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List of works by Laurent R. Chiarelli

2-Carboxyquinoxalines kill mycobacterium tuberculosis through noncovalent inhibition of DprE1

scientific article

4-aminoquinolone piperidine amides: noncovalent inhibitors of DprE1 with long residence time and potent antimycobacterial activity

scientific article

A Coumarin-Based Analogue of Thiacetazone as Dual Covalent Inhibitor and Potential Fluorescent Label of HadA in <i>Mycobacterium tuberculosis</i>

scientific article published on 22 February 2021

A Phenotypic Based Target Screening Approach Delivers New Antitubercular CTP Synthetase Inhibitors

scientific article published on 5 May 2017

A multitarget approach to drug discovery inhibiting Mycobacterium tuberculosis PyrG and PanK.

scientific article published on 16 February 2018

A new variant of phosphoglycerate kinase deficiency (p.I371K) with multiple tissue involvement: molecular and functional characterization.

scientific article published on 30 May 2012

An Overview on the Potential Antimycobacterial Agents Targeting Serine/Threonine Protein Kinases from Mycobacterium tuberculosis

scientific article published on 01 January 2019

Analogous mechanisms of resistance to benzothiazinones and dinitrobenzamides in Mycobacterium smegmatis

scientific article published in 2011

Antivirulence compounds: a future direction to overcome antibiotic resistance?

scientific article published on 01 March 2020

BEL β-trefoil: a novel lectin with antineoplastic properties in king bolete (Boletus edulis) mushrooms

scientific article

Biochemical Characterization of Glutamate Racemase-A New Candidate Drug Target against Burkholderia cenocepacia Infections

scientific article

Biochemical signatures of doppel protein in human astrocytomas to support prediction in tumor malignancy ⬇️

scientific article published on October 14, 2010

Biochemistry of lipolytic enzymes secreted byPenicillium solitumandCladosporium cladosporioides

scientific article published on 16 April 2014

Biological and structural characterization of the Mycobacterium smegmatis nitroreductase NfnB, and its role in benzothiazinone resistance

scientific article

Burkholderia cenocepacia Infections in Cystic Fibrosis Patients: Drug Resistance and Therapeutic Approaches

scientific article published on 22 August 2017

Cell-cycle inhibition by Helicobacter pylori L-asparaginase

scientific article

Competitive fitness of essential gene knockdowns reveals a broad-spectrum antibacterial inhibitor of the cell division protein FtsZ

article

Design, Syntheses, and Anti-TB Activity of 1,3-Benzothiazinone Azide and Click Chemistry Products Inspired by BTZ043.

scientific article published on 4 January 2016

Discovery and development of novel salicylate synthase (MbtI) furanic inhibitors as antitubercular agents

scientific article published on 18 June 2018

Discovery of new diketopiperazines inhibiting Burkholderia cenocepacia quorum sensing in vitro and in vivo

scientific article published on September 2016

Engineering of Helicobacter pylori L-asparaginase: characterization of two functionally distinct groups of mutants

scientific article

Erythrocyte adenylate kinase deficiency: characterization of recombinant mutant forms and relationship with nonspherocytic hemolytic anemia.

scientific article

Functional analysis of pyrimidine 5'-nucleotidase mutants causing nonspherocytic hemolytic anemia

scientific article

Helicobacter pyloril-asparaginase: a promising chemotherapeutic agent

scientific article

Hereditary erythrocyte pyrimidine 5'-nucleotidase deficiency: a biochemical, genetic and clinical overview.

scientific article

Human erythrocyte pyruvate kinase: characterization of the recombinant enzyme and a mutant form (R510Q) causing nonspherocytic hemolytic anemia

scientific article published in November 2001

Inosine monophosphate dehydrogenase variability in renal transplant patients on long-term mycophenolate mofetil therapy.

scientific article

Investigating the Mechanism of Action of Diketopiperazines Inhibitors of the Quorum Sensing Synthase CepI: A Site-Directed Mutagenesis Study

scholarly article by Silvia Buroni et al published 2018 in Frontiers in Pharmacology

