List of works - Maria Pia Longhese

A Tel1/MRX-dependent checkpoint inhibits the metaphase-to-anaphase transition after UV irradiation in the absence of Mec1.

scientific article

A balance between Tel1 and Rif2 activities regulates nucleolytic processing and elongation at telomeres

scientific article

A central role for DNA replication forks in checkpoint activation and response

scientific article published in May 2003

Analysis of De Novo Telomere Addition by Southern Blot

scientific article published in January 2018

Cell cycle progression in the presence of irreparable DNA damage is controlled by a Mec1- and Rad53-dependent checkpoint in budding yeast

scientific article published on August 1999

Characterization of mec1 kinase-deficient mutants and of new hypomorphic mec1 alleles impairing subsets of the DNA damage response pathway

scientific article published on June 2001

Coupling end resection with the checkpoint response at DNA double-strand breaks.

scientific article published on 3 May 2016

DNA binding modes influence Rap1 activity in the regulation of telomere length and MRX functions at DNA ends

scientific article published on 01 March 2020

DNA damage checkpoint in budding yeast.

scientific article

Dephosphorylation of gamma H2A by Glc7/protein phosphatase 1 promotes recovery from inhibition of DNA replication.

scientific article

Distinct Cdk1 requirements during single-strand annealing, noncrossover, and crossover recombination.

scientific article

Dominant TEL1-hy mutations compensate for Mec1 lack of functions in the DNA damage response

scientific article published on 22 October 2007

Dpb4 promotes resection of DNA double-strand breaks and checkpoint activation by acting in two different protein complexes

scientific article published on 06 August 2021

Erratum: Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation

article

Escape of Sgs1 from Rad9 inhibition reduces the requirement for Sae2 and functional MRX in DNA end resection.

scientific article published on 30 January 2015

Functional and physical interactions between yeast 14-3-3 proteins, acetyltransferases, and deacetylases in response to DNA replication perturbations

scientific article published on 5 March 2007

G(1)/S and G(2)/M cyclin-dependent kinase activities commit cells to death in the absence of the S-phase checkpoint

scientific article

Hyperactivation of the yeast DNA damage checkpoint by TEL1 and DDC2 overexpression.

scientific article

Interaction between Set1p and checkpoint protein Mec3p in DNA repair and telomere functions.

scientific article

Interplays between ATM/Tel1 and ATR/Mec1 in sensing and signaling DNA double-strand breaks

scientific article published on 13 August 2013

Irreparable telomeric DNA damage and persistent DDR signalling as a shared causative mechanism of cellular senescence and ageing.

scientific article

Local unwinding of double-strand DNA ends by the MRX complex promotes Exo1 processing activity

scientific article published on 24 August 2018

Mec1/ATR regulates the generation of single-stranded DNA that attenuates Tel1/ATM signaling at DNA ends

scientific article

Mec1p is essential for phosphorylation of the yeast DNA damage checkpoint protein Ddc1p, which physically interacts with Mec3p.

scientific article

Mechanisms and regulation of DNA end resection

scientific article published on 20 July 2010

Multiple pathways regulate 3' overhang generation at S. cerevisiae telomeres.

scientific article

Mutants with changes in different domains of yeast replication protein A exhibit differences in repairing the control region, the transcribed strand and the non-transcribed strand of the Saccharomyces cerevisiae MFA2 gene.

scientific article

PP2A Controls Genome Integrity by Integrating Nutrient-Sensing and Metabolic Pathways with the DNA Damage Response

scientific article published on 12 June 2017

Physical and functional interactions between nucleotide excision repair and DNA damage checkpoint

scientific article

RNA-processing proteins regulate Mec1/ATR activation by promoting generation of RPA-coated ssDNA

scientific article published on 19 December 2014

RPA regulates telomerase action by providing Est1p access to chromosome ends

scientific article

Rad9/53BP1 protects stalled replication forks from degradation in Mec1/ATR-defective cells.

scientific article published on 4 January 2018

Regulation of telomere metabolism by the RNA processing protein Xrn1.

scientific article published on 4 February 2017

Regulation of the DNA damage response by cyclin-dependent kinases.

scientific article

Resection is responsible for loss of transcription around a double-strand break in Saccharomyces cerevisiae

scientific article published on 31 July 2015

Rif1 supports the function of the CST complex in yeast telomere capping.

scientific article

Saccharomyces cerevisiae Rif1 cooperates with MRX-Sae2 in promoting DNA-end resection.

