List of works - Craig Hutton

1,3-Phenylene bis(ketoacid) derivatives as inhibitors of Escherichia coli dihydrodipicolinate synthase.

scientific article

A general method for interconversion of boronic acid protecting groups: trifluoroborates as common intermediates.

scientific article published on 28 May 2015

A new method for peptide synthesis in the N→C direction: amide assembly through silver-promoted reaction of thioamides

scientific article published on 01 December 2014

A new robust kinetic assay for DAP epimerase activity

scientific article published on 6 July 2013

Automated preparation of 2-[18 F]fluoropropionate labeled peptides using a flexible, multi-stage synthesis platform (iPHASE Flexlab).

scientific article

Automated preparation of clinical grade [68Ga]Ga-DOTA-CP04, a cholecystokinin-2 receptor agonist, using iPHASE MultiSyn synthesis platform

scientific article published on 23 August 2019

Beyond RGD; nanoclusters of syndecan- and integrin-binding ligands synergistically enhance cell/material interactions

scientific article published on 04 October 2018

Biochemical characterization of a recombinant thermoalkalophilic lipase and assessment of its substrate enantioselectivity

Biomaterials functionalized with nanoclusters of integrin- and syndecan-binding ligands improve cell adhesion and mechanosensing under shear flow conditions

scientific article published on 03 June 2020

Blood-borne amyloid-beta dimer correlates with clinical markers of Alzheimer's disease

scientific article

Celogentin mimetics as inhibitors of tubulin polymerization

scientific article published on 17 December 2019

Characterisation of dihydrodipicolinate synthase (DHDPS) from Bacillus anthracis.

scientific article published on 10 July 2009

Characterization and Identification of Dityrosine Cross-Linked Peptides Using Tandem Mass Spectrometry

scientific article published on 28 April 2017

Conformationally constrained diketopimelic acid analogues as inhibitors of dihydrodipicolinate synthase.

scientific article published on 3 December 2007

Conserved main-chain peptide distortions: A proposed role for Ile203 in catalysis by dihydrodipicolinate synthase

scientific article

Copper binding and redox chemistry of the Aβ16 peptide and its variants: insights into determinants of copper-dependent reactivity.

scientific article published in February 2017

Copper-free palladium-catalyzed Sonogashira and Hiyama cross-couplings using aryl imidazol-1-ylsulfonates

Crystallization and preliminary X-ray diffraction analysis of diaminopimelate epimerase from Escherichia coli

scientific article published on 25 December 2009

Deprotection of pinacolyl boronate esters via hydrolysis of intermediate potassium trifluoroborates

scientific article published in November 2005

Dimerization of Bacterial Diaminopimelate Epimerase Is Essential for Catalysis

scientific article

Effects of PPAR gamma ligands on TGF-beta1-induced epithelial-mesenchymal transition in alveolar epithelial cells.

scientific article

Enantioselective preparation of a stable boronate complex stereogenic only at boron.

scientific article

Establishing Signature Fragments for Identification and Sequencing of Dityrosine Cross-Linked Peptides Using Ultraviolet Photodissociation Mass Spectrometry

scientific article published on 11 September 2019

Expression, purification, crystallization and preliminary X-ray diffraction analysis of dihydrodipicolinate synthase from Bacillus anthracis in the presence of pyruvate

scientific article published on 31 January 2009

Heterocyclic inhibitors of dihydrodipicolinate synthase are not competitive.

scientific article

Hormetic potential of methylglyoxal, a side-product of glycolysis, in switching tumours from growth to death

scientific article published on 15 September 2017

Inhibiting dihydrodipicolinate synthase across species: towards specificity for pathogens?

scientific journal article

Inhibiting protein-protein interactions as an emerging paradigm for drug discovery.

scientific article published on February 2007

Inhibition of lysine biosynthesis: an evolving antibiotic strategy

scientific article

Inhibitors of lysine biosynthesis as antibacterial agents

scientific article

Irreversible inhibition of dihydrodipicolinate synthase by 4-oxo-heptenedioic acid analogues

scientific article

LC-MS and NMR characterization of the purple chromophore formed in the o-aminobenzaldehyde assay of dihydrodipicolinate synthase

scientific article published on 16 December 2010

Methylglyoxal, a glycolysis side-product, induces Hsp90 glycation and YAP-mediated tumor growth and metastasis.

scientific article published on 19 October 2016

Novel conjugated quinoline-indoles compromise Plasmodium falciparum mitochondrial function and show promising antimalarial activity

scientific article published on 26 July 2013

Oligomers, fact or artefact? SDS-PAGE induces dimerization of β-amyloid in human brain samples.