Iron Acquisition Pathways as Targets for Antitubercular Drugs

scientific article

Letter to the editor regarding Shibayama et al.: Biochemical and pathophysiological characterization of Helicobacter pylori asparaginase

scientific article published on 01 June 2012

Mechanism of action of 5-nitrothiophenes against Mycobacterium tuberculosis

scientific article published on 18 February 2014

Mechanochemical Synthesis and Biological Evaluation of Novel Isoniazid Derivatives with Potent Antitubercular Activity

scientific article published in September 2017

Micellar electrokinetic chromatography as a complementary method to sodium dodecyl sulfate-polyacrylamide gel electrophoresis for studying limited proteolysis of proteins

scientific article published on 01 September 1999

Molecular basis of pyrimidine 5'-nucleotidase deficiency caused by 3 newly identified missense mutations (c.187T>C, c.469G>C and c.740T>C) and a tabulation of known mutations

scientific article published in May 2008

Molecular insights on pathogenic effects of mutations causing phosphoglycerate kinase deficiency

scientific article published in 2012

Monitoring of inosine monophosphate dehydrogenase activity and expression during the early period of mycophenolate mofetil therapy in de novo renal transplant patients

scientific article

Multitargeting Compounds: A Promising Strategy to Overcome Multi-Drug Resistant Tuberculosis

scientific article published on 09 March 2020

Mycobacterium abscessus, an Emerging and Worrisome Pathogen among Cystic Fibrosis Patients

scientific article published on 22 November 2019

Mycobacterium tuberculosis phosphoribosylpyrophosphate synthetase: biochemical features of a crucial enzyme for mycobacterial cell wall biosynthesis

scientific article

Natural products against key Mycobacterium tuberculosis enzymatic targets: Emerging opportunities for drug discovery

scientific article published in 2021

New Chromane-Based Derivatives as Inhibitors of Salicylate Synthase (MbtI): Preliminary Biological Evaluation and Molecular Modeling Studies

scientific article published on 21 June 2018

New Insights into the Mechanism of Action of the Thienopyrimidine Antitubercular Prodrug TP053

scientific article published on 02 December 2019

New and Old Hot Drug Targets in Tuberculosis.

scientific article published on 31 August 2016

New insight into structure-activity of furan-based salicylate synthase (MbtI) inhibitors as potential antitubercular agents

scientific article published on 01 December 2019

New prodrugs against tuberculosis.

scientific article published on 17 September 2016

Nitric oxide-releasing compounds for the treatment of lung infections

scientific article published on 09 November 2020

PEGylated mucus-penetrating nanocrystals for lung delivery of a new FtsZ inhibitor against Burkholderia cenocepacia infection

scientific article published on 25 October 2019

Phenylacetyl Coenzyme A, Not Phenylacetic Acid, Attenuates CepIR-Regulated Virulence in Burkholderia cenocepacia

scientific article published on 27 November 2019

Protein recognition by short peptide reversible inhibitors of the chromatin-modifying LSD1/CoREST lysine demethylase

scientific article

Pyrimidine 5'-nucleotidase activities detected in real samples by means of micellar electrokinetic chromatography

scientific article published in October 2004

Pyruvate kinase deficiency: the genotype-phenotype association.

scientific article published on 13 March 2007

Quorum Sensing as Antivirulence Target in Cystic Fibrosis Pathogens

scientific article published on 13 April 2019

Red cell pyruvate kinase deficiency: 17 new mutations of the PK-LR gene

scientific article published in June 2005

Rv0579 Is Involved in the Resistance to the TP053 Antitubercular Prodrug

scientific article published on 25 February 2020

Rv2466c mediates the activation of TP053 to kill replicating and non-replicating Mycobacterium tuberculosis

scientific article

Structural Basis for Benzothiazinone-Mediated Killing of Mycobacterium tuberculosis

scientific article

Structural and energetic basis of protein kinetic destabilization in human phosphoglycerate kinase 1 deficiency.

scientific article

Structure and function of human erythrocyte pyruvate kinase. Molecular basis of nonspherocytic hemolytic anemia

scientific article

Structure of a lectin with antitumoral properties in king bolete (Boletus edulis) mushrooms

scientific article

Tackling Critical Catalytic Residues in Helicobacter pylori L-Asparaginase.

scientific article published on 27 March 2015

The Crystal Structure of Burkholderia cenocepacia DfsA Provides Insights into Substrate Recognition and Quorum Sensing Fatty Acid Biosynthesis

scientific article

The DprE1 enzyme, one of the most vulnerable targets of Mycobacterium tuberculosis

scientific article published on 14 September 2013

The Redox State Regulates the Conformation of Rv2466c to Activate the Antitubercular Prodrug TP053.

scientific article

The allosteric regulation of pyruvate kinase

scientific article

ThermoFAD, a Thermofluor-adapted flavin ad hoc detection system for protein folding and ligand binding

scientific article

Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG

scientific article published on 18 June 2015

Various Evolutionary Trajectories Lead to Loss of the Tobramycin-Potentiating Activity of the Quorum-Sensing Inhibitor Baicalin Hydrate in Burkholderia cenocepacia Biofilms

scientific article published on 27 March 2019

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