scientific article

Sae2 Function at DNA Double-Strand Breaks Is Bypassed by Dampening Tel1 or Rad53 Activity

scientific article published on 19 November 2015

Shelterin-like proteins and Yku inhibit nucleolytic processing of Saccharomyces cerevisiae telomeres

scientific article

Sudden telomere lengthening triggers a Rad53-dependent checkpoint in Saccharomyces cerevisiae

scientific article

Tbf1 and Vid22 promote resection and non-homologous end joining of DNA double-strand break ends

scientific article published on 7 December 2012

Tel1 and Rif2 Regulate MRX Functions in End-Tethering and Repair of DNA Double-Strand Breaks

scientific article

Tel1/ATM Signaling to the Checkpoint Contributes to Replicative Senescence in the Absence of Telomerase

scientific article published on 07 August 2019

Tel1/ATM prevents degradation of replication forks that reverse after topoisomerase poisoning.

scientific article

Telomere-end processing: mechanisms and regulation

scientific article published on 12 October 2013

Telomeres and DNA damage checkpoints.

scientific article

Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation

scientific article published on 18 March 2012

The ATP-bound conformation of the Mre11-Rad50 complex is essential for Tel1/ATM activation

scientific article published on 01 April 2019

The MRX complex plays multiple functions in resection of Yku- and Rif2-protected DNA ends

scientific article published on 30 November 2010

The MRX complex regulates Exo1 resection activity by altering DNA end structure

scientific article published on 19 June 2018

The Mec1p and Tel1p checkpoint kinases allow humanized yeast to tolerate chronic telomere dysfunctions by suppressing telomere fusions

scientific article published on 28 November 2008

The RNA binding protein Npl3 promotes resection of DNA double-strand breaks by regulating the levels of Exo1.

scientific article published on 2 May 2017

The Rad53CHK1/CHK2-Spt21NPAT and Tel1ATM axes couple glucose tolerance to histone dosage and subtelomeric silencing

scientific article published on 19 August 2020

The Saccharomyces cerevisiae 14-3-3 proteins are required for the G1/S transition, actin cytoskeleton organization and cell wall integrity

scientific article published on 28 April 2006

The Saccharomyces cerevisiae Sae2 protein negatively regulates DNA damage checkpoint signalling

scientific article published on February 2006

The Saccharomyces cerevisiae Sae2 protein promotes resection and bridging of double strand break ends.

scientific article published on 13 September 2005

The Yku70-Yku80 complex contributes to regulate double-strand break processing and checkpoint activation during the cell cycle

scientific article published on 4 July 2008

The cellular response to chromosome breakage.

scientific article

The functions of budding yeast Sae2 in the DNA damage response require Mec1- and Tel1-dependent phosphorylation

scientific article published on May 2004

The novel DNA damage checkpoint protein ddc1p is phosphorylated periodically during the cell cycle and in response to DNA damage in budding yeast.

scientific article

The role of shelterin in maintaining telomere integrity

scientific article published on January 2012

Uncoupling Sae2 Functions in Downregulation of Tel1 and Rad53 Signaling Activities

article

List of works by Maria Pia Longhese

A Tel1/MRX-dependent checkpoint inhibits the metaphase-to-anaphase transition after UV irradiation in the absence of Mec1.

A balance between Tel1 and Rif2 activities regulates nucleolytic processing and elongation at telomeres

A central role for DNA replication forks in checkpoint activation and response

Analysis of De Novo Telomere Addition by Southern Blot

Cell cycle progression in the presence of irreparable DNA damage is controlled by a Mec1- and Rad53-dependent checkpoint in budding yeast

Characterization of mec1 kinase-deficient mutants and of new hypomorphic mec1 alleles impairing subsets of the DNA damage response pathway

Coupling end resection with the checkpoint response at DNA double-strand breaks.

DNA binding modes influence Rap1 activity in the regulation of telomere length and MRX functions at DNA ends

DNA damage checkpoint in budding yeast.

Dephosphorylation of gamma H2A by Glc7/protein phosphatase 1 promotes recovery from inhibition of DNA replication.

Distinct Cdk1 requirements during single-strand annealing, noncrossover, and crossover recombination.

Dominant TEL1-hy mutations compensate for Mec1 lack of functions in the DNA damage response

Dpb4 promotes resection of DNA double-strand breaks and checkpoint activation by acting in two different protein complexes

Erratum: Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation

Escape of Sgs1 from Rad9 inhibition reduces the requirement for Sae2 and functional MRX in DNA end resection.