scientific article

One-step radiosynthesis of 4-nitrophenyl 2-[(18) F]fluoropropionate ([(18) F]NFP); improved preparation of radiolabeled peptides for PET imaging

scientific article published on 16 September 2013

Optimization of 2-Anilino 4-Amino Substituted Quinazolines into Potent Antimalarial Agents with Oral in Vivo Activity

scientific article published on 12 January 2017

Potentially Macrocyclic Peptidyl Boronic Acids as Chymotrypsin Inhibitors

scientific article published in February 1997

Preparation of Cyclic Peptide Alkaloids Containing Functionalized Tryptophan Residues

scientific article published on 18 September 2007

Preparation of beta-nitroalanine using the Easton three-component coupling method

scientific article published on 20 March 2006

Preparation of diazabicyclo[4.3.0]nonene-based peptidomimetics

scientific article published on 8 August 2007

Preparation of the Central Tryptophan Moiety (I) of the Celogentin/Moroidin Family of Antimitotic Cyclic Peptides

Preparation of the Central Tryptophan Moiety of the Celogentin/Moroidin Family of Anti-Mitotic Cyclic Peptides

Rapid, Traceless, AgI -Promoted Macrocyclization of Peptides Possessing an N-Terminal Thioamide

scientific article published on 08 March 2019

Recent developments in radiolabelled peptides for PET imaging of cancer

article

Role of 2-oxo and 2-thioxo modifications on the fragmentation reactions of the histidine radical cation

scientific article published on 01 January 2011

Role of 2-oxo and 2-thioxo modifications on the proton affinity of histidine and fragmentation reactions of protonated histidine.

scientific article published on September 2010

Solid-phase synthesis of homodimeric peptides: preparation of covalently-linked dimers of amyloid β peptide

article

Structure of olefin-imidacloprid and gas-phase fragmentation chemistry of its protonated form.

scientific article published on 4 January 2016

Structure-Activity Relationships of cyclo(l-Tyrosyl-l-tyrosine) Derivatives Binding to Mycobacterium tuberculosis CYP121: Iodinated Analogues Promote Shift to High-Spin Adduct

scientific article published on 31 October 2019

Substrate-mediated Stabilization of a Tetrameric Drug Target Reveals Achilles Heel in Anthrax

scientific article

Sulfonation of Tyrosine as a Method To Improve Biodistribution of Peptide-Based Radiotracers: Novel 18F-Labeled Cyclic RGD Analogues

scientific article published on 13 February 2017

Synthesis and antioxidant capacity of novel stable 5-tellurofuranose derivatives.

scientific article published on 5 March 2018

Synthesis of Peptides by Silver-Promoted Coupling of Carboxylates and Thioamides: Mechanistic Insight from Computational Studies.

scientific article published on 27 January 2016

Synthesis of beta-hydroxy-beta-(fluoronitrophenyl)alanines: vital components in the assembly of biologically active cyclic peptides

scientific article published on 01 July 1999

Synthesis of cyclic peptide hemicryptophanes: enantioselective recognition of a chiral zwitterionic guest

scientific article published on 01 October 2013

Synthesis of the C-Terminal Macrocycle of Asperipin-2a

scientific article published on 06 March 2019

Synthesis of the beta-hydroxydopa-gamma-hydroxy-delta-sulfinylnorvaline component of ustiloxins A and B.

scientific article published on 3 February 2005

Synthesis of the side chain cross-linked tyrosine oligomers dityrosine, trityrosine, and pulcherosine.

scientific article published in September 2005

Synthesis of β,γ-dihydroxyhomotyrosines by a tandem Petasis-asymmetric dihydroxylation approach

scientific article published on 11 May 2011

Synthetic dityrosine-linked β-amyloid dimers form stable, soluble, neurotoxic oligomers

article

Target Validation and Identification of Novel Boronate Inhibitors of the Plasmodium falciparum Proteasome

scientific article published on 7 November 2018

The crystal structure of dihydrodipicolinate synthase from Escherichia coli with bound pyruvate and succinic acid semialdehyde: Unambiguous resolution of the stereochemistry of the condensation product ⬇️

scientific article published on June 4, 2012

The enantioselective synthesis of APTO and AETD: polyhydroxylated beta-amino acid constituents of the microsclerodermin cyclic peptides

scientific article published on 17 August 2007

Total Synthesis of Seongsanamide B

scientific article published on 28 May 2020

Total Synthesis of Ustiloxin D Utilizing an Ammonia-Ugi Reaction

scientific article published on 22 September 2015

Total Synthesis of the Putative Structure of Asperipin-2a and Stereochemical Reassignment

scientific article published on 22 September 2020

Total synthesis of (-)-reveromycin B

scientific article published on 01 January 2000

Total synthesis of mycocyclosin

scientific article published on 20 April 2012

Total synthesis of the epidermal growth factor inhibitor (-)-reveromycin B.

