of amyloid precursor protein processing by synthetic ceramide analogues.

scientific article published on 26 May 2010

Molecular analysis of prion strain variation and the aetiology of 'new variant' CJD.

scientific article

Molecular and clinical classification of human prion disease ⬇️

scientific article published on January 1, 2003

Molecular biology of prion propagation.

scientific article

Molecular classification of sporadic Creutzfeldt-Jakob disease.

scientific article published in June 2003

Molecular screening of sheep for bovine spongiform encephalopathy

article

Molecular typing of PrPres in human sporadic CJD brain tissue

scientific article published in January 2008

Mouse-adapted sporadic human Creutzfeldt-Jakob disease prions propagate in cell culture

scientific article

Multiple folding pathways for heterologously expressed human prion protein

article

Neurotoxicity in Alzheimer's disease: is covalently crosslinked A beta responsible?

scientific article published on 07 December 2007

New variant Creutzfeldt-Jakob disease in France

scientific article published in The Lancet

Not a day without microRNA

scientific article published on 01 August 2015

Novel miR-29b target regulation patterns are revealed in two different cell lines

scientific article published on 25 November 2019

Novel prion protein insert mutation associated with prolonged neurodegenerative illness

scientific article

Obstacles and opportunities in the functional analysis of extracellular vesicle RNA - an ISEV position paper

scientific article

Oncogenic H-ras reprograms Madin-Darby canine kidney (MDCK) cell-derived exosomal proteins following epithelial-mesenchymal transition

scientific article published on 03 May 2013

Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis

scientific article published on 24 June 2021

Overview and recent advances in neuropathology. Part 2: Neurodegeneration

scientific article published on February 2011

PBT2 inhibits glutamate-induced excitotoxicity in neurons through metal-mediated preconditioning

scientific article

Packaging of prions into exosomes is associated with a novel pathway of PrP processing.

scientific article

Pathogenic mechanisms of prion protein, amyloid-β and α-synuclein misfolding: the prion concept and neurotoxicity of protein oligomers.

scientific article published on 16 August 2016

Pathogenic mutations within the hydrophobic domain of the prion protein lead to the formation of protease-sensitive prion species with increased lethality

scientific article published on 18 December 2013

Polyalanine expansions drive a shift into α-helical clusters without amyloid-fibril formation

scientific article published on 16 November 2015

Polyglutamine aggregation in Huntington and related diseases.

scientific article published on January 2012

Possible link between bovine spongiform encephalopathy and sporadic Creutzfeldt-Jakob disease

scientific article

PrPC-related signal transduction is influenced by copper, membrane integrity and the alpha cleavage site.

scientific article

Prion infection impairs cholesterol metabolism in neuronal cells.

scientific article

Prion protein glycosylation.

scientific article

Prion subcellular fractionation reveals infectivity spectrum, with a high titre-low PrPres level disparity.

scientific article

Prion‐infected cells regulate the release of exosomes with distinct ultrastructural features ⬇️

scientific article published on July 5, 2012

Prognostic serum miRNA biomarkers associated with Alzheimer's disease shows concordance with neuropsychological and neuroimaging assessment.

scientific article published on 28 October 2014

Protease-resistant prion protein produced in vitro lacks detectable infectivity

scientific article

Proteasome-mediated degradation of the C-terminus of the Alzheimer's disease beta-amyloid protein precursor: effect of C-terminal truncation on production of beta-amyloid protein

scientific article published in November 2003

Proteomic analysis of extracellular vesicles reveals an immunogenic cargo in rheumatoid arthritis synovial fluid

scientific article published on 07 November 2020

Quantitative Analysis of Exosomal miRNA via qPCR and Digital PCR.

scientific article published on January 2017

Regulation of prion gene expression by transcription factors SP1 and metal transcription factor-1.

scientific article

Rescue of neurophysiological phenotype seen in PrP null mice by transgene encoding human prion protein

article

Residues surrounding the glycosylphosphatidylinositol anchor attachment site of PrP modulate prion infection: insight from the resistance of rabbits to prion disease.

scientific article published on 28 April 2010

Restraint Stress Alters Expression of Glucocorticoid Bioavailability Mediators, Suppresses Nrf2, and Promotes Oxidative Stress in Liver Tissue

scientific article published on 11 September 2020

Revealing the Proteome of Motor Cortex Derived Extracellular Vesicles Isolated from Amyotrophic Lateral Sclerosis Human Postmortem Tissues

scientific article published on 16 July 2020

Reversible conversion of monomeric human prion protein between native and fibrilogenic conformations.