Functional and physical interactions between yeast 14-3-3 proteins, acetyltransferases, and deacetylases in response to DNA replication perturbations

G(1)/S and G(2)/M cyclin-dependent kinase activities commit cells to death in the absence of the S-phase checkpoint

Hyperactivation of the yeast DNA damage checkpoint by TEL1 and DDC2 overexpression.

Interaction between Set1p and checkpoint protein Mec3p in DNA repair and telomere functions.

Interplays between ATM/Tel1 and ATR/Mec1 in sensing and signaling DNA double-strand breaks

Irreparable telomeric DNA damage and persistent DDR signalling as a shared causative mechanism of cellular senescence and ageing.

Local unwinding of double-strand DNA ends by the MRX complex promotes Exo1 processing activity

Mec1/ATR regulates the generation of single-stranded DNA that attenuates Tel1/ATM signaling at DNA ends

Mec1p is essential for phosphorylation of the yeast DNA damage checkpoint protein Ddc1p, which physically interacts with Mec3p.

Mechanisms and regulation of DNA end resection

Multiple pathways regulate 3' overhang generation at S. cerevisiae telomeres.

Mutants with changes in different domains of yeast replication protein A exhibit differences in repairing the control region, the transcribed strand and the non-transcribed strand of the Saccharomyces cerevisiae MFA2 gene.

PP2A Controls Genome Integrity by Integrating Nutrient-Sensing and Metabolic Pathways with the DNA Damage Response

Physical and functional interactions between nucleotide excision repair and DNA damage checkpoint

RNA-processing proteins regulate Mec1/ATR activation by promoting generation of RPA-coated ssDNA

RPA regulates telomerase action by providing Est1p access to chromosome ends

Rad9/53BP1 protects stalled replication forks from degradation in Mec1/ATR-defective cells.

Regulation of telomere metabolism by the RNA processing protein Xrn1.

Regulation of the DNA damage response by cyclin-dependent kinases.

Resection is responsible for loss of transcription around a double-strand break in Saccharomyces cerevisiae

Rif1 supports the function of the CST complex in yeast telomere capping.

Saccharomyces cerevisiae Rif1 cooperates with MRX-Sae2 in promoting DNA-end resection.

Sae2 Function at DNA Double-Strand Breaks Is Bypassed by Dampening Tel1 or Rad53 Activity

Shelterin-like proteins and Yku inhibit nucleolytic processing of Saccharomyces cerevisiae telomeres

Sudden telomere lengthening triggers a Rad53-dependent checkpoint in Saccharomyces cerevisiae

Tbf1 and Vid22 promote resection and non-homologous end joining of DNA double-strand break ends

Tel1 and Rif2 Regulate MRX Functions in End-Tethering and Repair of DNA Double-Strand Breaks

Tel1/ATM Signaling to the Checkpoint Contributes to Replicative Senescence in the Absence of Telomerase

Tel1/ATM prevents degradation of replication forks that reverse after topoisomerase poisoning.

Telomere-end processing: mechanisms and regulation

Telomeres and DNA damage checkpoints.

Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation

The ATP-bound conformation of the Mre11-Rad50 complex is essential for Tel1/ATM activation

The MRX complex plays multiple functions in resection of Yku- and Rif2-protected DNA ends

The MRX complex regulates Exo1 resection activity by altering DNA end structure

The Mec1p and Tel1p checkpoint kinases allow humanized yeast to tolerate chronic telomere dysfunctions by suppressing telomere fusions

The RNA binding protein Npl3 promotes resection of DNA double-strand breaks by regulating the levels of Exo1.

The Rad53CHK1/CHK2-Spt21NPAT and Tel1ATM axes couple glucose tolerance to histone dosage and subtelomeric silencing

The Saccharomyces cerevisiae 14-3-3 proteins are required for the G1/S transition, actin cytoskeleton organization and cell wall integrity

The Saccharomyces cerevisiae Sae2 protein negatively regulates DNA damage checkpoint signalling

The Saccharomyces cerevisiae Sae2 protein promotes resection and bridging of double strand break ends.

The Yku70-Yku80 complex contributes to regulate double-strand break processing and checkpoint activation during the cell cycle

The cellular response to chromosome breakage.

The functions of budding yeast Sae2 in the DNA damage response require Mec1- and Tel1-dependent phosphorylation

The novel DNA damage checkpoint protein ddc1p is phosphorylated periodically during the cell cycle and in response to DNA damage in budding yeast.

The role of shelterin in maintaining telomere integrity

Uncoupling Sae2 Functions in Downregulation of Tel1 and Rad53 Signaling Activities