scientific article

Two new irreversible inhibitors of dihydrodipicolinate synthase: diethyl (E,E)-4-oxo-2,5-heptadienedioate and diethyl (E)-4-oxo-2-heptenedioate.

scientific article

Unimolecular reactivity of organotrifluoroborate anions, RBF3- , and their alkali metal cluster ions, M(RBF3 )2- (M = Na, K; R = CH3 , CH3 CH2 , CH3 (CH2 )3 , CH3 (CH2 )5 , c-C3 H5 , C6 H5 , C6 H5 CH2 , CH2 CHCH2 , CH2 CH, C6 H5 CO)

scientific article published on 27 May 2018

List of works by Craig Hutton

1,3-Phenylene bis(ketoacid) derivatives as inhibitors of Escherichia coli dihydrodipicolinate synthase.

A general method for interconversion of boronic acid protecting groups: trifluoroborates as common intermediates.

A new method for peptide synthesis in the N→C direction: amide assembly through silver-promoted reaction of thioamides

A new robust kinetic assay for DAP epimerase activity

Automated preparation of 2-[18 F]fluoropropionate labeled peptides using a flexible, multi-stage synthesis platform (iPHASE Flexlab).

Automated preparation of clinical grade [68Ga]Ga-DOTA-CP04, a cholecystokinin-2 receptor agonist, using iPHASE MultiSyn synthesis platform

Beyond RGD; nanoclusters of syndecan- and integrin-binding ligands synergistically enhance cell/material interactions

Biochemical characterization of a recombinant thermoalkalophilic lipase and assessment of its substrate enantioselectivity

Biomaterials functionalized with nanoclusters of integrin- and syndecan-binding ligands improve cell adhesion and mechanosensing under shear flow conditions

Blood-borne amyloid-beta dimer correlates with clinical markers of Alzheimer's disease

Celogentin mimetics as inhibitors of tubulin polymerization

Characterisation of dihydrodipicolinate synthase (DHDPS) from Bacillus anthracis.

Characterization and Identification of Dityrosine Cross-Linked Peptides Using Tandem Mass Spectrometry

Conformationally constrained diketopimelic acid analogues as inhibitors of dihydrodipicolinate synthase.

Conserved main-chain peptide distortions: A proposed role for Ile203 in catalysis by dihydrodipicolinate synthase

Copper binding and redox chemistry of the Aβ16 peptide and its variants: insights into determinants of copper-dependent reactivity.

Copper-free palladium-catalyzed Sonogashira and Hiyama cross-couplings using aryl imidazol-1-ylsulfonates

Crystallization and preliminary X-ray diffraction analysis of diaminopimelate epimerase from Escherichia coli

Deprotection of pinacolyl boronate esters via hydrolysis of intermediate potassium trifluoroborates

Dimerization of Bacterial Diaminopimelate Epimerase Is Essential for Catalysis

Effects of PPAR gamma ligands on TGF-beta1-induced epithelial-mesenchymal transition in alveolar epithelial cells.

Enantioselective preparation of a stable boronate complex stereogenic only at boron.

Establishing Signature Fragments for Identification and Sequencing of Dityrosine Cross-Linked Peptides Using Ultraviolet Photodissociation Mass Spectrometry

Expression, purification, crystallization and preliminary X-ray diffraction analysis of dihydrodipicolinate synthase from Bacillus anthracis in the presence of pyruvate

Heterocyclic inhibitors of dihydrodipicolinate synthase are not competitive.

Hormetic potential of methylglyoxal, a side-product of glycolysis, in switching tumours from growth to death

Inhibiting dihydrodipicolinate synthase across species: towards specificity for pathogens?

Inhibiting protein-protein interactions as an emerging paradigm for drug discovery.

Inhibition of lysine biosynthesis: an evolving antibiotic strategy

Inhibitors of lysine biosynthesis as antibacterial agents

Irreversible inhibition of dihydrodipicolinate synthase by 4-oxo-heptenedioic acid analogues

LC-MS and NMR characterization of the purple chromophore formed in the o-aminobenzaldehyde assay of dihydrodipicolinate synthase

Methylglyoxal, a glycolysis side-product, induces Hsp90 glycation and YAP-mediated tumor growth and metastasis.