scientific article

Review: Extracellular Vesicles in Joint Inflammation.

scientific article published on 19 February 2017

Role of ABCG1 and ABCA1 in regulation of neuronal cholesterol efflux to apolipoprotein E discs and suppression of amyloid-beta peptide generation

scientific article published on 22 November 2006

SERF protein is a direct modifier of amyloid fiber assembly.

scientific article published on 26 July 2012

Selective intracellular release of copper and zinc ions from bis(thiosemicarbazonato) complexes reduces levels of Alzheimer disease amyloid-beta peptide

scientific article

Sex-specific transcriptional and proteomic signatures in schizophrenia

scientific article published on 02 September 2019

Small RNA Library Construction for Exosomal RNA from Biological Samples for the Ion Torrent PGM™ and Ion S5™ System

scientific article

Small RNA deep sequencing discriminates subsets of extracellular vesicles released by melanoma cells--Evidence of unique microRNA cargos

scientific article

Small RNA fingerprinting of Alzheimer's disease frontal cortex extracellular vesicles and their comparison with peripheral extracellular vesicles

scientific article published on 04 June 2020

Species-barrier-independent prion replication in apparently resistant species

article published in the Proceedings of the National Academy of Sciences of the United States of America

Species-barrier-independent prion replication in apparently resistant species.

scientific article

Stimulating the Release of Exosomes Increases the Intercellular Transfer of Prions

scientific article published on 14 January 2016

Strain-specific prion-protein conformation determined by metal ions

article

Subclinical prion infection in humans and animals ⬇️

scientific article published on January 1, 2003

Subclinical prion infection.

scientific article published on December 2003

Sublethal concentrations of prion peptide PrP106-126 or the amyloid beta peptide of Alzheimer's disease activates expression of proapoptotic markers in primary cortical neurons.

scientific article published in April 2001

Summary of the ISEV workshop on extracellular vesicles as disease biomarkers, held in Birmingham, UK, during December 2017.

scientific article

Techniques used for the isolation and characterization of extracellular vesicles: results of a worldwide survey

scientific article published on 31 October 2016

The Prion Protein Preference of Sporadic Creutzfeldt-Jakob Disease Subtypes ⬇️

scientific article published on August 28, 2012

The brain to gut pathway: a possible route of prion transmission

scientific article published on December 2010

The detection of microRNA associated with Alzheimer's disease in biological fluids using next-generation sequencing technologies.

scientific article published on 08 August 2013

The hypoxia imaging agent CuII(atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson's disease

scientific article published on 2 April 2012

The neutral sphingomyelinase pathway regulates packaging of the prion protein into exosomes

scientific article

The prion protein constitutively controls neuronal store-operated Ca(2+) entry through Fyn kinase

scientific article published on 28 October 2015

The role of extracellular vesicles in neurodegenerative diseases.

scientific article published on 19 September 2016

The role of lipids in α-synuclein misfolding and neurotoxicity.

scientific article published on 7 May 2019

The same prion strain causes vCJD and BSE

scientific article published in Nature

The secret life of extracellular vesicles in metal homeostasis and neurodegeneration

scientific article published on June 2015

Tissue distribution of protease resistant prion protein in variant Creutzfeldt-Jakob disease using a highly sensitive immunoblotting assay

scientific article published in The Lancet

Towards mechanisms and standardization in extracellular vesicle and extracellular RNA studies: results of a worldwide survey

scientific article published on 24 October 2018

Tracking mutant huntingtin aggregation kinetics in cells reveals three major populations that include an invariant oligomer pool.

scientific article

Type of prion protein in UK farmers with Creutzfeldt-Jakob disease

scientific article published in The Lancet

Ubiquitin-like protein 3 (UBL3) is required for MARCH ubiquitination of major histocompatibility complex class II and CD86

scientific article published on 11 April 2022

Unaltered susceptibility to BSE in transgenic mice expressing human prion protein

scientific article

Updating the MISEV minimal requirements for extracellular vesicle studies: building bridges to reproducibility.

scientific article

Vesiclepedia: a compendium for extracellular vesicles with continuous community annotation

scientific article

Wild type and Tangier disease ABCA1 mutants modulate cellular amyloid-β production independent of cholesterol efflux activity

scientific article

iSRAP - a one-touch research tool for rapid profiling of small RNA-seq data.

scientific article

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