Novel conjugated quinoline-indoles compromise Plasmodium falciparum mitochondrial function and show promising antimalarial activity

Oligomers, fact or artefact? SDS-PAGE induces dimerization of β-amyloid in human brain samples.

One-step radiosynthesis of 4-nitrophenyl 2-[(18) F]fluoropropionate ([(18) F]NFP); improved preparation of radiolabeled peptides for PET imaging

Optimization of 2-Anilino 4-Amino Substituted Quinazolines into Potent Antimalarial Agents with Oral in Vivo Activity

Potentially Macrocyclic Peptidyl Boronic Acids as Chymotrypsin Inhibitors

Preparation of Cyclic Peptide Alkaloids Containing Functionalized Tryptophan Residues

Preparation of beta-nitroalanine using the Easton three-component coupling method

Preparation of diazabicyclo[4.3.0]nonene-based peptidomimetics

Preparation of the Central Tryptophan Moiety (I) of the Celogentin/Moroidin Family of Antimitotic Cyclic Peptides

Preparation of the Central Tryptophan Moiety of the Celogentin/Moroidin Family of Anti-Mitotic Cyclic Peptides

Rapid, Traceless, AgI -Promoted Macrocyclization of Peptides Possessing an N-Terminal Thioamide

Recent developments in radiolabelled peptides for PET imaging of cancer

Role of 2-oxo and 2-thioxo modifications on the fragmentation reactions of the histidine radical cation

Role of 2-oxo and 2-thioxo modifications on the proton affinity of histidine and fragmentation reactions of protonated histidine.

Solid-phase synthesis of homodimeric peptides: preparation of covalently-linked dimers of amyloid β peptide

Structure of olefin-imidacloprid and gas-phase fragmentation chemistry of its protonated form.

Structure-Activity Relationships of cyclo(l-Tyrosyl-l-tyrosine) Derivatives Binding to Mycobacterium tuberculosis CYP121: Iodinated Analogues Promote Shift to High-Spin Adduct

Substrate-mediated Stabilization of a Tetrameric Drug Target Reveals Achilles Heel in Anthrax

Sulfonation of Tyrosine as a Method To Improve Biodistribution of Peptide-Based Radiotracers: Novel 18F-Labeled Cyclic RGD Analogues

Synthesis and antioxidant capacity of novel stable 5-tellurofuranose derivatives.

Synthesis of Peptides by Silver-Promoted Coupling of Carboxylates and Thioamides: Mechanistic Insight from Computational Studies.

Synthesis of beta-hydroxy-beta-(fluoronitrophenyl)alanines: vital components in the assembly of biologically active cyclic peptides

Synthesis of cyclic peptide hemicryptophanes: enantioselective recognition of a chiral zwitterionic guest

Synthesis of the C-Terminal Macrocycle of Asperipin-2a

Synthesis of the beta-hydroxydopa-gamma-hydroxy-delta-sulfinylnorvaline component of ustiloxins A and B.

Synthesis of the side chain cross-linked tyrosine oligomers dityrosine, trityrosine, and pulcherosine.

Synthesis of β,γ-dihydroxyhomotyrosines by a tandem Petasis-asymmetric dihydroxylation approach

Synthetic dityrosine-linked β-amyloid dimers form stable, soluble, neurotoxic oligomers

Target Validation and Identification of Novel Boronate Inhibitors of the Plasmodium falciparum Proteasome

The crystal structure of dihydrodipicolinate synthase from Escherichia coli with bound pyruvate and succinic acid semialdehyde: Unambiguous resolution of the stereochemistry of the condensation product ⬇️

The enantioselective synthesis of APTO and AETD: polyhydroxylated beta-amino acid constituents of the microsclerodermin cyclic peptides

Total Synthesis of Seongsanamide B

Total Synthesis of Ustiloxin D Utilizing an Ammonia-Ugi Reaction

Total Synthesis of the Putative Structure of Asperipin-2a and Stereochemical Reassignment

Total synthesis of (-)-reveromycin B

Total synthesis of mycocyclosin

Total synthesis of the epidermal growth factor inhibitor (-)-reveromycin B.

Two new irreversible inhibitors of dihydrodipicolinate synthase: diethyl (E,E)-4-oxo-2,5-heptadienedioate and diethyl (E)-4-oxo-2-heptenedioate.

Unimolecular reactivity of organotrifluoroborate anions, RBF3- , and their alkali metal cluster ions, M(RBF3 )2- (M = Na, K; R = CH3 , CH3 CH2 , CH3 (CH2 )3 , CH3 (CH2 )5 , c-C3 H5 , C6 H5 , C6 H5 CH2 , CH2 CHCH2 , CH2 CH, C6 H5 CO)